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Results 301 - 350 of 2994
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Wong Christopher J CJ Division of General Internal Medicine, Department of Medicine, University of Washington, 4245 Roosevelt Way Northeast, Box 354760, Seattle, WA 98105, USA. Electronic address: - - 2014
Involuntary weight loss, defined as 5% or greater weight loss occurring within 6 to 12 months, may have a prevalence as high as 7% in the adult population. In case series, malignant, gastrointestinal, and psychiatric conditions were common, although unidentified causes were still prevalent after evaluation. Patients without malignancy are more ...
Sutton Eliza L EL Department of Medicine, University of Washington, 4245 Roosevelt Way Northeast, Box 354765, Seattle, WA 98105, USA. Electronic address: - - 2014
Insomnia, as the term is used by patients and in primary care, is a symptom: dissatisfaction with the quality or quantity of sleep obtained, despite attempts. For acute insomnia, reversal of the trigger (if possible) and treatment with safe, effective sleep medication are advised. For chronic insomnia, as with other ...
Hale Natalie N Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, - - 2014
Headaches are the most common constellation of neurologic disorders observed in clinical practice. This article discusses the clinical features of the most common headache subtypes and helps elucidate the more nuanced features of newly recognized and frequently misdiagnosed headache disorders. The physical examination, recommendations regarding imaging, treatment, and the differentiation ...
Vary Jay C JC Division of Dermatology, Department of Internal Medicine, The University of Washington, Box 354697, 4225 Roosevelt Way Northeast, 4th Floor, Seattle, WA 98195, USA. Electronic address: - - 2014
This review discusses common dermatologic presentations as they would appear in a primary care office, exploring the differential diagnoses for each. Tips are provided on choosing an appropriate topical drug and vehicle and advising patients on its use. Etiology, differential diagnosis, and treatment options are discussed for the following: alopecias ...
Manos Daria D Department of Diagnostic Radiology, QE II Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address: - - 2014
Despite the positive outcome of the recent randomized trial of computed tomography (CT) screening for lung cancer, substantial implementation challenges remain, including the clear reporting of relative risk and suggested workup of screen-detected nodules. Based on current literature, we propose a 6-level Lung-Reporting and Data System (LU-RADS) that classifies screening ...
Moore William A WA 1 Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX - - 2014
The purpose of this article is to review abdominopelvic applications of diffusion-weighted imaging (DWI), discuss advantages and limitations of DWI, and illustrate these with examples. High-quality abdominopelvic DWI can be performed routinely on current MRI systems and may offer added value in image interpretation. Particularly in unenhanced MRI examinations, DWI ...
Yuan Wei-Hsin WH 1 Division of Radiology, Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan, Republic of - - 2014
The objective of our study was to evaluate the CT characteristics of globe rupture. The medical records of patients seen in the emergency department with blunt, penetrating, or explosive orbit injury were retrospectively reviewed. A total of 75 patients (76 injured globes) were included (56 males and 19 females; average ...
Parez N N Service de Pédiatrie, Hôpital Louis Mourier, Colombes, France. Electronic address: - - 2014
Rotavirus gastroenteritis is a vaccine-preventable disease that confers a high medical and economic burden in more developed countries and can be fatal in less developed countries. Two vaccines with high efficacy and good safety profiles were approved and made available in Europe in 2006. We present an overview of the ...
Bielska Agata A AA Diabetic Cardiovascular Disease Center, Washington University School of Medicine , St. Louis, Missouri 63110, United - - 2014
Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), are key regulators of cholesterol homeostasis. New evidence suggests that the alteration of membrane structure by 25-HC contributes to its regulatory effects. We have examined the role of oxysterol membrane effects on cholesterol accessibility within the membrane using perfringolysin O (PFO), a cholesterol-dependent cytolysin ...
Eisenberg Jonathan D JD 1 Department of Radiology, Massachusetts General Hospital Institute for Technology Assessment, 101 Merrimac St, 10th Fl, Boston, MA - - 2014
The purpose of this article is to evaluate whether examination-specific radiation dose metrics reliably measure an institution's success in reducing cancer risks. We projected health benefits from dose-reduction programs in a hypothetical institution that sought to decrease exposures from abdominopelvic CT. Using modeling techniques to project radiation-induced cancer risks and ...
McDonald Elizabeth S ES 1 Department of Radiology, University of Washington School of Medicine, Seattle Cancer Care Alliance, 825 Eastlake Ave E, G3-200, Seattle, WA - - 2014
The purpose of this study is to assess associations between patient characteristics and apparent diffusion coefficient (ADC) values of normal breast fibroglandular tissue on diffusion-weighted imaging (DWI) at 3 T. The retrospective study included 103 women with negative bilateral findings on 3-T breast MRI examinations (BI-RADS category 1). DWI was ...
Whitney Cynthia G - - 2014
The Vaccines for Children (VFC) program was created by the Omnibus Budget Reconciliation Act of 1993 and first implemented in 1994. VFC was designed to ensure that eligible children do not contract vaccine-preventable diseases because of inability to pay for vaccine and was created in response to a measles resurgence ...
Robbins Cheryl L - - 2014
Problem/Condition: Promoting preconception health can potentially improve women's health and pregnancy outcomes. Evidence-based interventions exist to reduce many maternal behaviors and chronic conditions that are associated with adverse pregnancy outcomes such as tobacco use, alcohol use, inadequate folic acid intake, obesity, hypertension, and diabetes. The 2006 national recommendations to improve ...
He Yulong Y Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. - - 2014
The incidence of gastrointestinal stromal tumor(GIST) is 1-2 per 100 000. Micro GIST with a size less than 1 cm are found in 3%-35% elderly population. These small-size GIST are usually located in the middle or upper stomach, with gain-function KIT or PDGFRA mutation. In this review, the clinicopathological features ...
Shen Lin L Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China. - - 2014
The Gastrointestinal Stromal Tumor Experts Committee amended and complemented the Chinese Consensus on the Diagnosis and Treatment of Gastrointestinal Stromal Tumors(2013 version) based on the previous edition(2011 version) after broad consulation, repeat discussion on new results of clinical trials in recent years and the opinions of many experts. In the ...
Liang Han H Department of Gastrointestinal Surgery, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China. - - 2014
Targeted therapy is the first line treatment for patients with recurrent/metastatic gastrointestinal stromal tumors(GIST). Sunitinib is effective for patients who have failed imatinib, specially with c-kit exon 9 gene mutation. Tyrosine kinase inhibitors combined with partial hepatectomy may increase the overall survival of GIST patients with liver metastasis. Selective patients ...
Cao Hui H Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. - - 2014
Gastrointestinal stromal tumors(GIST) are the most common mesenchymal tumors of the gastrointestinal tract, and are mostly characterized by c-kit or PDGFRA gain-of-function mutation. About 10%-15% of GIST do not harbor any mutations in the c-kit and PDGFRA genes and are defined as wild-type GIST. There are significant differences in molecular ...
Pan Zhizhong Z Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangdong 510060, China. - - 2014
Gastrointestinal stromal tumors(GIST) are known for their molecular alterations in KIT or PDGFR genes, and have become the paradigm of molecularly targeted therapies for solid tumors. Recent researches of genotype and phenotype demonstrate that molecular subtypes can predict the response to treatment with tyrosine kinase inhibitors and are related with ...
Zhang Li L Department of Gastrointestinal Cancer, Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China. - - 2014
To evaluate the impact of primary site, NIH risk and imatinib treatment on the prognosis of patients with gastrointestinal stromal tumors(GIST). Clinicopathological data of 156 adult patients with GIST treated by imatinib in the Cancer Institute and Hospital of Tianjin Medical University from January 2006 to December 2010 were retrospectively ...
Zhang Xinhua X Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. - - 2014
To investigate the feasibility and short-term efficacy of laparoscopic resection of primary local gastric and intestinal gastrointestinal stromal tumors(GIST). Clinicopathological data of 26 patients with GIST, 20 located at the stomach and 6 at the intestine, undergoing laparoscopic complete resection from October 2010 to April 2013 were retrospectively analyzed. Hand-assisted ...
Liu Licheng L Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, China. - - 2014
To analyze the efficacy and prognosis of different treatments on small intestinal gastrointestinal stromal tumors(SIGIST). Clinical data of 63 patients with SIGIST who were admitted to the Chinese PLA General Hospital from January 2004 to December 2013 were analyzed retrospectively. According to resection procedure and postoperative use of imatinib, patients ...
Wang Ying Y Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China. - - 2014
To assess the efficacy and safety of endoscopic submucosal excavation(ESE) for gastric gastrointestinal stromal tumors(GISTs). Clinical data of 86 gastric GISTs patients undergoing ESE in our department from January 2007 to January 2013 were analyzed retrospectively. The whole tumor biopsy was used to determine the risk stratification. Complication of ESE ...
Xu Ao A Center of General Surgery of PLA, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. - - 2014
To assess the effect of radical laparoscopy-assisted gastrectomy(LG) for patients with chronic obstructive pulmonary disease (COPD). Clinical data of 340 gastric cancer patients with COPD undergoing radical gastrectomy with lymphadenectomy at Southwest Hospital, Third Military Medical University between January 2010 and October 2013 were analyzed retrospectively. The clinical outcomes for ...
Xu Chao C Department of Colon and Rectum Surgery, Fujian Medical University Union Hospital, Fuzhou 35001, China. - - 2014
To investigate the associated factors for postoperative ileus following radical resection for colorectal cancer. Clinical data of 1366 colorectal cancer patients undergoing radical resection by the same surgical team in our hospital from January 2000 to September 2011 were analyzed retrospectively. Univariate analysis and multivariate logistic regression analysis were used ...
Sun Yandong Y Department of General Sugery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. - - 2014
To evaluate the safety and short-term outcomes of laparoscopic-assisted surgery for rectal cancer by comparing the efficacy of laparoscopy and open surgery. Clinical data of patients with rectal cancer treated by laparoscopy or open surgery in Zhongshan Hospital from April 2011 to June 2012 were analyzed retrospectively, and the clinical ...
Liu Yingjun Y Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China. - - 2014
To compare the efficacy of proximal gastrectomy(PG) and total gastrectomy(TG) for adenocarcinoma of esophagogastric junction. Clinical trials comparing PG with TG for adenocarcinoma of esophagogastric junction published from 1990 to 2012 were searched in Cochrane library, Medline, Embase and China National Knowledge Infrastructure (CNKI), Wanfang Data. Review manager 5.0 was ...
Yu Sheng S Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou 310014, China. - - 2014
To study the expression of phospholipase C epsilon-1(PLCE1) and its clinical significance in gastric cancer. Surgical specimens were collected from 125 patients who underwent radical gastrectomy between 2005 and 2007 in the Zhejiang Provincial Peoples' Hospital. Expression level of PLCE1 protein was measured by immunohistochemistry in these 125 surgical specimens, ...
Gu Jun J Research Institute of Biliary Tract Disease, Laboratory of General Surgery and Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. - - 2014
To prepare cisPLLAtin-loaded polylactic acid/cnts, and to study the anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines(MGC803 and MNK45). 5-FU-PLLA-CNTs were prepared with ultrasound emulsification. The morphology of 5-FU-PLLA-CNTs was determined by scanning electron microscope(SEM), and its drug loading and drug release curve in vitro were detected by ...
Jiang Yannan Y Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. - - 2014
The gene knockout is based on the DNA homologous recombination and embryonic stem cell technology. It is an experimental method for modification of specific gene loci, which is one of the most direct means to clarifying gene functions. The similarity of genomes between mouse and human is as high as ...
Beaucham Catherine - - 2014
Indoor firing ranges are a source of lead exposure and elevated blood lead levels (BLLs) among employees, their families, and customers, despite public health outreach efforts and comprehensive guidelines for controlling occupational lead exposure. There are approximately 16,000-18,000 indoor firing ranges in the United States, with tens of thousands of ...
Levitt Alexandra - - 2014
In 2012, the World Health Assembly of the World Health Organization (WHO) declared completion of polio eradication a programmatic emergency. Polio cases are detected through surveillance of acute flaccid paralysis (AFP) cases and subsequent testing of stool specimens for polioviruses (PVs) at WHO-accredited laboratories within the Global Polio Laboratory Network ...
Gavin Loretta - - 2014
This report provides recommendations developed collaboratively by CDC and the Office of Population Affairs (OPA) of the U.S. Department of Health and Human Services (HHS). The recommendations outline how to provide quality family planning services, which include contraceptive services, pregnancy testing and counseling, helping clients achieve pregnancy, basic infertility services, ...
Shi Yinan Y Department of Minimally Invasive Surgery, Shanxi Tumor Hospital, Taiyuan 030013, China. - - 2014
Gastrointestinal stromal tumors(GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Most of these stromal tumors are characterized by mutations in the KTT or platelet-derived growth factor receptor α (PDGFRA) genes, resulting in the constitutive activation of tyrosine kinase signaling. Tyrosine kinase inhibitors(TKI), such as imatinib and sunitinib, ...
Ning Liang L Department of General Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. - - 2014
To investigate the clinicopathological features and prognosis of patients with gastrointestinal stromal tumor(GIST) after surgery in Shandong Province. Clinicopathological data of GIST patients undergoing surgery from January 2001 to June 2013 in four university teaching hospitals in Shandong Province were reviewed. Pathology results were rechecked. Patients were followed up. The ...
Wu Xiaojun X Department of Colorectal Surgery, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China. - - 2014
To explore the clinicopathological characteristics, efficacy, and prognostic factors for patients with rectal gastrointestinal stromal tumor(GIST). Clinicopathological and follow-up data of 61 patients with rectal GIST in our department from January 1990 to October 2012 were analyzed retrospectively and pathology specimens were reviewed. Kaplan-Meier method was used to calculate the ...
Tu Lin L Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. - - 2014
To improve the differential diagnosis and treatment between heterotopic pancreas and gastrointestinal stromal tumor. Clinical and follow-up data of 14 cases who were diagnosed preoperatively as gastrointestinal stromal tumor whereas were confirmed as heterotopic pancreas in the gastrointestinal tract by postoperative pathological results in Renji Hospital from January 2007 to ...
Zhao Guibin G Department of Thoracic Surgery, The Fourth Hospital of Harbin Medical University, Harbin 150001, China. - - 2014
To evaluate the effect of early enteral nutrition(EEN) on immune response and clinical outcomes after esophageal cancer operation. Sixty patients with esophageal cancer undergoing radical operation between March 2010 and July 2011 were randomly divided into two groups using envelope method: EEN group(n=30, administration of water and enteral nutrition early ...
Mu Linjun L Department of Gastrointestinal Surgery, Provincial Hospital, Shandong University, Jinan 250021, China. - - 2014
To compare the expressions of hypoxia-inducible factor 1 alpha(HIF-1α) and Semaphorin 4D(Sema4D) in colorectal carcinoma and normal colorectal tissues, and to investigate their correlation and clinical significance. The expressions of HIF-1α and Sema4D were examined in 86 cases of colorectal carcinoma and 52 normal colorectal tissues by SP immunohistochemical staining. ...
Matsumoto Hisako H Department of Respiratory Medicine, Kyoto University, Kyoto, - - 2014
Chronic airway inflammation and remodeling are fundamental features of asthma. Even with adequate inhaled corticosteroid (ICS) treatment, there are still patients who exhibit Th2/eosinophilic inflammation and develop airflow limitation, a functional consequence of airway remodeling. There are few biomarkers that are applicable in the clinical setting that reflect refractory Th2/eosinophilic ...
Ohta Nobuo N Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Yamagata University, Yamagata, - - 2014
Periostin is a 90-kDa member of the fasciclin-containing family; it functions as part of matricellular proteins, and its production by airway epithelial cells is induced by IL-4 and IL-13. Periostin is secreted by fibroblasts and upregulated in the airway epithelia of patients with bronchial asthma; it is considered to contribute ...
Kanemitsu Yoshihiro Y Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, - - 2014
Patients with asthma show a steeper age-related decline in pulmonary function than healthy subjects, which is often alleviated after the initiation of treatment with inhaled corticosteroids (ICS). However, there still are patients who develop irreversible airflow limitations despite receiving adequate ICS treatment. The identification of the characteristics of such patients ...
Saito Mikio M Laboratory of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Life Sciences, Niigata, - - 2014
Background: There are problems in diagnosis of allergy to amide-type local anesthetic agents (ALAs), because definitive diagnosis is not obtained by in vivo tests, which are used for the diagnosis. Consequently, patients may be exposed to risk. There are few diagnoses based on in vitro tests, and there are almost ...
Nakamura Masashi M Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan; General Research and Development Institute, Hoyu Co., Ltd., Aichi, - - 2014
Background: Immediate-type wheat allergy caused by a specific hydrolyzed wheat protein (HWP-IWA), Glupearl 19S (GP19S), typically develops food-dependent exercise-induced anaphylaxis (FDEIA), but is different from conventional FDEIA, or simple wheat allergy in many aspects. The skin prick test (SPT) is considered to be the most effective method for diagnosis of ...
Yamaguchi Yukie Y Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Kanagawa, - - 2014
Extracellular matrix (ECM) is not only involved in the maintenance of normal physiological tissue but also in interactions with other ECM components, tissue remodeling, and modulating immune responses. The skin provides a distinctive environment characterized by rich fibroblasts producing various ECM proteins, epithelial-mesenchymal interactions, and immune responses induced by external ...
Murakami Yoko Y Department of Paediatrics, National Hospital Organization Fukuoka National Hospital, Fukuoka, - - 2014
Background: Exercise-induced wheezing (EIW) may be a symptom of asthma and is a predictor of exercise-induced bronchoconstriction, transient narrowing of the lower airway following exercise in the presence or absence of diagnosed asthma. Population-based studies with a large sample of EIW in relation to age, sex, current asthma severity and ...
Ozawa Naoko N Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, - - 2014
Background: There are reports that the maternal diet during pregnancy may affect development of babies' eczema. We sought to investigate the association between the maternal diet during pregnancy and the risk of eczema in infancy in Japan. Methods: A birth cohort was set up at 2 hospitals in Chiba city. ...
Socias Christina M - - 2014
Falls remain a leading cause of unintentional injury mortality nationwide [corrected].Among workers, approximately 20% of fall injuries involve ladders. Among construction workers, an estimated 81% of fall injuries treated in U.S. emergency departments (EDs) involve a ladder. To fully characterize fatal and nonfatal injuries associated with ladder falls among workers ...
Zipprich Jennifer - - 2014
Measles is a highly contagious, acute viral illness that can lead to severe complications and death. Even patients who experience uncomplicated acute measles have a small risk for developing a devastating neurologic illness, subacute sclerosing panencephalitis, years after their infection. Measles was documented as eliminated (defined as interruption of continuous ...
Mofrad Farshid Babapour FB Faculty of Engineering, Science and Research Branch, Islamic Azad University (IAU), Tehran, 14515-775, Iran, - - 2014
Liver-shape analysis and quantification is still an open research subject. Quantitative assessment of the liver is of clinical importance in various procedures such as diagnosis, treatment planning, and monitoring. Liver-shape classification is of clinical importance for corresponding intra-subject and inter-subject studies. In this research, we propose a novel technique for ...
Wen Fengtong F School of Mathematical Sciences, University of Jinan, Jinan, 250022, China, - - 2014
Secure and efficient user mutual authentication is an essential task for integrated electronic patient record (EPR) information system. Recently, several authentication schemes have been proposed to meet this requirement. In a recent paper, Lee et al. proposed an efficient and secure password-based authentication scheme used smart cards for the integrated ...
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