Antimicrobial and anti-inflammatory activity against P. acnes.
Article Type: Report
Subject: Acne (Care and treatment)
Medicine, Botanic (Research)
Medicine, Herbal (Research)
Materia medica, Vegetable (Health aspects)
Plant extracts (Health aspects)
Inflammation (Health aspects)
Author: Finney-Brown, Tessa
Pub Date: 06/22/2010
Publication: Name: Australian Journal of Medical Herbalism Publisher: National Herbalists Association of Australia Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 National Herbalists Association of Australia ISSN: 1033-8330
Issue: Date: Summer, 2010 Source Volume: 22 Source Issue: 2
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: Australia Geographic Code: 8AUST Australia
Accession Number: 232178429
Full Text: Tsai T, Tsai T, Wu W, Tseng J, Tsai P. 2010. In vitro antimicrobial and anti-inflammatory effects of herbs against Propionibacterium acnes. FoodChem 119:3;964-8.

Acne is a skin condition involving the pilosebaceous follicles. Whilst the etiogenesis of the condition is multifactorial, the bacterium Propionibacterium acnes plays an important role in the formation of comedones and via the induction of inflammatory cytokines from monocytes. These cytokines include interleukins (IL) 1p and IL8 as well as tumour necrosis factor alpha (TNF-[alpha]). Knowledge of this role has lead to the use of conventional antibiotic agents (both topical and systemic) and anti-inflammatories in the treatment of acne.

A number of herbal medicines have proven antimicrobial and anti-inflammatory activity and may be valid alternatives to drug treatment for this condition. The current study was undertaken to assess the efficacy of several herbal extracts on reducing the inflammatory reactions specifically incited by P. acnes. They were assessed for their ability to inhibit the growth of this bacterium and for their anti-inflammatory effects.

The dried herbs assessed were juhua (Chrysanthemum morifolium), honeysuckle (Lonicera japonica), jasmine (Jasminum sambac), lavender (Lavandula angustifolia), rose (Rosa damascene), osmanthus (Osmanthus fragrans), duzhong (Eucommia ulmoides), jiaogulan (Gynostemmapentaphyllum), lemongrass (Cymbopogon citrates), and yerba mate (Ilexparaguariensis), many of which are popular teas in a number of Asian countries. The herbs were ground up and extracted with methanol in a series of steps. They were tested against P. acnes by determining the minimum inhibitory concentration (MIC), defined as the lowered concentration of a test compound which inhibited the growth of P. acnes. Inflammation was assessed by stimulation of cytokines from isolated human monocytic THP-1 cells both alone or in combination with different concentrations of herbal extracts.

The herbs which demonstrated the most notable antimicrobial activity against P. acnes were Eucommia ulmoides, Ilex paraguariensis and Rosa damascene in that order. All three of these also inhibited TNF-a in dose dependent manners and duzhong and yerba mate also inhibited IL-8 production. The results of this study suggest that duzhong and yerba mate may be useful in the treatment of acne, perhaps in a topical application. Further study is required to assess the active constituents and possible mechanisms of action.

Tessa Finney-Brown mnhaa
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