Bone mineral metabolism and its relationship to kidney disease in a residential care home population: a cross-sectional study/Kemik mineral metobolizmasi ve bobrek hastaligi ile iliskisi.
Abstract: In 188 residents not receiving vitamin D/calcium [mean age 85 (range 68- 100) years, 75% female] and in 52 residents receiving vitamin D/calcium, in the former, median PTH increased with declining GFR (P<0.0001), particularly as GFR (mL/min/1.73 m(2)) fell below 45. PTH was suppressed by increasing 25-D, but not 1,25-D (P>0.05) concentration. Nearly all (92%)had 25-D deficiency or insufficiency and this was uninfluenced by kidney function (P>0.05). Concentration of 1,25- D declined with worsening renal function but 1,25-D deficiency was prevalent at all stages of kidney disease, including amongst residents receiving vitamin D/calcium supplementation. Vitamin D deficiency and secondary hyperparathyroidism are common irrespective of renal function. However, as GFR falls below 45, the prevalence of secondary hyperparathyroidism and 1,25-D deficiency increases.
Article Type: Author abstract
Subject: Vitamin D deficiency (Complications and side effects)
Calcium, Dietary (Physiological aspects)
Kidney diseases (Development and progression)
Kidney diseases (Risk factors)
Authors: Carter, J.L.
O'Riordan, S.E.
Eaglestone, G.L.
Delaney, M.P.
Lamb, E.J.
Pub Date: 08/01/2008
Publication: Name: From the Osteoporosis World Publisher: Galenos Yayincilik Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2008 Galenos Yayincilik ISSN: 1300-9141
Issue: Date: August, 2008
Product: Product Code: 2834791 Calcium Supplements; 2819821 Calcium NAICS Code: 325412 Pharmaceutical Preparation Manufacturing; 325188 All Other Basic Inorganic Chemical Manufacturing SIC Code: 2819 Industrial inorganic chemicals, not elsewhere classified; 2834 Pharmaceutical preparations
Accession Number: 195755868
Full Text: Carter JL, O'Riordan SE, Eaglestone GL, Delaney MP, Lamb EJ

Nephrol Dial Transplant 2008, (Epub ahead of print]
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