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Lopez Jay Patrick JP Department of Medicine, University of Colorado at Denver, Denver, CO, - - 2014
Soft tissue sarcomas are a heterogenous group of malignancies with relatively high mortality rates. The outlook for these patients has been poor, with only a few drugs showing measurable activity. Trabectedin is a new alkylating agent with significant activity in sarcomas, but particularly in liposarcomas and leiomyosarcomas, both as a ...
Flores-Suárez Luis Felipe LF Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Col. Sección XVI, Tlalpan, Mexico City, Mexico, - - 2014
The vasculitides are a group of protean diseases, some of which are caused by conditions including infections, other autoimmune diseases, or neoplasias. They are a challenge to the clinician, in terms of both diagnosis and therapy. No diagnostic criteria exist, although a multinational effort to develop them is in progress. ...
Davis Margot M Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Falk Cardiovascular Research Center #273, Stanford, CA, 94305-5406, - - 2014
Radiation-induced heart disease (RIHD) represents a spectrum of cardiovascular disease in patients who have undergone mediastinal, thoracic, or breast radiotherapy (RT). RIHD may involve any cardiac structure and is a major cause of morbidity and mortality in cancer survivors. While large cohort studies have demonstrated that symptomatic RIHD is a ...
Hakky Tariq S TS University of South Florida, 2 Tampa General Circle, Tampa, FL, 33602, USA, - - 2014
Historically, early surgical treatment for erectile dysfunction involved the placement of rigid devices outside of the corpora cavernosa. This practice resulted in high rates of erosion and infection. Today, most urologists in the United States place an inflatable penile prosthesis (IPP) with an infection-retardant coating inside the corpora cavernosa. In ...
Kharadjian Talar B TB Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1373, Houston, TX, 77030, - - 2014
Inguinal lymph node dissection is a diagnostic and potentially curative treatment for penile carcinoma, which has historically been associated with high morbidity rates. This review summarizes the initial outcomes of robotic-assisted inguinal lymphadenectomy (RAIL) compared with the outcomes of the standard open and endoscopic approaches. The early experience suggests that ...
Napier Catherine C Institute of Genetic Medicine, Newcastle University, and Endocrine Unit, Royal Victoria Infirmary, Newcastle upon Tyne, - - 2014
The purpose of this article is to review the current therapy of Addison's disease and to highlight recent developments in this field. Conventional steroid replacement for Addison's disease consists of twice or three-times daily oral hydrocortisone and once-daily fludrocortisone; however, new treatment modalities such as modified-released hydrocortisone and continuous subcutaneous ...
Yahagi K K CVPath Institute, Inc., Gaithersburg, MD, USA - - - 2014
Peripheral artery disease (PAD) is an emerging problem especially with aging population and increase in the incidence of diabetes and metabolic syndrome. The disease is histologically characterized by the presence of moderate to severe calcification and fibrous plaques as compared to coronary and carotid atherosclerotic disease, which are richer in ...
Franzone A A Division of Cardiology Department of Advanced Biomedical Sciences "Federico II" University, Naples, Italy - - - 2014
The treatment of in-stent restenosis (ISR) in the femoro-popliteal artery (FPA) is one of the major challenges of endovascular therapy, occurring in up to 40% of femoro-popliteal lesions treated with bare-metal stents within 1 year of treatment. Drug-eluting technologies, involving local delivery of paclitaxel, are providing a new paradigm for ...
Kirkley Andrew G AG Committee on Molecular Pathogenesis and Molecular Medicine, University of Chicago, Chicago, IL, - - 2014
Rates of metabolic diseases have increased at an astounding rate in recent decades. Even though poor diet and physical inactivity are central drivers, these lifestyle changes alone fail to fully account for the magnitude and rapidity of the epidemic. Thus, attention has turned to identifying novel risk factors, including the ...
Schmid Marianne M Department of Urology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, - - 2014
In 2008, urothelial carcinoma of the bladder (UCB) was the 8th most common cause of death in Germany. An increasing body of evidence suggests differences in the presentation and prognosis of UCB between genders. Large population-based and multi-institutional studies have found a higher incidence of UCB in men, while women ...
Gooren Louis J LJ VU University Medical Center, Amsterdam, The - - 2014
Hormonal treatment of transgender people is becoming a normal part of medicine, though numbers of subjects remain small because of low prevalence. Information on treatment is scattered and this review brings together the latest information on treatment goals and potential side-effects of androgen treatment of female-to-male transsexual subjects. Androgen treatment ...
Singh G D GD University of California Davis Medical Center, Division of Cardiovascular Medicine and the Vascular Center Sacramento, CA, USA - - - 2014
Nitinol self-expanding stents are increasingly used to treat symptomatic peripheral arterial disease. Despite reduction in procedural complications and rates of stent fracture, femoropopliteal in-stent restenosis (FP-ISR) remains a common and important clinical problem. Due to heterogenous patient and angiographic characteristics, treatment of FP-ISR continues to evolve. Multiple modalities have been ...
Jayasuriya S S Dana 3 Cardiology, FACC Yale University New Haven, CT, USA - - - 2014
The prevalence of PAD is expected to increase as the population ages and the treatment for chronic disease becomes more sophisticated. The safety, efficacy, and lower cost of endovascular treatment for peripheral vascular disease of the lower extremities when compared with surgical revascularization are well known. Despite the clinical improvements ...
Beschorner U U Department Angiology University‑Heart Center Freiburg‑Bad Krozingen Bad Krozingen, Germany - - - 2014
Mechanical atherectomy for instent restenosis (ISR) seems to be limited by a low patency rate. This might be due to the mechanical trauma that induces an inflammatory response leading to recurrent ISR. Addition of drug eluting balloon angioplasty could overcome these challenges while preserving the advantages of a better acute ...
Van den Berg J C JC Service of Interventional Radiology Ospedale Regionale di Lugano, Lugano, Switzerland - - - 2014
This paper will describe the technique of the treatment of in-stent restenosis of the infrainguinal arteries, using a combined technique of laser debulking followed by drug-eluting balloon angioplasty. The results of this technique from the literature will be discussed, and a comparison with other techniques that are currently used will ...
Vida V L VL Pediatric and Congenital Cardiac Surgery Unit Department of Cardiac, Thoracic and Vascular Surgery University of Padua, Padua, Italy - - - 2014
The aim of this study was to evaluate the efficacy and cost-effectiveness of fibrinogen/thrombin-coated collagen patch (FTCCP)(TachoSil®) during intraoperative hemostasis in patients with congenital heart disease, who required a reoperation during childhood. We reviewed data on the intraoperative blood product requirements and hospital costs of children (age <16 years) who ...
Kirmani Batool F BF Epilepsy Center, Department of Neurology, Scott and White Neuroscience Institute, Temple, TX, USA, - - 2014
Elderly people are one of the fastest-growing populations in the United States, and the incidence of epilepsy in older people is much higher than in other population subgroups. This age group is the most vulnerable because of the increased incidence of multiple medical comorbidities, including stroke. The diagnosis of epilepsy ...
Kwan Alan C AC From the Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center, 10 Center Dr, Building 10/1C355, Bethesda, MD 20892 (A.C.K., G.C., C.T.S., K.R., D.A.B.); Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah (H.T.M., D.L.L., J.B.M., J.L.A.); Cardiology Division, Department of Medicine, Johns Hopkins University, Baltimore, Md (B.D.R., J.A.C.L.); and Cardiology Division, University of Utah, Salt Lake City, Utah (D.L.L., J.B.M., - - 2014
Purpose To determine the relationship between coronary plaque detected with coronary computed tomographic (CT) angiography and clinical parameters and cardiovascular risk factors in asymptomatic patients with diabetes. Materials and Methods All patients signed institutional review board-approved informed consent forms before enrollment. Two hundred twenty-four asymptomatic diabetic patients (121 men; mean ...
Bullapur Harsha M HM Department of General Surgery, Children's Hospital at Westmead, Westmead, New South Wales, - - 2014
Role of ultrasonography in diagnosis of acute appendicitis in children is being debated. This study was conducted ahead of a clinical trial and aimed to evaluate the adjunctive role of ultrasonography in this group. Retrospective chart review of consecutive children undergoing appendicectomy in an Australian tertiary children's hospital over 24 ...
Ibrahim Badr M BM Department of Pharmacology and Toxicology (BMI, MF, AAR-R), Brody School of Medicine, East Carolina University, Greenville, North - - 2014
The molecular mechanisms of the acute hypotensive and indirectly assessed cardiac depressant effect of ethanol (EtOH)-evoked myocardial depression and hypotension in female rats are not known. We tested the hypothesis that a time-dependent myocardial depression caused by EtOH is initiated by its direct and indirect (cardiac vagal dominance) effects and ...
Kim Theresa H M - - 2014
Context • The positive effects of physical activity on the well-being of older adults have been well documented. Tai chi is a suitable form of physical activity, with known physical and psychological benefits for older adults. Objective • The objective of the current study was to compare the effects of ...
Böger Rainer H - - 2014
L-Arginine is a precursor for nitric oxide (NO) synthesis. NO is a ubiquitous mediator that is formed by a family of enzymes called NO synthases (NOSs). In the brain, NO acts as a neurotransmitter; in the immune system, it acts as a mediator of host defense; and in the cardiovascular ...
Kor Daryl J DJ From the Department of Anesthesiology (D.J.K.), Department of Health Sciences Research (R.K.L., R.E.C.), and Department of Medicine, Division of Pulmonary and Critical Care Medicine (O.G.), Mayo Clinic, Rochester, Minnesota; Department of Surgery (P.K.P.) and Department of Anesthesiology (J.M.B.), University of Michigan School of Medicine, Ann Arbor, Michigan; Department of Surgery (H.L.A.), St Joseph Mercy Hospital, Ann Arbor, Michigan; Department of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (P.C.H.); Department of Surgery, Wake Forest University Health Sciences, Winston-Salem, North Carolina (J.J.H.); Departme nt of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (E.K.B.); Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina (R.R.B.); Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, Texas (A.A.); Department of Critical Care, Mayo Clinic, Jacksonville, Florida (E.F.); Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (M.N.G.); and Department of Anaesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts - - 2014
Acute respiratory distress syndrome (ARDS) remains a serious postoperative complication. Although ARDS prevention is a priority, the inability to identify patients at risk for ARDS remains a barrier to progress. The authors tested and refined the previously reported surgical lung injury prediction (SLIP) model in a multicenter cohort of at-risk ...
Mancuso Andrea A Medicina Interna 1, ARNAS Civico-Di Cristina-Benfratelli, Palermo, Italy. Epatologia e Gastroenterologia, Ospedale Niguarda Cà Granda, Milano, - - 2014
The topic of this paper is to report an update on management of Budd-Chiari syndrome (BCS). Actually, the flow-chart of BCS management comes from experts opinion and is not evidence-based due to the rarity of BCS. Management of BCS follows a step-wise strategy. Anticoagulation and medical therapy should be the ...
Ridruejo Ezequiel E Hepatology Section, Department of Medicine, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno "CEMIC". Ciudad Autónoma de Buenos Aires, Argentina; Hepatology and Liver Transplant Unit, Hospital Universitario Austral. Pilar, Provincia de Buenos Aires, - - 2014
Background and aims. Entecavir (ETV) is effective and safe in patients with chronic hepatitis B in the short term, but its long term efficacy and safety has not been established. Material and methods. We evaluated HBV DNA clearance, HBeAg/antiHBe and HBsAg/antiHBs seroconversion rates in HBeAg-positive and negative NUC naïve HBV ...
Fang Liu L Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 P. R. - - 2014
Introduction. The diagnosis of malignant ascites is a challenging problem in clinical practice, non-invasive techniques should be developed to improve diagnostic accuracy. The diagnostic performances of tumor markers in malignant ascites remained unsettled. Our aim was to evaluate diagnostic performance of tumor markers in differential diagnosis of benign and malignant ...
Normann Nicoline N Department of Psychology, University of Copenhagen, Copenhagen, - - 2014
Metacognitive therapy (MCT) is a relatively new approach to treating mental disorders. The aim of the current meta-analysis was to examine the efficacy of MCT in patients with mental disorders. A comprehensive literature search revealed 16 published as well as unpublished studies on the efficacy of MCT, of which nine ...
Kefeng Dou D Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of - - 2014
Liver transplantation is regarded as an effective treatment for Wilson's disease (WD), and recently has been shown to improve not only hepatic but also neurologic manifestations. Conventional auxiliary liver transplantation for WD is orthotopic liver transplantation and heterotopic liver transplantation. But the conventional procedure could not avoid the problem of ...
Plasschaert Robert N RN Department of Cell & Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, - - 2014
Genes that are subject to genomic imprinting in mammals are preferentially expressed from a single parental allele. This imprinted expression of a small number of genes is crucial for normal development, as these genes often directly regulate fetal growth. Recent work has also demonstrated intricate roles for imprinted genes in ...
Munné María S MS Laboratorio Nacional de Referencia de Hepatitis Virales, Instituto Nacional de Enfermedades Infecciosas, ANLIS "Carlos G. Malbrán", Buenos Aires, - - 2014
By using molecular surveillance of hepatitis A virus, we characterized for the first time a subgenotype IB imported case in Argentina, a country with universal vaccination since 2005. The case was a crew member of a cruise ship. We consider this a case alert because of its multiple implications.
Pahari Shankar S Department of Biological Sciences, University of Lethbridge, Lethbridge, AB TIK 3M4, - - 2014
Asymmetric localization of PIN proteins controls directionality of auxin transport and many aspects of plant development. Directionality of PIN1 within the marginal epidermis and the presumptive veins of developing leaf primordia is crucial for establishing leaf vein pattern. One mechanism that controls PIN protein distribution within the cell membranes is ...
Shabbir Asim A Department of Surgery, National University Hospital Singapore, - - 2014
Energy sealing has advanced rapidly in the last decade with many new devices becoming available. The rate and variety of advances in technology facilitate new and existing techniques, with ultrasonic shears and electrothermal bipolar graspers forming a vital but changing part of the modern surgeon's armamentarium. Advances including the combination ...
Mimatsu Kenji K Department of Surgery, Social Insurance Yokohama Central Hospital, Yokohama, - - 2014
Laparoscopic Nissen fundoplication (LNF) and gastrostomy are often performed in children with gastroesophageal reflux disease. With a population that is increasingly aging, the number of elderly patients with paraesophageal hernia who have a nutritional disorder due to dysphagia has increased. In these patients with feeding difficulties, LNF and percutaneous endoscopic ...
Hovorka Roman R Corresponding author: Roman Hovorka, - - 2014
OBJECTIVE To evaluate feasibility, safety, and efficacy of overnight closed-loop insulin delivery in free-living youth with type 1 diabetes. RESEARCH DESIGN AND METHODS Overnight closed loop was evaluated at home by 16 pump-treated adolescents with type 1 diabetes aged 12-18 years. Over a 3-week period, overnight insulin delivery was directed ...
Sunagawa Hiroki H Department of Surgery, Nakagami Hospital, Okinawa, - - 2014
Laparoscopic distal pancreatectomy for pancreatic cancer is being applied increasingly in selected cases. Open radical antegrade modular pancreatosplenectomy (RAMPS) was introduced to obtain a higher rate of tumor-free margins and a higher lymph node (LN) count. However, there is no standard laparoscopic technique for pancreatic cancer. We treated three patients ...
Del Favero Simone S Corresponding author: Claudio Cobelli, - - 2014
OBJECTIVE Inpatient studies suggest that model predictive control (MPC) is one of the most promising algorithms for artificial pancreas (AP). So far, outpatient trials have used hypo/hyperglycemia-mitigation or medical-expert systems. In this study, we report the first wearable AP outpatient study based on MPC and investigate specifically its ability to ...
Kumar Santosh S Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, - - 2014
Laparoendoscopic single-site surgery is being adapted for widespread indications because it offers minimal invasiveness. Herein, we report a case of synchronous bilateral cortex-preserving adrenalectomy for bilateral large adrenal pheochromocytomas. We used conventional laparoscopic instruments and trocars through a single-port site. The total operative time was 110 min. There were no perioperative ...
Beck Roy W RW Corresponding author: Roy W. Beck, - - 2014
OBJECTIVE To assess the effect of overnight insulin pump suspension in an automated predictive low glucose suspend system on morning blood glucose and ketone levels in an attempt to determine whether routine measurement of ketone levels is useful when a closed-loop system that suspends insulin delivery overnight is being used. ...
Kodama Koichi K Department of Urology, Toyama City Hospital, Toyama, - - 2014
Despite improved diagnostic modalities for psoas abscesses, the optimum management strategy is not uniform. A 67-year-old man presented with bilateral psoas abscesses secondary to L1-L2 pyogenic discitis. On contrast-enhanced CT, the largest of these abscesses measured 13 × 14 × 33 mm on the right. The patient developed sepsis caused by Klebsiella pneumonia. There were ...
Raz Itamar I Corresponding author: Itamar Raz, - - 2014
OBJECTIVE To evaluate safety and efficacy of DiaPep277 in preserving β-cell function in type 1 diabetic patients. RESEARCH DESIGN AND METHODS DIA-AID 1 is a multinational, phase 3, balanced-randomized, double-blind, placebo-controlled, parallel-group clinical study. Newly diagnosed patients (N = 457, aged 16-45 years) were randomized to subcutaneous injections of DiaPep277 ...
Beppu Toru T Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan; Department of Multidisciplinary Treatment for Gastroenterological Cancer, Innovation Center for Translational Research, Kumamoto University Hospital, Kumamoto, - - 2014
Metachronous rectal liver metastasis (15 mm in segment 8 ventral) was managed with laparoscopic hepatectomy using segmental blood flow occlusion with radiofrequency ablation. During liver dissection, the ischemic area was visible as a distinct hypoechoic area on intraoperative enhanced ultrasound; with a photodynamic eye camera, it appeared as a discolored lesion. ...
Morita Kiyomi K Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo, - - 2014
Fluorescence imaging using indocyanine green (ICG) has recently been applied to laparoscopic surgery to identify cancerous tissues, lymph nodes, and vascular anatomy. Here we report the application of ICG-fluorescence imaging to visualize the boundary between the liver and subserosal tissues of the gallbladder during laparoscopic full-thickness cholecystectomy. A patient with ...
Chow Elaine E Department of Cardiovascular Science, University of Sheffield, Sheffield, - - 2014
Recent trials of intensive glycemic control suggest a possible link between hypoglycemia and excess cardiovascular mortality in patients with type 2 diabetes. Hypoglycemia might cause arrhythmias through effects on cardiac repolarization and changes in cardiac autonomic activity. Our aim was to study the risk of arrhythmias during spontaneous hypoglycemia in ...
Goda Kenichi K Department of Endoscopy, The Jikei University School of Medicine, Tokyo, - - 2014
Barrett's esophagus (BE) is a metaplastic condition that occurs secondary to gastroesophageal reflux disease. BE is also a precursor to esophageal adenocarcinoma, which, although still rare in Japan, is one of the most rapidly increasing cancers in Western countries. However, the prevalence of gastroesophageal reflux disease has increased significantly over ...
Alphs Larry L Therapeutic Area Leader Psychiatry, Janssen Scientific Affairs, LLC , 1125 Trenton-Harbourton Road-A32404, Titusville, NJ 08560 , USA +1 609 730 3693 ; +1 609 730 3125 ; - - 2014
Introduction: Several long-acting injectable (LAI) second-generation antipsychotics are now available for the management of schizophrenia. As patients with schizophrenia frequently present with diverse and challenging symptoms, it is important to understand the effects of antipsychotics in treating these different symptom subgroups and the timing of these responses. Areas covered: For ...
Fernandez-Montero Jose Vicente JV Hospital Carlos III, Department of Infectious Diseases , Madrid , Spain - - 2014
Introduction: Antiretroviral therapy has evolved dramatically and more potent, safer and convenient drugs have replaced former compounds. Dolutegravir (DTG) is the most recently approved integrase inhibitor. It displays attractive properties such as one pill once daily (QD) dosing, high barrier to resistance and clean safety profile. Moreover, it is planned ...
Jiang Ying Y Departments of Epidemiology & Biostatistics (Y.J., S.M.D.), Pathology (M.J., S.B., A.N.F.), Division of Information Technology Services (R.B., M.G.), Case Western Reserve University, Cleveland, OH; Department of Ophthalmology & Visual Sciences (S.R., L.B.S.-F.) and University Hospitals Eye Institute, University Hospitals Case Medical Center, Cleveland, OH; and Alcon Research Ltd. (J.K.), Fort Worth, - - 2014
To assess risk factors associated with substantial microbial bioburden of lids, conjunctivae, contact lenses, and storage cases during daily wear of silicone hydrogel contact lenses. Two hundred eighteen patients were fit to lotrafilcon A lenses, randomized to use either a multipurpose solution or a hydrogen peroxide care system, and followed ...
Ichijima Hideji H GPR & Research Department (H.I., K.M.), Menicon Co, Ltd, Nagoya, Japan; Shimamoto Eye Clinic (S.S., Y.A.), Fukui, Japan; and Department of Ophthalmology (H.D.C.), University of Texas, Southwestern Medical Center at Dallas, Dallas, - - 2014
To conduct a survey of contact lens (CL) wearers who use their CLs with satisfaction in Japan and to establish the actual circumstances of CL use. An Internet survey was conducted in 1,000 CL wearers in Japan with questionnaires concerning CL purchase/change, compliance with the duration of wear, and occurrence ...
Chen Ding D School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, - - 2014
To monitor corneal epithelial healing under bandage contact lens (BCL) using ultrahigh-resolution optical coherence tomography (UHR-OCT) after pterygium surgery. Thirty-nine eyes of 39 patients undergoing pterygium excision and conjunctival autografting were randomly allocated into 2 groups: 20 eyes were covered with silicone hydrogel BCLs at the end of surgery and ...
Lehoux Juan J Department of Surgery, University of Rochester Medical Center, Strong Memorial Hospital, Rochester, NY, - - 2014
Left ventricular hypertrophy (LVH) frequently accompanies the progression of aortic valve disease in children. The extent of LVH regression following surgical relief of aortic valve disease in children has not been clearly elucidated. We hypothesized that significant regression of LVH will occur in children following the Ross procedure. We examined ...
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