Search Results
Results 251 - 300 of 1962
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Byun S J SJ Department of Surgery, Wonkwang University School of Medicine, Iksan, Republic of Korea. - - 2014
AMP-activated protein kinase (AMPK) is suggested to exert cytoprotective and anti-inflammatory effects in endothelial cells, but the precise mechanisms are not fully understood. It has been reported that pharmacological activation of AMPK induces endothelial heme oxygenase-1 (HO-1) expression. β-Lapachone (BL), a well-known substrate of quinone oxidoreductase (NQO1), stimulates AMPK activation ...
Sun X-Z XZ Department of Pediatrics, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, P. R. China. - - 2014
The aim of this study was to investigate the effects of Rho kinase inhibitor-Fasudil on hypoxic pulmonary hypertension (HPH) and pulmonary vascular remodeling in rats. A total of 24 Sprague Dawley rats were evenly randomized into control, model and Fasudil intervention groups. Light and transmission electron microscopy were utilized to ...
Ebrahimzadeh M A MA Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. - - 2014
Many pharmacological activities have been reported in Vicia (V.) genus. The aim of present study was to investigate antidepressant and antihemolytic activities of aerial parts of V. sojakii. Antidepressant activity of methanolic extract was evaluated by forced swimming test (FST) and tail suspension tests (TST) in male Swiss albino mice. ...
Liang B B Department of Cardiology, The Second Hospital of Shanxi Medical University, Taiyuan, China. - - 2014
ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in reverse cholesterol transport and anti-atherosclerosis. Cyclic AMP (cAMP) could increase the ABCA1 expression. Angiotensin (Ang)-(1-7) can protect endothelial cells, inhibit smooth muscle cell growth, ameliorate inflammation and exert anti-atherosclerotic effects. In this study, we attempted to clarify the effect of ...
Angeletti G G NESMOS Department (Neuroscience, Mental Health and Sensory Organs), School of Medicine and Psychology, Saint Andrea Hospital of Rome, Sapienza University of Rome, Rome, Italy. - - 2014
Evidence has shown that psychotherapy is effective for depression, whereas the outcome for suicide risk is unclear. It was to investigate whether possible pre-treatment predictors of suicide risk (SR) decrease after a brief psychodynamic psychotherapy treatment and at follow-up. Forty-one patients were assessed at: baseline (T0) for clinical history, clinical ...
Zhang Y Y Department of Pediatrics, Chinese PLA General Hospital, Beijing, P.R. China. - - 2014
To investigate the effect of multimodality treatment of advanced paediatric hepatoblastoma and the factors affecting the prognosis. 35 childhood patients were treated with multimodality treatments consisting of chemotherapy, surgery, interventional therapy, and autologous peripheral blood stem cell transplantation. Patients were followed up every month. 33 patients completed the follow-up, of ...
Yin W-Z WZ Department of Gastroenterology, the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China. - - 2014
Increasing evidence indicates that MicroRNAs, a class of small RNA molecules, play crucial roles in tumorigenesis, through affecting cell proliferation, apoptosis and metastasis. The present study aimed to investigate the effect of miR-205 on gastric cancer cell proliferation. The expression of miR-205 was examined in the gastric cancer tissues and ...
Demirel I I Department of Anesthesiology and Reanimation, Firat University, Faculty of Medicine, Elazig, Turkey. - - 2014
Just as hip prosthesis, most of the patients undergoing orthopedic lower extremity surgery (OLES) belong to the advanced age group. Sciatic nerve block combined with psoas compartment block is used as a technique alternative to central neuraxial block and GA. In geriatric patients that will undergo partial hip prosthesis, the ...
Yao N N Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun, China. - - 2014
Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratinocytes. Fibroblast growth factor 10 (FGF10) acts as a growth factor for keratinocyte proliferation. The aim of this study is to investigate whether FGF10 blockage, a new monoclonal antibody against FGF10 we generated, could mitigate topical propranolol-induced psoriasis-like ...
Danisman N N Department of High Risk Pregnancies, Zekai Tahir Burak Women's Health and Research Hospital, Ankara, Turkey. - - 2014
The treatment of patients with peripartum hemorrhage is unfortunately characterized by inadequate treatment that does not adhere to standard therapeutic measures. Assessment of different management strategies among patients with severe hemorrhage, particularly the ones with "near-miss" maternal morbidity and mortality to establish clinically useful guidelines for the prevention and management ...
C Kitchener Henry H Institute of Cancer Sciences, University of Manchester, Manchester, - - 2014
The ARTISTIC (A Randomised Trial In Screening To Improve Cytology) trial originally reported after two rounds of primary cervical screening with human papillomavirus (HPV). Extended follow-up of the randomised trial cohort through a third round could provide valuable insight into the duration of protection of a negative HPV test, which ...
Tanaka Toshio T Authors' Affiliations: Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, - - 2014
Cytokines are soluble mediators, which aid cell-to-cell communication in immune responses, and interleukin-6 (IL-6) is a prototypical cytokine featuring redundant and pleiotropic activity. The complete elucidation of the IL-6-mediated signal transduction system has provided a molecular basis for the characteristic features of cytokines. When tissue damage or inflammation due to ...
Chiocca E Antonio EA Authors' Affiliations: Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston - - 2014
Oncolytic viruses (OV) selectively replicate and kill cancer cells and spread within the tumor, while not harming normal tissue. In addition to this direct oncolytic activity, OVs are also very effective at inducing immune responses to themselves and to the infected tumor cells. OVs encompass a broad diversity of DNA ...
Bogod Nicholas M - - 2014
Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) is a promising investigational intervention for treatment-resistant depression (TRD), but long-term outcome data are limited. Serial neuropsychological evaluations, using a comprehensive battery, were conducted on four subjects with TRD prior to surgery, and up to 42 months post-operatively. Reliable change ...
Toufexis Megan - - 2014
Perianal streptococcal dermatitis is an infection caused by group A streptococcus (GAS). Children with a pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) phenotype may have tics or obsessive compulsive symptoms secondary to a systemic immune activation by GAS infecting perianal areas. In this retrospective case series, the authors ...
L Goodman B B MPH, Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCDVAMC), Cleveland, Ohio, US. Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, Ohio, - - 2014
Objective: Repeated hospital admissions (RHA) for ongoing pressure ulcer (PU) care remains a significant challenge in the clinical management of the spinal cord injury/disorders (SCI/D) population. The current study investigated the significance of risk factors for PU treatment and RHA. Method: A retrospective chart review of veterans admitted to the ...
D O Halloran P P MRCS, FRCGP, The Gratton Surgery, Sutton Scotney, Winchester, - - 2014
Objective: To evaluate a novel aqueous oxygen peroxide (AOP) wound therapy (BioxyQuell) in a multi-centre, primary care-based, randomised, double-blind, placebo-controlled, parallel-group trial, monitoring long-term healing outcomes over 12 months. Method: Sixty-one patients with chronic, stable venous leg ulceration were treated with either AOP solution or sterile water placebo applied as ...
Iizaka S S RN, PHN, PhD, Department of Gerontological Nursing/Wound Care Management, University of Tokyo, Tokyo, - - 2014
Objective: Granulation tissue colour may be an indicator for nutritional assessment in pressure ulcer (PU) care. This study evaluated the relationship between nutritional status, anaemia and diabetes, and granulation tissue colour of PUs by colour analysis of digital photographs in the clinical setting. Method: The cross-sectional study included 42 older ...
Sulaiman N A NA Universiti Kebangsaan Malaysia, Faculty of Health Sciences, School of Diagnostic and Applied Health Sciences, Forensic Science Program, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. - - 2014
Deaths due to blunt force trauma to the head as a result of assault are some of the most common cases encountered by the practicing forensic pathologist. Previous studies have shown inflicting injury to the head region is one of the most effective methods of murder. The important factors that ...
Parihar A A Department of Pathology, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi, India. - - 2014
Neural fibrolipomatous hamartoma is a rare benign tumour commonly involving the median nerve. Other less frequently involved nerves include the ulnar, radial, brachial plexus, superficial peroneal nerve, inferior calcaneal nerve and median plantar nerve. Involvement of sural nerve has not been reported in the available literature so far. A three-year-old ...
Niikura Takahiro - - 2014
The authors describe a tactile surgical navigation system using custom 3-dimensional (3D) models of the bony pelvis for complex acetabular fracture surgery. The bone area of interest was extracted from the Digital Imaging and Communications in Medicine (DICOM) data of computed tomography scans. A standard triangulated language file was used ...
Flanigan David C - - 2014
The purpose of this study was to determine the sensitivity and positive predictive value of magnetic resonance imaging (MRI) in the identification of full-thickness articular cartilage defects in the porcine knee. Seventy-two full-thickness chondral defects (small or large; circular, oval, or triangular) were created in 12 porcine knees. The authors ...
Cunningham Brian - - 2014
Posterior wall acetabular fractures that involve 10% to 40% of the posterior wall may or may not require an open reduction and internal fixation. Dynamic stress examination of the acetabular fracture under fluoroscopy has been used as an intraoperative method to assess joint stability. The aim of this study was ...
Xia Liheng - - 2014
Controversy exists regarding the clinical outcomes of reamed vs unreamed intramedullary nailing in the treatment of closed tibial fractures. This study assessed the effects of reamed vs unreamed intramedullary nailing for closed tibial fractures. The authors searched PubMed, EMBASE, BIOSIS, and the Cochrane Controlled Trials Register for randomized and quasi-randomized ...
Bonutti Peter M - - 2014
The current study was conducted to examine the clinical and radiographic outcomes of cementless bipolar arthroplasty in patients who had type C bone at the time of the procedure. A total of 87 patients (105 hips) who had type C femora and had undergone cementless bipolar hemiarthroplasty with a proximally ...
Ding Hao - - 2014
Free vascularized fibular grafting (FVFG) is an effective method to treat corticosteroid-induced osteonecrosis of the femoral head (ONFH). Some patients continued to receive maintenance doses of corticosteroids to treat the primary disease postoperatively. This study was performed to evaluate outcomes of FVFG for corticosteroid-induced ONFH in patients who continued to ...
Sugaya Hisashi - - 2014
The goal of this study was to quantify the frequency of advanced spinal epidural lipomatosis (SEL) detected on lumbar magnetic resonance imaging (MRI) scans performed at the authors' hospital and to compare the frequency, cause, and progression of SEL in these cases with that reported in the literature. The total ...
Chinzei Nobuaki - - 2014
This study investigated the efficacy of tibial tubercle osteotomy (TTO) with screw fixation as part of the surgical treatment of primary complicated total knee arthroplasty (TKA) and revision TKA. From January 2000 to April 2011, 15 patients (15 knees) underwent revision TKA and 20 patients (21 knees) underwent primary TKA. ...
Fitzgibbons Peter G - - 2014
Historically, the published literature on "terrible triad" injuries has shown a high rate of unacceptable results. The use of systematic treatment protocols may improve functional outcome. The authors performed a retrospective study of all patients aged 18 years or older who underwent surgical treatment for "terrible triad" elbow fracture dislocation ...
Lu Cheng-Chang - - 2014
Intramedullary titanium elastic nails have been reported to fix displaced midclavicular fractures with excellent functional outcomes and minor complications. This study reports and analyzes the complications and technical pitfalls associated with titanium elastic nail fixation of displaced midclavicular fractures and describes how to prevent these problems. The authors operated on ...
Liu Guo-Dong - - 2014
In this study, the difference in expression of human beta-defensin-3 in periprosthetic tissue and cancellous bone was observed in the periprosthetic tissue and cancellous bone of patients in the periprosthetic joint infection group, the aseptic loosening group, and the spacer treatment group as well as the synovial membrane and ilium ...
Meijer Karim A - - 2014
Synthetic cannabinoids have become a worldwide epidemic because they provide a sometimes legal, easily accessible, and presumably safe alternative to marijuana. Recently published reports have linked acute psychosis, myocardial infarctions, convulsions, self-harm, and even terrorist organizations to these designer substances. This case report outlines the first reported case of Black ...
Banka Trevor R - - 2014
This article presents a case of early intraprosthetic dislocation of a dual-mobility hip prosthesis after revision total hip arthroplasty for instability. A 70-year-old woman was revised to a dual-mobility cup for multiple hip dislocations. She dislocated the dual-mobility construct twice, which was closed reduced. Postreduction radiographs after the second closed ...
Pourtaheri Sina - - 2014
Osteochondroma (or osteocartilaginous exostosis) is the most common bone tumor of childhood, with an incidence ranging from 1 to 1.4 per 1,000,000. In the lumbar spine, osteochondromata usually arise from the posterior column at the secondary ossification center and grow away from the spinal canal without causing neurologic deficits. This ...
Khoriati Al-Achraf - - 2014
The incidence of vascular injuries associated with total hip arthroplasty (THA) is low. However, several vascular structures are at risk of injury within the pelvis. These include the external iliac, femoral, and obturator vessels. Both reaming of the acetabulum and drilling of the acetabular screw holes may place these structures ...
McKenna Gerald J GJ McKenna Recovery Center, Ke Ala Pono - Kaua'i, Lihue, - - 2014
Medical marijuana is currently a controversial issue in medicine. There are strong pro and con opinions but relatively little scientific data on which to base medical decisions. The unfortunate scheduling of marijuana in class I has limited research and only serves to fuel the controversy. This article will review the ...
Webb Charles W CW Keauhou Urgent Care Center, 78-6831 Alii Dr., Suite 418, Kailua Kona, HI - - 2014
Clinical research regarding the therapeutic benefits of cannabis ("marijuana") has been almost non-existent in the United States since cannabis was given Schedule I status in the Controlled Substances Act of 1970. In order to discover the benefits and adverse effects perceived by medical cannabis patients, especially with regards to chronic ...
Wada Cherisse C John A. Burns School of Medicine, University of Hawai'i, Honolulu, - - 2014
Dermatomyositis as a paraneoplastic consequence of gynecological malignancy has rarely been reported in literature and never been reported in Honolulu. This case report describes a local Honolulu resident who was diagnosed with endometrial adenocarcinoma upon presenting with acute dermatomyositis symptoms.
Nogi Masayuki M Department of Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI - - 2014
A case of the mid-ventricular variant of takotsubo cardiomyopathy is reported, occurring in a patient with Cannabinoid Hyperemesis Syndrome (CHS), and presented with a review of the relevant literature. The patient is a 32-year-old woman who presented with epigastric pain, nausea and vomiting. Her EKG showed dynamic T-wave changes associated ...
Halpern Joseph Y JY Computer Science Department, Cornell - - 2014
There have been two major lines of research aimed at capturing resource-bounded players in game theory. The first, initiated by Rubinstein (), charges an agent for doing costly computation; the second, initiated by Neyman (), does not charge for computation, but limits the computation that agents can do, typically by ...
Amiel S A - - 2014
‘To keep in equilibrium’, one of the Oxford English Dictionary’s many definitions of balance, is a desirable target for anylife, but has special meaning for the life of a person with diabetes. Achieving balance—between hypo- and hyperglycaemia; between energy intake and energy consumption; between insulin action and insulin secretion; between ...
Barnes Kerri T - - 2014
To determine whether ureteric stent extraction strings affect stent-related quality of life (QoL) or increase complications after ureteroscopy (URS) for stone disease. In all, 68 patients undergoing URS (October 2011 to May 2013) for stone disease were randomised to receive a ureteric stent with or without an extraction string. Patients ...
Li Zheng Z Department of Ophthalmology, 1st People's Hospital affiliated to Chenzhou City, Nanhua University, Chenzhou, Hunan 423000, - - 2014
Neovascular glaucoma is a refractory disease, and difficult to manage. The aim of this study was to evaluate the clinical outcomes of Ahmed glaucoma valve implantation (AGVI) in neovascular glaucoma (NVG) and non-NVG patients. This prospective, non-randomized study included 55 eyes of 55 patients with refractory glaucoma; 27 had NVG ...
Shen Yinchen Y Department of Ophthalmology, Shanghai First People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai 200080, China; Shanghai Jiao Tong University School of Medicine, Shanghai 200025, - - 2014
Diabetic macular edema (DME) is one of the major causes of visual impairment in patients with diabetes mellitus. DME shows a variety of clinical characteristics with unpredictable results to treatment. The purpose of this study was to investigate the characteristics of fundus autofluorescence (FAF) in DME, which is a rapid, ...
Chen Yanyun Y Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Science Key Laboratory, Beijing 100730, - - 2014
With the increasing popularity of cosmetic facial filler injections in recent years, more and more associated complications have been reported. However, the causative surgical procedures and preventative measures have not been studied well up to now. The aim of this stady was to investigate the clinical characteristics and visual prognosis ...
Lu Yi Y Department of Ophthalmology, First People's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai 200080, - - 2014
The common pathological characteristics of corneal injury include inflammatory factors activation, vascular endothelial cells or inflammatory cells infiltration into lesions, corneal edema, corneal neovascularization (CNV), and scar formation. PEDF-34 is the functional fragment of pigment epithelium-derived factor (PEDF) that has anti-angiogenic and anti-inflammatory properties and contains an N-terminal 34-amino acid ...
Guan Xiaoming X Department of Orthopaedics Surgery, Second Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Department of Orthopaedics Surgery, Da Yi Hospital, Shanxi Medical University, Taiyuan, Shanxi 030032, - - 2014
Recent studies have indicated that human nucleus pulposus contain mesenchymal stem cells (NP-MSCs). However, the immunophenotypic variation of NP-MSCs in vitro was unclear. The present study was conducted to address the immunophenotypic variation of mesenchymal stem cells in nucleus pulposus under continuous proliferation in vitro and show the difference between ...
Jimmy Juang Jyh-Ming JJ Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, Taiwan University Hospital and Taiwan University College of Medicine, Taipei, Taiwan, - - 2014
Congenital long QT syndrome (LQTS) is an ion channelopathy associated with genetic mutations. It is well known that most LQTS patients (91%) have a single mutation. The purpose of this study was to investigate the clinical characteristics of congenital LQTS patients with bigenic mutations in Taiwan, China. Congenital LQTS patients ...
Li Zhi Z Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, - - 2014
There are few comparative studies regarding kyphoplasty (KP) and vertebroplasty (VP) for the treatment of painful vertebral compression fractures (VCF) in patients with cancer. The purpose of this study is to retrospectively compare KP with VP in pain improvement, cement leakage incidence, and the cost of treatment of malignant VCF. ...
Liu Gang G Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, - - 2014
The incidence of chronic ulcerative colitis (CUC) in China is remarkably increasing, while little information on surgical treatment has been reported. This study aimed to completely describe and analyze the clinical outcome of restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for CUC in China. Ninety-five consecutive patients, who suffered CUC ...
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