Search Results
Results 51 - 100 of 2001
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Castaman G G Department of Cell Therapy and Hematology, Hemophilia and Thrombosis Center, San Bartolo Hospital, Vicenza, - - 2014
The deficiency or abnormal function of von Willebrand factor (VWF) causes von Willebrand disease (VWD), the most frequent inherited bleeding disorder. The laboratory diagnosis of VWD can be difficult as the disease is heterogeneous and an array of assays is required to describe the phenotype. Basic classification of quantitative (type ...
Blanchette V S VS Division of Hematology/Oncology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, ON, - - 2014
Effective healthcare delivery necessitates evaluation of the effect of interventions in the form of outcome assessment. Treatment effect includes measurement of how the patient feels, functions and survives following healthcare interventions. In haemophilia, which is a rare bleeding disorder, outcome assessment was characterized by a lack of validated outcome measurement ...
Michaux Hélène H Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, St-Hyacinthe, QC, J2S 2M2, - - 2014
Objective-To describe the optimal thoracoscopic approach to the bovine pleural cavity and evaluate the short-term effects of thoracoscopy on cardiovascular and pulmonary function of healthy cattle. Sample-6 healthy adult Holstein cows (12 hemithoraxes). Procedures-For each cow, thoracoscopy was performed in both the left and right hemithoraxes with a 24-hour interval ...
Gweon Hye Mi HM Department of Radiology, Gangnam Severance Hospital, 211 Eonjuro, Dogok-Dong, Gangnam-Gu, Seoul 135-720, Korea. - - 2014
Objectives- The purpose of this study was to evaluate the diagnostic performance and interobserver agreement of 2-dimensional (2D) and 3-dimensional (3D) sonography for evaluating extrathyroidal extension of papillary thyroid carcinoma. Methods- A total of 79 papillary thyroid carcinomas in 79 patients who underwent both 2D and 3D sonography for preoperative ...
Rombach Nicole N Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI - - 2014
Objective-To determine the gross morphology of the multifidus, longus colli, and longus thoracis muscles in the cervical and cranial thoracic portions of the equine vertebral column. Sample-15 horse cadavers. Procedures-The vertebral column was removed intact from the first cervical vertebra (C1) to the seventh thoracic vertebra (T7). After removing the ...
Scott D W DW Department of Medicine, Uniformed Services, University for the Health Sciences, Bethesda, MD, - - 2014
The immune response against therapeutic clotting factors VIII and IX (FVIII and FIX) is a major adverse event that can effectively thwart their effectiveness in correcting bleeding disorders. Thus, a significant number of haemophilia patients form antibodies, called inhibitors, which neutralize the procoagulant functions of therapeutic cofactors FVIII (haemophilia A) ...
Muffly Tyler M TM From the *Division of Female Pelvic Medicine and Reconstructive Surgery, University of Colorado Anschutz Medical Campus, Aurora; and †Department of Obstetrics & Gynecology, Kaiser Permanente Medical Center, Denver, - - 2014
The purpose of this study was to determine the publication rate of full-text articles after the presentation of abstracts at consecutive annual meetings of the American Urogynecologic Society (AUGS) over a 2-year period. Using abstract books published by the Journal of Pelvic Medicine and Surgery, we obtained the text of ...
Peyvandi F F Department of Pathophysiology and Transplantation, Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Luigi Villa Foundation, Milan, - - 2014
Haemophilia therapy is experiencing an unprecedented expansion in the number and novelty of clotting factor concentrates. Every product must be licensed by regulatory authorities, primarily on the basis of its safety and efficacy profiles. The low prevalence of haemophilia, and other inherited bleeding disorders, presents a significant challenge to patient ...
Zhang Haibin H Department of Ultrasound, PLA 210th Hospital, 116011 Dalian, Liaoning, China. - - 2014
Objectives- The purpose of this study was to investigate how the myocardial acceleration during isovolumic contraction changed in rats with diabetic cardiomyopathy and a normal left ventricular ejection fraction (LVEF) by using velocity vector imaging. Methods- Velocity vector imaging was performed in 12 control rats and 15 rats with streptozotocin-induced ...
Churgin Sarah M SM Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI - - 2014
Objective-To compare pharmacokinetics after a single IM or SC injection of ceftiofur crystalline-free acid (CCFA) to bearded dragons (Pogona vitticeps). Animals-8 adult male bearded dragons. Procedures-In a preliminary experiment, doses of 15 and 30 mg/kg, SC, were compared in 2 animals, and 30 mg/kg resulted in a more desirable pharmacokinetic ...
Carcao M M Division of Haematology/Oncology, Department of Pediatrics, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, ON, - - 2014
Beginning in the 1960s the care of persons with haemophilia began to improve dramatically through a series of transformative improvements in care: development of lyophilized factor concentrates, home care programmes, prophylaxis and (due to the tragedy of HIV/hepatitis) the development of virally safer plasma-derived and recombinant factor concentrates. Prophylaxis, if ...
Walter Paige J PJ From the *Department of Obstetrics and Gynecology, Duke University Medical Center, Durham; and †Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, - - 2014
This study aimed to examine how anticholinergic medication exposure affects the risk of failed postoperative void trial (VT) in women undergoing urogynecologic surgery. We conducted a retrospective cohort study of women undergoing outpatient prolapse or incontinence surgery. We evaluated perioperative anticholinergic exposure via the validated anticholinergic risk scale (ARS). Total ...
Roberts Andrew W AW UNC Eshelman School of Pharmacy, Campus Box 7573, Kerr Hall 2206, 301 Pharmacy Ln., Chapel Hill, NC 27599. - - 2014
Nonmedical use of prescription medications-particularly controlled substances-has risen dramatically in recent decades, resulting in alarming increases in overdose-related health care utilization, costs, and mortality. The Centers for Disease Control and Prevention estimate that 80% of abused and misused controlled substances originate as legal prescriptions. As such, policymakers and payers have ...
Segura J J Institut Hospital del Mar d'Investigacions Mèdiques IMIM, , Barcelona, - - 2014
The collection of blood, its storage as red blood cell (RBC) concentrates and its reinjection is prohibited; until now, the practice cannot be reliably detected. A recent innovation-the haematological module of the athlete's biological passport-can provide authorities with indications towards autologous blood transfusion. In situations where a given athlete has ...
Rylski Bartosz B Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; Heart Center Freiburg University, Freiburg, - - 2014
Transcatheter aortic valve implantation (TAVI) is contraindicated in the presence of an ascending aortic aneurysm. Our aim was to design a composite endovascular device enabling ascending aortic repair and TAVI. From 2007 to 2013, among 1196 patients with severe aortic stenosis screened for TAVI, 79 nonbicuspid patients had ascending aortic ...
Honkaniemi Emma E 1Department of Pediatrics, Astrid Lindgren Children`s Hospital, Karolinska University Hospital-Huddinge, Department of Clinical Science Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, - - 2014
Background: Alterations in the tumor suppressor gene TP53 have been associated with poor outcome in adult hematological malignancies. We have earlier reported an increased expression of the TP53 encoded protein p53, in bone marrow samples from pediatric patients with aggressive leukemia. Our aim was now to evaluate p53 protein expression ...
Dunn Guinn Ellen GE From the *Department of Obstetrics and Gynecology, and †Department of Family and Preventative Medicine, University of Utah School of Medicine, Salt Lake City, UT; and ‡College of Nursing, University of Utah, Salt Lake City, - - 2014
The aim of this study was to describe how women experience vaginal mesh complications after optimized tertiary care level treatment. We conducted telephone interviews in 2012 with women at least 6 months after presentation to our tertiary care clinic between 2006 and 2011 for complications related to vaginal mesh and ...
Cortese Victor S VS Department of Veterinary Operations Cattle/Equine, Zoetis, 746 Veechdale Rd, Simpsonville, KY - - 2014
Objective-To determine whether a flexible vaccination regimen provides protection against challenge exposure with a virulent Leptospira borgpetersenii serovar Hardjo isolate. Animals-Fifty-five 4-week-old calves seronegative for antibodies against L borgpetersenii serovar Hardjo. Procedures-Calves were assigned to 3 groups and administered 2 doses of adjuvant (control calves; n = 11), 1 dose ...
Greenfield Thomas K TK Alcohol Research Group, Public Health Institute, Emeryville, - - 2014
The harms of second-hand smoke motivated tobacco control legislation. Documenting the effects of harms from others' drinking might increase popular and political will for enacting alcohol policies. We investigated the individual-level relationship between having experienced such harms and favouring alcohol policy measures, adjusting for other influences. We used the landline ...
Gao Yong Y MS, Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Rd, Nanning, 530021 Guangxi, China. - - 2014
Objectives- The purpose of this study was to prospectively assess the accuracy of sonography versus magnetic resonance imaging (MRI) for a diagnosis of primary nasopharyngeal carcinoma. Methods- A total of 150 patients suspected of having nasopharyngeal carcinoma underwent sonography and MRI. A diagnosis was obtained from an endoscopic biopsy that ...
Pypendop Bruno H BH Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA - - 2014
Objective-To characterize the relationship between plasma dexmedetomidine concentration and the temperature difference between the thermal threshold and skin temperature (ΔT) and between plasma dexmedetomidine concentration and sedation score in healthy cats. Animals-5 healthy adult spayed female cats. Procedures-Cats received IV administrations of saline (0.9% NaCl) solution, dexmedetomidine (5, 20, or ...
Favaloro E J EJ Diagnostic Haemostasis, Haematology Department, Institute of Clinical Pathology and Medical Research (ICPMR), Pathology West, Westmead Hospital, Westmead, NSW, - - 2014
Inhibitor assays are performed when patients present with unexplained prolonged routine coagulation test times and unexpected and/or unusual bleeding (potential for acquired haemophilia) as well as being a part of normal congenital haemophilia management and monitoring, particularly when bleeding occurs on therapy, or when increments in factor levels post-factor replacement ...
Baker Jan J From the Departments of *Obstetrics and Gynecology, and †Department of Occupational Therapy, University of Utah School of Medicine, Salt Lake City, - - 2014
The objective of this study is to compare the effects of mindfulness-based stress reduction (MBSR) versus yoga on urinary urge incontinence (UI) at 8 weeks, 6 months, and 1 year after beginning an 8-week program. Participants in this prospective randomized single-masked pilot study were women aged 18 years or older ...
Iacobellis Francesca F Department of Radiology, Azienda Ospedaliero Universitaria di Cagliari-Polo di Monserrato, SS 554 Monserrato, 09045 Cagliari, Italy. - - 2014
Objectives- The aim of this study was to detect the onset, evolution, and meaning of extraluminal free fluid in a rat model of small-bowel obstruction using high-frequency microsonography. Methods- Small-bowel obstruction was surgically created in 8 rats divided into 2 groups of 4 rats each. All rats were examined by ...
Chen Rui-Rui RR Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Nanjing, Jiangsu Province, - - 2014
In S. exigua, ingestion of Cry1Ac reduces larval growth, shortens lifespan, and decreases copulation and oviposition of the adults. Cadherin-like protein SeCad1b in S. exigua has recently been published. Here, we tested whether SeCad1b mediates the negative effects of Cry1Ac. We identified three potential Cry toxin binding regions in SeCad1b, ...
Reddy Uma M UM Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 4B03F, Bethesda, MD 20892-7510 USA. - - 2014
Given that practice variation exists in the frequency and performance of ultrasound and magnetic resonance imaging (MRI) in pregnancy, the Eunice Kennedy Shriver National Institute of Child Health and Human Development hosted a workshop to address indications for ultrasound and MRI in pregnancy, to discuss when and how often these ...
Kehl Sven S Department of Obstetrics and Gynecology, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. - - 2014
Objectives- The purpose of this study was to compare different methods for measuring the fetal lung area-to-head circumference ratio and to investigate their prediction of postpartum survival and the need for neonatal extracorporeal membrane oxygenation (ECMO) therapy in fetuses with isolated congenital diaphragmatic hernias. Methods- This prospective study included 118 ...
Garcia Maria M MM University of Massachusetts Medical School, Department of Medicine, 55 Lake Ave., N., Worcester, MA 01655. - - 2014
The utilization of prescription opioids has increased over the last 2 decades. Associated with this is the misuse of prescription opioids for nonmedical purposes. Medicaid programs have struggled with developing strategies that balance best practice models, appropriate utilization, and reduction in costs associated with the opioid medication class.  To examine ...
Luckert Christian C Department of Pediatric Surgery, University Medical Center Hamburg Eppendorf, Hamburg, - - 2014
Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been demonstrated on a variety of human cancer cells. However, data on neuroblastoma is lacking. Therefore, our aim was to evaluate the effect ...
Shin Na-Young NY Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-ku, Seoul 120-752, Korea. - - 2014
Objectives- The purpose of this study was to assess the diagnostic performance of transient elastography and sonography for noninvasive evaluation of liver fibrosis in infants with biliary atresia. Methods- Forty-seven infants with biliary atresia who underwent both transient elastography and sonography before surgery were included in this study. Two types ...
Beckwith-Cohen Billie B Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, - - 2014
Objective-To determine baseline tear pH in dogs, horses, and cattle by use of a microelectrode. Animals-28 dogs, 24 horses, and 29 cattle. Procedures-Under manual restraint, tears were collected from each subject's left eye with cotton spears. A Schirmer tear test was performed in the right eye. Tears were extracted from ...
Lee Tae Kil TK Department of Radiology, Severance Hospital, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea. - - 2014
Objectives- The purpose of this prospective study was to investigate the usefulness of acoustic radiation force impulse (ARFI) elastography of the pancreas for predicting postoperative pancreatic fistula occurrence after pancreatic resection. Methods- Twenty-five patients underwent ARFI elastography of the pancreas before pancreatic resection (11 men and 14 women; mean age, ...
Oldenburg J J Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, - - 2014
Currently, new clotting factor concentrates are becoming available or are in advanced clinical studies that will significantly improve the treatment of patients with Haemophilia A or Haemophilia B. Various technologies are applied to extend half-life and/or allow for alternative routes of administration, e.g. subcutaneous route. Today, the advances for recombinant ...
Parthan Anju A Optum, HEOR, P.O. Box 9472, Minneapolis, MN 55440. - - 2014
Adjuvant trastuzumab treatment is administered to early stage breast cancer patients in physician office (POV) or hospital outpatient (HOP) settings.  To identify treatment patterns, utilization, and costs by site of care (POV vs. HOP) of patients with adjuvant treatment of breast cancer with trastuzumab. This retrospective analysis identified adult, female ...
Pypendop Bruno H BH Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA - - 2014
Objective-To characterize the pharmacokinetics of dexmedetomidine after IV administration of a bolus to conscious healthy cats. Animals-5 healthy adult spayed female cats. Procedures-Dexmedetomidine was administered IV as a bolus at 3 doses (5, 20, or 50 μg/kg) on separate days in a random order. Blood samples were collected immediately before ...
Lillicrap D D Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, - - 2014
It is known that a large number of both genetic and environmental factors contribute to the risk of inhibitor development, but underlying pathogenetic mechanisms are still under investigation. The clinical research on inhibitors towards factor VIII (FVIII) is challenged by the fact that this is an infrequent event occurring in ...
Huang Alison J AJ From the *Department of Medicine, University of California San Francisco, San Francisco, CA; †Icahn School of Medicine at Mt Sinai, New York, NY; Departments of ‡Obstetrics, Gynecology, and Reproductive Sciences, and §Urology, University of California San Francisco, San Francisco, - - 2014
The aim of this study is to examine the feasibility, efficacy, and safety of a group-based yoga therapy intervention for middle-aged and older women with urinary incontinence. We conducted a pilot randomized trial of ambulatory women aged 40 years and older with stress, urgency, or mixed-type incontinence. Women were randomized ...
Dolan G G Nottingham University Hospitals, Nottingham, - - 2014
Clinical registries or databases have an increasing role in the management of inherited bleeding disorders. Initially, research-based registries provided valuable data and now national databases are increasingly being developed with multiple stakeholders, including persons with haemophilia (PWH) and payers, to enable improvements and efficiencies in care. Registries are extending to ...
Jones Stephen C SC Comparative Orthopaedics and Biomechanics Laboratory, College of Veterinary Medicine, University of Florida, Gainesville, FL - - 2014
Objective-To compare accuracy of a noninvasive single-plane fluoroscopic analysis technique with radiostereometric analysis (RSA) for determining 3-D femorotibial poses in a canine cadaver stifle joint treated by tibial-plateau-leveling osteotomy (TPLO). Sample-Left pelvic limb from a 25-kg adult mixed-breed dog. Procedures-A CT scan of the left pelvic limb was performed. The ...
de Brasi C C Instituto de Medicina Experimental (IMEX), CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina; Instituto de Investigaciones Hematologicas Mariano R Castex, Academia Nacional de Medicina, Buenos Aires, - - 2014
The aim of molecular genetic analysis in families with haemophilia is to identify the causative mutation in an affected male as this provides valuable information for the patient and his relatives. For the patient, mutation identification may highlight inhibitor development risk or discrepancy between different factor VIII assays. For female ...
Macdonald Lois S LS From the Department of Radiology, Royal Blackburn Hospital, Haslingden Rd, Blackburn, Lancashire BB2 3HH, England (L.S.M., S.L.); and Department of Clinical Biochemistry, University College London Hospitals, London, England - - 2014
History An 80-year-old woman presented to the on-call surgical team with a 2-day history of abdominal distention and vomiting. Clinical examination revealed a distended tympanic abdomen with generalized tenderness but no evidence of peritoneal signs at physical examination. Relevant surgical history included previous intervention for renal stones, cholecystectomy, and cardiovascular ...
König Niklas N University Outpatient Clinic, Sports Medicine and Sports Orthopedics, University of Potsdam, Am Neuen Palais 10, Haus 12, 14469 Potsdam, Germany. - - 2014
Objectives- Sonography of muscle architecture provides physicians and researchers with information about muscle function and muscle-related disorders. Inter-rater reliability is a crucial parameter in daily clinical routines. The aim of this study was to assess the inter-rater reliability of sonographic muscle architecture assessments and quantification of errors that arise from ...
Haxaire C C Arthritis & Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, - - 2014
One of the main complications of haemophilia A is haemophilic arthropathy (HA), a debilitating disease with a significant negative impact on motility and quality of life. Despite major advances in the treatment of haemophilia A, many patients still suffer from HA. We wish to develop new treatments for HA, but ...
Pergolizzi Joseph V JV 840 111th Ave., N., Ste. 9, Naples, FL 34108. - - 2014
Literature has shown that chronic pain patients prescribed opioids are at an increased risk for experiencing drug-drug interactions as a result of polypharmacy. In addition, chronic, noncancer pain patients who experience drug-drug interactions have been shown to have greater health care utilization and costs. However, no study has focused on ...
Moroni Rafael Mendes RM From the Urogynecology, Gynecological and Pelvic Reconstructive Surgery Division, Department of Gynecology and Obstetrics, Ribeirao Preto School of Medicine, University of São Paulo, São Paulo, - - 2014
This study aimed to report a unique perineal abscess after placement of a transobturator sling, involving the thighs and obturator regions bilaterally without involving mesh exposure. A 66-year-old woman treated for stress urinary incontinence with a transobturator sling developed a late bilateral obturator infection 30 months after surgery. This complication ...
Dvorak Jiri J FIFA, , Zürich, - - 2014
Prominent doping cases in certain sports have recently raised public awareness of doping and reinforced the perception that doping is widespread. Efforts to deal with doping in sport have intensified in recent years, yet the general public believes that the 'cheaters' are ahead of the testers. Therefore, there is an ...
Yang Dal Mo DM Department of Radiology, Kyung Hee University Hospital at Gangdong, 149 Sangil-Dong, Gangdong-Gu, Seoul 134-090, Korea. E-mail; - - 2014
The purpose of this series was to describe the sonographic findings of tuberculous vasitis. We conducted a retrospective analysis of 3 cases of tuberculous vasitis. The following grayscale and color Doppler sonographic features were analyzed: location, echogenicity of the lesion, epididymal or testicular involvement, presence of hydrocele, and blood flow ...
Prestipino Filippo F Department of Cardiovascular Science, Unit of Cardiovascular Surgery, University Campus Bio-Medico of Rome, Rome, - - 2014
Nickel hypersensitivity is reported in about 10-15% of the general population and manifests mainly with dermatological signs. Chest discomfort, palpitations, signs and symptoms of pericarditis, and migraine are symptoms reported in rare cases of nickel hypersensitivity after implantation of a cardiac device made of nickel. We present the case of ...
High K H KH Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, - - 2014
After many reports of successful gene therapy studies in small and large animal models of haemophilia, we have, at last, seen the first signs of success in human patients. These very encouraging results have been achieved with the use of adeno-associated viral (AAV) vectors in patients with severe haemophilia B. ...
Lourenço Olga O CICS-UBI Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, Covilhã, Castelo Branco 6200-506, Portugal. - - 2014
Allergic rhinitis and asthma (ARA) are frequent respiratory diseases that often coexist, causing a high social and economic impact. It is important to maintain ARA disease control to reduce the disease burden. To assess control in patients with 1 or both pathologies through the application of validated questionnaires at community ...
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