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Bone mineral metabolism and its relationship to kidney
disease in a residential care home population: a cross-sectional
study/Kemik mineral metobolizmasi ve bobrek hastaligi ile
iliskisi.
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| Abstract: | In 188 residents not receiving vitamin D/calcium [mean age 85 (range 68- 100) years, 75% female] and in 52 residents receiving vitamin D/calcium, in the former, median PTH increased with declining GFR (P<0.0001), particularly as GFR (mL/min/1.73 m(2)) fell below 45. PTH was suppressed by increasing 25-D, but not 1,25-D (P>0.05) concentration. Nearly all (92%)had 25-D deficiency or insufficiency and this was uninfluenced by kidney function (P>0.05). Concentration of 1,25- D declined with worsening renal function but 1,25-D deficiency was prevalent at all stages of kidney disease, including amongst residents receiving vitamin D/calcium supplementation. Vitamin D deficiency and secondary hyperparathyroidism are common irrespective of renal function. However, as GFR falls below 45, the prevalence of secondary hyperparathyroidism and 1,25-D deficiency increases. |
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| Article Type: | Author abstract |
| Subject: |
Vitamin D deficiency
(Complications and side effects) Calcium, Dietary (Physiological aspects) Kidney diseases (Development and progression) Kidney diseases (Risk factors) |
| Authors: |
Carter, J.L. O'Riordan, S.E. Eaglestone, G.L. Delaney, M.P. Lamb, E.J. |
| Pub Date: | 08/01/2008 |
| Publication: | Name: From the Osteoporosis World Publisher: Galenos Yayincilik Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2008 Galenos Yayincilik ISSN: 1300-9141 |
| Issue: | Date: August, 2008 |
| Product: | Product Code: 2834791 Calcium Supplements; 2819821 Calcium NAICS Code: 325412 Pharmaceutical Preparation Manufacturing; 325188 All Other Basic Inorganic Chemical Manufacturing SIC Code: 2819 Industrial inorganic chemicals, not elsewhere classified; 2834 Pharmaceutical preparations |
| Accession Number: | 195755868 |
| Full Text: |
Carter JL, O'Riordan SE, Eaglestone GL, Delaney MP, Lamb EJ Nephrol Dial Transplant 2008, (Epub ahead of print] |
| Gale Copyright: | Copyright 2008 Gale, Cengage Learning. All rights reserved. |