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McMahon Caitlin M CM Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 - - 2014
A palladium-catalyzed, intermolecular Heck-type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in the β position. The mild catalytic conditions enable intermolecular CC bond formations with a diverse ...
Sharma P P Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2014
The potential impact of concomitant iron deficiency on hemoglobin A2 (HbA2)-based identification of β-thalassemia trait (βTT) is a worrisome issue for screening laboratories. This is especially true for resource-constrained settings where iron deficiency is widespread and molecular confirmatory tests for borderline low HbA2 values may be unavailable. Obligate βTT carrier ...
Plotnik Meir M Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, - - 2014
Freezing of gait (FOG) is an episodic gait disturbance that is commonly seen in Parkinson's disease (PD). To date, treatment efficacy is limited. We tested the hypothesis that an intervention that utilizes motor learning provided through intensive cueing can alleviate this symptom. Fifteen subjects with PD suffering from FOG participated ...
Golder Su S Centre for Reviews and Dissemination (CRD), University of York, York, - - 2014
Research indicates that the methods used to identify data for systematic reviews of adverse effects may need to differ from other systematic reviews. To compare search methods in systematic reviews of adverse effects with other reviews. The search methodologies in 849 systematic reviews of adverse effects were compared with other ...
Bazarek Stanley S Center for Stem Cell and Regenerative Medicine, Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL, - - 2014
There is little cell replacement following neurological injury, limiting the regenerative response of the CNS. Progress in understanding the biology of neural stem cells has raised interest in using stem cells for replacing neurons lost to injury or to disease. Stem cell therapy may also have a role in rebuilding ...
Fatima Mahino M Aquatic Toxicology Research Laboratory, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, U.P., India, - - 2014
The aim of the study was to evaluate the effect of heavy-metal contamination on two fish species (Channa striatus and Heteropneustes fossilis) inhabiting a small freshwater body of northern India. After being captured, each specimen was weighed, measured, and analyzed for heavy metals (chromium [Cr], nickel [Ni], and lead [Pb]). ...
Lee Minji M Department of Chemistry and Nano Science, Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Korea. - - 2014
A new tetranaphthoimidazolium receptor was synthesized and reported to be a selective fluorescent chemosensor for phytate, myo-inositol hexakisphosphate (IP6). In a 100% aqueous solution at pH 7.4, chemosensor 1 showed a selective fluorescence enhancement for IP6 over IP3, phosphates, pyrophosphates, AMP, ADP and ATP. An excimer emission at 465 nm ...
Muto L L Department of Physical Therapy, Speech Therapy and Occupational Therapy, School of Medicine of the University of Sao Paulo, Sao Paulo, Brazil - - - 2014
Fibromyalgia (FM) is a rheumatic disease characterized by chronic widespread pain and symptoms such as fatigue, sleep disturbances, cognitive difficulties, and depression. Postural instability is a debilitating disorder increasingly recognized as part of FM. To assess and compare postural control and balance selfefficacy in women with and without FM and ...
Dobrivojević Marina M Department of Histology and Embryology, School of Medicine, University of Zagreb, Šalata 3, Zagreb, - - 2014
Stroke is the third leading cause of death in the Western world. Ischemic stroke is characterized by a rapid loss of brain function due to disturbance in the blood supply to a part of the brain. Due to fixed intracranial space, any increase in intracranial fluid volume, or progressive brain ...
Beermann Kristi J KJ Department of Pharmacy, Duke University Health - - 2014
Racial differences among kidney transplant recipients may impact the total daily tacrolimus dose required to achieve therapeutic tacrolimus concentrations. Previous studies suggest that African Americans require higher doses to achieve similar therapeutic drug concentrations compared to Caucasians. Data were collected on a total of 147 de novo kidney transplant recipients. ...
Wada Shogo S Division of Regenerative Medical Engineering, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, - - 2014
Skeletal muscles contain several subtypes of myofibers that differ in contractile and metabolic properties. Transcriptional control of fiber-type specification and adaptation has been intensively investigated over the past several decades. Recently, microRNA (miRNA)-mediated posttranscriptional gene regulation has attracted increasing attention. MiR-23a targets key molecules regulating contractile and metabolic properties of ...
Boneva Temenushka T Military Medical Academy, Sofia, - - 2014
Multiple myeloma (MM) is a malignant disorder characterized by neoplastic transformation of mature B cells in the bone marrow (BM), accompanied by complex genetic changes. The disease is heterogeneous at both the clinical and genomic levels. Molecular genetics and genomic investigations have demonstrated that disease evolution is associated with an ...
Maurin Hervé H Experimental Genetics Group LEGTEGG, Department of Human Genetics, KU Leuven, Campus Gasthuisberg ON1 06.602, Herestraat 49, B-3000, Leuven, - - 2014
The microtubule-associated protein Tau is responsible for a large group of neurodegenerative disorders, known as tauopathies, including Alzheimer's disease. Tauopathy result from augmented and/or aberrant phosphorylation of Tau. Besides aging and various genetic and epigenetic defects that remain largely unknown, an important non-genetic agent that contributes is hypothermia, eventually caused ...
Frevel D D CaritasKrankenhaus Bad Mergentheim GmbH, Neurology, Bad Mergentheim, Germany - - - 2014
Balance disorders are common in multiple sclerosis. Aim of the study is to investigate the effectiveness of an Internet-based home training program (eTraining) to improve balance in patients with multiple sclerosis. A randomized, controlled study. Academic teaching hospital in cooperation with the therapeutic riding center Gut Üttingshof, Bad Mergentheim. Eighteen ...
Kumar Manisha - - 2014
Abstract Background: Fetal autopsy is included in the basic protocol of investigating a perinatal death, parental refusal is the main reason for its low rate. Aim: To increase acceptance of fetal autopsy and to provide better counselling to the couple regarding risk of recurrence in future pregnancies. Material and method: ...
Kacerovsky Marian M Biomedical Research Center, University Hospital Hradec Kralove, Czech - - 2014
Abstract Objective: To determine the vaginal fluid interleukin (IL)-6 and IL-8 concentrations in pregnancies complicated by preterm prelabor rupture of membranes and their correlation to microbial invasion of the amniotic cavity (MIAC) as well as histological chorioamnionitis (HCA) Methods: Sixty-eight women with singleton pregnancies were included in this study. Vaginal ...
Smiljanic Kosara K Department of Neurobiology, Institute for Biological Research, University of Belgrade, Bul. despota Stefana 142, 11060, Belgrade, - - 2014
Maintaining cholesterol homeostasis in the brain is vital for its proper functioning. While it is well documented that dietary restriction modulates the metabolism of cholesterol peripherally, little is known as to how it can affect cholesterol metabolism in the brain. The present study was designed to elucidate the impact of ...
Tsai Wei-Bor - - 2014
Specific drug delivery to solid tumors remains one of the challenges in cancer therapy. The aim of this study was to combine three drug-targeting strategies, polymer-drug conjugate, ligand presentation and ultrasound treatment, to enhance the efficacy and selectivity of doxorubicin (DXR) to hepatoma cells. The conjugation of DXR to γ-poly(glutamic ...
Chen Zi-Wei ZW Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, - - 2014
While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A (GABAA) receptors, the binding sites that mediate these actions have not been definitively identified. This study was conducted to synthesize neurosteroid analogue photolabeling reagents that closely mimic the biological effects of endogenous neurosteroids and have photochemical properties that ...
Zhang Yi Y Department of Surgery, The Third Affiliated Hospital of Jianghan University, Wuhan, 430300, Hubei, - - 2014
A consistent positive association between cigarette smoking and the human esophageal cancer has been confirmed all over the world. However, details in the association need to be more focused on and be identified. Recently, aberrantly expressed microRNAs (miRNAs) have been shown to be promising biomarkers for understanding the tumorigenesis of ...
Hansen Melissa V MV Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark, - - 2014
Depression, anxiety and sleep disturbances are known problems in patients with breast cancer. The effect of melatonin as an antidepressant in humans with cancer has not been investigated. We investigated whether melatonin could lower the risk of depressive symptoms in women with breast cancer in a three-month period after surgery ...
Nerowski Alexander - - 2014
Here we present electrochemically grown ultrathin platinum nanowires and demonstrate that their morphology and crystalline structure can be tuned by the waveform of the alternating voltage applied to the microelectrodes. The structure of the nanowires was analyzed by scanning and transmission electron microscopy. The voltage signal, applied to grow the ...
Yao Qi-Wei QW School of Stomatology, Shandong University, Jinan, 250012, People's Republic of - - 2014
The objective is to evaluate the association of periodontal disease with the risk of oral cancer. Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model to pool the odds ratio (OR) according to the test ...
Wu Jian Hui JH Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, No.23, Pingjiang Road, Tianjin, China, 300211, - - 2014
Genetic polymorphism of endothelial nitric oxide synthase (NOS3) rs1799983 (Glu298Asp) has been implicated to alter the risk of prostate cancer, but the results are controversial. Two investigators independently searched the PubMed, Cochrane Library, and Embase electronic databases up to September 30, 2013. Summary odds ratios (OR) and 95 % confidence interval ...
Dodou D D Department of BioMechanical Engineering, Delft University of Technology, Delft, the - - 2014
This random-effects meta-analysis investigates the accuracy of self-reported colorectal cancer screening history as a function of screening mode (colonoscopy, flexible sigmoidoscopy, faecal occult blood testing - FOBT, double-contrast barium enema - DCBE) and survey mode (written, telephone, face-to-face). Summary estimates of sensitivity, specificity, positive predictive value (PPV) and area under ...
Fricker Michael M University of Newcastle and Hunter Medical Research Institute, Priority Research Centre for Asthma and Respiratory Disease , New Lambton Heights, New South Wales , - - 2014
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for development of this disease. COPD is a progressive disease that is typically characterised by chronic pulmonary inflammation, mucus hypersecretion, airway remodelling and emphysema that ...
Zhao Meng-Qiang MQ Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, P. R. China. zhang-qiang@mails.tsinghua.edu.cn - - 2014
As one of the most important and land-mark structures found in nature, a double helix consists of two congruent single helices with the same axis or a translation along the axis. This double helical structure renders the deoxyribonucleic acid (DNA) the crucial biomolecule in evolution and metabolism. DNA-like double helical ...
Steinhauser Georg G Department of Environmental and Radiological Health Sciences, Colorado State University , Fort Collins, Colorado 80523, United - - 2014
In environmental monitoring campaigns for anthropogenic radionuclides released in the course of the Fukushima nuclear accident (2011), most focus had been on gamma-emitting radionuclides. More than 99% of the released activity was due to radionuclides of the elements Kr, Te, I, Xe, and Cs. However, little work had been done ...
Ziabakhsh Tabary S S Department of Cardiac Surgery, Mazandaran University of Medical Sciences, Sari, Iran - - - 2014
Mitral regurgitation (MR) is considered as an independent factor in determining prognosis of patients with myocardial infarction and impacts of untreated insufficiency on long-term results of patients undergoing CABG is well recognized. Regarding proper treatment of mild to moderate regurgitation of mitral valve is controversial and there is little research ...
Gould A L AL Rutherford Appleton Laboratory, Harwell Oxford Didcot, Oxon, OX11 0FA, UK. - - 2014
AuAg nanoclusters are promising supported co-catalysts for photocatalytic hydrogen reduction. However, beyond the quantum regime (N > 100) little is known about how the electronic properties of these nanoparticles are affected by chemical ordering. We investigate the effects of chemical ordering on the properties of 147-atom cuboctahedral AuAg nanoclusters, using ...
Aldersley Michael F MF New York Center for Astrobiology and the Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA, - - 2014
The montmorillonite-catalyzed reactions of the 5'-phosphorimidazolide of adenosine in the presence of fluoride were investigated to complete our study on the effect of salts on this type of reaction. Both anions and cations have been found to influence the oligomerization reactions of the activated nucleotides, being used here as a ...
Hierso Régine R Inserm U 1134, Pointe-à-Pitre, Guadeloupe, France; Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe, France; Laboratory of Excellence GR-Ex, Paris, - - 2014
Sickle cell anaemia (SS) and sickle cell-haemoglobin C disease (SC) patients exhibit severe red blood cell (RBC) rheological alterations involved in the development of several complications. The contribution of oxidative stress in these haemorheological abnormalities is still unknown. We compared RBC reactive oxygen species (ROS) and glutathione (GSH) content, and ...
Hansrani Vivak Chander VC Musculoskeletal Department, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, UK, - - 2014
The 18-week target to treatment government initiative was implemented in 2004. In order for this to work, patients need to accept operative dates provided, otherwise the pathway will fail. The aim of this prospective study was to identify the earliest time patients would accept surgical intervention following assessment at an ...
Beaudoin-Ryan Leanne L Department of Psychology, University of Chicago, - - 2014
Stem-cell research. Euthanasia. Personhood. Marriage equality. School shootings. Gun control. Death penalty. Ethical dilemmas regularly spark fierce debate about the underlying moral fabric of societies. How do we prepare today's children to be fully informed and thoughtful citizens, capable of moral and ethical decisions? Current approaches to moral education are ...
George D A DA Department of Trauma and Orthopaedics, Barnet Hospital, Wellhouse Lane, Barnet, EN5 3DJ, UK, - - 2014
Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin. It has been shown to reduce blood loss in trauma and other haemorrhagic conditions and has recently been utilised in elective orthopaedic surgery. There are various methods of administering TXA described in the literature. ...
Akbar S Md SM Department of Biochemistry, Gulbarga University, Gulbarga, 585106, Karnataka, - - 2014
Cotton bollworm, Helicoverpa armigera, is one of the most damaging polyphagous pests worldwide, which has developed high levels of resistance to commonly applied insecticides. Mitochondrial P-glycoprotein (Pgp) was detected in the insecticide-resistant strain of H. armigera using C219 antibodies, and its possible role was demonstrated in the efflux of xenobiotic ...
Hammar J J Institute of Freshwater Research, Department of Aquatic Resources, Swedish University of Agricultural Sciences, Stångholmsvägen 2, SE-178 93 Drottningholm, Sweden; Science Branch, Department of Fisheries and Oceans, P.O. Box 5667, St John's, NL, A1C 5X1, - - 2014
The Arctic charr Salvelinus alpinus species complex has been shown to be exceptionally vulnerable to rapid abiotic and biotic changes. Salvelinus alpinus, however, inhabit environmental extremes ranging from lakes and rivers in the High Arctic to deep multi-fish species lakes far outside the polar region. Long-term responses to post-glacial environmental ...
Xia Bo B School of Civil Engineering and Built Environment, Queensland University of Technology, Brisbane, Queensland, - - 2014
Facilities in retirement villages form a supportive environment for older residents. The purpose of this paper is to investigate the provision of these facilities in retirement villages, which are regarded as a viable accommodation option for the ever-increasing ageing population in Australia. A content analysis of facilities in 124 retirement ...
Giusti G G Stone Center at Department of Urology, Humanitas Clinical and Research Center, Rozzano, - - 2014
To evaluate the effectiveness and safety of retrograde intrarenal surgery (RIRS) for stones up to 2 cm in diameter in patients with solitary kidney. From January 2008 to January 2013, we prospectively enrolled all consecutive patients with solitary kidney and renal stones. Plain abdominal computed tomography scan was performed preoperatively and 1 month ...
Liu H L HL Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of - - 2014
MicroRNAs (miRNAs) are small noncoding RNAs that are involved in key biological processes, including development, differentiation, and regeneration. The global miRNA expression profile that regulates the regenerative potential of the neonatal mouse heart has not been reported. We performed deep sequencing to determine the genome-wide miRNA expression profile of the ...
Tuley Alfred A Department of Chemistry, Texas A&M University, College Station, TX 77843, USA. - - 2014
Using a mutant pyrrolysyl-tRNA synthetase-tRNA pair, 3-formyl-phenylalanine is genetically incorporated into proteins at amber mutation sites in Escherichia coli. This non-canonical amino acid readily reacts with hydroxylamine dyes, leading to rapid and site-selective protein labelling.
Lee Jiunn-Tat JT Division of Plastic Surgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, - - 2014
The proximal lateral lower leg flap is a flap suited for the reconstruction of small and thin defects. The purpose of this study was to map the position and consistency of the perforator vessels and to review its reliability and technical considerations clinically. The location, number, and size of perforator ...
Chen Hui H Department of Neurology, Military General Hospital of Beijing PLA, No.5 Nanmencang, Dongsi, Beijing, 100700, - - 2014
Accumulating studies have evaluated the association of Alpha-2-Macroglobulin gene (A2M) 5 bp insertion/deletion (5 bp I/D, rs3832852) and Ile1000Val (rs669) polymorphisms with Alzheimer's disease (AD) risk, but the results remain inconclusive. To investigate whether these two polymorphisms facilitate the susceptibility to AD, we conducted a comprehensive systematic review and meta-analysis. Databases of ...
Fahrner René R Division of Visceral Surgery and Medicine, University Hospital Bern, 3010, Bern, - - 2014
Surgical site infections (SSI) are associated with increased costs and length of hospital stay, readmission rates, and mortality. The aim of this study was to identify risk factors for SSI in patients undergoing laparoscopic cholecystectomy. Analysis of 35,432 laparoscopic cholecystectomies of a prospective multicenter database was performed. Risk factors for ...
Dhasaiyan Prabhu P Physical and Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune (411 008) - - 2014
The formation of giant-vesicle-like structures by self-assembling linolenic acid sophorolipid (LNSL) molecules is revealed. Sophorolipids belong to the class of bolaamphiphilic glycolipid biosurfactants. Interestingly, the number of double bonds present in the hydrophobic core of sophorolipids is seen to have a great influence on the type of self-assembled structures formed. ...
Ramsay William J - - 2014
The binding of phosphine ligands to molybdenum sites on the faces of a supramolecular cube served to inhibit allosterically the encapsulation of a neutral or anionic guest. The edges of the cube also provided a distinct second allosteric site, where the binding of tetra-phenylborate also allosterically inhibited anion binding in ...
Saint-Charles Johanne J Center for Interdisciplinary Research in Well-Being, Health, Society and Environment, Université du Québec à Montréal, C.P. 8888, succ. Centre-ville, Montreal, QC, Canada, - - 2014
This forum paper proposes a reflection on the "field of ecohealth" and on how best to sustain a supportive environment that enables the evolution of diverse partnerships and forms of collaboration in the field. It is based on the results of a preconference workshop held in October 2012, in Kunming, ...
Batalha Nuno N a Research Centre of Sports, Health and Human Development, Department of Sport and Health , University of Évora , Évora , - - 2014
Abstract The continuous execution of swimming techniques may cause muscle imbalances in shoulder rotators leading to injury. However, there is a lack of published research studies on this topic. The aim of this study was to analyze the influence of a competitive swim period on the shoulder rotator-cuff balance in ...
Ferris Mark J MJ Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, - - 2014
Chronic N-methyl-d-aspartate receptor (NMDAR) hypofunction has been proposed as a contributing factor to symptoms of schizophrenia. However, it is unclear how sustained NMDAR hypofunction throughout development affects other neurotransmitter systems that have been implicated in the disease. Dopamine neuron biochemistry and activity were examined to determine whether sustained NMDAR hypofunction ...
Fontanil Tania T Department of Biochemistry and Molecular Biology, University of Oviedo, 33006 Oviedo, Asturias, - - 2014
Polyserase-1/TMPRSS9 is a type II transmembrane serine protease showing a complex molecular architecture characterized by the presence of three tandem serine protease domains in its amino acid sequence. This protease is widely expressed in mouse and human tissues, however, its functional significance is unknown in both normal and pathological conditions. ...
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