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Schneider Francisco Santos FS Departamento de Bioquímica e Imunologia, Instituto Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, - - 2014
The snake Bothrops atrox is responsible for the majority of envenomings in the northern region of South America. Severe local effects, including hemorrhage, which are mainly caused by snake venom metalloproteinases (SVMPs), are not fully neutralized by conventional serum therapy. Little is known about the immunochemistry of the P-I SVMPs ...
Kager Liesbeth M LM Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands; Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The - - 2014
During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). APC has both anticoagulant and ...
Barajas Daniel D Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of - - 2014
Assembling of the membrane-bound viral replicase complexes (VRCs) consisting of viral- and host-encoded proteins is a key step during the replication of positive-stranded RNA viruses in the infected cells. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host have revealed the involvement of eleven cellular ...
Nie Qing-Miao QM Department of Computational Science and Engineering, Nagoya University, Nagoya, Japan; Institute for Molecular Science, Okazaki, Japan; Department of Applied Physics, Zhejiang University of Technology, Hangzhou, P. R. - - 2014
An important unresolved problem associated with actomyosin motors is the role of Brownian motion in the process of force generation. On the basis of structural observations of myosins and actins, the widely held lever-arm hypothesis has been proposed, in which proteins are assumed to show sequential structural changes among observed ...
Zheng Xiangzi X Department of Biochemistry, Centre for Plant Molecular Biology, Eberhard Karls University, Tübingen, - - 2014
Genome sequences of several economically important phytopathogenic oomycetes have revealed the presence of large families of so-called RXLR effectors. Functional screens have identified RXLR effector repertoires that either compromise or induce plant defense responses. However, limited information is available about the molecular mechanisms underlying the modes of action of these ...
Maciejewski Wes W Department of Mathematics, The University of British Columbia, Vancouver, British Columbia, - - 2014
Evolutionary graph theory is a well established framework for modelling the evolution of social behaviours in structured populations. An emerging consensus in this field is that graphs that exhibit heterogeneity in the number of connections between individuals are more conducive to the spread of cooperative behaviours. In this article we ...
Pollitt Laura C LC Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America; Centre for Immunology, Infection and Evolution, The University of Edinburgh, Edinburgh, United - - 2014
The evolution of drug resistance, a key challenge for our ability to treat and control infections, depends on two processes: de-novo resistance mutations, and the selection for and spread of resistant mutants within a population. Understanding the factors influencing the rates of these two processes is essential for maximizing the ...
Zelezniak Aleksej A European Molecular Biology Laboratory, Heidelberg, Germany; Technical University of Denmark, Kgs. Lyngby, - - 2014
One of the primary mechanisms through which a cell exerts control over its metabolic state is by modulating expression levels of its enzyme-coding genes. However, the changes at the level of enzyme expression allow only indirect control over metabolite levels, for two main reasons. First, at the level of individual ...
Stauch Anette A Department of Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, - - 2014
The elimination of infectious diseases requires reducing transmission below a certain threshold. The Visceral Leishmaniasis (VL) Elimination Initiative in Southeast Asia aims to reduce the annual VL incidence rate below 1 case per 10,000 inhabitants in endemic areas by 2015 via a combination of case management and vector control. Using ...
Nana-Djeunga Hugues C HC Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, Yaounde, Cameroon; Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaounde, - - 2014
For two decades, onchocerciasis control has been based on mass treatment with ivermectin (IVM), repeated annually or six-monthly. This drug kills Onchocerca volvulus microfilariae (mf) present in the skin and the eyes (microfilaricidal effect) and prevents for 3-4 months the release of new mf by adult female worms (embryostatic effect). ...
Telleria Erich Loza EL Yale School of Public Health, Department of Epidemiology of Microbial Diseases, LEPH, New Haven, Connecticut, United States of - - 2014
The agents of sleeping sickness disease, Trypanosoma brucei complex parasites, are transmitted to mammalian hosts through the bite of an infected tsetse. Information on tsetse-trypanosome interactions in the salivary gland (SG) tissue, and on mammalian infective metacyclic (MC) parasites present in the SG, is sparse. We performed RNA-seq analyses from ...
Teixeira Clarissa C Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America; Centro de Pesquisas Gonçalo Moniz, Fiocruz, Bahia, - - 2014
Mice exposed to sand fly saliva are protected against vector-transmitted Leishmania major. Although protection has been related to IFN- γ producing T cells, the early inflammatory response orchestrating this outcome has not been defined. Mice exposed to uninfected P. duboscqi bites and naïve mice were challenged with L. major-infected flies ...
Obiero George F O GF Molecular Biology and Bioinformatics Unit, International Center of Insect Physiology and Ecology (icipe), Nairobi, Kenya; South African Bioinformatics Institute (SANBI), South African MRC Bioinformatics Unit, University of the Western Cape, Bellville, South - - 2014
Tsetse flies use olfactory and gustatory responses, through odorant and gustatory receptors (ORs and GRs), to interact with their environment. Glossina morsitans morsitans genome ORs and GRs were annotated using homologs of these genes in Drosophila melanogaster and an ab initio approach based on OR and GR specific motifs in ...
Deshong Alison J AJ Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of - - 2014
Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated to promote the obligate crossover is not well understood. PCH-2 is a highly conserved meiotic ...
Kuntz Steven G SG QB3 Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, California, United States of America; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of - - 2014
Temperature affects both the timing and outcome of animal development, but the detailed effects of temperature on the progress of early development have been poorly characterized. To determine the impact of temperature on the order and timing of events during Drosophila melanogaster embryogenesis, we used time-lapse imaging to track the ...
Chang Yun C YC Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, NIAID, NIH Bethesda, Maryland, United States of - - 2014
Cryptococcus neoformans encounters a low oxygen environment when it enters the human host. Here, we show that the conserved Ras1 (a small GTPase) and Cdc24 (the guanine nucleotide exchange factor for Cdc42) play an essential role in cryptococcal growth in hypoxia. Suppressor studies indicate that PTP3 functions epistatically downstream of ...
Schmidt Thomas S B TS Institute for Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, Zürich, - - 2014
Operational Taxonomic Units (OTUs), usually defined as clusters of similar 16S/18S rRNA sequences, are the most widely used basic diversity units in large-scale characterizations of microbial communities. However, it remains unclear how well the various proposed OTU clustering algorithms approximate 'true' microbial taxa. Here, we explore the ecological consistency of ...
Alam Mohammad Murshid MM Centre for Vaccine Sciences, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, - - 2014
Multiple infections with diverse enterotoxigenic E. coli (ETEC) strains lead to broad spectrum protection against ETEC diarrhea. However, the precise mechanism of protection against ETEC infection is still unknown. Therefore, memory B cell responses and affinity maturation of antibodies to the specific ETEC antigens might be important to understand the ...
Zangger Haroun H Department of Biochemistry, University of Lausanne, Epalinges, Vaud, - - 2014
Infection with Leishmania parasites causes mainly cutaneous lesions at the site of the sand fly bite. Inflammatory metastatic forms have been reported with Leishmania species such as L. braziliensis, guyanensis and aethiopica. Little is known about the factors underlying such exacerbated clinical presentations. Leishmania RNA virus (LRV) is mainly found ...
Rose Clair C Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United - - 2014
Tsetse flies serve as biological vectors for several species of African trypanosomes. In order to survive, proliferate and establish a midgut infection, trypanosomes must cross the tsetse fly peritrophic matrix (PM), which is an acellular gut lining surrounding the blood meal. Crossing of this multi-layered structure occurs at least twice ...
Benoit Joshua B JB Division of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of - - 2014
In tsetse flies, nutrients for intrauterine larval development are synthesized by the modified accessory gland (milk gland) and provided in mother's milk during lactation. Interference with at least two milk proteins has been shown to extend larval development and reduce fecundity. The goal of this study was to perform a ...
Cho Hyong-Ho HH Pediatric Neuroscience Research Program, Papé Family Pediatric Research Institute, Department of Pediatrics, Portland, Oregon, United States of America; Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju, - - 2014
The establishment of correct neurotransmitter characteristics is an essential step of neuronal fate specification in CNS development. However, very little is known about how a battery of genes involved in the determination of a specific type of chemical-driven neurotransmission is coordinately regulated during vertebrate development. Here, we investigated the gene ...
Attardo Geoffrey M GM Yale School of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, Connecticut, United States of - - 2014
Regulation of tissue and development specific gene expression patterns underlies the functional specialization of organs in multi-cellular organisms. In the viviparous tsetse fly (Glossina), the female accessory gland is specialized to generate nutrients in the form of a milk-like secretion to support growth of intrauterine larva. Multiple milk protein genes ...
Nsoesie Elaine O EO Children's Hospital Informatics Program, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America; Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of - - 2014
Hantavirus pulmonary syndrome (HPS) is a life threatening disease transmitted by the rodent Oligoryzomys longicaudatus in Chile. Hantavirus outbreaks are typically small and geographically confined. Several studies have estimated risk based on spatial and temporal distribution of cases in relation to climate and environmental variables, but few have considered climatological ...
Mitra Sreyoshi S Molecular Mycology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, - - 2014
Specification of the centromere location in most eukaryotes is not solely dependent on the DNA sequence. However, the non-genetic determinants of centromere identity are not clearly defined. While multiple mechanisms, individually or in concert, may specify centromeres epigenetically, most studies in this area are focused on a universal factor, a ...
Rodrigues Vasco V CNRS FR3636, Université Paris Descartes, Paris, France; Parasite Disease Group, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, - - 2014
Leishmania infantum causes a chronic infectious disease named visceral leishmaniasis (VL). We employed a non-human primate model to monitor immune parameters over time and gain new insights into the disease. Rhesus macaques were infected with L. infantum and the T helper and B cell immunological profiles characterized during acute and ...
Dosik Jonathan S JS TKL Research, Inc., Rochelle Park, New - - 2014
Phase 1 studies were conducted to determine the sensitization (PEP005-005; NCT00357916; http://clinicaltrials.gov/ct2/show/NCT00357916), photoirritation (PEP005-023; NCT00850811; http://clinicaltrials.gov/ct2/show/NCT00850811?term=PEP005-023&rank=1), and photoallergic (photosensitizing) potential (PEP005-024; NCT00850681; http://clinicaltrials.gov/ct2/show/NCT00850681?term=PEP005-024&rank=1) of ingenol mebutate gel 0.01% versus vehicle on normal skin. Healthy volunteers were enrolled in single-center, randomized, controlled, within-subject comparison trials. PEP005-005 was designed as a repeat-insult ...
Nestor Mark S MS Center for Cosmetic Enhancement, Aventura, Florida; ; Department of Dermatology and Cutaneous Surgery, University of Miami, Miller School of Medicine, Miami, - - 2014
To evaluate the safety, efficacy, and durability of treating axillary hyperhidrosis with high-intensity micro-focused ultrasound plus visualization. Two randomized double-blind, sham-controlled pilot studies. For Study 1, the primary endpoint was response defined as ≥50-percent reduction in baseline sweat production as measured gravimetrically. For Study 2, the primary endpoint was response ...
Van Acker Monica M MM Michigan State University College of Osteopathic Medicine, East Lansing, - - 2014
The objective of this study was to determine if delivery of wound care instruction pre-Mohs micrographic surgery versus the typical, post-Mohs surgery would allow for greater patient retention. A non-blinded, randomized, controlled trial receiving institutional review board exemption from Michigan State University was conducted over a three-month period. Patients scheduled ...
Benoit Joshua B JB Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut, United States of - - 2014
Tsetse flies undergo drastic fluctuations in their water content throughout their adult life history due to events such as blood feeding, dehydration and lactation, an essential feature of the viviparous reproductive biology of tsetse. Aquaporins (AQPs) are transmembrane proteins that allow water and other solutes to permeate through cellular membranes. ...
Mei-Dan Omer - - 2014
Femoral derotational osteotomy is an acceptable treatment for excessive femoral torsion. The described procedure is a minimally invasive single-incision technique based on an intramedullary saw that enables an inside-out osteotomy, preserving the periosteum and biological activity in the local bone and soft tissue. After the osteotomy is complete and correction ...
Abbasi Mohammad - - 2014
Although coronary artery bypass graft surgery has significant effects on reducing the symptoms of coronary artery disease, there is not enough knowledge and understanding of lived experience of patients after surgery. Understanding lived experience of this group of patients would be helpful for healthcare staff to provide better services to ...
Abdolahian Somayeh - - 2014
There are a wide variety of non- pharmacologic pain relief techniques for labor which include pelvic movement, upright position, back massage and partner support during the first stage of labor. The effectiveness of dance labor- which is a combination of these techniques- has not been evaluated. This study aimed to ...
Khan Muhammad Shahzeb MS Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan. - - 2014
The primary objective of the study was to find out the frequency of tobacco smoking among health care providers in tertiary care hospitals of Karachi. The secondary objective was to identify the common factors responsible for the continuation of smoking. This cross sectional study was conducted in the wards and ...
Balla Siham Ahmed SA University of Khartoum. - - 2014
Hypertension is emerging as an alarming public-health problem causes organ damage. To identify prevalence of hypertension and predictor factors among rural population in four states in Sudan. A community based cross-sectional study was conducted in sixteen rural areas in Sudan during April 2012. A total of 3020 adult were interviewed ...
Sheikhmoonesi Fatemeh F Psychiatry and Behavioral Sciences research center, Mazandaran university of Medical Sciences. - - 2014
Self- discharged patients are at high risk for readmission and ultimately higher cost for care.We intended to find the proportion of patients who leave hospital against medical advice and explore some of their characteristics. This prospective study of discharge against medical advice was conducted in psychiatric wards of Zare hospital ...
D'Onofrio Mirko M Mirko D'Onofrio, Stefano Canestrini, Stefano Crosara, Riccardo De Robertis, Roberto Pozzi Mucelli, Department of Radiology, University Hospital G.B. Rossi, University of Verona, 37134 Verona, - - 2014
The aim of this study was to determine whether contrast enhanced ultrasound (CEUS) quantitative perfusion analysis allows an objective characterization of ductal adenocarcinoma (ADK) of the pancreas. Patients with pancreatic ADK underwent CEUS. All examinations were performed on an Acuson S2000 system (Siemens, Erlangen, Germany) after the iv administration of ...
Annunziata Salvatore S Salvatore Annunziata, Carmelo Caldarella, Institute of Nuclear Medicine, Catholic University of the Sacred Heart, 00168 Rome, - - 2014
To systematically review published data on the cost-effectiveness of Fluorine-18-Fluorodeoxyglucose positron emission tomography (FDG-PET) or PET/computed tomography (PET/CT) in tumours other than lung cancer. A comprehensive literature search of studies published in PubMed/MEDLINE, Scopus and Embase databases through the 10(th) of October in 2013 was carried out. A search algorithm ...
Ranade Rohit R Rohit Ranade, Pradeep Thapa, Sandip Basu, Radiation Medicine Centre (B.A.R.C), Tata Memorial Centre Annexe, Mumbai 400012, - - 2014
Adrenal metastasis is an unusual site of disease involvement in the natural course of differentiated thyroid carcinoma (DTC). This paper discusses the clinical and imaging features of DTC with adrenal metastasis. An unusual case of unilateral solitary asymptomatic adrenal metastasis in the setting of DTC is described in this report ...
Galinimoghaddam Tahereh - - 2014
Failure to progress remains a key indication for cesarean section which caused by different factors including uterine contractions. If it is diagnosed in the primary phase of labor, a better prognosis can thus be made. The purpose of this study was to find a possible correlation between pattern of uterine ...
Sritharan Jeavana J University of Ontario Institute of Technology. - - 2014
In Ontario, there are significant geographical disparities in colorectal cancer incidence. In particular, the northern region of Timiskaming has the highest incidence of colorectal cancer in Ontario while the southern region of Peel displays the lowest. We aimed to identify non-nutritional modifiable environmental factors in Timiskaming that may be associated ...
Khan Muhammad Shahzeb MS Dow University of Health Sciences. - - 2014
There are two basic ways of performing coronary artery bypass graft surgery (CABG): on pump CABG and off pump CABG. Off pump CABG is relatively a newer procedure to on-pump CABG and does not require the use of the cardiopulmonary bypass machine. On pump CABG is the more traditional method ...
Bakhit Mahsa M 1.Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2.Department of Audiology, School of Rehabilitation, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.. - - 2014
Over administration of diagnostic tests in health care settings is a critical issue, imposing a great deal of expenditure on health sector. Vertigo and dizziness are common complaints of many patients who seek medical advice, and the vast majority of them undergo several evaluations, including Brain Magnetic Resonance Imaging (MRI), ...
Yue Grace Gar-Lee GG Institute of Chinese Medicine, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong, People's Republic of - - 2014
The dried roots of Cynanchum stauntonii in having cough-relieving efficacy are commonly included in traditional antitussive formulas. The active components in a C. stauntonii root extract responsible for airway relaxation were isolated using an ex vivo bioassay-guided fractionation method, in which subfractions were evaluated for their inhibitory effects on the ...
Ahmadian Maryam M Universiti Putra Malaysia. - - 2014
This paper presents the findings of a cross-sectional survey on the risk and protective factors of premarital sexual behavior among rural female adolescents in Peninsular Malaysia. We investigated data on 770 female respondents aged 13-17 years in rural areas to identify predictive factors for premarital sexual intercourse. Data were analyzed ...
Liu Kai - - 2014
Micro bimorph coils driven by a metalinsulator phase transition in VO2 function as powerful torsional muscles. Reversible torsional motion over one million cycles without degradation is demonstrated, with a superior rotational speed up to ca. 200,000 rpm, an amplitude of 500° per mm length, and a power density up to ...
Gautam Vini - - 2014
A polymer bulk heterojunction structure utilized as an active photosensitive platform to evoke neuronal activity in a blind retina. The features of the elicited action potentials correlate with the optoelectronic properties of the polymer/electrolyte interface, and resembles the natural response of the retina to light. The polymer interface can be ...
Joly L L Institut de Physique et de Chimie des Materiaux de Strasbourg, Université de Strasbourg, UMR 7504, 23 Rue du Loess, BP 43, 67034 Strasbourg Cedex 2, - - 2014
In order to improve the efficiency of X-ray absorption data recording, a fast scan method, the Turboscan, has been developed on the DEIMOS beamline at Synchrotron SOLEIL, consisting of a software-synchronized continuous motion of the monochromator and undulator motors. This process suppresses the time loss when waiting for the motors ...
Mohacsi Istvan I Paul Scherrer Institut, 5232 Villigen, - - 2014
High-efficiency nanofocusing of hard X-rays using stacked multilevel Fresnel zone plates with a smallest zone width of 200 nm is demonstrated. The approach is to approximate the ideal parabolic lens profile with two-, three-, four- and six-level zone plates. By stacking binary and three-level zone plates with an additional binary zone ...
Chen Wen Hao WH Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, People's Republic of - - 2014
Quantifying three-dimensional spatial distributions of pores and material compositions in samples is a key materials characterization challenge, particularly in samples where compositions are distributed across a range of length scales, and where such compositions have similar X-ray absorption properties, such as in coal. Consequently, obtaining detailed information within sub-regions of ...
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