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Momeni Shima S aDepartment of Pharmaceutical Biosciences, Section of Neuropharmacology, Addiction and Behaviour bDepartment of Surgical Sciences, Section of Forensic Medicine, Uppsala University, Uppsala, - - 2014
Some personality traits and comorbid psychiatric diseases are linked to a propensity for excessive alcohol drinking. The objective of this study was to investigate the association between individual differences in risk-related behaviors, voluntary alcohol intake and preference. Outbred male Wistar rats were tested in a novel open field, followed by ...
Burne Thomas H J TH aQueensland Brain Institute bDiscipline of Psychiatry, The University of Queensland, Brisbane cQueensland Centre for Mental Health Research, Wacol, Queensland, - - 2014
Developmental vitamin D (DVD) deficiency has been proposed as a risk factor for schizophrenia. DVD-deficient rats show selective cognitive deficits and novelty-induced hyperlocomotion and enhanced locomotor responses from acute treatment with psychomimetic drugs, such as amphetamine and MK-801. Here we aimed to examine the effect of a drug from a ...
Sadek Bassem B aDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates bDepartment of Technology and Biotechnology of Drugs, Medical College, Faculty of Pharmacy, Jagiellonian University, Kraków, Poland cInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine University, Düsseldorf, - - 2014
To determine the potential of histamine H3 receptor (H3R) ligands as new antiepileptic drugs (AEDs), aromatic ether, and diether derivatives (1-12) belonging to the nonimidazole class of ligands, with high in-vitro binding affinity at human H3R, were tested for their in-vivo anticonvulsive activity in the maximal electroshock (MES)-induced and pentylenetetrazole ...
Noto Davide D Dipartimento Biomedico di Medicina Interna e Specialistica, Università degli Studi di Palermo, Palermo, Italy, - - 2014
Statins are the first-line therapy in LDL-Cholesterol (LDL-C) reduction and its clinical use has contributed to significant prevention and treatment of atherosclerotic vascular disease. Yet, a significant proportion of patients remain at high risk. Recently, a number of new therapies have been developed to further lower LDL-C. These agents may ...
McIntyre H David HD University of Queensland, Mater Medical Research Institute Level 3, South Brisbane, Queensland, Australia, - - 2014
The International Association of Diabetes in Pregnancy Study Groups (IADPSG) recommended a new protocol of 1-step testing with a 75 g oral glucose tolerance test for gestational diabetes in 2010. Since that time, these recommendations have been carefully scrutinized and accepted by a variety of organizations, but challenged or rejected by ...
Brown Jubilee J Department of Gynecologic Oncology and Reproductive Sciences, The University of Texas M.D. Anderson Cancer Center, 1155 Herman Pressler Blvd, Unit 1362, P.O. Box 301439, Houston, TX, 77030-1439, USA, - - 2014
Mucinous tumors of the ovary represent a spectrum of neoplastic disorders, including benign mucinous cystadenoma, pseudomyxoma peritonei, mucinous tumors of low malignant potential (borderline), and invasive mucinous ovarian carcinoma. These tumors are related closely to each other and are distinct from other histologic subtypes of epithelial ovarian neoplasms from a ...
Tominaga Takako T *Radiation Emergency Medical Assistance Team (REMAT), National Institution of Radiological Sciences (NIRS), Chiba, - - 2014
A huge earthquake struck the northeast coast of the main island of Japan on 11 March 2011, triggering a tsunami with more than 10-m-high waves hitting the area. The earthquake was followed by numerous sustained aftershocks. The earthquake and aftershocks left almost 16,000 people dead and more than 2,800 missing ...
Griffiths Nina M NM *Laboratoire de RadioToxicologie, CEA/DSV/iRCM, Bruyères le Châtel, 91297 ARPAJON, - - 2014
There is an important requirement following accidental actinide contamination of wounds to limit the dissemination and retention of such alpha-emitting radionuclides. To reduce wound and systemic contamination, treatment approaches include chelation therapy with or without wound excision. However, it has been hypothesized that wound excision could lead to increased contaminant ...
Koerner John F JF *Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, U.S. Department of Health and Human Services, Washington, DC 20201; †Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD; ‡AAAS Science and Technology Policy Fellow, Washington - - 2014
Effective decision making during a rapidly evolving emergency such as a radiological or nuclear incident requires timely interim decisions and communications from onsite decision makers while further data processing, consultation, and review are ongoing by reachback experts. The authors have recently proposed a medical decision model for use during a ...
Leitgeb Norbert N *Institute of Health Care Engineering with European Notified Body of Medical Devices, Graz University of Technology, Kopernikusgasse 24, 8010 Graz, - - 2014
The debate on potential health hazards associated with delivering electric discharges to incapacitated subjects, in particular on whether electric discharge weapons are lethal, less lethal or non-lethal, is still controversial. The cardiac fibrillation risks of Taser weapons X26 and X3 have been investigated by measuring the delivered high-tension pulses in ...
Goulko Guennadi G * Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Neuherbergstr. 11, 80937 Munich, - - 2014
The release of radioactive material due to accidents or terroristic actions can result in radioactive contamination of the environment and may lead to intake and incorporation of radionuclides with the consequence of prolonged radiation exposure. In this case, a decision about countermeasures must be carried out as soon as possible ...
Abend Michael M *Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, Germany; †Southern Urals Biophysics Institute (SUBI), Russian Federation; ‡Bundeswehr Medical Office, Department IX 1, CBRN Med Defence, Munich, Germany; §Research Unit of Radiation Cytogenetics, Integrative Biology Group, Helmholtz Center, Munich, - - 2014
The authors evaluated gene expression in the peripheral blood in relation to occupational exposure in Mayak workers to find out about the existence of a permanent post exposure signature. Workers were exposed to combined incorporated Pu and external gamma rays (n = 82) or to external gamma rays only (n ...
Osovets Sergey V SV *Southern Urals Biophysics Institute (SUBI), 456780 Ozyorsk, Russian Federation; † Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, - - 2014
Chromosome aberration (translocation) yield was investigated by mFISH in peripheral blood lymphocytes of Mayak Production Association (PA) workers with prolonged occupational exposure to ionizing radiation (IR). A dose threshold for cytogenetic indication of a prolonged occupational radiation exposure was estimated for Mayak PA workers using functions of dose distributions. Two ...
Drouet Michel M *Institut de Recherche Biomédicale des Armées, Department of Radiobiology, BP73, 91223, Brétigny sur Orge, - - 2014
Acute radiation syndrome represents the clinical response of radiation-sensitive key tissues (i.e., hematopoietic, gastrointestinal and neurovascular) following exposure to high doses of ionizing radiation. In this context, the hematopoietic syndrome remains the first therapeutic challenge. Today, identifying new drugs and developing new strategies to cope with acute radiation syndrome remain ...
Singh Vijay K VK *Armed Forces Radiobiology Research Institute, Bethesda, MD; †Department of Radiation Biology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD; ‡Tech Micro Services, 4417 Maple Avenue, Bethesda, - - 2014
The authors demonstrate the efficacy of a bridging therapy in a preclinical animal model that allows the lymphohematopoietic system of severely immunocompromised individuals exposed to acute, high-dose ionizing irradiation to recover and to survive. CD2F1 mice were irradiated acutely with high doses causing severe, potentially fatal hematopoietic or gastrointestinal injuries ...
Reeves Glen G *Applied Research Associates, Inc., 801 N. Quincy St., Suite 700, Arlington, VA, - - 2014
Depression of hematopoietic elements due to significant levels of whole-body or partial-body irradiation due to radiation-induced suppression of mitosis in the stem and progenitor cells can result in life-threatening injury. Successful administration of intensive care of patients experiencing acute radiation sickness (ARS; also called acute radiation syndrome) is dependent upon ...
Casey-Sawicki Kate K *Department of Radiation Oncology, University of Florida Health Cancer Center, Gainesville, FL; †BioPowerTech, 4734 Bluegrass Pkwy, Tuscaloosa, AL 35406; ‡Department of Pharmaceutics, University of Florida, College of Pharmacy, University of Florida, Gainesville, FL; §DiaCarta, LLC, Hayward, CA - - 2014
The effects of fibroblast growth factors and their potential as broad-spectrum agents to treat and mitigate radiation injury have been studied extensively over the past two decades. This report shows that a peptide mimetic of basic fibroblast growth factor (FGF-P) protects and mitigates against acute radiation syndromes. FGF-P attenuates both ...
Riccobono Diane D *Institut de Recherche Biomédicale des Armées (IRBA), Département des Effets Biologiques des Rayonnements, BP 73, Brétigny sur Orge Cedex, France; †Institut für Radiobiologie der Bundeswehr, Neuherbergstraße 11, 80937 München, - - 2014
Cutaneous radiation syndrome is the delayed consequence of localized skin exposure to high doses of ionizing radiation. Adipocyte derived stem cells injection may improve tissue regeneration through secreted factors. Thus mesenchymal stem cells secretome optimization, using transient transfection, may represent a new strategy to treat this syndrome. Sonic hedgehog, a ...
Kiang Juliann G JG *Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute; † Department of Radiation Biology; ‡ Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, - - 2014
Exposure to ionizing radiation alone (radiation injury, RI) or combined with traumatic tissue injury (radiation combined injury, CI) is a crucial life-threatening factor in nuclear and radiological accidents. It is well documented that RI and CI occur at the molecular, cellular, tissue, and system levels. However, their mechanisms remain largely ...
Moroni Maria M *Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; †Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, MHH, Hannover, Germany; ‡Bundeswehr Institute of Radiobiology affiliated to the University Ulm, Munich, - - 2014
The minipig is emerging as a potential alternative non-rodent animal model. Several biological markers (e.g., blood counts, laboratory parameters, and clinical signs) have been proposed for rapid triage of radiation victims. Here, the authors focus on the significance of bio-indicators for prediction of survivors after irradiation and compare it with ...
Yin Liangjie L *Department of Radiation Oncology, University of Florida Shands Cancer Center, Cancer and Genetics Research Complex, 2033 Mowry Road, Box 103633, Gainesville, FL - - 2014
Electrolyte and nutrient absorption occur in villous epithelial cells. Radiation often results in reduced electrolyte and nutrient absorption, which leads to gastrointestinal toxicity. Therefore, the authors studied: (1) radiation-induced changes in glucose and amino acid absorption across ileal tissues and (2) the effect of amino acid mixtures on absorptive capacity. ...
Hérodin Francis F *Department of Radiobiology, Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France; †Bundeswehr Institute of Radiobiology, Munich, - - 2014
Although less urgent than the physical injuries caused by an unexpected nuclear and radiological (NR) event, radiation damages can be treated more effectively if the intensity and extent of the exposure are evaluated rapidly. In this work, the authors followed within the first 7 d after exposure a few early ...
Swartz Harold M HM *EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth College, Department of Radiology, 48 Lafayette Street, Lebanon, NH, 03766; †Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Neuherbergstrasse 11, 80937 Munich, - - 2014
The aim of this paper is to compare and contrast the needs for biodosimetry for initial triage for military forces and civilian populations when there are radiation exposures that involve potentially a large number of persons. Several differences in the likely scenarios for exposure of military forces include a greater ...
Romm H H *Bundesamt fuer Strahlenschutz (Germany); †Public Health England (United Kingdom); ‡Universitat Autonoma de Barcelona (Spain); §Institut de Radioprotection et de Sûreté Nucleaire (France); **Bundeswehr Institute of Radiobiology affiliated to the University of Ulm (Germany); ††Stockholm University (Sweden); ‡‡Radiation and Nuclear Safety Authority (Finland); §§Institute of Nuclear Chemistry and Technology (Poland); ***University of Ghent - - 2014
Large scale radiological emergencies require high throughput techniques of biological dosimetry for population triage in order to identify individuals indicated for medical treatment. The dicentric assay is the "gold standard" technique for the performance of biological dosimetry, but it is very time consuming and needs well trained scorers. To increase ...
Ossetrova Natalia I NI *Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University of the Health Sciences (USUHS), 8901 Wisconsin Avenue, Bethesda, MD - - 2014
Nuclear accidents or terrorist attacks could expose large numbers of people to ionizing radiation. Early biomarkers of radiation injury will be critical for triage, treatment, and follow-up of such individuals. The authors evaluated the utility of multiple blood biomarkers for early-response assessment of radiation exposure using a murine (CD2F1, males) ...
De Amicis Andrea A *Sezione di Immunologia e Tossicologia, Centro Studi e Ricerche di Sanità e Veterinaria, Via Santo Stefano Rotondo, 4 00184 Roma, - - 2014
In cases of an accidental overexposure to ionizing radiation, it is essential to estimate the individual absorbed dose of a potentially radiation-exposed person. For this purpose, biological dosimetry can be performed to confirm, complement or even replace physical dosimetry when this proves to be unavailable. The most validated biodosimetry techniques ...
Trompier Francois F *Institut de Radioprotection et de Sûreté Nucléaire, IRSN, BP17, 92262 Fontenay-aux-Roses, France; †Hôpital d'Instruction des Armées Percy, Service d'Hématologie, BP 410, 92141 Clamart Cedex, France; ‡Hôpital d'Instruction des Armées Percy, Service de Chirurgie Plastique, BP 410, 92141 Clamart Cedex, France; and §Hôpital d'Instruction des Armées Percy, CTS Jean Julliard, BP 410, 92141 Clamart Cedex, - - 2014
For localized irradiation to hands, in case of sources accidentally handled, it is very difficult to estimate the dose distribution by calculation. Doses may reach several tens of grays, and the dose distribution is usually very heterogeneous. Until recently, doses in such situations could be estimated only by analysis of ...
Gris Georgia G Drug Discovery and Preclinical Development, Esteve, Parc Científic de Barcelona, Barcelona, - - 2014
The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental neuropathic pain, but not in inflammatory pain models. The present study investigated the effect of the intraperitoneal administration of S1RA on the hind paw withdrawal response to thermal and mechanical stimulation following an ...
Ruckdeschel Emily E University of Colorado, Denver ACHD Program, Leprino Office Building, B132, 12401 East 17th Avenue, Room 534, Aurora, CO, 80045, - - 2014
Patients with tetralogy of Fallot (TOF) are living longer than ever because of advances in surgery in childhood since the 1950s. However, surgery in childhood is not a cure and remains only a palliative procedure because almost all patients will require further intervention throughout life. The most common intervention required ...
De Sanctis S S *Sezione di Immunologia e Tossicologia-Centro Studi e Ricerche di Sanità e Veterinaria, Via Santo Stefano Rotondo, 4 00184 Roma, - - 2014
The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is one of the best standardized and validated techniques for individual radiation dose assessment. This method has been proposed as an alternative to the dicentric chromosome assay, which is considered the "gold standard" in biological dosimetry because it requires less time and ...
Kashcheev Valery V VV *Federal State Institution Medical Radiological Research Center of the Russian Ministry of Health, 4 Korolyov str., Obninsk, Kaluga Region, 249036, - - 2014
The current study has two aims: the first is to quantify the difference between radiation risks estimated with the use of organ or effective doses, particularly when planning pediatric and adult computed tomography (CT) examinations. The second aim is to determine the method of calculating organ doses and cancer risk ...
Achterberg E J Marijke EJ aDepartment of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University bDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands cDepartment of Science, Section of Biomedical Sciences and Technologies, University 'Roma Tre', Rome, - - 2014
Reconsolidation is the process whereby consolidated memories are destabilized upon retrieval and restabilized to persist for later use. Although the neurobiology of the reconsolidation of both appetitive and aversive memories has been intensively investigated, reconsolidation of memories of physiologically relevant social rewards has received little attention. Social play, the most ...
Schroeder Stephen R SR University of - - 2014
Severe problem behaviors, like aggression, self-injury, and repetitive behaviors, in people with intellectual and developmental disabilities often appear during early development and may persist without early intervention. The frequencies of self-injurious behavior, aggression, tantrums, property destruction and stereotyped behavior among 17 infants and toddlers at risk for developmental delays and ...
Lewis Jamal S JS J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL - - 2014
Microparticulate systems are beginning to show promise for delivery of modulatory agents for immunotherapeutic applications which modulate dendritic cell (DC) functions. Co-administration of multiple factors is an emerging theme in immune modulation which may prove beneficial in this setting. Herein, we demonstrate that localized, controlled delivery of multiple factors can ...
Ravikumar Madhumitha M Case Western Reserve University, Department of Biomedical Engineering, 2071 Martin Luther King Jr. Drive, Wickenden Building, Cleveland, OH, 44106, - - 2014
A major limitation to the use of microelectrode technologies in both research and clinical applications is our inability to consistently record high quality neural signals. There is increasing evidence that recording instability is linked, in part, to neuroinflammation. A number of factors including extravasated blood products and macrophage released soluble ...
Benedek Pálma P Heim Pál Gyermekkórház Fül-orr-gégészeti és Bronchológiai Osztály Budapest Üllői út. 86. - - 2014
Treatment of pediatric obstructive sleep apnea syndrome is surgical. The incidence of postoperative respiratory complications in this population is 5-25%. The aim of the authors was to present the preoperative evaluation and monitoring procedure elaborated in Heim Pál Children Hospital, Budapest. 142 patients were involved in the study. Patient history ...
Sideris Michail M Department of Colorectal Surgery, Hambleden Wing, 3rd Floor, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, U.K. - - 2014
Colorectal cancer (CRC) is the second leading cause of cancer-related death. Despite the progress that has been made towards the identification of the molecular mechanisms involved in CRC, currently there are many unclear points. The current opinion is that microsatellite instability (MSI), CpG island methylator phenotype (CIMP) and chromosomal instability ...
Syrios John J Medical Oncologist, 6A Samou Street, 15344 Gerakas, Attiki, Greece. - - 2014
Ovarian cancer is the most frequent cause of death from gynaecological malignancy in the Western countries, and differences in outcome among different histological subtypes are being increasingly recognized. It is generally considered as chemosensitive, but resistant clones evolve in the majority of cases, at varying rates. In this brief review, ...
Lasithiotakis Konstantinos K Professor of Surgical Oncology, Department of Surgical Oncology, University Hospital of Heraklion, Medical Department, University of Crete, Greece. - - 2014
Aim: Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life. A systematic review of the literature from 1980 ...
Gebauer Niklas N Institut für Pathologie, Referenzzentrum für Lymphknotendiagnostik und Hämatopathologie, Universität zu Lübeck, 23538 Lübeck, Deutschland. - - 2014
MicroRNAs are regulators of gene expression implicated in vital cellular processes including differentiation, cell growth and apoptosis. Distinct microRNA signatures have been identified for many malignancies including follicular lymphoma (FL). However, no microRNA expression profile characteristic of FL subtypes, e.g. FL with B-cell lymphoma-6 (BCL6) locus rearrangement (FL(BCL2+/BCL6+), FL(BCL2-/BCL6+)) or ...
Song Yong Sub YS Department of Radiology, Seoul National University Hospital, 101, Daehangno, Jongno-gu, Seoul 110-744, Korea. - - 2014
Aim: To determine the reproducibility of histogram and texture parameters derived from intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) of FN13762 rat breast carcinomas. IVIM diffusion-weighted MRI was performed twice, nine days after tumor implantation in 11 rats. At each session, histogram and texture parameters of entire tumors ...
Alegre Melissa M MM Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, 84602, U.S.A. - - 2014
Thymidine kinase 1 (TK1) is a biomarker elevated in several malignancies, including lung cancer. Up-regulation of TK1 is an early event in carcinogenesis and therefore a target for early cancer detection. We have developed a novel Enzyme Linked Immunosorbent Assay (ELISA) to detect TK1 in serum. Forty patients with pulmonary ...
Imaoka Tatsuhiko T 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. - - 2014
Background/Aim: NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells. Public microarray data were used to analyze gene expression in human and rat breast ...
Minafra Luigi L Contrada Pietrapollastra-Pisciotto, 90015-Cefalù, PA, Italy. luigi.minafra@ibfm.cnr.it, - - 2014
Background/Aim: Epithelial-mesenchymal transition (EMT) is a process co-opted by cancer cells to invade and form metastases. In the present study we analyzed gene expression profiles of primary breast cancer cells in culture in order to highlight genes related to EMT. Microarray expression analysis of primary cells isolated from a specimen ...
Jia Shuqin S Department of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China. E-mail: Jiashuqin2001@gmail.com or Wen G. Jiang, Cardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K. - - 2014
WAVE2 plays a crucial role in actin polymerisation and cell migration. We aimed to investigate the expression and cellular functions of WAVE2 in human gastric cancer (GC). The level of WAVE2 was determined using quantitative PCR (Q-PCR) in a cohort of human gastric tissues. Expression of WAVE2, ARP2, NWASP, ROCK1 ...
Trendowski Matthew M Department of Biology, Syracuse University, 107 College Place; Syracuse, NY 13244, U.S.A. - - 2014
Background/Aim: Sonodynamic therapy (SDT) is a form of ultrasound therapy in which chemotherapeutic agents known as sonosensitizers are administered to increase the efficacy of ultrasound's preferential damage to neoplastic cells. Perhaps one of the most intriguing capabilities of ultrasound is its ability to preferentially lyse cells based on size. Cytochalasin ...
Murakami Sae S Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. - - 2014
Intraductal papillary neoplasm of the bile duct (IPNB) is a novel and increasingly-occurring disease. Its characteristics remain uncertain because of the lack of an in vitro culture system. We established and characterized a novel cell line from a human IPNB. We obtained tumor tissue from a surgical specimen from a ...
DE Oliveira Joana T JT Institute of Molecular Pathology and Immunology of the, University of Porto, Porto, Portugal and Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal. - - 2014
Galectin-1 and galectin-3 are carbohydrate-binding proteins that have been implicated in the pathobiology of several types of cancer. The aim of the present study was to investigate the expression pattern of both these galectins in canine non-neoplastic mammary tissues and mammary tumors (CMT). Protein and mRNA expression of galectin-1 and ...
Cheng Tsu-Yao TY Laboratory of Molecular and Cellular Toxicology, Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen Ai Road, Taipei 10051, Taiwan, R.O.C. - - 2014
Formyl peptide receptor 1 (FPR1) as a regulator of innate inflammatory response has been implicated in tumor progression of gliomas. The purpose of the present study was to evaluate the prognostic significance and the ligand-receptor interaction of FPR1 in gastric cancer (GC). FPR1 was immunohistochemically-analyzed in tissue sections originating from ...
Ruanghirun Thidarat T Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences and Cell-based Drug and Health Product Development Research Unit, Chulalongkorn University, Bangkok, 10330 Thailand. - - 2014
A human steroid hormone, ouabain, has been shown to play a role in several types of cancer cell behavior; however, its effects on cancer metastasis are largely unknown. Herein, we demonstrate that sub-toxic concentrations of ouabain facilitate cancer cell detachment from the extracellular matrix in human lung cancer cells. Ouabain ...
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