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Ross David M DM Haematology Directorate, SA Pathology, Adelaide, SA, Australia; School of Medicine, University of Adelaide, Adelaide, SA, Australia; Flinders University and Medical Centre, Bedford Park, SA, - - 2014
Treatment-free remission (TFR) has recently emerged as a goal of treatment in chronic myeloid leukaemia (CML). Molecular remission is sustained in around 30% of imatinib-treated patients who stop treatment after ≥2 years with undetectable minimal residual disease (UMRD) by conventional real-time reverse transcription polymerase chain reaction. An additional 20-30% of patients ...
Zhang Juan J Life Sciences Institute, Zhejiang University, Hangzhou, 310058, - - 2014
Transforming growth factor-β (TGF-β) members are key cytokines that control embryogenesis and tissue homeostasis via transmembrane TGF-β type II (TβR II) and type I (TβRI) and serine/threonine kinases receptors. Aberrant activation of TGF-β signaling leads to diseases, including cancer. In advanced cancer, the TGF-β/SMAD pathway can act as an oncogenic ...
Tian Xin X Molecular Oncology Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, - - 2014
Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a molecular chaperone involved in multi-drug resistance and antiapoptosis in some human tumors, but its regulatory mechanisms have not been revealed in esophageal squamous cell carcinoma. In this study, 138 specimens of esophageal squamous cell carcinoma (ESCC) were analyzed. TRAP1 was overexpressed ...
Wang Jianjun J State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China, - - 2014
At present, autotransporter protein mediated surface display has opened a new dimension in the development of whole-cell biocatalysts. Here, we report the identification of a novel autotransporter Xcc_Est from Xanthomonas campestris pv campestris 8004 by bioinformatic analysis and application of Xcc_Est as an anchoring motif for surface display of γ-lactamase ...
Hershkovitz Avital A Geriatric Rehabilitation Ward, "Beit Rivka" Geriatric Rehabilitation Center , Petach Tikva , Israel - - 2014
Abstract Purpose: To present our experience in measuring rehabilitation achievements of post-acute hip fractured patients with the FIM instrument; assess its appropriateness as to the patients' various disability levels and describe our experience with other measuring tools in patients less sensitive to changes in the FIM instrument. Methods: A retrospective ...
Abouzeid Amr Abdelhamid AA Department of Pediatric Surgery, Ain-Shams University, Ramsis Street, Abbassya, Cairo, 11566, Egypt, - - 2014
Anteriorly displaced anus is an anomaly that is debated with regard to its nomenclature, diagnosis and management. To describe MRI anatomy of the anal canal in children with anteriorly displaced anus and its impact on the process of defecation. We prospectively examined ten children (7 girls, 3 boys; age range ...
Tonnelier Arnaud A INRIA, 655 avenue de l'Europe, Montbonnot, 38334 , Saint Ismier, France, - - 2014
Many biological oscillators have a cyclic structure consisting of negative feedback loops. In this paper, we analyze the impact that the addition of a positive or a negative self-feedback loop has on the oscillatory behavior of the three negative feedback oscillators proposed by Tsai et al. (Science 231:126-129, 2008) where, ...
Ho Hee Hwa HH Department of Cardiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore, - - 2014
Drug-eluting bioresorbable vascular scaffold (BVS) is a revolutionary treatment option for obstructive coronary artery disease in percutaneous coronary intervention. It restores blood flow to the myocardium but unlike permanent metallic stent, BVS dissolves in the body within 2 years. This allows the coronary vessel to regain its normal function and motion. ...
Chen En-Dong - - 2014
Metastasis to the thyroid is extremely rare. There is a lack of awareness of and adequate preparation for this situation, especially in an individual without a past history of malignancy. We describe a rare case of a 61-year-old man in whom a primary distal esophageal carcinoma gave rise to a ...
Zhou Ying-Xue - - 2014
Although medical education has developed rapidly in the last decade, and the National College Entrance Examination (NCEE) is used as the "gold standard" for admission to medical college in mainland China, there is a lack of literature regarding the influence of NCEE score and other factors on the academic performance ...
Drageset J J Faculty for Health and Social Science, Bergen University College, Bergen, - - 2014
Studies of hospitalisation of cognitively intact nursing home (NH) residents with cancer are scarce. Knowledge about associations between socio-demographic, medical and social support variables and hospital admissions aids in preventing unnecessary admissions. This is part of a prospective study from 2004 to 2005 with follow-up to 2010 for admission rates. ...
Xia Bo B School of Civil Engineering and Built Environment, Queensland University of Technology, Brisbane, Queensland, - - 2014
Facilities in retirement villages form a supportive environment for older residents. The purpose of this paper is to investigate the provision of these facilities in retirement villages, which are regarded as a viable accommodation option for the ever-increasing ageing population in Australia. A content analysis of facilities in 124 retirement ...
Magin Parker P Discipline of General Practice, University of Newcastle, Newcastle, New South Wales, - - 2014
To explore the prescribing, and the rationale for this prescribing, of potentially inappropriate medications (PIMs) in older persons by Australian general practitioners (GPs). This was a qualitative study employing semistructured interviews and thematic analysis. GPs who had patients taking at least one PIM were invited to participate. PIMs were defined ...
Yu Xin X Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers-The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, - - 2014
Loss of function of p53, either through mutations in the gene or through mutations to other members of the pathway that inactivate wild-type p53, remains a critically important aspect of human cancer development. As such, p53 remains the most commonly mutated gene in human cancer. For these reasons, pharmacologic activation ...
Licciardello Alessio A Division of General Surgery, Civil Hospital of Lentini, C/da Colle Roggio, 96016, Lentini, SR, Italy, - - 2014
Internal hernias account for 0.2-0.9 % of all small bowel obstructions and are associated with a mortality rate of 50 % when strangulation is present. Congenital mesocolic hernias, traditionally called paraduodenal hernias, caused by an abnormal rotation of the primitive midgut, are the most common type of internal hernia. They can be ...
Takenaka Shota S Japan Community Health care Organization Osaka Hospital, 4-2-78 Fukushima, Osaka, 553-0003, Japan, - - 2014
Investigation of preoperative manifestations of thoracic myelopathy in a large population has not been reported. The aim of this study was to identify symptoms specific to anatomical pathology or compressed segments in thoracic myelopathy through investigation of preoperative manifestations. Subjects were 205 patients [143 men, 62 women; mean age, 62.2 ...
Link Achim A Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel (Switzerland) - - 2014
Axially chiral compounds are of significant importance in modern synthetic chemistry and particularly valuable in drug discovery and development. Nonetheless, current approaches for the preparation of pure atropisomers often prove tedious. We demonstrate here a synthetic method that efficiently transfers the stereochemical information of a secondary amine organocatalyst into the ...
Gallagher Carla A CA Department of Sport and Exercise Sciences, University of Chichester, College Lane, Chichester, West Sussex, PO19 6PE, - - 2014
This study investigated the response of the ventilatory threshold (VT) to acute normobaric hypoxia and compared the agreement between software-based algorithms which use automatic detection to identify the VT. Results were used to examine whether the VT can be used as a physiological parameter to prescribe and monitor exercise intensity ...
Liu Tao T Department of Dermatology and Venereology, Tangdu Hospital, The Fourth Military Medical University, No.569 Xinsi Road, Xi'an, 710038, China, - - 2014
GNF-351 is a candidate drug used to treat some diseases through antagonizing aryl hydrocarbon receptor. In the present study, molecular docking method was employed to understand the interaction between ketoconazole and GNF-351. The structure of cytochrome P450 (CYP) 3A4 was obtained from protein data bank, and 2-dimensional structure of GNF-351 ...
Guo Wei W Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011, Hebei, - - 2014
The Ras-Association Domain Family 1 (RASSF1) gene, which is located on the small arm of chromosome 3, contains two CpG islands and generates seven transcripts (RASSF1A-RASSF1G) by differential promoter usage and alternative splicing. As the main transcript, RASSF1A, B and C may play different roles in tumorigenesis. The present study ...
Shihab Fuad S FS Division of Nephrology, University of Utah School of Medicine, Salt Lake City, UT, - - 2014
Tacrolimus exposure and renal function data to 36 months post-transplant were analyzed from the prospective, observational Mycophenolic acid Observational REnal transplant (MORE) registry in which de novo kidney transplant patients were managed according to local practice. Tacrolimus trough (C0 ) concentration at month 12 was stratified as low (<6ng/mL), moderate ...
Lekei Elikana E - - 2014
Pesticides in Tanzania are extensively used for pest control in agriculture. Their usage and unsafe handling practices may potentially result in high farmer exposures and adverse health effects.The aim of this study was to describe farmers' pesticide exposure profile, knowledge about pesticide hazards, experience of previous poisoning, hazardous practices that ...
Chen Zi-Wei ZW Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, 63110, - - 2014
While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A (GABAA) receptors, the binding sites that mediate these actions have not been definitively identified. This study was conducted to synthesize neurosteroid analogue photolabeling reagents that closely mimic the biological effects of endogenous neurosteroids and have photochemical properties that ...
Lloyd Mark C - - 2014
Breast carcinoma can be classified as either Estrogen Receptor (ER) positive or negative by immunohistochemical phenotyping, although ER expression may vary from 1 to 100% of malignant cells within an ER + tumor. This is similar to genetic variability observed in other tumor types and is generally viewed as a ...
Baran A A Department of Dermatology and Venereology Medical University of Bialystok, 15-540 Bialystok, Zurawia 14 St, - - 2014
Abstract Objectives: Psoriasis has been considered as a systemic disease associated with obesity, cardiovascular diseases and metabolic syndrome. Adipokines have influence on many metabolic processes. Aim of these study was to evaluate the effect of conventional topical treatment on serum adiponectin and leptin levels in patients with psoriasis. Methods: Forty-nine ...
Nagashima Hiroshi H Division of Gross Anatomy and Morphogenesis, Niigata University Graduate School of Medical and Dental Sciences, Niigata, - - 2014
The turtle shell provides a fascinating model for the investigation of the evolutionary modifications of developmental mechanisms. Different conclusions have been put forth for its development, and it is suggested that one of the causes of the disagreement could be the differences in the species of the turtles used - ...
Poma Giulia G CNR-IRSA, Water Research Institute, Via del Mulino 19, 20861, Brugherio, MB, Italy, - - 2014
Because of the reduction in the use of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecane (HBCD), novel brominated flame retardants (NBFRs), including 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE), decabromodiphenyl ethane (DBDPE), hexabromobenzene (HBB), and pentabromoethylbenzene (PBEB), started to be marketed as alternatives to the banned formulations. In this study, the spatial distribution and accumulation ...
Malewar Nikhil N Lupin Ltd. (Research Park) , Nande Village, Mulshi Taluka, Pune, Mahrarashtra , India - - 2014
Abstract Context: Venlafaxine Hydrochloride (VH) is a highly soluble and highly permeable antidepressant compound. Thus controlling VH release from tablet dosage form over a prolonged period is a challenge. Objective: The objective of this work was to study the effect of various barrier layer formulation compositions, its orientations and manufacturing ...
Mehdi Elnur E Department of Radiology, Bezmialem Vakif University School of Medicine, Adnan Menderes blv, Fatih, Istanbul, Turkey, - - 2014
During the follow-up of recurrent pneumonia in a 9-month-old girl, rhinorrhea with discharge of a positional and intermittent nature was discovered. Radiological assessment was requested to detect any skull base openings and cerebrospinal fluid (CSF) leakage. T2-weighted MR cisternography showed bilateral inner ear dysplasia, communication of the internal auditory canal ...
Xu Ben - - 2014
To report on the perioperative outcomes of laparoscopic partial nephrectomy (LPN) for multilocular cystic renal cell carcinoma (MCRCC) and evaluate the feasibility of this minimally invasive technique as a potential gold standard treatment for MCRCC. We retrospectively reviewed the database of surgically pathological findings of patients who were diagnosed with ...
Altunay Ilknur Kivanc IK Department of Dermatology and Venereology, Sisli Hamidiye Etfal Training and Research Hospital, 34377, Sisli, Istanbul, Turkey, - - 2014
Functional pruritus (FP) is a type of chronic pruritus that is a somatoform disease in nature, triggered by psychogenic factors. Psoriasis is a chronic, inflammatory, and pruritic skin disease that causes significant cosmetic problems and psychological distress. In this study, we aimed to investigate the effects of functional pruritus on ...
Goswami Lalit N LN International Institute of Nano and Molecular Medicine, School of Medicine, University of Missouri, Columbia, Missouri 65211-3450, USA. - - 2014
The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine ((19)F) magnetic resonance spectroscopy ((19)F-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl)phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo-B12(2-)-core via suitable linkers. The (19)F-MRS and fluorescence imaging ...
Aitken Sarah J SJ Research Department of Pathology, UCL Cancer Institute, London, UK; Sarah Cannon/University College London Advanced Diagnostics Molecular Profiling Research Laboratories, London, UK; Department of Pathology, Addenbrooke's Hospital, Cambridge, - - 2014
Erdheim Chester disease (ECD) is a rare, non-Langerhans' cell histiocytic neoplastic disorder that usually presents in patients in their fifties. ECD often presents as a multi-system macrophagic infiltration and common sites of involvement are the central nervous system, cardiovascular system, respiratory system, retroperitoneum, and skin. Extra-skeletal involvement is usually responsible ...
Ambure Pravin P Jadavpur University, Department of Pharmaceutical Technology, Drug Theoretics and Cheminformatics Laboratory , Kolkata 700032 , India kunalroy_in@yahoo.com , - - 2014
Introduction: Alzheimer's disease (AD) is one of the lethal diseases, mainly affecting older people. The unclear root cause and involvement of various enzymes in the pathological conditions confirm the complexity of the disease. Quantitative structure-activity relationship (QSAR) techniques are of great significance in the design of drugs against AD. Areas ...
McCain Megan L ML Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California , Los Angeles, CA , - - 2014
This review article discusses a recent work using engineered cardiac cells to study the function of the intercalated disc putting emphasis on mechanical and electrical coupling.
Ha Byung Geun BG Department of Nutriproteomics, Graduate School of Medicine, The University of Tokyo, Bunkyo-Ku, Tokyo, - - 2014
Many active components derived from edible natural resources such as plant extracts have recently attracted attention for their potential use as functional foods or drugs for preventing and treating metabolic diseases such as diabetes. To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library ...
Vergano Luca L Division of Otorhinolaryngology, University Hospital Città della Salute e della Scienza di Torino, Turin, - - 2014
The benefits of tonsillectomy in IgA nephropathy (IgAN) are still debated. Tonsillectomy may remove pathogen sources and reduce the mucosal associated lymphoid tissue (MALT), limiting degalactosylated IgA1 (deGal-IgA1) production, which is considered to be the initiating pathogenetic event leading to IgA glomerular deposition. In the European network VALIGA, 62/1147 IgAN ...
Valtanen Kerttu K Büsgen Institute, Forest Botany and Tree Physiology, Georg August University Göttingen, Büsgenweg 2, 37077, Göttingen, - - 2014
To determine the exchange of nitrogen and carbon between ectomycorrhiza and host plant, young beech (Fagus sylvatica) trees from natural regeneration in intact soil cores were labelled for one growing season in a greenhouse with (13)CO2 and (15)NO3 (15)NH4. The specific enrichments of (15)N and (13)C were higher in ectomycorrhizas ...
Ahmed Sohail S Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. - - 2014
An octa-nuclear heterobimetallic complex [Y2Cu6Cl0.7(dmae)6(OAc)7.3(OH)4(H2O)2]·3H2O·0.3CH3C6H5 (dmae = dimethylaminoethanoate; OAc = acetato) was synthesized, characterized by melting point analysis, elemental analysis, FT-IR, and single crystal X-ray diffraction analysis and implemented at 600 °C under an oxygen atmosphere for the deposition of Y2CuO4-5CuO composite thin films by aerosol assisted chemical vapor deposition ...
Murakami K K School of Agriculture, Meiji University, Tama-ku, Kawasaki, Kanagawa, 214-8571, - - 2014
We evaluated genetic introgression from domesticated pigs into the Ryukyu wild boar (RWB) population on Iriomote Island based on their genetic structure and diversity. We used a combination of mitochondrial DNA D-loop region (596 bp) polymorphisms and 23 microsatellite markers. RWBs (n = 130) were collected from 18 locations on Iriomote Island and ...
Raja R R Central Rice Research Institute, Cuttack, 753 006, Odisha, - - 2014
An experiment was conducted to assess the effect of fly ash deposition without and with (0.25, 0.50, 1.0 and 1.5 g m(-2 )day(-1)) foliar dusting on the photosynthesis, stomatal conductance, transpiration, leaf temperature, albedo and productivity of rice. Dusting of 0.5 g m(-2 )day(-1) fly ash and above significantly reduced the photosynthesis, stomatal conductance, transpiration and ...
Lim Soo-Yeon - - 2014
Although a lot of mitochondria-targeting biothiol probes have been developed and applied to cellular imaging through thiol-induced disulfide cleavage or Michael addition reactions, relatively few probes assess mitochondrial GSH with high selectivity over Cys and Hcy and with NIR fluorescence capable of noninvasive imaging in biological samples. In order to ...
Isene Rune R Department of Gastroenterology, Oslo University Hospital , Oslo , - - 2014
Abstract Background. Patients with inflammatory bowel disease (IBD) have proven an increased risk of venous thromboembolism (VTE), particularly when hospitalized. The estimate of the true risk varies considerably between studies, primarily due to differences in methodology. We set out to determine the incidence of VTE in a population-based European inception ...
Yin Shutong S Institute of Animal Nutrition, Northeast Agricultural University , Harbin , P.R. - - 2014
Abstract Context: Zearalenone (ZEN) is a common contaminant that is present in feedstuff of high humidity and high temperatures. Objective: The aim of this study was to investigate the effects of diets contaminated with different concentrations of ZEN on immunomodulation in early pregnant rats. Materials and methods: Forty-eight pregnant Sprague ...
Chauhan Divya D Centre for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, U.P., 208016, - - 2014
Enhanced removal application of both forms of inorganic arsenic from arsenic-contaminated aquifers at near-neutral pH was studied using a novel electrospun chitosan/PVA/zerovalent iron (CPZ) nanofibrous mat. CPZ was carefully examined using scanning electron microscopy (SEM) equipped with energy-dispersive X-ray analysis (EDX), transmission electron microscopy (TEM), atomic fluorescence spectroscopy (AFM), X-ray ...
Li Jinrang J Department of Otorhinolaryngology Head & Neck Surgery, Navy General Hospital, Beijing, 100048, China, - - 2014
The grading system of the severity of obstructive sleep apnea hypopnea syndrome (OSAHS) used presently showed that the severe OSAHS had an extensive range of apnea hypopnea index (AHI) (≥30, even over 100). So this grading system is not rational. From Jan 1999 to June 2011, there were 2,618 patients ...
Barragan Paul P Polyclinique Les Fleurs, Ollioules, - - 2014
Aims: The aim of this study was to characterise the coronary stent longitudinal resistance of new coronary stents under worst case clinical crossing simulated configurations. Methods and results: Six coronary balloon-expandable stents were evaluated using two different tests. The first was a direct parallel plates longitudinal crush resistance test: it ...
Mohee K K Division of Cardiovascular & Diabetes Research, Leeds Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, - - 2014
Cardioprotective drug regimens improve outcomes in patients with stable coronary artery disease. Revascularization is recommended for the persistence of symptoms despite optimal medical therapy (OMT) or in patients likely to derive prognostic benefit. Our objective is to comment on recent evidence that initiation of OMT is suboptimal in patients undergoing ...
Mora Marylú M Laboratorio de Neurobiología, Centro de Investigaciones Biomédicas, Instituto Venezolano de Investigaciones Científicas (IVIC), Hospital Universitario de Maracaibo, 9no Piso, Maracaibo, 4002, Estado Zulia, - - 2014
The toxicity caused by high concentrations of manganese (Mn) could be due to a production of free radicals. Minocycline is an effective antioxidant with a high potential to capture free radicals. We investigated the effect of minocycline in the activities of superoxide dismutase (SOD) and catalase, and in the concentrations ...
Calışkan Cüneyt C Department of Emergency and Disaster Management, Canakkale Onsekiz Mart University, Canakkale, - - 2014
Emergency and core ambulance personnel work under all environmental conditions, including severe weather condtions. We evaluated emergency medical personnel in Çanakkale, Turkey, for their degree of preparedness. A descriptive study was conducted in Çanakkale, Turkey, within 112 emergency service units and their 17 district stations. Surveys were developed to measure ...
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