Anticancer mechanism of tomatoes revealed.
Article Type: Brief article
Subject: Lycopene (Health aspects)
Tomatoes (Health aspects)
Cancer (Care and treatment)
Cancer (Patient outcomes)
Cancer (Methods)
Authors: Klatz, Ronald
Goldman, Robert
Pub Date: 08/01/2012
Publication: Name: Townsend Letter Publisher: The Townsend Letter Group Audience: General; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 The Townsend Letter Group ISSN: 1940-5464
Issue: Date: August-Sept, 2012 Source Issue: 349-350
Product: Product Code: 8000432 Cancer Therapy; 0160200 Tomatoes NAICS Code: 621 Ambulatory Health Care Services; 111219 Other Vegetable (except Potato) and Melon Farming SIC Code: 0161 Vegetables and melons
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 303012880
Full Text: Tomatoes are rich in lycopene, a carotenoid compound with potent antioxidant properties. In that cancer cells employ the mechanism known as angiogenesis to connect to the body's blood supply, Mridula Chopra and colleagues from the University of Portsmouth (UK) observed that lycopene disabled the angiogenic ability of cancer cells. Writing, "The anti-angiogenic effects of lycopene in the present study were shown at a concentration that should be achievable by dietary means," the study authors conclude, "These results extend our knowledge of one of the putative anti-cancer actions of lycopene."

Elgass 5, Cooper A, Chopra M. Lycopene inhibits angiogenesis in human umbilical vein endothelial cells and rat aortic rings. Br J Nutr. 2011 Dec 6:1-9.

by Ronald Klatz, MD, DO, and Robert Goldman, MD, PhD, DO, FAASP

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