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Greenfield Thomas K TK Alcohol Research Group, Public Health Institute, Emeryville, - - 2014
The harms of second-hand smoke motivated tobacco control legislation. Documenting the effects of harms from others' drinking might increase popular and political will for enacting alcohol policies. We investigated the individual-level relationship between having experienced such harms and favouring alcohol policy measures, adjusting for other influences. We used the landline ...
Oldenburg J J Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, - - 2014
Currently, new clotting factor concentrates are becoming available or are in advanced clinical studies that will significantly improve the treatment of patients with Haemophilia A or Haemophilia B. Various technologies are applied to extend half-life and/or allow for alternative routes of administration, e.g. subcutaneous route. Today, the advances for recombinant ...
Goodeve A C AC Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust and Haemostasis Research Group, Department of Cardiovascular Science, University of Sheffield, Sheffield, - - 2014
Molecular genetic tools are widely applied in inherited bleeding disorders. New genes involved in haemorrhagic disorders have been identified by genome wide linkage analysis on families with a specific phenotype. LMNA1 or MCFD in combined FV/FVIII-deficiency and VKORC1 in vitamin K coagulation factor deficiency type 2 are two examples. Identification ...
James P P Department of Medicine, Queen's University, Kingston, - - 2014
Rare bleeding disorders (RBDs) are inherited deficiencies of coagulation factors such as fibrinogen, factor (F) II, FV, FVII, combined FV+FVIII, FX, FXI and FXIII. These disorders usually have a low prevalence in the general population and constitute approximately 3-5% of all coagulation disorders. However, in some countries they may have ...
Carcao M M Division of Haematology/Oncology, Department of Pediatrics, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, - - 2014
Beginning in the 1960s the care of persons with haemophilia began to improve dramatically through a series of transformative improvements in care: development of lyophilized factor concentrates, home care programmes, prophylaxis and (due to the tragedy of HIV/hepatitis) the development of virally safer plasma-derived and recombinant factor concentrates. Prophylaxis, if ...
Yin Senlin S Department of Cardiovascular Surgery, Pediatric Heart Center of West China Hospital, Sichuan University, Chengdu, Sichuan, - - 2014
Ventricular septal defect (VSD) is a common congenital heart disease. Open surgical repair with cardiopulmonary bypass (CPB) and sternotomy is the classic treatment. Percutaneous device closure is a minimally invasive alternative in treating selected VSDs, but it is limited by vascular access as well as radiation exposure especially in pediatric ...
Pergolizzi Joseph V JV 840 111th Ave., N., Ste. 9, Naples, FL 34108. - - 2014
Literature has shown that chronic pain patients prescribed opioids are at an increased risk for experiencing drug-drug interactions as a result of polypharmacy. In addition, chronic, noncancer pain patients who experience drug-drug interactions have been shown to have greater health care utilization and costs. However, no study has focused on ...
Lafeuille Marie-Hélène MH Groupe d'analyse, Ltée, 1000 De La Gauchetière W., Ste. 1200, Montréal, QC H3B 4W5. - - 2014
With the growing use of oral anticancer medications, understanding adherence patterns has become increasingly important. Abiraterone acetate (AA) is a prodrug of abiraterone, a novel androgen biosynthesis inhibitor. AA is approved for use in combination with prednisone for treatment of patients with metastatic castration-resistant prostate cancer.  To evaluate AA and ...
Lourenço Olga O CICS-UBI Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, Covilhã, Castelo Branco 6200-506, Portugal. - - 2014
Allergic rhinitis and asthma (ARA) are frequent respiratory diseases that often coexist, causing a high social and economic impact. It is important to maintain ARA disease control to reduce the disease burden. To assess control in patients with 1 or both pathologies through the application of validated questionnaires at community ...
König Niklas N University Outpatient Clinic, Sports Medicine and Sports Orthopedics, University of Potsdam, Am Neuen Palais 10, Haus 12, 14469 Potsdam, Germany. - - 2014
Objectives- Sonography of muscle architecture provides physicians and researchers with information about muscle function and muscle-related disorders. Inter-rater reliability is a crucial parameter in daily clinical routines. The aim of this study was to assess the inter-rater reliability of sonographic muscle architecture assessments and quantification of errors that arise from ...
Lee Tae Kil TK Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea. - - 2014
Objectives- The purpose of this prospective study was to investigate the usefulness of acoustic radiation force impulse (ARFI) elastography of the pancreas for predicting postoperative pancreatic fistula occurrence after pancreatic resection. Methods- Twenty-five patients underwent ARFI elastography of the pancreas before pancreatic resection (11 men and 14 women; mean age, ...
Yang Zun Z Affiliated Hospital of Stomatology, Chongqing Medical University, 426 Songshi North St, Yubei District, 401147 Chongqing, China. - - 2014
Objectives- Low-intensity pulsed ultrasound (US) can accelerate fracture healing and osteogenic differentiation. The aim of this study was to investigate the osteogenic effect of low-intensity pulsed US on human periodontal ligament cells and to determine whether bone morphogenetic protein (BMP)-Smad signaling was involved. Methods- Human periodontal ligament cells were exposed ...
Bucknoff Melissa C MC Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA - - 2014
Objective-To determine whether thromboelastography is more accurate than conventional methods of evaluating hemostasis for the prediction of clinical bleeding in thrombocytopenic dogs following total body irradiation (TBI) and bone marrow transplantation (BMT). Animals-10 client-owned thrombocytopenic dogs with multicentric lymphoma. Procedures-Results of a kaolin-activated thromboelastography assay, platelet count, and buccal mucosal ...
Churgin Sarah M SM Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI - - 2014
Objective-To compare pharmacokinetics after a single IM or SC injection of ceftiofur crystalline-free acid (CCFA) to bearded dragons (Pogona vitticeps). Animals-8 adult male bearded dragons. Procedures-In a preliminary experiment, doses of 15 and 30 mg/kg, SC, were compared in 2 animals, and 30 mg/kg resulted in a more desirable pharmacokinetic ...
Michaux Hélène H Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC, J2S 2M2, - - 2014
Objective-To describe the optimal thoracoscopic approach to the bovine pleural cavity and evaluate the short-term effects of thoracoscopy on cardiovascular and pulmonary function of healthy cattle. Sample-6 healthy adult Holstein cows (12 hemithoraxes). Procedures-For each cow, thoracoscopy was performed in both the left and right hemithoraxes with a 24-hour interval ...
Beckwith-Cohen Billie B Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, - - 2014
Objective-To determine baseline tear pH in dogs, horses, and cattle by use of a microelectrode. Animals-28 dogs, 24 horses, and 29 cattle. Procedures-Under manual restraint, tears were collected from each subject's left eye with cotton spears. A Schirmer tear test was performed in the right eye. Tears were extracted from ...
Berndt M C MC Faculty of Health Sciences, Curtin University, Perth, Western Australia, - - 2014
At the same time as biophysical and omics approaches are drilling deeper into the molecular details of platelets and other blood cells, as well as their receptors and mechanisms of regulation, there is also an increasing awareness of the functional overlap between human vascular systems. Together, these studies are redefining ...
Kitchen S S Coagulation Laboratory, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, - - 2014
The dawning era of novel recombinant factor VIII and factor IX concentrates, many of which have been bioengineered to achieve prolonged activity, brings with it the need to consider the most appropriate clinical laboratory approaches for potency assignment, as well as the measurement of postinfusion levels. This session will highlight ...
Favaloro E J EJ Diagnostic Haemostasis, Haematology Department, Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, Westmead Hospital, Westmead, NSW, - - 2014
The diagnosis and management of bleeding disorders is made difficult by the complexity and variety of disorders, clinical symptoms and bleeding type and severity. von Willebrand disease (VWD) and platelet disorders are disorders of primary haemostasis and together represent the most common inherited bleeding disorders. In this article, we describe ...
Scott D W DW Department of Medicine, Uniformed Services, University for the Health Sciences, Bethesda, MD, - - 2014
The immune response against therapeutic clotting factors VIII and IX (FVIII and FIX) is a major adverse event that can effectively thwart their effectiveness in correcting bleeding disorders. Thus, a significant number of haemophilia patients form antibodies, called inhibitors, which neutralize the procoagulant functions of therapeutic cofactors FVIII (haemophilia A) ...
Fischer K K Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The - - 2014
Prophylaxis has become the standard mantra of care for those individuals with severe haemophilia A and B. Primary prophylaxis is advocated to prevent the occurrence of symptomatic acute spontaneous haemarthroses and to preserve joint structure and function. Typically, twice or thrice weekly infusions of factor VIII or IX concentrates are ...
Prestipino Filippo F Department of Cardiovascular Science, Unit of Cardiovascular Surgery, University Campus Bio-Medico of Rome, Rome, - - 2014
Nickel hypersensitivity is reported in about 10-15% of the general population and manifests mainly with dermatological signs. Chest discomfort, palpitations, signs and symptoms of pericarditis, and migraine are symptoms reported in rare cases of nickel hypersensitivity after implantation of a cardiac device made of nickel. We present the case of ...
Kozma Chris M CM 84 Tomahawk Trail, St. Helena Island, SC 29920. - - 2014
Approaches to pain management are diverse, requiring prescribers to evaluate an array of clinical issues and potential solutions. In addition to the difficult task of selecting a treatment option, pain treatment may be further complicated by multiple prescribers, multiple medications, and multiple mechanisms of pain origination. To describe patient demographics ...
Armstrong Edward P EP College of Pharmacy, University of Arizona, Tucson, AZ 85721. - - 2014
Health systems have developed interventions to reduce harm associated with drug-drug interactions. Pharmacy benefit managers are in an important position to identify the coprescribing of medications known to interact, since they process data on a large portion of prescription claims in the United States. Electronic health records and electronic prescribing ...
Rombach Nicole N Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI - - 2014
Objective-To determine the gross morphology of the multifidus, longus colli, and longus thoracis muscles in the cervical and cranial thoracic portions of the equine vertebral column. Sample-15 horse cadavers. Procedures-The vertebral column was removed intact from the first cervical vertebra (C1) to the seventh thoracic vertebra (T7). After removing the ...
Pypendop Bruno H BH Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA - - 2014
Objective-To characterize the pharmacokinetics of dexmedetomidine after IV administration of a bolus to conscious healthy cats. Animals-5 healthy adult spayed female cats. Procedures-Dexmedetomidine was administered IV as a bolus at 3 doses (5, 20, or 50 μg/kg) on separate days in a random order. Blood samples were collected immediately before ...
Pypendop Bruno H BH Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA - - 2014
Objective-To characterize the relationship between plasma dexmedetomidine concentration and the temperature difference between the thermal threshold and skin temperature (ΔT) and between plasma dexmedetomidine concentration and sedation score in healthy cats. Animals-5 healthy adult spayed female cats. Procedures-Cats received IV administrations of saline (0.9% NaCl) solution, dexmedetomidine (5, 20, or ...
Jones Stephen C SC Comparative Orthopaedics and Biomechanics Laboratory, College of Veterinary Medicine, University of Florida, Gainesville, FL - - 2014
Objective-To compare accuracy of a noninvasive single-plane fluoroscopic technique with radiostereometric analysis (RSA) for determining 3-D femorotibial poses in a canine cadaver with normal stifle joints. Sample-Right pelvic limb from a 25-kg adult mixed-breed dog. Procedures-A CT scan of the limb was obtained before and after metal beads were implanted ...
Santos Marcos P MP Department of Clinical Veterinary Medicine, University of Illinois, Urbana-Champaign, IL - - 2014
Objective-To compare the mechanical properties of laryngeal tie-forward (LTF) surrogate constructs prepared with steel fixtures and No. 5 braided polyester or braided polyethylene by use of a standard or a modified suture placement technique. Sample-32 LTF surrogate constructs. Procedures-Surrogate constructs were prepared with steel fixtures and sutures (polyester or polyethylene) ...
Cortese Victor S VS Department of Veterinary Operations Cattle/Equine, Zoetis, 746 Veechdale Rd, Simpsonville, KY - - 2014
Objective-To determine whether a flexible vaccination regimen provides protection against challenge exposure with a virulent Leptospira borgpetersenii serovar Hardjo isolate. Animals-Fifty-five 4-week-old calves seronegative for antibodies against L borgpetersenii serovar Hardjo. Procedures-Calves were assigned to 3 groups and administered 2 doses of adjuvant (control calves; n = 11), 1 dose ...
Ialomiteanu Anca R AR Social and Epidemiological Research Department, Centre for Addiction and Mental Health, Toronto, - - 2014
The aim of our paper is to present trend data concerning public opinion on alcohol policy in the Canadian province of Ontario over a 16-year period (1996-2011), to assess if the level of support for alcohol control policies changed over this period and if any changes in public support for ...
Srivastava A A Department of Haematology, Christian Medical College, Vellore, - - 2014
Care for people with haemophilia (PWH) has improved much over the last two decades leading to near normal lives for those receiving early regular prophylaxis with clotting factor concentrates (CFC). Yet, there are significant limitations of those practices. In the absence of a well-defined optimal prophylaxis protocol, there are wide ...
Haxaire C C Arthritis & Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, - - 2014
One of the main complications of haemophilia A is haemophilic arthropathy (HA), a debilitating disease with a significant negative impact on motility and quality of life. Despite major advances in the treatment of haemophilia A, many patients still suffer from HA. We wish to develop new treatments for HA, but ...
Shima M M Department of Pediatrics, Nara Medical University, Kashihara, Nara, - - 2014
The primary major issue in haemophilia treatment remains the development of inhibitors. Recently two novel bypassing products have been developed. First, a humanized bispecific antibody against FIXa and FX, termed hBS23, was produced utilizing these two molecules placed into a spatially appropriate position to mimic FVIIIa, and recently this mimetic ...
High K H KH Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, - - 2014
After many reports of successful gene therapy studies in small and large animal models of haemophilia, we have, at last, seen the first signs of success in human patients. These very encouraging results have been achieved with the use of adeno-associated viral (AAV) vectors in patients with severe haemophilia B. ...
de Brasi C C Instituto de Medicina Experimental (IMEX), CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina; Instituto de Investigaciones Hematologicas Mariano R Castex, Academia Nacional de Medicina, Buenos Aires, - - 2014
The aim of molecular genetic analysis in families with haemophilia is to identify the causative mutation in an affected male as this provides valuable information for the patient and his relatives. For the patient, mutation identification may highlight inhibitor development risk or discrepancy between different factor VIII assays. For female ...
Castaman G G Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bartolo Hospital, Vicenza, - - 2014
The deficiency or abnormal function of von Willebrand factor (VWF) causes von Willebrand disease (VWD), the most frequent inherited bleeding disorder. The laboratory diagnosis of VWD can be difficult as the disease is heterogeneous and an array of assays is required to describe the phenotype. Basic classification of quantitative (type ...
van den Berg H M HM Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the - - 2014
Inhibitor development is a serious complication of treatment with coagulation products. Presently, 25-30% of all newly diagnosed patients with severe haemophilia A are diagnosed with inhibitors. An increasing number of genetic and non-genetic risk factors have been reported to be involved, although the impact of them in understanding the aetiology ...
Lillicrap D D Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, - - 2014
It is known that a large number of both genetic and environmental factors contribute to the risk of inhibitor development, but underlying pathogenetic mechanisms are still under investigation. The clinical research on inhibitors towards factor VIII (FVIII) is challenged by the fact that this is an infrequent event occurring in ...
Favaloro E J EJ Diagnostic Haemostasis, Haematology Department, Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, Westmead Hospital, Westmead, NSW, - - 2014
Inhibitor assays are performed when patients present with unexplained prolonged routine coagulation test times and unexpected and/or unusual bleeding (potential for acquired haemophilia) as well as being a part of normal congenital haemophilia management and monitoring, particularly when bleeding occurs on therapy, or when increments in factor levels post-factor replacement ...
Botsios Spiridon S Department of Thoracic- and Cardiovascular Surgery, St.-Johannes Hospital Dortmund, Dortmund, Germany; Faculty of Health, University Witten/Herdecke, Witten, - - 2014
This study evaluated the long-term results of thoracic endovascular aortic repair (TEVAR) of nontraumatic rupture of the descending thoracic aorta. This was a retrospective and observational single-center study. During the 10-year study period, 21 patients (6 males) with an average age of 66.1 ± 12.4 (range 31-81) years underwent emergency TEVAR for ...
Rylski Bartosz B Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Heart Center Freiburg University, Freiburg, - - 2014
Transcatheter aortic valve implantation (TAVI) is contraindicated in the presence of an ascending aortic aneurysm. Our aim was to design a composite endovascular device enabling ascending aortic repair and TAVI. From 2007 to 2013, among 1196 patients with severe aortic stenosis screened for TAVI, 79 nonbicuspid patients had ascending aortic ...
Prifti Edvin E Division of Cardiac Surgery, University Hospital Center of Tirana, Tirana, - - 2014
The aim of this study was to evaluate the outcome in a series of patients with Ebstein's anomaly and a failing right ventricle (RV) undergoing tricuspid valve (TV) repair and bidirectional Glenn cavopulmonary anastomosis (BDG). Between January 2006 and September 2013, 11 consecutive patients diagnosed with severe forms of Ebstein's ...
Garcia Maria M MM University of Massachusetts Medical School, Department of Medicine, 55 Lake Ave., N., Worcester, MA 01655. - - 2014
The utilization of prescription opioids has increased over the last 2 decades. Associated with this is the misuse of prescription opioids for nonmedical purposes. Medicaid programs have struggled with developing strategies that balance best practice models, appropriate utilization, and reduction in costs associated with the opioid medication class.  To examine ...
Roberts Andrew W AW UNC Eshelman School of Pharmacy, Campus Box 7573, Kerr Hall 2206, 301 Pharmacy Ln., Chapel Hill, NC 27599. - - 2014
Nonmedical use of prescription medications-particularly controlled substances-has risen dramatically in recent decades, resulting in alarming increases in overdose-related health care utilization, costs, and mortality. The Centers for Disease Control and Prevention estimate that 80% of abused and misused controlled substances originate as legal prescriptions. As such, policymakers and payers have ...
Parthan Anju A Optum, HEOR, P.O. Box 9472, Minneapolis, MN 55440. - - 2014
Adjuvant trastuzumab treatment is administered to early stage breast cancer patients in physician office (POV) or hospital outpatient (HOP) settings.  To identify treatment patterns, utilization, and costs by site of care (POV vs. HOP) of patients with adjuvant treatment of breast cancer with trastuzumab. This retrospective analysis identified adult, female ...
Levin Philip A PA MODEL Clinical Research, Greater Baltimore Medical Center, 6535 N. Charles St., Ste. 400 N, Baltimore, MD 21204. - - 2014
Patients with uncontrolled type 2 diabetes mellitus (T2DM), despite therapy with 2 oral antidiabetic drugs (OADs), may add a third OAD or a glucagon-like peptide-1 receptor agonist (GLP-1) or initiate insulin therapy. The transition to insulin has been shown to be delayed in current practice, potentially through clinical inertia-the failure ...
Honkaniemi Emma E 1Department of Pediatrics, Astrid Lindgren Children`s Hospital, Karolinska University Hospital-Huddinge, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, - - 2014
Background: Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 protein expression ...
Marin Daniele D From the Department of Radiology, Duke University Medical Center, Box 3808, Room 1531, Erwin Rd, Durham, NC - - 2014
Recent technologic advances in computed tomography (CT)-enabling the nearly simultaneous acquisition of clinical images using two different x-ray energy spectra-have sparked renewed interest in dual-energy CT. By interrogating the unique characteristics of different materials at different x-ray energies, dual-energy CT can be used to provide quantitative information about tissue composition, ...
Macdonald Lois S LS From the Department of Radiology, Royal Blackburn Hospital, Haslingden Rd, Blackburn, Lancashire BB2 3HH, England (L.S.M., S.L.); and Department of Clinical Biochemistry, University College London Hospitals, London, England - - 2014
History An 80-year-old woman presented to the on-call surgical team with a 2-day history of abdominal distention and vomiting. Clinical examination revealed a distended tympanic abdomen with generalized tenderness but no evidence of peritoneal signs at physical examination. Relevant surgical history included previous intervention for renal stones, cholecystectomy, and cardiovascular ...
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