Am J Vet Res.: Effects of butorphanol on the minimum anesthetic concentration for sevoflurane in guineafowl (Numida meleagris).
Article Type: Reprint
Subject: Butorphanol (Dosage and administration)
Sevoflurane (Dosage and administration)
Guineafowl (Drug therapy)
Pub Date: 06/01/2012
Publication: Name: Journal of Avian Medicine and Surgery Publisher: Association of Avian Veterinarians Audience: Academic Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2012 Association of Avian Veterinarians ISSN: 1082-6742
Issue: Date: June, 2012 Source Volume: 26 Source Issue: 2
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 298292718
Full Text: Effects of butorphanol on the minimum anesthetic concentration for sevoflurane in guineafowl (Numida meleagris). Escobar A, Valadao CAA, Brosnan RJ, et al. Am J Vet Res. 2012;73:183-188.

The objective was to determine the minimum anesthetic concentration (MAC) for sevoflurane and measure the dose and temporal effects of butorphanol on the MAC for sevoflurane in guineafowl. Ten healthy adult guineafowl were used. Each bird was anesthetized with sevoflurane, and a standard bracketing method was used to measure the MAC in response to a noxious electrical stimulus. Subsequently, conditions were adjusted so that each bird was anesthetized with sevoflurane at a fraction of its respective MAC (eg, 0.7 times the MAC for that bird). Butorphanol tartrate (2 mg/kg IV) was administered, and a noxious stimulus was applied every 15 minutes until the bird moved in response. The reduction in MAC was estimated with logistic regression by use of a standard quantal method. After an interval of [greater than or equal to] 1 week, the MAC reduction experiment was repeated with an increased butorphanol dosage (4 mg/kg). Individual mean [+ or -] standard error MAC for sevoflurane was 2.9% [+ or -] 0.1%. At 15 minutes after administration of 2 mg/kg of butorphanol, estimated reduction in the MAC for sevoflurane was 9% [+ or -] 3%. At 15 and 30 minutes after administration of 4 mg/kg of butorphanol, estimated reduction in the MAC for sevoflurane was 21% [+ or -] 4% and 11% [+ or -] 8%, respectively. In guineafowl, the MAC for sevoflurane was similar to values reported for other species. Increasing the butorphanol dosage decreased the MAC for sevoflurane, but the effect was small and of short duration for dosages up to 4 mg/kg.

Escobar A, Valadao CAA, Brosnan RJ, et al.
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