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Arch Phys Med Rehabil: Nonsteroidal anti-inflammatory
drug or glucosamine reduced pain and improved muscle strength with
resistance training in a randomized controlled trial of knee
osteoarthritis patients.
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| Article Type: | Brief article |
| Subject: |
Osteoarthritis
(Drug therapy) Osteoarthritis (Research) Nonsteroidal anti-inflammatory drugs (Research) Nonsteroidal anti-inflammatory drugs (Health aspects) Weight training (Usage) |
| Authors: |
Petersen, S.G. Beyer, N. Hansen, M. |
| Pub Date: | 12/01/2011 |
| Publication: | Name: Alternative Medicine Review Publisher: Thorne Research Inc. Audience: Academic; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2011 Thorne Research Inc. ISSN: 1089-5159 |
| Issue: | Date: Dec, 2011 Source Volume: 16 Source Issue: 4 |
| Topic: | Event Code: 310 Science & research |
| Geographic: | Geographic Scope: United States Geographic Code: 1USA United States |
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| Accession Number: | 277520410 |
| Full Text: |
OBJECTIVES: To investigate the effect of 12 weeks of strength
training in combination with a nonsteroidal anti- inflammatory drug
(NSAID), glucosamine, or placebo on muscle cross-sectional area (CSA),
strength (primary outcome parameters), and function, power, pain, and
satellite cell number (secondary outcome parameters) in patients with
knee osteoarthritis (OA). DESIGN: Double- blinded, randomized controlled
trial. SETTING: Hospital. PARTICIPANTS: Patients (N=36; 20 women, 16
men; age range, 50-70y) with bilateral tibiofemoral knee OA. A total of
181 patients were approached, and 145 were excluded. INTERVENTIONS:
Patients were randomly assigned to treatment with the NSAID ibuprofen
(n=12), glucosamine (n=12), or placebo (n=12) during 12 weeks of
quadriceps muscle strength training. MAIN OUTCOME MEASURES: Muscle CSA
and strength. RESULTS: No differences between groups were observed in
gains in muscle CSA. Training combined with ibuprofen increased maximal
isometric strength by an additional .22Nm/kg (95% confidence interval
[CI], .01-.42; P=.04), maximal eccentric muscle strength by .38Nm/kg
(05% CI, .05-.70; P=.02), and eccentric muscle work by .27J/kg (95% CI,
.01-.53; P=.04) in comparison with placebo. Training combined with
glucosamine increased maximal concentric muscle work by an additional
.24J/kg versus placebo (95% CI, .06-.42; P=.01). CONCLUSIONS: In
patients with knee OA, NSAID or glucosamine administration during a
12-week strength- training program did not improve muscle mass gain, but
improved maximal muscle strength gain in comparison with treatment with
placebo. However, we do not find that the benefits are large enough to
justify taking NSAIDs or glucosamine. PMID: 21807137 2011;92:1185-1893. |
| Gale Copyright: | Copyright 2011 Gale, Cengage Learning. All rights reserved. |