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Ahmadova Zhala Z Clinic for Vascular and Endovascular Surgery, University Hospital Frankfurt, Frankfurt, Germany. - - 2014
Activation of vascular endothelial growth factor receptor 1 (VEGFR1/FLT1) and 2 (VEGFR2/KDR) involves receptor dimerization. Formation of VEGFR dimer has so far not been visualized in single intact cells. In the present study we describe different optical assays which can be used to observe dimerization of VEGFR1 and VEGFR2. Bimolecular ...
Mercado Jose J Department of Physiology & Biophysics and 2 Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA - - 2014
Transient receptor potential vanilloid 4 (TRPV4) channels are Ca(2+)-permeable, nonselective cation channels expressed in multiple tissues, including smooth muscle. Although TRPV4 channels play a key role in regulating vascular tone, the mechanisms controlling Ca(2+) influx through these channels in arterial myocytes are poorly understood. Here, we tested the hypothesis that ...
Genovesi Domenico D Department of Radiotherapy SS. Annunziata Hospital, via dei Vestini, 66100 Chieti, Italy. - - 2014
Aim: To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. The multidisciplinary team identified a reference guideline using appraisal of guidelines for research and evaluation (AGREE) tool based on ...
Takata Akihiro A Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University 2-2, E2, Yamadaoka, Suita, Osaka 565-0871, Japan. - - 2014
Esophageal squamous cell carcinoma (ESCC) has a poor prognosis because invasion and metastasis are prevalent. To improve diagnosis, it is important to identify and characterize tumor-specific molecular markers in ESCC. FOXM1 is overexpressed and correlates with pathogenesis in a variety of human malignancies. We aimed to investigate the clinical significance ...
Holzer Peter P Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, - - 2014
This themed issue of the British Journal of Pharmacology contains review and research articles on recent advances in transient receptor potential (TRP) channel pharmacology. The review articles, written by a panel of distinguished experts, address the rapid progress in TRP channel research in fields as diverse as oncology, urology, dermatology, migraine, inflammation ...
- - 2014
Reports an error in "Personality types in adolescence: Change and stability and links with adjustment and relationships: A five-wave longitudinal study" by Wim Meeus, Rens Van de Schoot, Theo Klimstra and Susan Branje (Developmental Psychology, 2011[Jul], Vol 47[4], 1181-1195). In the article, the BFs (Bayes factors) as reported for H1.1 ...
Hume J B JB Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, - - 2014
Reported here are several deviations (n = 15; 1·96%) from typical morphology in a large sample (n = 767) of European brook lamprey Lampetra planeri from a single population in the Loch Lomond catchment; this includes one specimen bearing a true anal fin. A brief review of petromyzontid teratology is ...
Kim Eun-Ju EJ School of Environmental Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 790-784, Republic of Korea. - - 2014
The objective of this study was to determine the effects of solution properties and light on the metal uptake and release in a nanosized, poorly crystalline manganese oxide (δ-MnO2) system. The results from synthetic water matrices revealed that the aggregation state was strongly affected by ionic strength, Ca(2+), and humic ...
Mäenpää Johannna J Professor of Radiotherapy and Oncology, Tampere University, School of Medicine, Tampere University Hospital, PO Box 607, FI-33101 Tampere, Finland. - - 2014
Aim: Cancer-related anemia has a negative impact on the health-related quality of life (HRQoL). Our aim was to evaluate prospectively the effect of treatment of anemia with an erythropoietin on the hemoglobin level and HRQoL in cancer patients with anemia. Consecutive patients (N=114) treated for the first time with epoetin ...
Tsubamoto Hiroshi H Department of Obstetrics and Gynaecology, Hyogo College of Medicine, Mukogawa 1-1, Nishinomiya, Hyogo 663-8501, Japan. - - 2014
After progression during chemotherapy, persistent ovarian cancer rarely responds to cytotoxic agents. We evaluated the use of adjunctive itraconazole for treating refractory ovarian cancer. Medical records of patients with ovarian cancer were retrospectively reviewed to select those with a history of platinum and taxane administration, clinical progression within six months ...
Sandora Thomas J TJ Division of Infectious Diseases, Department of Medicine and Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA. Electronic address: - - 2014
Bloodstream infection is the most common pediatric health care-associated infection and is strongly associated with catheter use. These infections greatly increase the cost of hospital stay. To assess the association between needleless connector (NC) change frequency and central line-associated bloodstream infection (CLABSI) rate, we modeled monthly pediatric stem cell transplant ...
Kórász Krisztián K Oxleas NHS Foundation Trust 68 The Heights, Charlton London SE7 8JH Egyesült - - 2014
The paper reviews the epidemiology of child maltreatment, forms of child abuse and possible consequences. British and Hungarian Law, guidelines and the psychiatrist's roles and responsibilities in relation to assessment of problems and treatment are also addressed in the paper. Orv. Hetil., 2014, 155(18), 694-702.
Neumeister Michael W MW Springfield, Ill. From the Institute of Plastic Surgery, Southern Illinois University School of - - 2014
After studying this article, the participant should be able to: (1) Describe and apply the current evidence-based treatment of acute flexor tendon injuries. (2) Compare and contrast the current postoperative therapy regimens following repair of flexor tendons. (3) Apply an evidence-based decision-making process for suture techniques of flexor tendon injuries. ...
Zoutman Dick E DE Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada; Quinte Health Care, Belleville, Canada. Electronic address: - - 2014
Environmental cleaning interventions have increased cleaning effectiveness and reduced antibiotic-resistant organisms in hospitals. This study examined cleaning in Canadian acute care hospitals with the goal of developing strategies to improve cleaning and reduce antibiotic-resistant organism rates. Managers most responsible for environmental services (EVS) completed an extensive online survey that assessed ...
Lalonde Donald H DH Saint John, New Brunswick, Canada From the Division of Plastic Surgery, Dalhousie - - 2014
After studying this article, the participant should be able to: (1) Describe and apply the best current high-level evidence in carpal tunnel syndrome. (2) Design a treatment plan to offer tourniquet-free, sedation-free local anesthesia for patients who wish it or who are at high risk with sedation. (3) Describe the ...
Li Yang Y Beijing, People's Republic of China; and Rochester, N.Y. From the Beijing Tongren Eye Center, Beijing Tongren Hospital, Ophthalmology and Visual Sciences Key Lab, Capital Medical University; and the Center for Visual Science, University of - - 2014
Severe orbital soft-tissue loss and contracted eye sockets often present in patients who have had enucleation, exenteration, or other ocular diseases. In this article, the authors report a novel contracted eye socket reconstruction technique using lateral upper arm free flaps and review the surgical outcome in patients with severe orbital ...
Burczynska Beata B BB 4550 Post Oak Place, Suite 224, Houston, TX, U.S.A. - - 2014
Ectopic secretion of human chorionic gonadotrophin free beta (hCGβ) by epithelial cancer is associated with aggressive tumors which more readily metastasize, possibly by acting as an autocrine anti-apoptotic agent. hCGβ is encoded by six homologous CGB genes, with poorly-understood variable transcriptionally active expression profiles; CGB1 and CGB2 have always been ...
Nojiri Kazunori K Department of Gastroenterological Surgery, Yokohama City University, Graduate School of Medicine, 236-0004 3-9 Fukuura, Kanazawa-ku, Yokohama City, Japan. - - 2014
Background and Aim: The aim of the present study was to evaluate the efficacy of liver resection for multinodular hepatocellular carcinoma (MNHCC). A total of 399 patients who underwent R0 resection for HCC from 1992 to 2011 were subjected to analysis. Out of these 399 patients, 107 patients had multinodular ...
Kempton Steve J SJ Madison, Wis. From the Division of Plastic and Reconstructive Surgery, University of Wisconsin Hospital and - - 2014
This work analyzes the utility of distraction osteogenesis as a surgical option for the management of acquired and traumatic hand deformities through a systematic review of the published literature. A PubMed search for articles reporting results of distraction osteogenesis in the hand was performed. Data collected included age, sex, cause, ...
Hansel Rachael A RA Center for Materials Innovation, and Medical Physics Division, Department of Radiation Oncology, Washington University in St. Louis, 4921 Parkview Place, Campus Box 8224, St. Louis, Mo - - 2014
The effects of high cumulative radiation dose on the luminescence properties of KCl:Eu(2+) are investigated. Pellet samples of KCl:Eu(2+) were given doses of up to 200 kGy at the Louisiana State University Synchrotron facility. After synchrotron irradiation, samples were optically bleached and given a clinical dose of 2 Gy from ...
Liu Zhiyang Z Department of Obstetrics and Gynecology, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan. - - 2014
Aim: The aim of the present study was to evaluate the correlation between WT1 expression levels and clinical features, to investigate the prognostic value of WT1 expression and to use lentiviral constructs to examine whether overexpression of WT1 affects cell proliferation and invasion in ovarian cancer patients. Real-time quantitative PCR ...
Kissova Jarmila J Department of Haematology, University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic. - - 2014
Aim: The aim of this work was to retrospectively analyze patients with Philadelphia-negative myeloproliferative neoplasms through evaluation of frequency and characteristics of second malignancies (other than acute leukaemia and myelodysplastic syndrome). Records of 172 patients were reviewed; an analysis was performed on data from 66 patients treated with hydroxyurea, 105 ...
Bak Mihály M Országos Onkológiai Intézet Budapest Ráth György u. 7-9. - - 2014
Introduction: Liquid-based cervical cytology has been developed as an alternative for conventional Papanicolaou cervical cytology. Aim: The aim of this study was to determine the quality assurance of liquid-based cervical cytology. Method: 4573 cervical cytology smears were classified according to the Bethesda (2001) system. Human papilloma virus infection was detected ...
Dalenberg Constance J CJ Trauma Research Institute, California School of Professional Psychology, Alliant International - - 2014
We respond to Lynn et al.'s (2014) comments on our review (Dalenberg et al., 2012) demonstrating the superiority of the trauma model (TM) over the fantasy model (FM) in explaining the trauma-dissociation relationship. Lynn et al. conceded that our meta-analytic results support the TM hypothesis that trauma exposure is a ...
DE Oliveira Joana T JT Institute of Molecular Pathology and Immunology of the, University of Porto, Porto, Portugal and Abel Salazar Institute of Biomedical Sciences, University of Porto, Porto, Portugal. - - 2014
Galectin-1 and galectin-3 are carbohydrate-binding proteins that have been implicated in the pathobiology of several types of cancer. The aim of the present study was to investigate the expression pattern of both these galectins in canine non-neoplastic mammary tissues and mammary tumors (CMT). Protein and mRNA expression of galectin-1 and ...
Yamamoto Yusuke Y Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku Kyoto 6028566, Japan. - - 2014
The prognostic value of lymph node (LN) status in patients who underwent resection for pancreatic cancer (PC) was examined in the present study. Fifty-six patients who underwent macroscopic curative resection for PC were analyzed. Twelve factors, including the number of LN metastases, LN ratio, and N category according to the ...
Aoki Mikiko M Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. - - 2014
Patellar tumors represent an uncommon etiology of anterior knee pain and their diagnosis is often delayed. We present an unusual case of conventional osteosarcoma arising in the patella of a 47-year-old man. The patient presented with a 1-year history of increasing anterior knee pain and swelling. Plain radiographs revealed a ...
Licciardone John C JC The Osteopathic Research Center, University of North Texas Health Science Center Texas College of Osteopathic Medicine, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2644. - - 2014
Osteopathic manual treatment (OMT) of somatic dysfunction is a unique approach to medical care that may be studied within a practice-based research network. To measure patient characteristics and osteopathic physician practice patterns within the Consortium for Collaborative Osteopathic Research Development-Practice-Based Research Network (CONCORD-PBRN). Design: Cross-sectional card study. Eleven member clinics ...
Imre I I Biology Department, Algoma University, 1520 Queen St East, Sault Ste Marie, ON, P6A 2G4, - - 2014
Using semi-natural enclosures, this study investigated (1) whether adult sea lamprey Petromyzon marinus show avoidance of damage-released conspecific cues, damage-released heterospecific cues and predator cues and (2) whether this is a general response to injured heterospecific fishes or a specific response to injured P. marinus. Ten replicate groups of 10 ...
Gebauer Niklas N Institut für Pathologie, Referenzzentrum für Lymphknotendiagnostik und Hämatopathologie, Universität zu Lübeck, 23538 Lübeck, Deutschland. - - 2014
MicroRNAs are regulators of gene expression implicated in vital cellular processes including differentiation, cell growth and apoptosis. Distinct microRNA signatures have been identified for many malignancies including follicular lymphoma (FL). However, no microRNA expression profile characteristic of FL subtypes, e.g. FL with B-cell lymphoma-6 (BCL6) locus rearrangement (FL(BCL2+/BCL6+), FL(BCL2-/BCL6+)) or ...
Ooi Hean H Departments of Medical Research & Nuclear Medicine, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua 500-06 Taiwan, R.O.C. Tel: +886 47238595 ext. 3090, - - 2014
Aim: To assess the correlation between thyroid transcription factor-1 (TTF1) protein expression in primary tumors from patients with non-small cell lung cancer (NSCLC) and fluorodeoxyglucose (FDG) uptake, and to determine its effect on survival outcomes. We categorized 112 patients with NSCLC according to TTF1 expression (TTF1(+): n=59, TTF1(-): n=53), and ...
Ward Melissa A MA Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, - - 2014
Hand hygiene is one of the most effective ways to prevent transmission of health care-associated infections. Electronic systems and tools are being developed to enhance hand hygiene compliance monitoring. Our systematic review assesses the existing evidence surrounding the adoption and accuracy of automated systems or electronically enhanced direct observations and ...
Hudak Kristen A KA Milwaukee, Wis. From the Department of Plastic Surgery, Medical College of - - 2014
Cranial bone grafting for an alveolar cleft obtains membranous bone from a low-morbidity donor site. Although iliac crest bone is the favored donor site, there are no objective analyses of three-dimensional radiologic outcomes with cranial bone grafting and no studies evaluating complications and long-term outcomes in a large series of ...
Murakami Sae S Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. - - 2014
Intraductal papillary neoplasm of the bile duct (IPNB) is a novel and increasingly-occurring disease. Its characteristics remain uncertain because of the lack of an in vitro culture system. We established and characterized a novel cell line from a human IPNB. We obtained tumor tissue from a surgical specimen from a ...
Goldstein Robert C RC Division of Infectious Diseases, Department of Medicine, Beth Israel Medical Center, New York, - - 2014
A retrospective cohort study was performed on 175 adult patients treated for community-acquired pneumonia with moxifloxacin or ceftriaxone/azithromycin in a nonintensive care unit. Both cohorts were very similar with regard to a wide range of characteristics including age, severity of disease, comorbidities, length of stay, and mortality. Multidrug-resistant organisms were ...
Costanzo Philip R PR Duke - - 2014
In this commentary, the common themes from the interesting articles in this special section of Developmental Psychology are considered as they illuminate the potential ontogenetic sources of the conscientiousness-well-being-longevity interconnections that have emerged in recent research. In particular, consideration is given to the changing nature of the expression of conscientiousness ...
Halvorson Eric G EG Boston, Mass.; Atlanta, Ga.; The Woodlands, Texas; and Finksburg, Md. From the Division of Plastic Surgery, Brigham & Women's Hospital; the Department of Surgery, Emory University; The University of Texas M. D. Anderson Cancer Center; and Little Vinnie's - - 2014
Traditional coloring techniques for nipple-areola tattooing ignore the artistic principles of light and shadow to create depth on a two-dimensional surface. The method presented in this article is essentially the inverse of traditional technique and results in a more realistic and three-dimensional reconstruction that can appear better than surgical methods. ...
Drolet Brian C BC Providence, R.I. From the Department of Plastic Surgery, Rhode Island Hospital; and the Warren Alpert Medical School, Brown - - 2014
Although resident duty hours are strictly regulated by the Accreditation Council for Graduate Medical Education, there are fewer restrictions on at-home call for residents. To date, no studies have examined the experience of home call for plastic surgery trainees or the impact of home call on patient care and education ...
Abern Michael R MR 820 S. Wood Street Suite 515, Chicago, IL, 60612, U.S.A. - - 2014
Background/Aim: In the cytokine era, cytoreductive nephrectomy (CN) improves survival for patients with metastatic renal cell carcinoma (mRCC). We analyzed the effect of CN on the survival of patients diagnosed with mRCC in the era of tyrosine kinase inhibitors (2005-present). The Surveillance, Epidemiology, and End Results (SEER) database was used ...
Rades Dirk D Department of Radiation Oncology, University of Lübeck, Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. - - 2014
Background/Aim: The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients. Data of 60 patients aged ≥65 years who were irradiated for an in-field recurrence of SCCM were retrospectively analyzed. The fractionation regimen of re-irradiation and ...
Ravisankar S S Department of Pediatrics, East Carolina University, Greenville, NC, - - 2014
Cronobacter species are Gram-negative rods that may cause life-threatening infections in neonates and infants. They belong to the family of Enterobacteriaceae. The first case was published in 1961 in England and about 150 cases have been reported thus far in the literature. The worst form of infection results in meningitis, ...
Netto-Ferreira A L AL Instituto de Ciências Biológicas, Universidade Federal do Pará, CEP 66075-110 - PO Box 479, Belém, PA, - - 2014
A new species of Rhinopetitia is described from the Rio Teles Pires, a major tributary of the Rio Tapajós. The new taxon is distinguished from its only congener, Rhinopetitia myersi, by having all premaxillary teeth in both rows with seven to nine cusps, maxillary teeth with seven or eight cusps, ...
Kishimoto Koji K Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama 700-8525, Japan. - - 2014
Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses ...
DE Iuliis Francesca F Experimental Medicine Department, Viale Regina Elena 324, University of Rome 'Sapienza', 00161 Roma, Italy. - - 2014
Bisphosphonates (BPs) are potent inhibitors of osteoclast-mediated bone resorption and are widely used in the treatment of bone metastases. Osteonecrosis of the jaw (ONJ) is the worst side-effect related to BP use. At our Center, we have implemented internal guidelines regarding the management of patients with bone metastases from solid ...
Lynn Steven Jay SJ Psychology Department, Binghamton University - - 2014
Dalenberg et al. (2012) argued that convincing evidence (a) supports the longstanding trauma model (TM), which posits that early trauma plays a key role in the genesis of dissociation; and (b) refutes the fantasy model (FM), which posits that fantasy proneness, suggestibility, cognitive failures, and other variables foster dissociation. We ...
As'adi Kamran K Tehran, Iran; and Cleveland, Ohio From the Department of Plastic and Reconstructive Surgery, St. Fatima Hospital, the Department of General Surgery, Motahari Burn Hospital, and the Department of Surgery, Shariati Hospital, Iran University of Medical Sciences; and the Department of Plastic Surgery, Case Western Reserve - - 2014
This study aimed to evaluate the long-term outcomes and the soft-tissue response to osseous genioplasty in patients with chin retrusion caused by early life facial burn injury. Twenty-two consecutive patients with retrusive chin as a result of severe childhood facial burn were included in this study. Cephalometric analysis and photographs ...
Rubio Carlos A CA Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176, Stockholm, Sweden. - - 2014
Fabry disease is an inherited (X-linked) lysosomal storage disorder caused by deficiency of α-galactosidase A, leading to accumulation of globotriaosylceramide in various tissues. A 57-year-old male with a family history and laboratory findings of Fabry disease, was consulted for severe abdominal pain, undulating pyrexia, weight loss and diarrhea. The tentative ...
Foley Theodore T TT Harrisburg and Hershey, Pa. From Leber & Wolf Plastic Surgery Limited; and the Division of Plastic Surgery, Department of Surgery, The Pennsylvania State University, College of - - 2014
Dexamethasone, a common therapy for reducing hypertrophic scar, sometimes fails. However, in cell culture, all dexamethasone-treated fibroblasts die. In co-cultures, gap junction intercellular communications between mast cells and fibroblasts promote profibrotic activities. Does the co-culture of mast cells with fibroblasts prevent dexamethasone-induced fibroblast death? Survival of fibroblasts co-cultured with RMC-1 ...
Oshima Takashi T Gastroenterological Center, Yokohama City University Medical Center, 4-57 Urafunecho, Minami-ku, Yokohama, Kanagawa 232-0024, Japan. - - 2014
Inhibin-βA (INHBA), a ligand belonging to the transforming growth factor-β superfamily, is associated with cell proliferation in cancer. We studied the relations of INHBA gene expression to clinicopathological factors and outcomes in 168 patients with gastric cancer who underwent curative surgery. Relative INHBA gene expression was measured in surgical specimens ...
Gevitz Norman N Senior Vice President, Academic Affairs, A.T. Still University, 800 W Jefferson St, Kirksville, MO 63501-1443. - - 2014
In the years following the American Osteopathic Association's sanctioning of the broad teaching of chemical and biological agents, osteopathic physicians moved closer to allopathic physicians with respect to diagnosis and treatment. In the 1930s, osteopathic colleges began to adopt standards and improve their basic science and clinical training, which allowed ...
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