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Numan Wouter C M WC Daniel den Hoed Cancer Center, Erasmus Medical Centre , Rotterdam , The Netherlands - - 2014
Abstract Magnetic resonance thermometry (MRT) offers non-invasive temperature imaging and can greatly contribute to the effectiveness of head and neck hyperthermia. We therefore wish to redesign the HYPERcollar head and neck hyperthermia applicator for simultaneous radio frequency (RF) heating and magnetic resonance thermometry. In this work we tested the feasibility ...
Schmitt David P DP Bradley - - 2014
Evolutionary psychologists have hypothesized that humans possess sex-differentiated mate preference adaptations. In the context of long-term mating, men are hypothesized to more strongly prefer cues to youth and fecundity, whereas women are hypothesized to more strongly prefer cues to status-related attributes. Eastwick, Luchies, Finkel, and Hunt (2014) recently asserted that ...
Alberdi-Otazu A - - 2014
INTRODUCTION. Brainstem dysgenesis is a heterogeneous clinical entity, with low incidence and high clinical variability, which affects structures in the brainstem. Diagnosis is based on the combination of symptoms, neuroimaging and neurophysiological studies. AIM. To determine the common clinical features, functional prognosis and rehabilitative treatment needs in a group of ...
Gao Han H Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA. - - 2014
Conventional biological wastewater treatment processes are energy-intensive endeavors that yield little or no recovered resources and often require significant external chemical inputs. However, with embedded energy in both organic carbon and nutrients (N, P), wastewater has the potential for substantial energy recovery from a low-value (or no-value) feedstock. A paradigm ...
Pless Stephan A SA Department of Anesthesiology, Pharmacology and Therapeutics, and 2 Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, - - 2014
Voltage-gated sodium (NaV) channels mediate electrical excitability in animals. Despite strong sequence conservation among the voltage-sensor domains (VSDs) of closely related voltage-gated potassium (KV) and NaV channels, the functional contributions of individual side chains in Nav VSDs remain largely enigmatic. To this end, natural and unnatural side chain substitutions were ...
Michálková V V Institute of Vertebrate Biology, v.v.i., Academy of Sciences of the Czech Republic, Květná 8, 603 65, Brno, Czech Republic; Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czech - - 2014
In this study, the effects of the eye fluke Diplostomum pseudospathaceum (Trematoda) infection on over-winter survival of young-of-the-year (YOY) European bitterling Rhodeus amarus (Cyprinidae) were examined between September 2010 and April 2011. The fish were reared in semi-natural conditions to ensure that results were not confounded by other parasite infections. ...
Ohtakara Kazuhiro K Department of Radiology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan. - - 2014
Aggressive giant invasive pituitary adenomas refractory to standard surgical or medical treatment remain a genuine challenge. In addition, communicating hydrocephalus (CH) attributed to malabsorption of cerebrospinal fluid (CSF) developing after radiotherapy for pituitary adenomas has not been previously reported. Herein, we describe the case of a 48-year-old male presenting with ...
Mackert Michael M Department of Advertising, The University of Texas at Austin, Austin, TX; The University of Texas Health Science Center at Houston School of Public Health, Houston, TX. Electronic address: - - 2014
Two posters were designed to encourage hospital staff hand hygiene. One focused on broad benefits of hand hygiene to patients and staff, and the other highlighted hand hygiene as a long-known measure to infection control. The former was better received in terms of attention, likability, and potential to promote hand ...
Bloom Jacob M P JM Rochester, N.Y. From the Division of Plastic Surgery, Department of Surgery, and the Department of Orthopaedic Surgery and Rehabilitation, University of Rochester Medical - - 2014
After studying this article, the participant should be able to: (1) Determine the need for operative treatment of metacarpal fractures. (2) Describe the position of immobilization for nonoperative treatment of fifth metacarpal fractures. (3) Assess the differences between intramedullary pinning and transverse pinning of displaced metacarpal fractures. (4) Compare the ...
Althubaiti Ghazi G Houston, Texas From the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer - - 2014
After studying this article, the participant should be able to: (1) Define the goals of abdominal wall and chest wall reconstruction. (2) Discuss the general principles of and the different surgical techniques for abdominal wall and chest wall reconstruction. (3) List the major advantages and disadvantages of synthetic and bioprosthetic ...
Chen Jianjun J Department of Pharmaceutical Science, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, TN 38163, U.S.A. - - 2014
Aim: To discover novel [20(OH)D3] analogs as antiproliferative therapeutics. We studied in vitro liver microsome stability, in vivo toxicity using mice, vitamin D receptor (VDR) translocation, in vitro antiproliferative effect, CYP enzyme metabolism. 20S- and 20R(OH)D3 had reasonable half-lives of 50 min and 30 min (average) respectively in liver microsomes. ...
Holdenrieder Stefan S Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Sigmund-Freud Str. 15, 53127 Bonn, Germany. - - 2014
To improve prognosis of patients with colorectal cancer, powerful blood-based biomarkers enabling for early detection are needed. As genome-wide DNA hypomethylation is associated with carcinogenesis, and cell-free DNA, thought to be of tumor origin, is found in the circulation of patients with cancer, we investigated the relevance of 5-methylcytosine-modified DNA ...
Zhao Zhi-Chang ZC Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, Fujian, - - 2014
Carbapenem-resistant Enterobacteriaceae (CRE) is widespread in China. To date, no study available has specifically determined the prevalence and risk factors of inpatients with CRE intestinal colonization in this region. Stool samples were screened for the presence of CRE in a Chinese university hospital. A case-control study was performed to identify ...
Biondani Pamela P Medical Oncology 1, Fondazione IRCCS Istituto Nazionale Tumori Via Venezian 1, 20133 Milan, Italy. - - 2014
Only scanty data are available to evaluate the impact of sequential TKIs on overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). This retrospective study investigated the efficacy of the sequence sorafenib-sunitinib (SO-SU) and vice versa (SU-SO) in a real-life scenario. Median progression free-survival (PFS) and OS were ...
Niazi Azfar Khan AK MBBS, Director, Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine and Tufts Cancer Center, 800 Washington Street, Boston, MA 02111, U.S.A. - - 2014
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract. GISTs originate from cells of Cajal and related stem cells. Surgery and imatinib therapy are the main lines of treatment. We report on a case with GIST in the colon treated with surgical resection followed by ...
Patrick Christopher J CJ Florida State - - 2014
In reviewing this impressive series of articles, I was struck by 2 points in particular: (a) the fact that the empirically oriented articles focused on analyses of data from very large samples, with the articles by Friedman, Kern, Hampson, and Duckworth (2014) and Kern, Hampson, Goldbert, and Friedman (2014) highlighting ...
Ruanghirun Thidarat T Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences and Cell-based Drug and Health Product Development Research Unit, Chulalongkorn University, Bangkok, 10330 Thailand. - - 2014
A human steroid hormone, ouabain, has been shown to play a role in several types of cancer cell behavior; however, its effects on cancer metastasis are largely unknown. Herein, we demonstrate that sub-toxic concentrations of ouabain facilitate cancer cell detachment from the extracellular matrix in human lung cancer cells. Ouabain ...
Snider Karen T KT Department of Osteopathic Manipulative Medicine, A.T. Still University-Kirksville College of Osteopathic Medicine, 800 W Jefferson St, Kirksville, MO 63501-1443. - - 2014
Somatic dysfunction as diagnosed by palpation should be associated with an objective measure. Bone mineral density (BMD) has been shown to be elevated in lumbar vertebrae with somatic dysfunction and in the lumbar region of individuals with chronic low back pain (LBP). To investigate the association of lumbar somatic dysfunction ...
Mroczek Daniel K DK Department of Psychology, Weinberg College of Arts and Sciences, Northwestern - - 2014
This commentary on the special section on conscientiousness and healthy aging focuses on several topics brought up in this collection of articles. One is the promise of personality interventions. Despite skepticism on the part of some, such interventions may ultimately prove successful. This is in part because of similarities between ...
Calvert Jay W JW Beverly Hills, Calif. From the ROX - - 2014
Costal cartilage grafts are used more frequently in secondary rhinoplasty. However, these procedures result in patients that require further revision operations that are not trivial. The purpose of this study was to assess the outcomes of reconstructive rhinoplasty performed on patients with a history of prior secondary or tertiary rhinoplasty ...
Romain Carmelle V CV Department of Pediatric Surgery, 2200 Children's Way, DOT 7100, Vanderbilt University Medical Center, Nashville, TN 37232-9780, U.S.A. - - 2014
It is unknown whether hypoxia regulates aurora kinase A (AURKA), a serine/threonine kinase, in neuroblastoma to stimulate cell growth or migration. We sought to determine whether AURKA mediates hypoxia-induced regulation of neuroblastoma tumorigenicity. Human neuroblastoma BE(2)-C cells were treated with CoCl2, a chemical hypoxia mimetic, and MLN8237, a pharmalogical inhibitor ...
Krikelis Dimitrios D Department of Medical Oncology, Papageorgiou Hospital, Nea Efkarpia Ring Road, PC 564 29, Thessaloniki, Greece. - - 2014
Although Kirsten rat sarcoma (KRAS) gene mutational testing is essential for the optimal design of therapeutic strategies for colorectal cancer, it is not always feasible or reliable. In this retrospective study, we examined whether (18)F-Fluorodeoxyglucose positron-emission tomography/computed tomography ((18)F-FDG PET/CT) scans can serve as a surrogate examination for KRAS mutational ...
Chien Chen-Yen CY Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Surgery, Makay Memorial Hospital, Mackay Medicine, Nursing and Management College, Taipei, - - 2014
Methicillin-resistant Staphylococcus aureus (MRSA) sternal wound infection (SWI) after cardiac surgery is endemic in our hospital. An infection control care bundle with preoperative chlorhexidine showering and povidone iodine paint before bathing was introduced in 2006. From 2001 to 2012, 23 (2.3%) of 1,010 patients undergoing off-pump coronary artery bypass had ...
Spear Scott L SL Washington, D.C. From the Department of Plastic Surgery, Georgetown University - - 2014
Although it is well established that reconstruction of the irradiated breast is associated with diminished cosmetic results and more frequent complications, little is known about the specific effects of radiation therapy on the reconstructive outcomes after nipple-sparing mastectomy. Patients who had nipple-sparing mastectomy and had either previous radiation therapy for ...
Check Jerome H JH 7447 Old York Road, Melrose Park, PA 19027, U.S.A. - - 2014
Mifepristone has been demonstrated to cause palliation from murine and human cancer, even in cancers not known to be positive for expression of progesterone receptors. The aim of the present study was to determine if rapidly advancing chronic lymphocytic leukemia responds to mifepristone therapy, and if so, is this effect ...
Cloutman-Green Elaine E Great Ormond Street Hospital NHS Foundation Trust, Camelia Botnar Laboratories, Department of Microbiology, Virology and Infection Prevention and Control, London, UK. Electronic address: - - 2014
Handwashing is one of the most important means of reducing the spread of infection. In this study, we investigated how sink location and visibility influences handwashing and microbial contamination detected on clinical sinks in 3 pediatric intensive care units. We conclude that the visibility of sinks directly impacts on handwashing ...
Israel Salomon S Department of Psychology and Neuroscience, Duke - - 2014
The articles in this special section bolster the already strong evidence base that personality differences in the trait of conscientiousness predict health. What is now needed is a research agenda for translating documented risk associations between low conscientiousness and poor health into policies and interventions that improve health outcomes for ...
Xiao Zhiyan Z Center of Materials Innovation, and Medical Physics Division, Department of Radiation Oncology, Washington University in St. Louis, 4921 Parkview Place, Campus Box 8224, St. Louis, MO - - 2014
The goal of this work is to understand the physical mechanism behind the signal stabilization process in KCl:Eu(2+), a storage phosphor material that has generated renewed interest due to its potential in radiation therapy dosimetry application. The temperature dependency of the photostimulated luminescence (PSL) spectra and intensity vs. time post ...
Lin Chih-Hsueh CH Terry Fox Cancer Research Lab, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R.O.C. datian@mail.cmuh.org.tw; - - 2014
Gastric cancer is one of the leading causes of tumor-related death worldwide, for which the prevalence and mortality rates are very high in developed countries. Caveolin-1 (Cav-1) is the main protein in the caveolin family and plays a role in tumorigenesis signaling. The contribution of CAV1 genetic variants to gastric ...
Syrios John J Medical Oncologist, 6A Samou Street, 15344 Gerakas, Attiki, Greece. - - 2014
Ovarian cancer is the most frequent cause of death from gynaecological malignancy in the Western countries, and differences in outcome among different histological subtypes are being increasingly recognized. It is generally considered as chemosensitive, but resistant clones evolve in the majority of cases, at varying rates. In this brief review, ...
Kim Joseph J Center for Lung Cancer, National Cancer Center, 323 Ilsanro, Ilsan, Goyang, Gyeonggi, 410-769, Republic of Korea. Tel: +82 319202330, - - 2014
Background/Aim: Distinguishing between primary and metastatic adenocarcinomas in the lung may sometimes be difficult by conventional histopathological methods. In addition, novel biomarkers are needed for the more accurate subtyping of primary lung carcinomas. MicroRNA microarrays were performed on 26 primary lung adenocarcinomas, 3 squamous cell carcinomas, 6 small cell lung ...
Christensen Doran M DM EMT-P, Oak Ridge Institute for Science and Education, 4301 Wilson Blvd, Suite 300, Arlington, VA 22202-1867. - - 2014
In the second of 5 articles on the management of injuries and illnesses caused by ionizing radiation, the authors discuss nontherapeutic radiologic/nuclear incidents: use of a radiologic exposure device, use of a radiologic dispersal device, nuclear power plant safety failure, and detonation of an improvised nuclear device. The present article ...
Bardarson H H Institute of Life and Environmental Sciences, University of Iceland, Sturlugata 7, 101, Reykjavík, - - 2014
Twenty-five Atlantic cod Gadus morhua otoliths were examined using eight shape measurements along with Fourier analysis of their outlines to test whether discrimination using otolith shape is affected by gluing broken otoliths. Small differences in seven of the eight shape measurements were found between unbroken otoliths and the same otoliths ...
Fotinos Anastasios A 185 South Orange Ave., Newark, NJ 07103, U.S.A. - - 2014
High bone morphogenetic protein (BMP)-2 expression in lung carcinoma correlates with poor patient prognosis. The present study explored strategies to repress BMP signaling. The cytotoxicity of BMP2-knockdown, dorsomorphin derivatives, and microRNAs was tested in transformed and non-transformed lung cells. Microarray analyses of 1,145 microRNAs in A549 lung adenocarcinoma cells and ...
Vikhreva Polina N PN DSci, Institute of Gene Biology, Russian Academy of Sciences, Moscow 119334, Russia. - - 2014
Programmed cell death 4 (Pdcd4) is a tumor suppressor frequently lost in tumors of various origins thus contributing to tumor progression. Expression of Pdcd4 in melanoma, however, has not been extensively studied to date. Pdcd4 protein levels were assessed in 23 human melanoma cell lines and in normal melanocytes by ...
Arsov Christian C Department of Urology, Medical Faculty, Heinrich-Heine University, Moorenstr. 5, 40225 Düsseldorf, Germany. - - 2014
Background/Aim: Initial inaccurate staging is a common problem associated with active surveillance (AS) for patients detected by transrectal ultrasound-guided prostate biopsy (TRUS-GB). Subsequently, repeated biopsies are necessary to monitor such patients. Thus, in addition to the already established clinicopathological criteria, there is a considerable demand for new, objective decision criteria ...
Wabler Michele M Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine , Baltimore - - 2014
Abstract Purpose: Magnetic iron oxide nanoparticles (MNPs) are used as contrast agents for magnetic resonance imaging (MRI) and hyperthermia for cancer treatment. The relationship between MRI signal intensity and cellular iron concentration for many new formulations, particularly MNPs having magnetic properties designed for heating in hyperthermia, is lacking. In this ...
Pastor J - - 2014
INTRODUCTION. The traditional surgical approach to treat drug-resistant focal epileptic patients is in the resection or disconnection of the epileptic focus. However, a significant minority of patients continue to experience seizures after surgery, which shows the incomplete level of knowledge that currently we have of this pathology. AIM. This paper ...
Steurer Stefan S Institute of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Bldg. N27, Room 00.008, Martinistr. 52, 20246 Hamburg, Germany. - - 2014
Aim: To identify molecular features associated with clinico-pathological parameters in renal cell cancer. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging was employed for a kidney cancer tissue microarray containing tissue samples from 789 patients for which clinical follow-up data were available. A comparison of mass spectrometric signals with clinico-pathological features ...
Hasty Robert T RT 300 W 27th St, Lumberton, NC 28359-3075 - - 2014
Since its launch in 2001, Wikipedia has become the most popular general reference site on the Internet and a popular source of health care information. To evaluate the accuracy of this resource, the authors compared Wikipedia articles on the most costly medical conditions with standard, evidence-based, peer-reviewed sources. The top ...
Wiemken Timothy L TL Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, KY. Electronic address: - - 2014
It is common practice to define a bacterium with unequal antibiotic susceptibility phenotypes as a different genotype. Here, we describe the utility of this practice for Acinetobacter baumannii. We determined antibiotic susceptibility for 19 clinical isolates of A baumannii. Repetitive sequence polymerase chain reaction method was used to determine genotypes. Although ...
English Tammy T Department of Psychology, Washington University in St. - - 2014
The articles appearing in this special section discuss the role that conscientiousness may play in healthy aging. Growing evidence suggests that conscientious individuals live longer and healthier lives. However, the question remains whether this personality trait can be leveraged to improve long-term health outcomes. We argue that even though it ...
Baines D C DC Department of Geology, University of Leicester, Leicester, LE1 7RH, - - 2014
Tooth microwear feature densities were significantly increased in a population of laboratory-reared three-spined stickleback Gasterosteus aculeatus in four days, after they were transferred from a limnetic feeding regime to a benthic feeding regime. These results show that even in aquatic vertebrates with non-occluding teeth, changes in feeding can cause changes ...
Seretis Fotios F Rectory Road, Sutton Coldfield, B75 7RR, Birmingham, United Kingdom. - - 2014
The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be ...
Bernués Marta M Hospital Universitari Son Espases, Genetics Department, Cra. Valldemossa 79, 07120 Palma de Mallorca, Mallorca, Balearic islands, Spain. - - 2014
Patients affected by chronic lymphocytic leukemia (CLL) have an increased risk of developing a second cancer. There is not a definitive explanation for this phenomenon, although some hypotheses have been postulated. The aim of the present work was to assess the presence of second cancer in untreated patients with CLL ...
Evers Jasmin N JN Department of Radiation Oncology, University of Lübeck, Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. - - 2014
Background/Aim: Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients. A total of 544 elderly patients (aged ≥65 years) receiving whole-brain radiotherapy alone were divided into a test (n=272) and a validation group (n=272). In the multivariate analysis ...
Cerrato Felecia E FE Boston, Mass. From the Department of Plastic and Oral Surgery, Boston Children's Hospital and Harvard Medical - - 2014
Pfeiffer syndrome is characterized by craniosynostosis and a variety of associated upper and lower extremity anomalies. The authors reviewed presentation and treatment of upper extremity anomalies in a series of genotyped patients with Pfeiffer syndrome. Medical records of patients with Pfeiffer syndrome seen at the authors' institution over a 16-year ...
Pardo-Vazquez J L - - 2014
Although the premotor cortex was initially viewed as the substrate of pure motor functions, it was soon realized that this cortical region is also involved in higher order cognitive processes. By using behavioral tasks together with electrophysiological recordings it has been possible to advance in our understanding on the functional ...
Alegre Melissa M MM Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, 84602, U.S.A. - - 2014
Thymidine kinase 1 (TK1) is a biomarker elevated in several malignancies, including lung cancer. Up-regulation of TK1 is an early event in carcinogenesis and therefore a target for early cancer detection. We have developed a novel Enzyme Linked Immunosorbent Assay (ELISA) to detect TK1 in serum. Forty patients with pulmonary ...
Barth Hilary H a Department of Psychology , Wesleyan University , Middletown , CT , - - 2014
By age 3, children track a speaker's record of past accuracy and use it as a cue to current reliability. Two experiments (N = 95 children) explored whether preschoolers' judgements about, and trust in, the accuracy of a previously reliable informant extend to other members of the informant's group. In Experiment 1, ...
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