Search Results
Results 351 - 400 of 1970
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Kunnoor N S NS Department of Pharmacology, St John's Medical College, Bangalore 560034, Karnataka, India. - - 2014
This study aimed to examine age- and gender-related differences in the comorbidities, drug utilisation and adverse drug reaction (ADR) patterns of patients admitted to a coronary care unit (CCU). The present study was a retrospective cohort study. Two trained physicians independently reviewed the case records of CCU patients over a ...
Abdullah S - - 2014
Melorheostosis is a rare, progressive bone disease accompanied by hyperostosis and soft tissue fibrosis. While affected adults present with contracture and pain, children present with limb length discrepancy and deformity. We report the case of a 20-year-old woman with melorheostosis since childhood who presented with right hand deformity and numbness. ...
Castillo R L RL Section of Dermatology, Department of Medicine, University of the Philippines-Philippine General Hospital, Taft Avenue, Manila, Philippines. - - 2014
Knowledge of both the common and atypical presentations of human immunodeficiency virus (HIV)-associated dermatoses may be helpful in arousing suspicion of HIV, especially in patients with no reported risk factors. Herein, we report the case of an otherwise healthy, nonpromiscuous 29-year-old man who presented to our institution with an eight-week ...
Roper Emily Ann EA Department of Health and Kinesiology, Sam Houston State University, Huntsville, - - 2014
Employing a grounded theory approach, the purpose of this study was to qualitatively examine the influence of service-learning (SL) on undergraduate kinesiology students' attitudes toward and experiences working with P-12 students with disabilities. Fourteen (9 female, 5 male) kinesiology students enrolled in an adapted physical education class participated in one ...
Adeleke Oluwatoyin A - - 2014
Carbamazepine (CBZ) is a leading molecule in the management of epilepsy. Surveys have revealed that a sufficient lack of therapeutically efficient CBZ transbuccal formulation exists. Therefore, this investigation was directed toward designing multiparticulate composite construct (MCC) for the transbuccal delivery of CBZ. The MCC was formulated using interphase, coparticulate–cosolvent homogenization ...
Li Yang Y Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing 100730, - - 2014
MicroRNAs (miRNAs) contribute to tumorigenesis by acting as either oncogenes or tumor suppressor genes. In this study, we investigated the role of miR-145 in the pathogenesis of uveal melanoma. Expression profiles of miRNAs in uveal melanoma were performed using Agilent miRNA array. Quantitative real-time polymerase chain reaction was used to ...
Wei Pingmin P Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, - - 2014
PB1-F2 protein has been proven to increase the pathogenicity of influenza A virus (IAV) strains in primary infection and in secondary bacterial infection. It can also regulate the activity of viral polymerase. However, it was shown in another retrospective study that a portion of IAVs do not express full-length PB1-F2 ...
Iezzi R R Department of Bioimaging and Radiological Sciences, Institute of Radiology, Catholic University of the Sacred Heart, School of Medicine, Rome, Italy. - - 2014
Stent-graft migration is a late-term complication of endovascular abdominal aortic aneurysm repair (EVAR). A recent published study suggests that stent graft migration could be explained only by aortic neck elongation, mimicking the appearance of distal stent graft migration. Several studies about the use of dynamic CT Angiography (CTA) in the ...
Ozenc S S Department of Family Medicine, Department of Cardiology, and Department of Surgery, Diyarbakir Military Hospital, Yenisehir, Diyarbakir, Turkey. - - 2014
The optimal approach is controversial in asymptomatic patients who are coincidentally found to have evidence of an accessory pathway (AP) on an ECG. The risk of sudden cardiac death (SCD) is low, and the risk of developing symptoms also appears to be low, although a wide range of incidences have ...
Nowrangi Milap A - - 2014
Executive functioning (EF) is an important cognitive domain that is negatively affected in a number of neuropsychiatric conditions. Neuroimaging methods have led to insights into the anatomical and functional nature of EF. The authors conducted a systematic review of the recent cognitive and neuroimaging literature to investigate how the neuroimaging ...
Narod S A SA Women's College Research Institute, University of Toronto, Toronto, - - 2014
The risk of breast cancer in carriers of BRCA1 and BRCA2 mutations is influenced by factors other than the genetic mutation itself. Modifying factors include a woman's reproductive history and family history of cancer. Risk factors are more likely to be present in women with breast cancer than in women ...
Hryniuk W W CAREpath Inc., Toronto, - - 2014
Our aim was to determine the extent to which comprehensive navigation augments the provincial health system for meeting the needs of newly-diagnosed cancer patients (clients). We also assessed reactions of attending physicians to comprehensive navigation. Clients who completed navigation as an employee benefit or through membership in an insurance organization ...
Peixoto R D RD BC Cancer Agency, Vancouver, - - 2014
In 2006, perioperative epirubicin, cisplatin, and 5-fluorouracil (ecf), compared with surgery alone, demonstrated a significant survival benefit in resectable gastroesophageal cancers. We report the results of our experience with that protocol. The BC Cancer Agency (bcca) is a multicentre institution that treats most oncology patients for the province. Characteristics of ...
Taniyama T K TK Department of Breast Oncology and Medical Oncology, National Cancer Center Hospital, Tokyo, - - 2014
Prediction of prognosis is important for patients so that they can make the most of the rest of their lives. Oncologists could predict survival, but the accuracy of such predictions is unclear. In this observational prospective cohort study, 14 oncologists treating 9 major adult solid malignancies were asked to complete ...
Niazi M T MT Segal Cancer Centre, Department of Oncology, Division of Radiation Oncology, Jewish General Hospital, McGill University, Montreal, - - 2014
Repair of radiation-induced dna double-strand breaks is a key mechanism in cancer cell radio-resistance. The synthesized compound NU7026 specifically inhibits dna-dependent protein kinase (dna-pk) within the non-homologous end-joining repair mechanism. Earlier studies demonstrated increased radiosensitivity in dna-pk deficient cells compared with wild-type cells. In chronic leukemia cells, NU7026 appears to ...
McKinnon M M Division of Palliative Care, Department of Medicine, University of Ottawa, Ottawa, ON. ; Bruyère Continuing Care, Ottawa, - - 2014
Palliative sedation (ps), the continuous use of sedating doses of medication to intentionally reduce consciousness and relieve refractory symptoms at end of life, is ethically acceptable if administered according to standards of best practice. Procedural guidelines outlining the appropriate use of ps and the need for rigorous documentation have been ...
Olson R A RA BC Cancer Agency Centre for the North, Prince George, BC. ; University of British Columbia, Vancouver, BC. ; University of Northern British Columbia, Prince George, - - 2014
The unmet needs of cancer survivors in rural, remote, and aboriginal communities are largely unexplored. We explored potential differences between rural survivors (rss) in 4 general population (gp) and 4 First Nations (fn) communities. We approached 4 gp and 4 fn rs communities to participate in a mixed-methods project. Participants ...
Cheifetz O O Hematology/Oncology Program, Hamilton Health Sciences, Hamilton, ON. ; School of Rehabilitation Sciences, McMaster University, Hamilton, - - 2014
Reliable and valid assessment of the disease burden across all forms of cancer is critical to the evaluation of treatment effectiveness and patient progress. The Edmonton Symptom Assessment System (esas) is used for routine evaluation of people attending for cancer care. In the present study, we used Rasch analysis to ...
Wei A C AC Princess Margaret Cancer Centre, University Health Network, Department of Surgery, University of Toronto, Toronto, ON. ; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, - - 2014
Surgery is a cornerstone of cancer treatment, but significant differences in the quality of surgery have been reported. Surgical process improvement tools (spits) modify the processes of care as a means to quality improvement (qi). We were interested in developing spits in the area of gastrointestinal (gi) cancer surgery. We ...
Bombard Y Y University of Toronto, Toronto, ON. ; Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, - - 2014
Determining the likely benefit of adjuvant chemotherapy for early-stage breast cancer patients depends on estimating baseline recurrence risk. Gene expression profile (gep) testing of tumours informs risk prediction, but evidence of its clinical utility is limited. We explored patient perceptions of gep testing and the impact of those perceptions on ...
Chen L L University of British Columbia, Vancouver, - - 2014
Cancer survivors (css) are frequently exposed to polypharmacy, which might increase their risk of drug interactions. Our study aimed to determine the relative prevalence of potential drug interactions (pdis) among css compared with non-cancer respondents (ncrs). Self-reported prescription data from 4975 patients were extracted from the U.S. National Health and ...
Jeon J J Healthcare Human Factors, University Health Network, Toronto, - - 2014
Computerized physician order entry (cpoe) systems allow for medical order management in a clinical setting. Use of a cpoe has been shown to significantly improve chemotherapy safety by reducing the number of prescribing errors. Usability of these systems has been identified as a critical factor in their successful adoption. However, ...
Fine S S Peel Regional Cancer Centre, Credit Valley Hospital, Mississauga, - - 2014
Data on real-life utilization of granulocyte colony-stimulating factors (g-csfs) in Canada are limited. The objective of the present study was to describe the reasons for, and the patterns of, g-csf use in selected outpatient oncology clinics in Ontario and Quebec. In a retrospective longitudinal cohort study, a review of medical ...
Sanford D D Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON. ; Department of Medicine, Division of Hematology, London Health Sciences Centre, University of Western Ontario, London, - - 2014
We used an interview-assisted survey of patients with chronic myeloid leukemia (cml) at a single tertiary care centre to explore patient reactions to and preferences for, and the risk-acceptability of, stopping tyrosine kinase inhibitor (tki) treatment. The study included patients with confirmed cml currently being treated with a tki. The ...
Meissner A A Département de Radio-Oncologie, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montreal, - - 2014
We set out to determine the rate, time-trend, and defining factors associated with publication of abstracts presented at two annual scientific meetings of the Canadian Association of Radiation Oncology (caro). All abstracts accepted for oral presentation in 2007 and 2010 were obtained from the caro program archives and searched using ...
Couban S S Department of Medicine, Dalhousie University, Halifax, - - 2014
Adult Philadelphia chromosome-positive (Ph+) or BCR-ABL-positive (BCR-ABL+) acute lymphoblastic leukemia (all) is an acute leukemia previously associated with a high relapse rate, short disease-free survival, and poor overall survival. In adults, allogeneic hematopoietic cell transplant in first remission remains the only proven curative strategy for transplant-eligible patients. The introduction of ...
Bredeson C C The Ottawa Hospital Research Institute, and Department of Medicine, University of Ottawa, Ottawa, - - 2014
Is there a benefit associated with the use of extracorporeal photopheresis (ecp) compared with other treatment options for patients who have received allogeneic stem-cell transplantation (sct) and are experiencing graft-versus-host disease (gvhd), if response rate, survival, or improvement in symptoms are the outcomes of interest? After allogeneic sct, gvhd is ...
Khan L L University of Toronto, Toronto, - - 2014
Predictive factors of recurrence were examined in 448 non-melanoma skin cancers (72% basal cell carcinoma, 28% squamous cell carcinoma) treated with radiotherapy. The overall recurrence rate was 15.8% at a median follow-up of 18.4 months. In multivariate analysis, significant factors for recurrence were age (p = 0.0197), tumour size 2 ...
Feldstain A A School of Psychology, University of Ottawa, Ottawa, ON. ; Division of Palliative Medicine, Élisabeth-Bruyère Hospital, Ottawa, - - 2014
Distress has been declared the 6th vital sign in Canadian cancer care. Accordingly, health care professionals in Canada are expected to screen for distress in patients with cancer, for which a toolkit has been developed. Identifying patients who may be in need of further resources has the potential to improve ...
Kiss N N Nutrition Department, Peter MacCallum Cancer Centre, East Melbourne, - - 2014
Patients undergoing myeloablative conditioning regimens and autologous stem-cell transplantation (asct) are at high risk of malnutrition. This randomized study aimed to determine if early nutrition support (commenced when oral intake is less than 80% of estimated requirements) compared with usual care (commenced when oral intake is less than 50% of ...
Klein J J Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, Toronto, - - 2014
Hepatocellular carcinoma (hcc) is a leading cause of cancer mortality, and its incidence is increasing in developed countries. Risk factors include cirrhosis from viral hepatitis or alcohol abuse. Metabolic syndrome is a newly recognized, but important, risk factor that is likely contributing to the increased incidence of hcc. Surgery is ...
de Blank P P Department of Pediatrics, Division of Pediatric Hematology and Oncology, Rainbow Babies and Children's Hospital, Cleveland, OH, - - 2014
Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with ...
Wong P P Radiation Medicine Program, Princess Margaret Cancer Centre, and Department of Radiation Oncology, University of Toronto, Toronto, ON. ; Département de radio-oncologie, Centre hospitalier de l'Université de Montréal, Hôpital Notre- Dame, Montreal, - - 2014
Li-Fraumeni syndrome is an autosomal dominant disorder characterized by germline TP53 mutation and increased susceptibility to cancer. Despite certain in vitro findings and a theoretical rationale for patients with TP53 mutation to be more radiosensitive and more prone to developing radiotherapy (rt)-induced secondary malignancies, corresponding clinical data remain elusive. Here, ...
Wallach J B JB Department of Radiation Oncology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY, - - 2014
Because of common risk factors, synchronous squamous cell carcinomas of the esophagus and head and neck are common, and their concurrent presence can significantly complicate disease eradication and survival. Here, we report the case of a patient with a history of extensive tobacco and alcohol use who was diagnosed with ...
Nestor Mark S MS Center for Cosmetic Enhancement, Aventura, Florida; ; Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, - - 2014
Objectives: To evaluate the safety, efficacy, and durability of treating axillary hyperhidrosis with high-intensity micro-focused ultrasound plus visualization. Design: Two randomized double-blind, sham-controlled pilot studies. Measurements: For Study 1, the primary endpoint was response defined as ≥50-percent reduction in baseline sweat production as measured gravimetrically. For Study 2, the primary ...
Dosik Jonathan S JS TKL Research, Inc., Rochelle Park, New - - 2014
Objectives: Phase 1 studies were conducted to determine the sensitization (PEP005-005; NCT00357916; http://clinicaltrials.gov/ct2/show/NCT00357916), photoirritation (PEP005-023; NCT00850811; http://clinicaltrials.gov/ct2/show/NCT00850811?term=PEP005-023&rank=1), and photoallergic (photosensitizing) potential (PEP005-024; NCT00850681; http://clinicaltrials.gov/ct2/show/NCT00850681?term=PEP005-024&rank=1) of ingenol mebutate gel 0.01% versus vehicle on normal skin. Design, setting, participants, and measurements: Healthy volunteers were enrolled in single-center, randomized, controlled, within-subject comparison trials. ...
Van Acker Monica M MM Michigan State University College of Osteopathic Medicine, East Lansing, - - 2014
Objective: The objective of this study was to determine if delivery of wound care instruction pre-Mohs micrographic surgery versus the typical, post-Mohs surgery would allow for greater patient retention. Design: A non-blinded, randomized, controlled trial receiving institutional review board exemption from Michigan State University was conducted over a three-month period. ...
Hunt Raegan D RD Department of Dermatology and Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, - - 2014
A 10-year-old girl with a history suggestive of nickel allergy presented with pruritic, eczematous plaques on her posterior thighs. Patch testing revealed sensitivities to nickel, cobalt, and chromium. The pattern of her involvement suggested an "outside job," and subsequent investigations confirmed that the exposed metal fasteners on her school chair ...
Shah Neil A NA Clarus Dermatology, Saint Anthony, - - 2014
Mondor's disease, a superficial thrombophlebitis, is a common complication of thoracoabdominal wall surgeries. While most patients experience disease resolution with expectant management, occasionally the disease may persist. The authors present a case of a 49-year-old woman who had persistent, symptomatic Mondor's disease 15 months status post-breast augmentation. The patient responded ...
Kim Dae-Young DY Department of Physiology, College of Medicine, Kyung Hee University, Republic of - - 2014
[Purpose] This study was conducted to determine the influence of Taekwondo as security martial arts training on anaerobic threshold, cardiorespiratory fitness, and blood lactate recovery. [Subjects and Methods] Fourteen healthy university students were recruited and divided into an exercise group and a control group (n = 7 in each group). ...
Lee Chae-Woo CW Department of Rehabilitation Science, Graduate School, Daegu University, Republic of - - 2014
[Purpose] The purpose of this study was to examine the influence of mat Pilates and apparatus Pilates on pain and static balance of businesswomen with chronic back pain. [Subjects and Methods] Participants were randomly allocated to Pilates mat exercises (PME) or Pilates apparatus exercise (PAE), and performed the appropriate Pilates ...
Cha Yuri Y Department of Physical Therapy, The Graduate School, Sahmyook University, Republic of - - 2014
[Purpose] The aim of this study was to investigate the effects of tempo changes in rhythmic auditory stimulation (RAS) on gait in stroke patients. [Subjects] Forty-one chronic stroke patients who had had a stroke with more than 6 months previously were recruited for this study. [Methods] All participants were asked ...
You Young Youl YY Bronco Memorial Hospital, Republic of - - 2014
[Purpose] This study investigated the effects of stretching and joint stabilization exercises applied to spastic shoulder joints on improving shoulder dysfunction in hemiplegic patients. [Subjects and Methods] Hemiplegic patients were classified into three groups: one group received 30 min of traditional exercise therapy for the spastic shoulder joint; one group received ...
Ji Sang-Goo SG Department of Physical Therapy, Eulji University Hospital, Republic of - - 2014
[Purpose] The aim of the present study was to examine whether mirror therapy in conjunction with FES in stroke patients can improve gait ability. [Subjects] This study was conducted with 30 subjects who were diagnosed with hemiparesis due to stroke. [Methods] Experimental group I contained 10 subjects who received mirror ...
Ohtsuki Keisuke K Rehabilitation Support Research institute: 223 Shikama-ku, Anasewatashiba, Himeji, Hyogo 672-8039, Japan ; Department of Rehabilitation, Kinoko Healthcare Facility for the Elderly, - - 2014
[Purpose] Elderly female patients with glenohumeral joint (GHJ) contracture, forced into prolonged immobility were examined. Range of motion exercises using humerus anatomical neck-shaft rotation were performed, and the immediate effect and adaptation were investigated. [Subjects and Methods] A total of ten individuals with a mean age of 79.4 ± 11.0 years ...
Kim Ju-Hyun JH Laboratory of Health Science and Nanophysiotherapy, Department of Physical Therapy, Graduate School, Yongin University, Republic of - - 2014
[Purpose] Brachial-ankle pulse wave velocity (BaPWV), which has been reported as an index of arterial stiffness, is very closely related to cardiovascular risk factors. A high BaPWV indicates high cardiovascular risk. However, BaPWV and pressure waveforms after stroke are not fully understood. [Methods] BaPWV was measured in thirty-two subjects (twenty-two ...
Lee Kyoung Jin KJ Department of Physical Therapy, Sahmyook University, Republic of - - 2014
[Purpose] The aim of the study was to assess the effect of an 8-week balance exercise program for enhancement of gait function on temporal and spatial parameters of school aged children with intellectual disabilities. [Subjects] Forty young people with intellectual disabilities were assigned either to the balance exercise program for ...
Lee Jeonhyeng J Department of Physical Therapy, Daegu Health University, Republic of - - 2014
[Purpose] The purpose of this study was to evaluate the effects of stair walking training on balance ability of chronic stroke patients. [Subjects and Methods] Forty stroke patients were allocated equally and randomly to an experimental group and a control group. The experimental group undertook 30 minutes of training therapy ...
Kim Yeonghun Y Human Centered CAD Laboratory, School of Mechanical and Aerospace Engineering, Seoul National University, Republic of - - 2014
[Purpose] The aim of this study was to present an individualized resistance training method to enable exercise while maintaining an exercise load that is set according to an individual's joint angle-torque using a haptic-based resistance training machine. [Methods] Five participants (machine group) performed individualized shoulder internal and external rotation training ...
Lee Changyoung C College of Humanitas, Kyung Hee University, Republic of - - 2014
[Purpose] Little data exist on systemic training programs to improve skating abilities in ice hockey players. The purpose of this study was to evaluate the effectiveness of a complex training program on skating abilities in ice hockey players. [Methods] Ten male ice hockey players (training group) that engaged in 12 ...
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