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Saettini Francesco F Department of Pediatrics, University of Milano-Bicocca, San Gerardo Hospital, Monza, - - 2014
The aim of this study was to assess the prognostic value of multifocality and the effectiveness of two different therapeutic strategies in patients with newly diagnosed hepatoblastoma. Between 1998 and 2011, 31 patients diagnosed with hepatoblastoma were referred to Ospedale Papa Giovanni XXIII, Bergamo, Italy. Patients were stratified according to ...
Egan Kathleen M KM Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, - - 2014
Genome-wide association studies have recently identified a cancer susceptibility locus at 10p12 mapping to MLLT10 associated with the onset of diverse tumors. We genotyped two tightly linked single-nucleotide polymorphisms (SNPs) at MLLT10 associated with meningioma (rs12770228) or ovarian cancer (rs1243180), and tested for associations among 295 meningioma cases, 606 glioma ...
Pan Li-Li LL 1] Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, China [2] Union Clinical Medical College, Fujian Medical University, Fuzhou, - - 2014
An inherited predisposition to acute myeloid leukaemia (AML) is exceedingly rare, but the investigation of these families will aid in the delineation of the underlying mechanisms of the more common, sporadic cases. Three AML predisposition genes, RUNX1, CEBPA and GATA2, have been recognised, but the culprit genes in the majority ...
Nam Tai-Seung TS Department of Neurology, Chonnam National University Medical School, Gwangju, Republic of - - 2014
Alexander disease (AxD) is an astrogliopathy that primarily affects the white matter of the central nervous system (CNS). AxD is caused by mutations in a gene encoding GFAP (glial fibrillary acidic protein). The GFAP mutations in AxD have been reported to act in a gain-of-function manner partly because the identified ...
Ouyang Yabo Y Beijing You An Hospital, Capital Medical University, Beijing, 100069, - - 2014
The genetic evolution of HIV-1 in the central nervous system (CNS) is different from that in peripheral tissues. We analyzed 121 clonal sequences of the V3-V5 regions of the env gene generated from paired cerebrospinal fluid (CSF) and plasma samples from nine chronically infected patients (four with HIV-associated neurocognitive disorder ...
Park Jin-Seok JS Department of Internal Medicine, Digestive Disease Center, Inha University School of Medicine, 27 Inhang-ro, Jung-gu, Incheon, 400-711, Republic of - - 2014
Endoscopic treatment for removal of large or impacted bile duct stones is challenging, and may not be successful. The aim of this study was to evaluate the safety and efficacy of endoscopic balloon dilation lithotripsy (EBDL) as a means of treating difficult extrahepatic bile duct stones refractory to failed conventional ...
Ogawa Tetsuo T Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, - - 2014
Low birth weight resulting from a non-optimal fetal environment is correlated epidemiologically to a higher risk of adult diseases, and which has also been demonstrated using animal models for maternal undernutrition. In this study, we subjected pregnant mice to 50% food restriction (FR), and profiled gene expression and promoter DNA ...
Lebel Sophie S School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, room 4016, Ottawa, Ontario, Canada, K1N6N5, - - 2014
Evidence suggests that fear of cancer recurrence (FCR) is one of the most frequently cited unmet needs among cancer survivors and is associated with psychological distress, stress-response symptoms, and lower quality of life, as well as increased use of health care resources. Despite these factors, few manualized interventions exist to ...
Wang Bo-Hui BH Department of Horticulture, College of Agriculture, Shihezi University, 832003, Shihezi, People's Republic of - - 2014
We isolated an MYB-like gene from Korla fragrant pear using differential display RT-PCR. Expression of this gene in flowers appears to be correlated with calyx persistence. Korla fragrant pear (Pyrus brestschneideri Rehd) is an economically important pear cultivar in China. A persistent calyx results in the deformation of the fruit. ...
Lou Yongbing Y School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China. - - 2014
Three new manganese coordination polymers, {[Mn2(1,4-NDC)2(phen)2](H2O)}n (), [Mn2(1,4-NDC)2(phen)(H2O)]n () and {[Mn4(1,4-NDC)4(phen)4](DMF)2}n () (1,4-H2NDC = 1,4-naphthalene dicarboxylic acid; phen = 1,10-phenanthroline; DMF = N,N-dimethylformamide), have been synthesized solvo/hydrothermally. 1,4-NDC(2-) ligands adopt different coordination modes under different solvents and concentrations which promotes different crystal structure formation. X-ray crystal structural data reveal that ...
Hendriks Lizza E L LE Department of Pulmonary Diseases, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center , Maastricht , The - - 2014
Median survival after diagnosis of brain metastases is, depending on the Recursive Partitioning Analysis (RPA) classes, 7.1 (class I) to 2.3 months (class III). In 2011 the Dutch guideline on brain metastases was revised, advising to withhold whole brain radiotherapy (WBRT) in RPA class III. In this large retrospective study, ...
Lasset Christine C Département de santé publique, Centre Léon Bérard, Université Lyon 1, CNRS UMR 5558, 28 rue Laennec, 69373, Lyon cedex 08, France, - - 2014
To use both quantitative and qualitative methods to investigate the evolution of practices and opinions regarding human papillomavirus (HPV) vaccination among French general practitioners. A cross-sectional study (self-questionnaires) was performed in 2007 and repeated in 2010 among 271 general practitioners. Semi-structured interviews were conducted on 27 voluntary participants by a ...
Yan Bin B Radboud University Nijmegen, Institute for Molecules and Materials, FELIX Facility, Toernooiveld 7, 6525 ED Nijmegen, The Netherlands. - - 2014
The conformational preferences of peptides are mainly controlled by the stabilizing effect of intramolecular interactions. In peptides with polar side chains, not only the backbone but also the side chain interactions determine the resulting conformations. In this paper, the conformational preferences of the capped dipeptides Ac-Phe-Ser-NH2 (FS) and Ac-Phe-Cys-NH2 (FC) ...
Bos Peter A PA Department of Psychology, Utrecht University, Utrecht, The Netherlands; Department of Psychiatry and Mental Health, University of Cape Town, J-Block, Groote Schuur Hospital, Cape Town, South - - 2014
Animal studies show that exposure to parental neglect alters stress regulation and can lead to neural hyposensitivity or hypersensitivity in response to cortisol, most pronounced in the hippocampus. Cortisol, the end product of the hypothalamic-pituitary-adrenal (HPA) axis, has also been related to parenting more directly, for example, in both sexes, ...
Reif Philipp P Department of Obstetrics and Gynecology, Medical University of Graz, Graz, - - 2014
Cancers in pregnancy affect about 0.1% of all pregnant women and large majority are of maternal origin. While more than 50 cases [1] of maternal cancers with metastases to the placenta and 14 cases [2] of transplacental transmission to the fetus have been reported, primary fetal malignancies with placental involvement ...
Hsieh Lin-Fen LF Department of Physical Medicine and Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, - - 2014
To evaluate aerobic capacity in patients with ankylosing spondylitis (AS) and determine possible relationships between aerobic capacity, pulmonary function, and disease-related variables. Forty-two patients with AS and 42 healthy controls were recruited in the study. Descriptive data, disease-related variables (grip strength, lumbosacral mobility, occiput-to-wall distance, chest expansion, finger-to-floor distance, Bath ...
Kapil U U Department of Human Nutrition, Public Health Nutrition, All India Institute of Medical Sciences, New Delhi, - - 2014
Iodine deficiency (ID) is an endemic health problem in Kangra District, Himachal Pradesh (HP). ID in pregnant mothers leads to neonatal hypothyroidism (NH), mental retardation, deaf mutism, squint, dwarfism, spastic dysplasia, neurological defects and congenital anomalies. NH can be assessed by estimating the thyroid stimulating hormone (TSH) in cord blood ...
Yousefi B B 1] Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [2] Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran [3] Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, - - 2014
Background/Objectives:Endothelial dysfunction, which can be manifested by loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiovascular diseases. Previous studies showed that diets affect endothelial function and modify cardiovascular risks. This study aimed to assess the effects of Ramadan fasting, as a diet intervention, on endothelial function.Subjects/Methods:The study population consisted ...
Gallagher Carla A CA Department of Sport and Exercise Sciences, University of Chichester, College Lane, Chichester, West Sussex, PO19 6PE, - - 2014
This study investigated the response of the ventilatory threshold (VT) to acute normobaric hypoxia and compared the agreement between software-based algorithms which use automatic detection to identify the VT. Results were used to examine whether the VT can be used as a physiological parameter to prescribe and monitor exercise intensity ...
Kunisaki Yuya Y Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Bronx, NY, 10461, USA, - - 2014
The fate decision of hematopoietic stem cells (HSCs), quiescence, proliferation or differentiation, is uniquely determined by functionally specialized microenvironments defined as the HSC niches. However, whether quiescence and proliferation of HSCs are regulated by spatially distinct niches is unclear. Although various candidate stromal cells have been identified as potential niche ...
Kumagai Shogo S Department of Hematology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, - - 2014
The prognosis of follicular lymphoma (FL) is significantly associated with host immunity and tumor microenvironment. Lymphopenia has been identified as a negative prognostic factor for FL. The association between monocytosis and progression-free survival (PFS) in FL remains controversial. It is unknown whether the ratio of peripheral blood absolute lymphocyte count ...
Venkateswarlu Vunnam V Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine and AcSIR, Canal Road, Jammu-180 001 - - 2014
Direct ortho-hydroxylation through CH oxygenation and N-trifluoroacylation of anilines was achieved in a single step under metal-free conditions by using a combination of TFA and oxone. The method allowed the formation of functionalised amino phenolic compounds such as ortho-hydroxy-N-trifluoroacetanilides in good yields with broad substrate scope.
Dvoriantchikova Galina G Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL, 33136, - - 2014
Toll-like receptor 4 (Tlr4) plays an important role in ischemia-reperfusion (IR)-induced retinal inflammation and damage. However, the role of two Tlr4-dependent signaling cascades, myeloid differentiation primary response 88 (Myd88) and TIR-domain-containing adapter inducing interferon-β (Trif), in retinal IR injury is poorly understood. In this study, we investigated the contribution of ...
Kerian Kevin S KS Purdue University, Department of Chemistry, 560 Oval Drive, West Lafayette, IN, USA. - - 2014
Touch spray, a spray-based ambient in situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state ...
Rosa Marlene Cristina MC Department of Health Sciences (Secção Autónoma de Ciências da Saúde - SACS), University of Aveiro , Aveiro , Portugal - - 2014
Abstract Purpose: To determine the validity of walking speed, muscle strength, function of the hemiparetic lower limb and self-perceived balance to predict and discriminate independent community walkers (ICW) within the first 6 months post-stroke. Methods: Inpatients with a first ischemic stroke (<3 months), able to walk, were evaluated (T0) and ...
Hershkovitz Avital A Geriatric Rehabilitation Ward, "Beit Rivka" Geriatric Rehabilitation Center , Petach Tikva , Israel - - 2014
Abstract Purpose: To present our experience in measuring rehabilitation achievements of post-acute hip fractured patients with the FIM instrument; assess its appropriateness as to the patients' various disability levels and describe our experience with other measuring tools in patients less sensitive to changes in the FIM instrument. Methods: A retrospective ...
Giusti Serena S Research Center "E. Piaggio", University of Pisa, - - 2014
Permeability studies across epithelial barriers are of primary importance in drug delivery as well as in toxicology. However, traditional in vitro models do not adequately mimic the dynamic environment of physiological barriers. Here we describe a novel two-chamber modular bioreactor for dynamic in-vitro studies of epithelial cells. The fluid dynamic ...
Tan Haiying - - 2014
Rheological behavior of three-arm and six-arm star polystyrene (SPS) with a small amount of polyhedral oligosilsesquioxane (POSS) was studied. Both linear oscillatory frequency sweep and steady state shear results of SPS/POSS composites showed the reduction of melt viscosity in the unentangled SPS matrix and the increase of viscosity in the ...
Sakai Yu Y Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, - - 2014
Background: Dental calculus is calcified plaque composed primarily of calcium phosphate mineral salts, and there is a clear association between the presence of calculus and the initiation/progression of periodontitis. However, it is still inconclusive whether dental calculus can be a direct causative factor. We examined the effect of nano/micro-sized calcium ...
Egnatios Jeremy J School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA, - - 2014
Retroperitoneal fibrosis has seldom been described in the pediatric literature. We present a child who presented with retroperitoneal fibrosis without any associated underlying vascular or inflammatory conditions. This is one of only a few cases of primary idiopathic retroperitoneal fibrosis in a pediatric patient to have been imaged extensively by ...
Lim Soo-Yeon - - 2014
Although a lot of mitochondria-targeting biothiol probes have been developed and applied to cellular imaging through thiol-induced disulfide cleavage or Michael addition reactions, relatively few probes assess mitochondrial GSH with high selectivity over Cys and Hcy and with NIR fluorescence capable of noninvasive imaging in biological samples. In order to ...
Wu Xiao-Nan XN Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 135, 10623 Berlin - - 2014
The gas-phase reactivity of [V2 O5 ](+) and [Nb2 O5 ](+) towards ethane has been investigated by means of mass spectrometry and density functional theory (DFT) calculations. The two metal oxides give rise to the formation of quite different reaction products; for example, the direct room-temperature conversions C2 H6 →C2 ...
Liu Tao T Department of Dermatology and Venereology, Tangdu Hospital, The Fourth Military Medical University, No.569 Xinsi Road, Xi'an, 710038, China, - - 2014
GNF-351 is a candidate drug used to treat some diseases through antagonizing aryl hydrocarbon receptor. In the present study, molecular docking method was employed to understand the interaction between ketoconazole and GNF-351. The structure of cytochrome P450 (CYP) 3A4 was obtained from protein data bank, and 2-dimensional structure of GNF-351 ...
Garcia Neus N Unitat d'Histologia i Neurobiologia (UHN), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, - - 2014
To date, four subtypes of adenosine receptors have been cloned (A1 R, A2A R, A2B R, and A3 R). In a previous study we used confocal immunocytochemistry to identify A1 R and A2A R receptors at mouse neuromuscular junctions (NMJs). The data shows that these receptors are localized differently in ...
Zong Yang Y a College of Pharmacy, Dalian Medical University , Dalian 116044 , - - 2014
Three new phenolic constituents 1-3 were obtained from the 95% ethanol extract of the roots of Phyllodium pulchellum (Leguminosae). Their structures were elucidated on the basis of spectroscopic analyses, such as NMR, UV, IR, HR-ESI-MS, and CD. Furthermore, in an in vitro bioassay, all compounds were tested for inhibitory effects ...
Suppo Jean-Simon JS Institut Charles Gerhardt Montpellier (ICGM), UMR 5253 CNRS-UM2-UM1-ENSCM, Ecole Nationale Supérieure de Chimie, 8 Rue de l'Ecole Normale, 34296 Montpellier Cedex 5 - - 2014
A mild, practical, and simple procedure for peptide-bond formation is reported. Instead of activation of the carboxylic acid functionality, the reaction involves an unprecedented use of activated α-aminoesters. The method provides a straightforward entry to dipeptides and was effective when a sensitive cysteine residue was used, as no epimerization was ...
Rodio Angelo A a Department of Human Sciences, Society and Health , University of Cassino e Southern Lazio , Cassino (FR) , - - 2014
Abstract Walking is the most natural physical activity to maintain and improve fitness and health. Walking downhill is usefully adopted to plan training programmes to improve the strength, particularly in older adults. The present research was aimed to evaluate the influence of downhill walking on leg strength in young adult. ...
Kühler Paul - - 2014
We report that plasmonic nanoantennas made by DNA origami can be used as reliable and efficient probes for surface enhanced Raman spectroscopy (SERS). The nanoantenna is built up by two gold nanoparticles that are linked together by a three-layered DNA origami block at a separation distance of 6 nm in ...
Cabezas J J Department of Animal Science, Faculty of Veterinary Sciences, Universidad de Concepción, Chillán, - - 2014
Endometrial stem cells have been identified in humans, mice and pigs. This study was designed to determine whether the uterine endometrium of cycling cows contains such cells, to identify markers of stemness and ultimately to isolate putative stem/progenitor cell and evaluate their capability to differentiate into mesodermal derivatives. Uteri from ...
Mavrogenis Stelios S National Institute of Oncology, Department of Uro-oncology, Budapest, - - 2014
The objective of the study was to evaluate the possible association of maternal factors with the risk of isolated true undescended testis (ITUT) diagnosed at third postnatal month because our knowledge is limited regarding the origin of ITUT. Acute and chronic diseases with related drug treatments were compared in the ...
Abouzeid Amr Abdelhamid AA Department of Pediatric Surgery, Ain-Shams University, Ramsis Street, Abbassya, Cairo, 11566, Egypt, - - 2014
Anteriorly displaced anus is an anomaly that is debated with regard to its nomenclature, diagnosis and management. To describe MRI anatomy of the anal canal in children with anteriorly displaced anus and its impact on the process of defecation. We prospectively examined ten children (7 girls, 3 boys; age range ...
Goeser Megan R MR Department of Dermatology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN, 55905, - - 2014
Cutaneous small-vessel vasculitis (CSVV) is a disorder characterized by neutrophilic inflammation predominantly limited to the superficial cutaneous postcapillary venules. CSVV may be idiopathic or may have a defined cause such as infection, medication, connective tissue disease, or malignancy. CSVV may also be associated with extracutaneous disease or systemic vasculitis. The ...
Brendel Esther E Department of Psychology, Johannes Gutenberg-Universität Mainz, 55099, Mainz, Germany, - - 2014
Recently, responses to looming visual stimuli have been shown to depend on the emotional content of the stimulus. A threatening stimulus is judged to arrive sooner compared to a neutral stimulus, possibly buying the organism time to prepare defensive actions. Here, we explored the underlying mechanism. We found that time-to-contact ...
Altunay Ilknur Kivanc IK Department of Dermatology and Venereology, Sisli Hamidiye Etfal Training and Research Hospital, 34377, Sisli, Istanbul, Turkey, - - 2014
Functional pruritus (FP) is a type of chronic pruritus that is a somatoform disease in nature, triggered by psychogenic factors. Psoriasis is a chronic, inflammatory, and pruritic skin disease that causes significant cosmetic problems and psychological distress. In this study, we aimed to investigate the effects of functional pruritus on ...
Al-Daghri Nasser M - - 2014
In this observational study, we aimed to see whether transition in Saudi students entering university life could be a breeding stage for cardiometabolic risk factor emergence and clustering. A total of 1878 apparently healthy Saudi students of the Preparatory Year, King Saud University, Riyadh, KSA (1112 men and 766 women) ...
Parodi Aurora A Section of Dermatology, Dipartimento di Scienze della Salute (DISSAL), University of Genoa and S. Martino University Hospital, Genoa, - - 2014
The pathogenesis of psoriasis is complex, with a significant role suggested for pro-inflammatory mediators. There is strong evidence of an association between psoriasis and the metabolic syndrome (MetS), a cluster of cardiovascular risk factors, which impose a substantial disease burden. This study aimed to evaluate the prevalence of MetS and ...
Kobayashi Reiko R Department of Radiology, University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, - - 2014
For clinically node negative (N0) breast cancer patients, sentinel node (SN) biopsy (SNB) is a standard technique and complete axillary lymph node dissection (ALND) remains the standard treatment when the SN is positive. However, the American College of Surgeons Oncology Group Z0011 trial and the International Breast Cancer Study Group ...
Govindaraj Chindu C Department of Immunology, Central Clinical School, Monash University, Melbourne, VIC, - - 2014
A major limitation to improved outcomes in acute myelogenous leukemia (AML) is relapse resulting from leukemic cells that persist at clinical remission. Regulatory T cells (Tregs), which are increased in AML patients, can contribute to immune evasion by residual leukemic cells. Tumor Necrosis Factor (TNF), a pro-inflammatory cytokine present at ...
Fu Peng P Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United - - 2014
Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell ...
Pang Gang G College of Material Science & Engineering and Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, P. R. China. - - 2014
A new solvothermal strategy combined with calcination has been developed to synthesize NaTi2(PO4)3-graphene nanocomposites. X-ray diffraction, thermogravimetric analysis, field-emission scanning electron microscopy and transmission electron microscopy were performed to characterize their microstructures and morphologies. It was found that NASICON-type structured NaTi2(PO4)3 nanoparticles with highly crystallinity were homogeneously anchored on the ...
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