Am J Clin Nutr: L-arginine supplementation improves exercise capacity after a heart transplant.
Article Type: Brief article
Subject: Arginine (Health aspects)
Arginine (Research)
Exercise (Health aspects)
Exercise (Research)
Blood circulation disorders (Risk factors)
Blood circulation disorders (Research)
Heart (Transplantation)
Heart (Complications and side effects)
Heart (Research)
Authors: Doutreleau, S.
Rouyer, O.
Di Marco, P.
Pub Date: 06/01/2010
Publication: Name: Alternative Medicine Review Publisher: Thorne Research Inc. Audience: Academic; Professional Format: Magazine/Journal Subject: Health Copyright: COPYRIGHT 2010 Thorne Research Inc. ISSN: 1089-5159
Issue: Date: June, 2010 Source Volume: 15 Source Issue: 2
Topic: Event Code: 310 Science & research
Geographic: Geographic Scope: United States Geographic Code: 1USA United States
Accession Number: 232175349
Full Text: BACKGROUND: Endothelial dysfunction is associated with the decreased exercise capacity observed in heart-transplant (HTx) recipients. L-arginine supplementation (LAS) stimulates the nitric oxide (NO) pathway and restores endothelial function. OBJECTIVE: We compared exercise capacity in healthy subjects and HTx patients and investigated whether chronic LAS might improve exercise capacity and NO/endothelin balance after an HTx. DESIGN: Clinical, echocardiographic, and exercise characteristics were measured in 11 control subjects and 22 HTx recipients. In a prospective, double-blind study, the 22 HTx recipients performed a 6-min exercise [6-min-walk test (6MWT)] and a maximal bicycle exercise test before and after a 6-wk period of placebo intake or LAS. Endothelial function was measured by analyzing blood NO metabolites, endothelin, and the resulting NO/endothelin balance. RESULTS: Exercise capacity decreased after transplantation. Unlike with the placebo intake, a 6-wk LAS improved quality of life in HTx recipients (mean [+ or -] SEM Minnesota Score: from 15.3 [+ or -] 1.3 to 10.6 [+ or -] 1.1; p< 0.001) and their submaximal exercise capacity. The distance walked during the 6MWT increased (from 525 [+ o r -] 20 to 580 [+ or -] 20 m; p=0.002), and the ventilatory threshold during the incremental test was delayed by 1.2 min (p=0.01). Central factors such as resting stroke volume, systolic pulmonary arterial pressure, cardiac systolodiastolic functions, and heart-rate reserve were not modified, but LAS significantly increased the NO:endothelin ratio (from 2.49 [+ or -] 0.38 to 3.31 [+ or -] 0.39; p=0.03). CONCLUSION: Oral LAS may be a useful adjuvant therapeutic to improve quality of life and exercise tolerance in HTx recipients.

2010 Mar 3. [Epub ahead of print]
Gale Copyright: Copyright 2010 Gale, Cengage Learning. All rights reserved.