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Results 301 - 350 of 2894
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Chen Candice - - 2014
Physician tracking systems are critical for health workforce planning as well as for activities to ensure quality health care - such as physician regulation, education, and emergency response. However, information on current systems for physician tracking in sub-Saharan Africa is limited. The objective of this study is to provide information ...
Beermann Kristi J KJ Department of Pharmacy, Duke University Health - - 2014
Racial differences among kidney transplant recipients may impact the total daily tacrolimus dose required to achieve therapeutic tacrolimus concentrations. Previous studies suggest that African Americans require higher doses to achieve similar therapeutic drug concentrations compared to Caucasians. Data were collected on a total of 147 de novo kidney transplant recipients. ...
Smiljanic Kosara K Department of Neurobiology, Institute for Biological Research, University of Belgrade, Bul. despota Stefana 142, 11060, Belgrade, - - 2014
Maintaining cholesterol homeostasis in the brain is vital for its proper functioning. While it is well documented that dietary restriction modulates the metabolism of cholesterol peripherally, little is known as to how it can affect cholesterol metabolism in the brain. The present study was designed to elucidate the impact of ...
Jang Hong-Gu HG Department of Polymer Science and Engineering, Dankook University, Yongin, Gyeonggi 448-701, Republic of Korea. - - 2014
Two structural isomers of the bipolar host material containing the dimesitylborane moiety were synthesized and their device performance was investigated. The quantum efficiency of the devices depends on the substituent position of the dimesitylborane moiety. The maximum external quantum efficiency of the device reached as high as 23.8% with a ...
Agúndez José A - - 2014
A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene ...
Stapleton Sarah C SC Department of Chemical and Biomolecular Engineering, University of Pennsylvania , Philadelphia, PA , - - 2014
Cell-cell adhesions serve to mechanically couple cells, allowing for long-range transmission of forces across cells in development, disease, and homeostasis. Recent work has shown that such contacts also play a role in transducing mechanical cues into a wide variety of cellular behaviors important to tissue function. As such, understanding the ...
Jarvik Jeffrey G - - 2014
Back pain represents a substantial burden globally, ranking first in a recent assessment among causes of years lived with disability. Though back pain is widely studied among working age adults, there are gaps with respect to basic descriptive epidemiology among seniors, especially in the United States. Our goal was to ...
Haas Marc H MH Department of Linguistics, University of Oxford, Oxford, UK, - - 2014
Schizophrenia has been suggested to involve linguistic pragmatic deficits. In this study, two aspects of pragmatic ability were assessed; comprehension and production. Drawing on relevance theory and Gricean implicatures to assess shared attention and interpretation in a linguistic context, discourse samples and proverb interpretation were transcribed from recorded interviews with ...
Haris Agnes A Nephrology Department, Szent Margit Hospital, 132 Bécsi Street, Budapest, 1032, Hungary, - - 2014
Older age is independently associated with mortality in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). We hypothesized that a reduced-dose immunosuppressive treatment would result in similar effectiveness and comparable treatment-related morbidity in elderly patients as the regular dose in younger patients. We also postulated that the higher baseline comorbidities may ...
Ribeiro Expedito E EE Department of Interventional Cardiology, Heart Institute-InCor, University of São Paulo, São Paulo, - - 2014
Aims: The INSPIRON-I trial is a first-in-man evaluation of the safety and efficacy of the Inspiron drug-eluting stent, a sirolimus-eluting stent with abluminal biodegradable polymer coating and thin cobalt-chromium alloy. Methods and results: This is a randomised, multicentre comparison between Inspiron and a stent with the same metallic structure but ...
Spitznagel Frank A FA Department of Prosthodontics, School of Dentistry, Albert-Ludwigs University, Freiburg, - - 2014
Resin bonding is essential for clinical longevity of indirect restorations. Especially in light of the increasing popularity of computer-aided design/computer-aided manufacturing-fabricated indirect restorations, there is a need to assess optimal bonding protocols for new ceramic/polymer materials and indirect composites. The aim of this article was to review and assess the ...
Raucci-Neto Walter W School of Dentistry, University of Ribeirão Preto-UNAERP, Avenida Constábile Romano, Ribeirão Preto, SP, CEP 14096-900, - - 2014
The aim of this study was to evaluate thermal changes, dentin ablation removal capacity, and morphological aspects of sound and demineralized human dentin surface irradiated with different output energies of an erbium: yttrium-aluminium-garnet (Er:YAG) laser. Eighty sound human tooth specimens were assigned into two groups: demineralized dentin and sound dentin ...
Jia Yan-Jun - - 2014
Berberine (BBR), a natural plant extract, has been shown to improve lipid metabolism. However, its effects on PCSK9, a key factor involving in the lipid metabolism, have not yet been evaluated in vivo. The aim of the present study was to investigate the effect of BBR on PCSK9 expression in ...
Frazão Paulo P Department of Public Health Practice, School of Public Health, University of São Paulo, São Paulo, - - 2014
We analyzed the association between food insecurity and dental caries in 7- to 9-yr-old schoolchildren. We performed a cross-sectional survey nested in a population-based cohort study of 203 schoolchildren. The participants lived in the urban area of a small town within the western Brazilian Amazon. Dental examinations were performed according ...
Ceelen Wim W Department of Surgery, Ghent University Hospital, Ghent, Belgium, - - 2014
In selected patients with colorectal peritoneal carcinomatosis (PC), cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) may improve survival. We aimed to assess whether neoadjuvant chemotherapy with or without bevacizumab is indicated in this patient population. Colorectal PC patients were treated with CRS and HIPEC using oxaliplatin (200-460 mg/m(2)) or mitomycin ...
Stephens Alexandre S AS School of Medical Science, Griffith University Gold Coast Campus, Southport, Queensland 4215, - - 2014
The RUNX2 transcription factor is indispensable for skeletal development and controls bone formation by acting as a signaling hub and transcriptional regulator to coordinate target gene expression. A signaling partner of RUNX2 is the nuclear vitamin D receptor (VDR) that becomes active when bound by its ligand 1,25-dihydroxyvitamin D3 (VD3). ...
Coronado Eugenio E Instituto de Ciencia Molecular (ICMol), Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna - - 2014
The present work reports the introduction of pyridine bisamine terdentate ligands in the structure of a pirouetting copper rotaxane. Rotaxane 2[PF6 ] constitutes the first example of the incorporation of imine-based dynamic covalent chemistry in the synthesis of switchable copper-complexed interlocked systems. In this rotaxane, the substitution of the classical ...
Montañez-Barragán Alejandra A Escuela Superior de Medicina del Instituto Politécnico Nacional, Ciudad de México, - - 2014
Vascular calcification in chronic kidney disease (CKD) patients is associated to increased mortality. Osteoprotegerin (OPG) is a soluble tumor necrosis factor (TNF) superfamily receptor that inhibits the actions of the cytokines receptor activator of nuclear factor kappa-B ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL) by preventing their binding to signaling ...
Menon Rajiv G RG Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, - - 2014
Magnetic resonance (MR)-based oxygen extraction fraction (OEF) measurement techniques that use blood oxygen level-dependent (BOLD)-based approaches require the measurement of the R2' decay rate and deoxygenated blood volume to derive the local oxygen saturation in vivo. We describe here a novel approach to measure OEF using rapid local frequency mapping. ...
Wang Yuqing - - 2014
Membrane transporter PhT2 (SLC15A3), which belongs to the proton-coupled oligopeptide transporter family, mediates the transport of di/tripeptides and histidine utilizing an inwardly-directed proton gradient and negative membrane potential. The aim of this study was to elucidate the molecular expression of PhT2 in macrophages and mouse tissues, and to explore the ...
Cabezas J J Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepción, Chillán, - - 2014
Endometrial stem cells have been identified in humans, mice and pigs. This study was designed to determine whether the uterine endometrium of cycling cows contains such cells, to identify markers of stemness and ultimately to isolate putative stem/progenitor cell and evaluate their capability to differentiate into mesodermal derivatives. Uteri from ...
Shimazaki Jiro - - 2014
There are few reported cases of colorectal metastasis from cancers of other organs, particularly other segments of the colon. Here we describe the long-term survival of a 68-year-old male patient with metachronous rectal metastasis from cecal cancer who underwent repetitive resection and chemotherapy. The patient underwent ileocecal resection and hepatectomy ...
Alia Shaun M SM Department of Chemical Engineering, University of Delaware, Newark, DE 19716 (USA), Fax: (+1) 302-831-1048; Department of Chemical and Environmental Engineering, University of California, Riverside, Riverside, CA 92521 - - 2014
Palladium (PdNTs) and gold nanotubes (AuNTs) were synthesized by the galvanic displacement of silver nanowires. PdNTs and AuNTs have wall thicknesses of 6 nm, outer diameters of 60 nm, and lengths of 5-10 and 5-20 μm, respectively. Rotating disk electrode experiments showed that the PdNTs and AuNTs have higher area normalized activities for ...
Chen Jim-Ray JR Department of Pathology, Keelung Chang Gung Memorial Hospital, 222 Maijin Road, Keelung, 204, Taiwan, - - 2014
Immunohistochemical expression of ERα, encoded by the ESR1 (estrogen receptor 1) gene located at 6q25.1, is the most important determinant of responsiveness to endocrine therapy in breast cancer. The prevalence and significance of ESR1 amplification in breast cancer remain controversial. We set out to assess ESR1 status and its relevance ...
Goto Masahide - - 2014
Marinesco-Sjogren syndrome (MSS) is an autosomal recessive multisystem disorder characterized by the tetralogy of cerebellar ataxia, congenital cataracts, intellectual disability, and progressive muscle weakness due to myopathy. MSS is extremely rare, and its clinical, pathological, and genetic features are not yet fully understood. We conducted a nationwide, questionnaire-based survey on ...
Araya Claudio - - 2014
Morphogenesis of the zebrafish neural tube requires the coordinated movement of many cells in both time and space. A good example of this is the movement of the cells in the zebrafish neural plate as they converge towards the dorsal midline before internalizing to form a neural keel. How these ...
Yang Hao - - 2014
In an effort to characterize the roles of each metal ion in metallo-beta-lactamase NDM-1, heterodimetallic analogs (CoCo-, ZnCo-, and CoCd-) of the enzyme were generated and characterized. UV-visible, 1H NMR, EPR and EXAFS spectroscopies were used to confirm the fidelity of the metal substitutions, including the presence of a homogeneous, ...
Yu Chenmin C Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: - - 2014
Two conjugated molecules, TADPP3 and TADPP2-TT, are reported, in which three and two dithienyldiketopyrrolopyrrole (DPP) moieties, respectively, are substituted at the meta positions of benzene. Based on cyclic voltammetry and absorption data, TADPP3 and TADPP2-TT possess similar HOMO and LUMO energies of about -5.2 and -3.4 eV, respectively. Thin films of ...
Boubakri Ali A Laboratory of Wastewater Treatment, Center of Researches and Water Technologies, PB 273, 8020, Soliman, Tunisia, - - 2014
Direct contact membrane distillation (DCMD) process using polyvinylidene fluoride (PVDF) membrane was used for fluoride removal from aqueous solution. This study has been carried out on heat and mass transfer analyses in DCMD. The dusty-gas model was used to analyze the mass transfer mechanism and to calculate the permeate flux. ...
Laas Kariina K Department of Psychology, University of Tartu, - - 2014
The functional polymorphism Asn(107) Ile (rs324981, A > T) of the neuropeptide S receptor (NPSR1) gene is involved in the modulation of traits that affect alcohol use. Hence, we have examined whether the NPSR1 A/T polymorphism is associated with alcohol use disorders (AUD) and alcohol use in a population-representative sample. Lifetime AUD were ...
Sun Xiang X Cambridge Institute of Public Health, University of Cambridge School of Clinical Medicine, Forvie Site, Cambridge Biomedical Campus, Cambridge, CB2 0SR, UK, - - 2014
Sex differences in social and communication behaviours related to autism spectrum conditions (ASC) have been investigated mainly in Western populations. Little research has been done in Chinese populations. This study explored sex differences related to ASC characteristics by examining differences in item responses and score distributions in relation to a ...
Madzimure James J Department of Animal Production and Technology, Chinhoyi University of Technology, P. Bag 7724, Chinhoyi, Zimbabwe, - - 2014
The objective of the current study was to evaluate the effects of feeding increasing levels of velvet bean seed meal (VBM; 0, 12, 24, and 36 %) on the performance of Mashona doelings. Dry matter intake was lower (P < 0.05) for the control diet compared to VBM diets, but linearly declined (P < 0.05) ...
Yang Xing-Lin XL Department of Rheumatology and Immunology, Provincial Hospital affiliated to Shandong University , Jinan , P. R. - - 2014
Objectives. To investigate the association of the polymorphisms in SPARC and NLRP2 with rheumatoid arthritis (RA) in a Chinese Han population. Methods. Four single nucleotide polymorphisms (SNPs) covering SPARC and three SNPs covering NLRP2 were investigated in 624 Chinese Han RA patients and 1920 healthy controls. Results. The A allele ...
Chinn Danielle C DC Division of Hematology/Oncology, UC Davis Cancer Center, 4501 X Street, Suite 3016, Sacramento, CA, 95817, - - 2014
Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and chromosomal instability, a contributor to tumorigenesis. MK-5108 is a potent inhibitor of Aurora A kinase that has shown preclinical potent activity in malignancies of breast, cervical, colon, ovarian, and pancreatic origin. We sought to ...
Marques Leonardo L Universidade Sagrado Coração, Rua Irmã Arminda 10-50, Bauru, São Paulo, Brazil, - - 2014
A new low-level laser therapy (LLLT) protocol is proposed and compared to another previously studied, in animal models, aiming to establish a more practical LLLT protocol. Protocol 1, the same used in other works and based on the clinical LLLT protocol for bone regeneration, consists of punctual transcutaneous applications in ...
Liu Hang H Department of Rheumatology and Immunology, The 1st Affiliated Hospital of China Medical University, Shenyang, 110001, China, - - 2014
The purpose of the study was to investigate the clinical features and outcomes of retroperitoneal fibrosis (RPF). Fifty-eight RPF treatment cases in the First Affiliated Hospital of China Medical University were retrospectively analyzed, including clinical characteristics and laboratory data. RPF was found predominantly in elderly men with atypical clinical manifestations ...
Kang Hongjun H Key Laboratory of PLA, Department of Orthopaedics, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing, 100853, - - 2014
The present study aims to investigate the feasibility of tissue-engineered cartilage constructed in vivo and in vitro by dynamically culturing adipose-derived stem cells (ADSCs) with an articular cartilage acellular matrix in a bioreactor and subsequently implanting the cartilage in nude mice. ADSCs were proliferated, combined with three dimensional scaffolds (cell ...
Abd Razak Nasrul Anuar - - 2014
The design and performance of a new development prosthesis system known as biomechatronics wrist prosthesis is presented in this paper. The prosthesis system was implemented by replacing the Bowden tension cable of body powered prosthesis system using two ultrasonic sensors, two servo motors and microcontroller inside the prosthesis hand for ...
Schiller Kilian K Department of Radiation Oncology, Technische Universität München Klinikum rechts der Isar, Ismaningerstr. 22, 81675, München, - - 2014
The goal of this study was to assess the impact of different setup approaches in image-guided radiotherapy (IMRT) of the prostatic gland. In all, 28 patients with prostate cancer were enrolled in this study. After the placement of an endorectal balloon, the planning target volume (PTV) was treated to a dose ...
Ma Xu-Dong XD the First Affiliated Hospital?Medical School of Xi'an Jiaotong University, Department of Neurosurgery , Xi'an, 710061 China Email: 747001758@qq.com , 515668506@qq.com , 329328237@qq.com , 397591604@qq.com , - - 2014
Abstract Ischemic postconditioning refers to controlling reperfusion blood flow during reperfusion after ischemia, which can induce an endogenous neuroprotective effect and reduce ischemia-reperfusion injury. Activation of endogenous neuroprotective mechanisms plays a key role in protecting against brain ischemia-reperfusion injury. The mechanisms of cerebral ischemic postconditioning are not completely clear, and ...
Muhammad Sohail S Department of Chemistry, Texas A&M University at Qatar, Doha, Qatar. - - 2014
Photolysis of CpRe(CO)3 in the presence of H3BNEt3 yields the trans-CpRe(CO)2(H)2 complex. This preliminary finding presents a rare example of transition metal mediated dehydrogenation of a tertiary amine-borane and suggests that the abstracted hydrogens may be stored in the form of metal hydride complexes.
Olona C C Digestive and General Surgery Department, University Hospital Joan XXIII Tarragona, 4th Dr. Mallafre Guasch St. 3th floor, 43007, Tarragona, Spain, - - 2014
Negative pressure therapy (NPT) is a widely recognised procedure for the temporary closure of open abdominal wounds. In this study, we compare two NPT products, the V.A.C.® abdominal dressing (AD) system and the new ABThera™ (ABT) system, in terms of the primary closure rates achieved, types of closure, and the ...
Gillespie Duncan O S DO Department of Biology, Stanford University, Stanford, CA, 94305, - - 2014
In the past six decades, lifespan inequality has varied greatly within and among countries even while life expectancy has continued to increase. How and why does mortality change generate this diversity? We derive a precise link between changes in age-specific mortality and lifespan inequality, measured as the variance of age ...
King Judy J Faculty of Health Sciences, School of Rehabilitation Sciences, Physiotherapy, University of Ottawa, 451 Smyth Road, Ottawa, ON, K1N 6 N5, Canada, - - 2014
There often exists a discrepancy between the information health care professionals (HCPs) provide to patients in preoperative teaching sessions and the information patients perceive as important. This study's purpose was to determine what information patients undergoing a lung cancer surgical resection wanted to learn before and after their surgery and ...
Kalva Sukesh S Department of Bioinformatics, SRM University, SRM Nagar, Kattankulathur, 603 203, Kancheepuram District, Chennai, - - 2014
Matrix metalloproteinase-8 (MMP-8) is the key mediator in initiating type I collagen degradation and is associated with rheumatoid arthritis. In the present study, a pharmacophore hypothesis was developed based on selective non zinc binding inhibitors of MMP-8. The pharmacophore hypothesis was refined manually and validated by observing structures and the interactions ...
Mao Guo-Jiang GJ Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China. xbzhang@hnu.edu.cn - - 2014
A novel coumarin-based fluorescent probe, , for quantitative detection of nitroxyl (HNO) was developed. exhibits a selective response to HNO over other biological reductants and was also applied for quantitative detection of HNO in bovine serum with satisfactory results.
Nam Tai-Seung TS Department of Neurology, Chonnam National University Medical School, Gwangju, Republic of - - 2014
Alexander disease (AxD) is an astrogliopathy that primarily affects the white matter of the central nervous system (CNS). AxD is caused by mutations in a gene encoding GFAP (glial fibrillary acidic protein). The GFAP mutations in AxD have been reported to act in a gain-of-function manner partly because the identified ...
Pang Gang G College of Material Science & Engineering and Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, P. R. China. - - 2014
A new solvothermal strategy combined with calcination has been developed to synthesize NaTi2(PO4)3-graphene nanocomposites. X-ray diffraction, thermogravimetric analysis, field-emission scanning electron microscopy and transmission electron microscopy were performed to characterize their microstructures and morphologies. It was found that NASICON-type structured NaTi2(PO4)3 nanoparticles with highly crystallinity were homogeneously anchored on the ...
Chen Chenlong C NSC Taiwan Consortium of Emergent Crystalline Materials, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung, 80424, Taiwan, Republic of China. - - 2014
Crystallographically aligned GaN nanobelt arrays were synthesized through a hybrid process of Au-assisted nucleation followed by non-Au-assisted anisotropy vapor-solid growth on a (100) γ-LiAlO2 substrate. To the best of our knowledge, this is the first report on aligned GaN nanobelts.
George D A DA Department of Trauma and Orthopaedics, Barnet Hospital, Wellhouse Lane, Barnet, EN5 3DJ, UK, - - 2014
Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin. It has been shown to reduce blood loss in trauma and other haemorrhagic conditions and has recently been utilised in elective orthopaedic surgery. There are various methods of administering TXA described in the literature. ...
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