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Tertipis Nikolaos N Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01 Karolinska University Hospital, 171 76 Stockholm, Sweden. - - 2014
Background/Aim: Patients with human papillomavirus (HPV)-positive tonsillar and base of tongue cancer have a better outcome than those with corresponding HPV-negative tumors (80% vs. 40% 5-year disease free survival with conventional radiotherapy). They should not all need chemoradiotherapy, but before tapering treatment, more markers are needed to predict treatment response. ...
Jeong Jae-Uk JU Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, 322 Seoyong-ro, Hwasun-eup, Hwasun-gun, Jeollanam-do 519-763, South Korea. - - 2014
Aim: We evaluated the relationship of early metabolic responses on (18)F-fluorodeoxyglucose-positron-emission tomography/computed tomography (PET/CT) performed within one month after concurrent chemoradiotherapy (CCRT) with local tumor control and survival in patients with advanced stage III non-small cell lung cancer (NSCLC). One hundred and nineteen patients with unresectable stage III NSCLC who ...
Lin Hsin-Lan HL Department of Nursing, Chi Mei Medical Center, Liouying, Tainan, Taiwan; Department of Nursing, Min-Hwei College of Health Care Management, Tainan, - - 2014
Oral care is an important component of the ventilator bundle; however, few studies have investigated the factors related to compliance with performing oral care among critical care nurses. In this observational study of 759 oral care opportunities performed by 133 critical care nurses, we found that the overall oral care ...
Reiss David D Yale Child Study Center, Yale - - 2014
In this special section, 9 studies and 6 commentaries make a unique contribution to the study of personality. They focus on the five-factor model and, in particular, one of those 5: conscientiousness. This trait has had astonishing success in the actuarial prediction of adaptive outcomes in adulthood and aging, but ...
Fearon Jeffrey A JA Dallas, Texas From The Craniofacial - - 2014
After studying this article, the participant should be able to: (1) Make the appropriate diagnosis for each of the single-sutural synostoses, based on the physical examination. (2) Explain the functional concerns associated with these synostoses and why surgical correction is indicated. (3) Distinguish between the different types of surgical corrections ...
Nault Marie-Lyne ML *Research Center, Sainte-Justine University Hospital Center, Montreal, Quebec, Canada †Department of Surgery, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada; and ‡Departement de genie de la production automatisee, Ecole de technologie superieure, Montreal, Quebec, - - 2014
This is a prospective case-control study. The objective of this study was to compare 3-dimensional (3D) morphological parameters of the spine at the first visit between a nonprogressive (NP) and a progressive (P) group of immature adolescent idiopathic scoliosis (AIS). Prediction of curve progression remains challenging in AIS at the ...
Arnes Marit M Department of Clinical Pathology, University Hospital of North Norway, N-9038 Tromsø, and Research group for Gynaecologic Cancer, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, N-9037 Tromsø, Norway. - - 2014
The main objective was to investigate if occurrence of hyperplastic polyps was reduced by use of the levonorgestrel-impregnated intrauterine system (LNG-IUS, Mirena®; Bayer) and if the LNG-IUS was more effective compared to oral medroxyprogesterone acetate (MPA) or observation-only. Patients (N=59) with hyperplastic polyps were given LNG-IUS, 10 mg oral MPA ...
Rowe Ian I Department of Biology, 2 Department of Chemistry and Biochemistry, and 3 Maryland Biophysics Program, University of Maryland, College Park, MD - - 2014
Cells actively regulate the macromolecular excluded volume of the cytoplasm to maintain the reciprocal fraction of free aqueous solution that is optimal for intracellular processes. However, the mechanisms whereby cells sense this critical parameter remain unclear. The mechanosensitive channel of small conductance (MscS channel), which is the major regulator of ...
Ito Akira A Department of Motor Function Analysis, Human Health Sciences, Graduate School of Medicine, Kyoto University , Kyoto - - 2014
Abstract Purpose: The purpose of this study was to identify reference genes showing stable expression in chondrocytes cultured under several different thermal environments and in different culture systems. Materials and methods: Human articular chondrocytes were cultured by monolayer or pellet culture system at 32 °C, 37 °C, and 41 °C for 3 days. ...
Sági Veronika V Zala Megyei Kórház Belgyógyászati Osztály Zalaegerszeg Zrínyi M. u. 1. - - 2014
The antitumour effect of statins has already been proven in animal experiments and human cancer cell lines in several gastrointestinal cancers. The chemopreventive mechanism is not completely clarified but the enhancement of oxidative stress, increased autophagy, altered expression of pro- and antiproliferative proteins and their influence on intracellular signaling pathways ...
Hou Ming-Mo MM Department of Investigational Cancer Therapeutics, Unit 0455, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A. - - 2014
We evaluated clinical outcomes of patients with metastatic cervical cancer referred to a Phase I Clinical Trials Program. We reviewed the electronic medical records of 54 consecutive phase I patients with metastatic cervical cancer over 6.5 years and analyzed the correlation between clinical outcome and potential predictors. All patients had ...
Rades Dirk D Department of Radiation Oncology, University of Lübeck, Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. - - 2014
Background/Aim: In patients irradiated for MSCC from NSCLC, the number of extraspinal organs involved by metastases was investigated for associations with survival. The data of 131 patients irradiated with 10×3 Gy in two weeks for MSCC were evaluated. The number of involved extraspinal organs plus eight other factors were retrospectively ...
Barnes Sue S Infection Prevention and Control, Quality and Safety Department, Program Office, Kaiser Permanente, Oakland, - - 2014
Surgical wound irrigation has long been debated as a potentially critical intraoperative measure taken to prevent the development of surgical site infection (SSI). Unlike many other SSI prevention efforts, there are no official practice guidelines or recommendations from any major medical group for the practice of surgical irrigation. As a ...
Eaton Charles C Jupiter, Fla. From The Hand - - 2014
After studying this article, the participant should be able to: (1) Describe features and clinical importance of Dupuytren diathesis. (2) Explain the difference between the new definition of recurrence used in collagenase studies compared with prior definitions of recurrence. (3) Compare and list the main advantage/main disadvantage of fasciectomy versus ...
Kim Jeong Tae JT Seoul and Guri, Korea; and Singapore From the Department of Plastic and Reconstructive Surgery, College of Medicine, Hanyang University; the Section of Plastic Reconstructive and Aesthetic Surgery, Department of General Surgery, Tan Tock Seng Hospital; and the Department of Plastic and Reconstructive Surgery, Hanyang University Guri - - 2014
Perineal reconstruction is a challenging prospect. Conventional flap reconstruction often involves the sacrifice of a source artery and muscle, resulting in significant donor morbidity. Perforator flaps sought to overcome this but required tedious dissection. In this article, the authors introduce a new concept in perineal reconstruction using perforator-based island flaps. ...
Song Yong Sub YS Department of Radiology, Seoul National University Hospital, 101, Daehangno, Jongno-gu, Seoul 110-744, Korea. - - 2014
Aim: To determine the reproducibility of histogram and texture parameters derived from intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) of FN13762 rat breast carcinomas. IVIM diffusion-weighted MRI was performed twice, nine days after tumor implantation in 11 rats. At each session, histogram and texture parameters of entire tumors ...
Schwameis Katrin K Department of Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. - - 2014
Gastroesophageal reflux disease (GERD) is a common chronic disease requiring adequate treatment since it represents one major cause of development of Barrett's esophagus and eventually carcinoma. Novel laparoscopic magnetic sphincter augmentation for GERD was evaluated prospectively. A total of 23 patients with GERD underwent minimally invasive implantation of LINX™ Reflux ...
Tinelli Raffaele R Department of Obstetrics and Gynecology, San Bassiano Hospital, Bassano del Grappa, Vicenza, Italy. raffaeletinelli@gmail.com, - - 2014
The aim of the present study was to demonstrate the advantages of laparoscopy versus laparotomy for treatment of extremely obese women with early-stage endometrial cancer. Seventy-five extremely obese patients with Body Mass Index >35 kg/m(2) and clinical stage I endometrial cancer underwent hysterectomy and bilateral salpingo-oophorectomy, and in all cases ...
Nikolakopoulou Adriani A Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, , Ioannina, - - 2014
This section of the journal is aimed at providing the essential information readers should know about the topics that are addressed in the 'Statistics in practice' paper published in the same issue of the journal. This stand-alone section has to be seen as an articulated summary of the main notions ...
Stern Michael D MD Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD - - 2014
The sinoatrial node, whose cells (sinoatrial node cells [SANCs]) generate rhythmic action potentials, is the primary pacemaker of the heart. During diastole, calcium released from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) interacts with membrane currents to control the rate of the heartbeat. This "calcium clock" takes the form ...
Dubé Eve E Institut national de santé publique du Québec, Québec City, Québec, Canada; Centre de recherche du CHU de Québec, Québec City, Québec, Canada. Electronic address: - - 2014
A decrease in seasonal influenza vaccine uptake was observed after the influenza A(H1N1) pandemic in 2009. The goal of our study was to assess seasonal influenza vaccine uptake in 2011-2012, 2 years after the influenza A(H1N1) pandemic mass immunization campaign and to identify the main reasons for having or not ...
Poulsen S B SB Department of Bioscience, Zoophysiology, Aarhus University, C.F.Møllers Allé 3, DK-8000, Aarhus C, - - 2014
Using rainbow trout Oncorhynchus mykiss, the present study demonstrated that: (1) calcium (Ca) increased the range of copper (Cu) concentrations that O. mykiss avoided; (2) Ca conserved the maintenance of pre-exposure swimming activity during inescapable acute (10 min) Cu exposure. Data showed that when presented with a choice of Cu-contaminated water ...
Minafra Luigi L Contrada Pietrapollastra-Pisciotto, 90015-Cefalù, PA, Italy. luigi.minafra@ibfm.cnr.it, - - 2014
Background/Aim: Epithelial-mesenchymal transition (EMT) is a process co-opted by cancer cells to invade and form metastases. In the present study we analyzed gene expression profiles of primary breast cancer cells in culture in order to highlight genes related to EMT. Microarray expression analysis of primary cells isolated from a specimen ...
Knox Aaron D C AD Vancouver, British Columbia, Montreal, Quebec, and Toronto, Ontario, Canada; and Ann Arbor, Mich. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of British Columbia; the Division of Plastic and Reconstructive Surgery, Department of Surgery, McGill University Health Center; the Section of Plastic and Reconstructive Surgery, Department of Surgery, University of Michigan; and the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of - - 2014
North American surgical education is beginning to shift toward competency-based medical education, in which trainees complete their training only when competence has been demonstrated through objective milestones. Pressure is mounting to embrace competency-based medical education because of the perception that it provides more transparent standards and increased public accountability. In ...
D┼żombeta Tihana T School of Medicine, University of Zagreb, Šalata 10, 10 000 Zagreb, Croatia. - - 2014
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract, believed to originate from the interstitial cells of Cajal or their stem cell-like precursors. Recent studies incidentally found the expression in interstitial cells of Cajal of the signal-transducing adaptor molecule-2 (STAM2), which is an endosomal protein ...
Lam Tai Hing TH Expert Panel on HIV Infection of Health Care Workers (2009-2012), Hong Kong SAR, China. Electronic address: - - 2014
We report the referral of an HIV-infected surgeon and a subsequent first-ever recommended look-back investigation in Hong Kong. Efficient coordination and effective implementation of the look-back investigation yielded a high response rate of 92.3% of priority patients, with none tested HIV positive. Our experience reconfirmed the very small risk of ...
Iida Tomonori T Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. - - 2014
A 63-year-old woman was admitted to our Hospital for treatment of pancreatic head ductal carcinoma, and underwent pancreaticoduodedectomy (PD) in October 2007. At one month after surgery, she received systemic adjuvant chemotherapy using S-1 for three months. Because the serum carbohydrate antigen 19-9 (CA19-9) value was elevated at 23 months ...
Bobek Vladimir V 3rd Faculty of Medicine Charles University Prague Department of Tumor Biology Ruska 87,100 97 Prague, Czech Republic. - - 2014
Malignant pleural mesothelioma (MPM) is an aggressive disease with very poor prognosis which tends to affect older patients. Progress in the management of this group of patients has been limited by the rarity of the disease and hence, difficulty in conducting randomized trials. The vast majority of cancer deaths occur ...
Cha Chaenyung C Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. Tel: +1-617-388-9271; ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, - - 2014
Hydrogels commonly used in tissue engineering are mechanically soft, thus often display structural weakness. Herein, we introduce a strategy for enhancing the structural integrity and fracture toughness of cell-laden hydrogels by incorporating a three-dimensional (3D) microfabricated scaffold as a structural element. A digital micromirror device projection printing (DMD-PP) system, a ...
Lasithiotakis Konstantinos K Professor of Surgical Oncology, Department of Surgical Oncology, University Hospital of Heraklion, Medical Department, University of Crete, Greece. - - 2014
Aim: Gastrectomy as a primary treatment for patients with metastatic gastric cancer (M1) is highly controversial. Herein, a review of the literature was undertaken with the aim of assessing evidence regarding associated morbidity and mortality, overall survival, palliation and quality of life. A systematic review of the literature from 1980 ...
Manferrari Fabio F Urological Unit of the Infermi Hospital, Viale L. Settembrini 2, 47924 Rimini (RN), Italy. - - 2014
Background/Aim: The Urological Clinic of the S. Orsola-Malpighi University Hospital, Bologna has been carrying out laparoscopic radical prostatectomy since 2002. In this study, we report the results after 10 years of LRP, analyzing in particular the oncological and functional aspects. Between March 2002 and August 2011, 400 patients underwent laparoscopic ...
Drolet Brian C BC Providence, R.I. From the Department of Plastic Surgery, Rhode Island Hospital, and the Warren Alpert Medical School of Brown - - 2014
After studying this article, the participant should be able to: (1) Identify the essential preoperative considerations for patients undergoing blepharoplasty. (2) Describe upper and lower eyelid anatomy and the relevance to blepharoplasty techniques. (3) Discuss a standard approach to upper and lower lid blepharoplasty, beginning with preoperative assessment, planning, and ...
Kim Maxwell Y MY Stanford and Palo Alto, Calif. From the Division of Plastic and Reconstructive Surgery, Stanford University Medical Center; and the Section of Plastic Surgery, VA Palo Alto Health Care - - 2014
Many unsolved problems in plastic and hand surgery are related to poor healing of acute and chronic tendon injuries. The authors hypothesized that tendon healing could be augmented by the addition of a tendon-derived, extracellular matrix hydrogel that would guide tissue regeneration. Both Achilles tendons of 36 Wistar rats were ...
Toribio-Diaz M E ME Hospital de Henares, Coslada, - - 2014
INTRODUCTION. Migraine may present with cranial autonomic symptoms typical of trigeminal-autonomic cephalalgias, thus posing diagnostic difficulties. AIM. To report a series of patients with prominent eyelid oedema associated with migraine. PATIENTS AND METHODS. Ten patients attending the headache offices in three hospitals (nine women, one man; age: 26-53 years-old) with ...
Imaoka Tatsuhiko T 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan. - - 2014
Background/Aim: NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells. Public microarray data were used to analyze gene expression in human and rat breast ...
Pasqual Enrico M EM Department of Surgery, S. Maria della Misericordia Hospital, 33100 Udine, Italy. - - 2014
The present study evaluates the accuracy of computed tomographic (CT) scan and positron emission tomography with (18)F-fluorodeoxyglucose (FDG-PET)/CT for the quantification of peritoneal carcinomatosis (PC) in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Data were retrospectively collected for 58 patients, who were considered for CRS and HIPEC. ...
Chicoli A A Neuroscience and Cognitive Science Program, University of Maryland, College Park, MD, 20742, - - 2014
To assess how flow affects school structure and threat detection, startle response rates of solitary and small groups of giant danio Devario aequipinnatus to visual looming stimuli were compared in flow and no-flow conditions. The instantaneous position and heading of each D. aequipinnatus was extracted from high-speed videos. Behavioural results ...
Jia Shuqin S Department of Surgery, the Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China. E-mail: Jiashuqin2001@gmail.com or Wen G. Jiang, Cardiff University-Peking University Cancer Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, U.K. - - 2014
WAVE2 plays a crucial role in actin polymerisation and cell migration. We aimed to investigate the expression and cellular functions of WAVE2 in human gastric cancer (GC). The level of WAVE2 was determined using quantitative PCR (Q-PCR) in a cohort of human gastric tissues. Expression of WAVE2, ARP2, NWASP, ROCK1 ...
Afeworki Y Y Department of Ocean Ecosystems, University of Groningen, Nijenborgh 7, Groningen, 9747 AG, The Netherlands; Department of Applied Marine Science, College of Marine Science and Technology, P. O. Box 170, Massawa, - - 2014
Temporal trends in growth of the rusty parrotfish Scarus ferrugineus were studied on a southern Red Sea fringing reef that experiences seasonal changes in environmental conditions and benthic algal resources. Length increment data from tagging and recapture were compared among periods and sexes and modelled using GROTAG, a von Bertalanffy ...
Jun Hyo Sub HS Departments of *Neurosurgery and †Orthopedics, Hallym University Sacred Heart Hospital, Anyang, - - 2014
Retrospective study. The purpose of this study was to analyze the relationship of the parameters of cervical sagittal alignment between those obtained from cervical CT and those obtained from radiography, as well as to determine which parameter would help predict physiological lordosis of the cervical spine. Sagittal balance in the ...
Hoch Stephan S Department of Otolaryngology, Head and Neck Surgery, Philipp University, Baldingerstr., 35043 Marburg, Germany. - - 2014
Parotid metastases from cutaneous squamous cell carcinoma (CSCC) are associated with poor prognosis. However, the incidence of occult parotid lymph node metastases in high-risk CSCC is unclear. Therefore, the role of elective parotidectomy is still controversial. The purpose of the present study was to analyze the value of elective parotidectomy ...
Farooq Sameen S Division of Infectious Diseases, Wayne State University, Detroit Medical Center, Detroit, - - 2014
Clinical outcomes of older and younger adults with extended-spectrum β-lactamase-producing Escherichia coli isolation were compared. Two hundred thirty-two older adults (aged ≥65 years), and 145 younger adults with infection were identified between February 2010 and July 2011. After controlling for the propensity score and receipt of effective therapy, older adults ...
Chung Christopher W CW Pittsburgh, Pa. From the University of Pittsburgh School of Medicine; and the Department of Plastic Surgery, University of Pittsburgh Medical - - 2014
Previous studies describe a relationship between pannus mass and panniculectomy-related complication rates. Patient management may be improved by elucidating the key factors influencing pannus formation. A retrospective review was conducted of 135 patients who had undergone laparoscopic Roux-en-Y gastric bypass from 1996 to 2010 and subsequent panniculectomy. Outcome measures included ...
Check Jerome H JH 7447 Old York Road, Melrose Park, PA 19027, U.S.A. - - 2014
Mifepristone, a progesterone receptor antagonist, has been found to provide palliative benefits for various types of spontaneous murine cancer in randomized controlled trials and in anecdotal reports from a variety of advanced metastatic human cancer not known to be associated with progesterone receptors. The theory of its mechanism is that ...
Masui Koji K Department of Radiology, Kyoto Prefectural University of Medicine, 465, Kajiicho, Kamigyou-ku, Kyoto-city, Kyoto-prefecture, 602-8566 Japan. - - 2014
Aim: We report on a minimally invasive computed tomography (CT)/magnetic resonance imaging (MRI)-based image-guided intracavitary brachytherapy (ICBT) for an elder patient with endometrial cancer, who was unfit for anesthesia, using a fine and soft flexible applicator. The patient was an 82-year-old female. She was identified as having T1bN0M0 (stage IB) ...
Thorns Chistoph C Institut für Pathologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. - - 2014
Pancreatic neuroendocrine neoplasms (pNEN) are rare tumors with a poor prognosis. Although increasing data have accumulated on the molecular pathology of pNEN, very scarce data exist on microRNAs in pNEN and no data are published on microRNAs as potential biomarkers of pNEN in serum. This study aimed to identify microRNA ...
Mian Michael M Department of Hematology & Oncology, Medical University of Innsbruck, Austria. - - 2014
Diffuse large B-cell lymphoma (DLBCL) is a rather aggressive disease and the natural course of this lymphoma is very dismal. However, first the introduction of anthracycline-containing chemotherapy regimens and then the addition of rituximab were important steps forward. Since no complete real-life analyses have yet been published, we analyzed all ...
Leeman K T KT 1] Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA [2] Harvard Stem Cell Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA [3] The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, - - 2014
Two siblings with a severe multiorgan polycystic disease presenting in the neonatal period were identified. Their genetic testing identified compound heterozygous NPHP3 gene mutations, parents being heterozygous carriers. The mutations included a splice-site (c.958-2A>G) and a missense mutation (c.2342G>A; p.G781D), both being extremely rare. NPHP3 encodes for nephrocystin 3 present ...
Wang X H XH Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, China; Fisheries College, Jimei University, Xiamen, 361005, - - 2014
A continuous cell line, LYCK, derived from the head kidney of large yellow croaker Pseudosciaena crocea was established and characterized. The LYCK cell line multiplied well in Leibovitz's-15 (L-15) medium supplemented with 10% foetal bovine serum (FBS) at 28° C. This cell line, with a population doubling time of 29·5 h ...
Brown Matthew M Cleveland, Ohio From the Department of Plastic Surgery, Case Western Reserve - - 2014
Enophthalmos is a challenging surgical problem to correct. Standard techniques to adjust orbital volume require invasive maneuvers such as osteotomies. Fat injection may provide a simple and less-invasive way of augmenting orbital volume to correct enophthalmos. The right eye orbital volume of 10 New Zealand White rabbits was augmented with ...
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