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Kuuranne Tiia T Doping Control Laboratory, United Medix Laboratories Ltd., , Helsinki, - - 2014
In the fight against doping, steroid profiling is a powerful tool to detect drug misuse with endogenous anabolic androgenic steroids. To establish sensitive and reliable models, the factors influencing profiling should be recognised. We performed an extensive literature review of the multiple factors that could influence the quantitative levels and ...
Iwasaki Akiko A Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, - - 2014
Influenza viruses are a major pathogen of both humans and animals. Recent studies using gene-knockout mice have led to an in-depth understanding of the innate sensors that detect influenza virus infection in a variety of cell types. Signalling downstream of these sensors induces distinct sets of effector mechanisms that block ...
Hasan A A Guy's Hospital, - - 2014
An appreciation of dental plaque and the host response provides an essential basis from which to understand the disease process and treatment rationale. This information will help the reader to understand not only the way that plaque may have an impact on oral tissues but also why regular effective cleaning ...
Colon P P Université Paris Diderot, Service d'Odontologie, Hôpital Rothschild, AP-HP, Paris, - - 2014
The therapeutic management of tooth wear lesions does not require the removal of diseased tissue. Nevertheless, diverse etiological factors may be associated with the condition and they could be difficult to eliminate; this has to be considered when planning therapy. Interceptive procedures should be reserved for such situations while regular ...
Thomson W Murray WM Sir John Walsh Research Institute, The University of Otago, Dunedin, New - - 2014
Aim This qualitative study sought to obtain children's accounts of having dental extractions under general anaesthesia (GA). The aim was to gain greater understanding of the physical and psychological impacts from a child's perspective.Method Ten children, aged 6-11 years, maintained a video diary to document their feelings and experiences before, ...
Gough Lesley I LI Public Health England (Cheshire and Merseyside - - 2014
Introduction An evaluation was undertaken to measure the dental health of five cohorts of 5-year-old children living in Halton and St Helens, each cohort having had a different length of time they were exposed to a population dental prevention programme before their fifth birthday.Method The dental health of each of ...
Rodd H H University of Sheffield, School of Clinical Dentistry, Claremont Crescent, Sheffield, S10 - - 2014
Aim This qualitative study sought to obtain children's accounts of having dental extractions under general anaesthesia (GA). The aim was to gain greater understanding of the physical and psychological impacts from a child's perspective.Method Ten children, aged 6-11 years, maintained a video diary to document their feelings and experiences before, ...
Milsom K M KM Honorary Professor of Population Health, 1829 Building, Countess of Chester Hospital, Liverpool Road, Chester, CH4 7 - - 2014
Introduction An evaluation was undertaken to measure the dental health of five cohorts of 5-year-old children living in Halton and St Helens, each cohort having had a different length of time they were exposed to a population dental prevention programme before their fifth birthday.Method The dental health of each of ...
Andrade Jason J From Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada (J.A., P.K., S.N.); Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (J.A.); and Faculty of Medicine, Institute of Pharmacology, University Duisburg-Essen, Essen, Germany - - 2014
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%-26%). The aim of this article is to review the clinical epidemiological features of AF and to relate them to underlying mechanisms. Long-established risk factors for AF include aging, male sex, hypertension, valve disease, left ventricular dysfunction, obesity, and ...
Tucker Nathan R NR From the Cardiovascular Research Center, Massachusetts General Hospital, - - 2014
Atrial fibrillation (AF) is the most common arrhythmia and is associated with increased morbidity. As the population ages and the prevalence of AF continues to rise, the socioeconomic consequences of AF will become increasingly burdensome. Although there are well-defined clinical risk factors for AF, a significant heritable component is also ...
Ling Julie J Head of Strategic Development, LauraLynn Ireland’s Children’s - - 2014
Working at the only children's hospice in Ireland has highlighted to me the essential role of fundraising in the provision of palliative care. Doubtless many palliative care services worldwide owe a huge debt of gratitude to the generosity of public donations. In an emotive area such as palliative care, and ...
Stenekes Simone S Clinical Nurse Specialist, Canadian Virtual - - 2014
Technology has affected health-care delivery in many ways. Both the internet and consumer empowerment have evolved (Lober and Flowers, 2011), and the health-care environment is attempting to keep pace with these rapid changes.
Rodriguez Alison A Senior Lecturer in Psychology, University of Huddersfield, Ramsden Building, Queensgate, Huddersfield, West Yorkshire, HD1 3DH, - - 2014
Aims: To explore the lived experience of caring and care planning for a child with a life-limiting condition (LLC). Method: Using van Manen's conceptualisation of hermeneutic phenomenology, three focus groups were conducted with 21 paediatric palliative care professionals, and interviews were conducted with 20 parents of children with LLCs. Findings: ...
Jennings Valerie V Palliative Care Clinical Nurse Specialist, Our Lady’s Children’s Hospital, Crumlin, Dublin, - - 2014
Background: Children's palliative care is a rapidly developing specialism internationally. Bereavement support is an integral component of children's palliative care but to date little research has investigated the bereavement support that mothers in Ireland use following the death of their child. Objective: The aim of this study was to explore ...
Mary Cowan Margaret M Advanced Nurse Practitioner, Home Care Team and Day Therapy Unit, Ellenor Lions Hospices, Cold Harbour Road, Gravesend DA11 7HQ, - - 2014
Background: Few ethnic minorities access specialist palliative care (SPC) services when caring for a dying relative at home. Objective: This project aimed to explore and understand the experiences of the Sikh population of south east England when caring for a dying relative at home without support from SPC. Methods: Six ...
Krumm Norbert N Research Assistant, Department of Palliative Medicine, University Hospital RWTH Aachen University, Pauwelsstraße 57, 52074 Aachen, - - 2014
Background: In the past decade, the palliative care approach has been used in the care of frail older people living with debilitating chronic conditions, including dementia. Aim: To describe health professionals' experiences of assessing the symptoms of people with dementia using a cancer-patient-oriented symptom-assessment tool from a palliative care context. ...
Strang Susann S Associate Professor, Sahlgrenska Academy, University of Gothenburg, Institute of Health and Care Sciences, Box 457, SE-405 30 Göteborg, Sweden, and Angered Local Hospital, - - 2014
Aim: To describe nursing students' reasoning about emotionally demanding questions concerning the care of dying patients. Methods: The Frommelt Attitude Toward Care of the Dying (FATCOD) Scale was completed by students at the beginning of their education, and there was great variation in the responses to five items. At a ...
Smyth Dion D Lecturer-Practitioner in Cancer and Palliative Care, Birmingham City University, Birmingham, - - 2014
Dion Smyth's review of the internet for palliative nursing.
Quimby Robert M RM Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa-shi, Chiba 277-8583, - - 2014
Objects of known brightness, like type Ia supernovae (SNIa), can be used to measure distances. If a massive object warps spacetime to form multiple images of a background SNIa, a direct test of cosmic expansion is also possible. However, these lensing events must first be distinguished from other rare phenomena. ...
Kay E E Foundation Dean, Peninsula Dental School, Peninsula Dental School, Plymouth University, Portland Square, Drake Circus, Plymouth, Devon, PL4 - - 2014
Education is key to shaping the future of the dental profession and careful thought must be given to the direction dental education is heading and whether it still allows for the necessary development and innovation that will lead the profession forth and raise it up.
Jamil F F DF2 Oral and Maxillofacial Surgery, Royal Surrey County Hospital, Egerton Rd, Guildford, GU2 - - 2014
Anterior gold basket crowns are a type of restoration worn among remote Amazonian communities, primarily placed for cosmetic and social reasons. There is very minimal literature reporting the use of these restorations in present day communities. This form of dental modification is outlined in the following article, as well as ...
Heijman Jordi J From the Institute of Pharmacology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (J.H., N.V., D.D.); Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada (S.N.); and Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada - - 2014
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated with increased morbidity and mortality. The incidence of AF is expected to continue to rise with the aging of the population. AF is generally considered to be a progressive condition, occurring first in a paroxysmal form, then ...
Chen Peng-Sheng PS From the Department of Medicine, Division of Cardiology, The Krannert Institute of Cardiology (P.-S.C., S.-F.L.) and Department of Neurology (L.S.C.), Indiana University School of Medicine, Indianapolis; Department of Pathology and Laboratory Medicine, University of California, Los Angeles (M.C.F.); Institute of Biomedical Engineering, National Chiao Tung University, Hsinchu, Taiwan (S.-F.L.); and Department of Medicine, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada - - 2014
Autonomic nervous system activation can induce significant and heterogeneous changes of atrial electrophysiology and induce atrial tachyarrhythmias, including atrial tachycardia and atrial fibrillation (AF). The importance of the autonomic nervous system in atrial arrhythmogenesis is also supported by circadian variation in the incidence of symptomatic AF in humans. Methods that ...
Woods Christopher E CE From the Division of Cardiology, University of California at San Francisco (C.E.W., J.O.); and Division of Cardiology Research, AUST Development, LLC, Mountain View, CA - - 2014
Atrial fibrillation (AF) is a complex disease with multiple inter-relating causes culminating in rapid, seemingly disorganized atrial activation. Therapy targeting AF is rapidly changing and improving. The purpose of this review is to summarize current state-of-the-art diagnostic and therapeutic modalities for treatment of AF. The review focuses on reviewing treatment ...
Smith Joan J Volunteer speaker on patient - - 2014
Can one person truly empathise with another? It is difficult to know what patients go through when faced with a life-threatening illness. In my case that illness was multiple myeloma-cancer of the plasma cells in the bone marrow.
Schwartz Jeffrey H JH Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, - - 2014
Lordkipanidze et al. (Research Article, 18 October 2013, p. 326) conclude, from gross morphological comparisons and geometric-morphometric analysis of general shape, that the five hominid crania from Dmanisi in Georgia represent a single regional variant of Homo erectus. However, dental, mandibular, and cranial morphologies all suggest taxic diversity and, in ...
Kashtan Nadav N Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, - - 2014
Extensive genomic diversity within coexisting members of a microbial species has been revealed through selected cultured isolates and metagenomic assemblies. Yet, the cell-by-cell genomic composition of wild uncultured populations of co-occurring cells is largely unknown. In this work, we applied large-scale single-cell genomics to study populations of the globally abundant ...
Zollikofer Christoph P E CP Anthropological Institute and Museum, University of Zurich, Zurich, - - 2014
Schwartz et al. hold that variation among the Dmanisi skulls reflects taxic diversity. The morphological observations to support their hypothesis, however, are partly incorrect, and not calibrated against intraspecific variation in living taxa. After proper adjustment, Schwartz et al.'s data are fully compatible with the hypothesis of a single paleodeme ...
Song Feng F National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, - - 2014
The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional regulation and other DNA-related biological processes. Here, we report the 11-angstrom-resolution cryogenic electron microscopy (cryo-EM) structures of 30-nanometer chromatin fibers reconstituted in the presence of linker histone H1 and with different nucleosome repeat lengths. The structures show a ...
Du Juana J Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, - - 2014
In contrast to the wealth of catalytic systems that are available to control the stereochemistry of thermally promoted cycloadditions, few similarly effective methods exist for the stereocontrol of photochemical cycloadditions. A major unsolved challenge in the design of enantioselective catalytic photocycloaddition reactions has been the difficulty of controlling racemic background ...
Bailey E E University of Manchester, School of Dentistry, Higher Cambridge Street, Manchester, M13 - - 2014
This paper compares the beneficial and harmful effects of paracetamol, ibuprofen and the novel combination of both in a single tablet for pain relief following the surgical removal of lower wisdom teeth. In this systematic review only randomised controlled double-blinded clinical trials were included. We calculated the proportion of patients ...
Trayanova Natalia A NA From the Department of Biomedical Engineering and Institute for Computational Medicine, Johns Hopkins University, Baltimore, - - 2014
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The mechanisms that govern AF initiation and persistence are highly complex, of dynamic nature, and involve interactions across multiple temporal and spatial scales in the atria. This article aims to review the mathematical modeling and computer simulation approaches to ...
Hodgkinson Alan A CHU Sainte-Justine Research Centre, Department of Pediatrics, Faculty of Medicine, Université de Montreal, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, - - 2014
Mutations in the mitochondrial genome are associated with multiple diseases and biological processes; however, little is known about the extent of sequence variation in the mitochondrial transcriptome. By ultra-deeply sequencing mitochondrial RNA (>6000×) from the whole blood of ~1000 individuals from the CARTaGENE project, we identified remarkable levels of sequence ...
- - 2014
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation ...
Berndt Andre A Department of Bioengineering, Stanford University, Stanford, CA 94305, - - 2014
Using light to silence electrical activity in targeted cells is a major goal of optogenetics. Available optogenetic proteins that directly move ions to achieve silencing are inefficient, pumping only a single ion per photon across the cell membrane rather than allowing many ions per photon to flow through a channel ...
Kleinfeld David D 1] Department of Physics, University of California, San Diego, La Jolla, California, USA. [2] Section of Neurobiology, University of California, San Diego, La Jolla, California, - - 2014
When rodents engage in the exploration of novel stimuli, breathing occurs at an accelerated rate that is synchronous with whisking. We review the recently observed relationships between breathing and the sensations of smell and vibrissa-based touch. We consider the hypothesis that the breathing rhythm serves not only as a motor ...
Valaperti Alan A Division of Cardiology, Heart and Stroke/Richard Lewar Centre of Excellence, Toronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada, - - 2014
c-Cbl-associated protein (CAP), also called Sorbs1 or ponsin, has been described as an essential adapter protein in the insulin-signalling pathway. Here, we describe for the first time a unique protective role for CAP in viral myocarditis. Mortality and heart failure development were increased in CAP(-/-) mice compared to CAP(+/+) littermates ...
Peate Ian I Editor in Chief British Journal of - - 2014
The Nursing and Midwifery Council (NMC) is the regulator for the largest group of health professionals in the UK with about 670,000 registered nurses and midwives on the professional register (NMC, 2013).
Macpherson Wilma W BJN Awards 2014 Lifetime Achievement - - 2014
My nursing career began almost by accident. In 1960 I was leaving school, accepted to commence a university degree programme, having no future career plan, when I developed an appendicitis and was admitted to the small local hospital. My fate was sealed. My love affair with nursing began.
Ansell Helen H Nurse Educator, Hawke’s Bay District Health - - 2014
This is an investigation into nurses' practice of when they would not take and record a patient's respiratory rate. It reports results of qualitative, descriptive research involving interviews with ten ward nurses from three hospitals in New Zealand. Results affirm that, despite it being the most sensitive vital sign for ...
White Mark M National Lead for the Productive Ward & Interim - - 2014
The Productive Ward: Releasing time to care (PW) initiative is predominantly a nurse-led quality improvement (QI) offering, designed to streamline ward work processes and clinical environments in an attempt to 'release time to care'. It has been implemented widely in the UK, recently attracting international interest. This paper systematically reviews ...
Tingle John J Reader in Health Law, Nottingham Law School, Nottingham Trent - - 2014
John Tingle discusses the Health Foundation's two recent publications, which provide important perspectives on putting patient interests first in the NHS.
Fowler John J General and mental health nurse. He has worked as an Educational Consultant to primary care trusts and as a Principal Lecturer in Nursing for many - - 2014
This series is exploring what reflection is and how it can be applied to your clinical practice. The previous five articles have examined the importance of reflection: what it is, ways to aid reflection, its relationship to feedback and reflective practice.
O'Rourke C C London Centre for Nanotechnology, 17-19 Gordon St, WC1H 0AH, London. Department of Physics & Astronomy, University College London, Gower St, WC1E 6BT, London. UCL Satellite, International Centre for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, - - 2014
Electrodes in dye sensitised solar cells are typically nanocrystalline anatase TiO2 with a majority (1 0 1) surface exposed. Generally the sensitising dye employs a carboxylic anchoring moiety through which it adheres to the TiO2 surface. Recent interest in exploiting the properties of differing TiO2 electrode morphologies, such as rutile nanorods exposing ...
Cák M M Atomistic Modelling and Simulation, ICAMS, Ruhr-Universität Bochum, Universitätstr. 150, 44780 Bochum, - - 2014
Bond-order potentials (BOPs) are based on the tight-binding approximation for determining the energy of a system of interacting atoms. The bond energy and forces are computed analytically within the formalism of the analytic BOPs. Here we present parametrizations of the analytic BOPs for the bcc refractory metals Nb, Ta, Mo ...
Kupčić I I Department of Physics, Faculty of Science, University of Zagreb, PO Box 331, HR-10002 Zagreb, - - 2014
The current-dipole Kubo formula for the dynamical conductivity of interacting multiband electronic systems derived in Kupčić et al (2013 J. Phys.: Condens. Matter 25 145602) is illustrated on the Peierls model for quasi-one-dimensional systems with the charge-density-wave (CDW) instability. Using the microscopic representation of the Peierls model, it is shown ...
Korotin Dm M DM Institute of Metal Physics, S. Kovalevskoy St. 18, 620990 Yekaterinburg, - - 2014
The monoclinic crystal structure of the undoped BaBiO3 can be described as a cubic perovskite which is distorted by the frozen breathing and tilting phonon modes of the BiO6 octahedra. The phonon mode softening is experimentally observed (Braden et al 1996 Europhys. Lett. 34 531) in Ba1-xKxBiO3 through potassium doping ...
Chakraborty Tanushree T Centre for Advanced Materials, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, - - 2014
BaTi0.95Fe0.05O3-δ has been suggested to be an intrinsic dilute magnetic oxide with a clear dependence of magnetism on oxygen vacancy concentration. However, it has also been shown that the dopant Fe ions distribute themselves rather inhomogeneously within the lattice, though without disrupting the crystal phase of the parent BaTiO3. With ...
Sipr O O Institute of Physics of the ASCR vvi, Cukrovarnická 10, CZ-162 53 Prague, Czech - - 2014
The substrate contribution to the magnetic anisotropy energy (MAE) of supported nanostructures can be assessed by a site-selective manipulation of the spin-orbit coupling (SOC) and of the effective exchange field Bex. A systematic study of Co adatoms and Co monolayers on the (1 1 1) surfaces of Cu, Ag, Au, Pd and ...
Oh J H JH Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, - - 2014
Starting with the indirect exchange model influenced by the Rashba and the Dresselhaus spin-orbit interactions, we derive the Dzyaloshinskii-Moriya interaction of localized spins. The strength of the Dzyaloshinskii-Moriya interaction is compared with that of the Heisenberg exchange term as a function of atomic distance. Using the calculated interaction strengths, we ...
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