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Results 201 - 250 of 2861
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Veillard Romain R Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M FR3038, ENSICAEN & Université de Caen Basse-Normandie, 6 bvd Maréchal Juin, 14050 Caen, France. carole.witulski-alayrac@ensicaen.fr - - 2014
A versatile synthesis of 1,2,3-triazolyl-4-phosphines from the borane complexes of phosphino-alkynes is reported. The efficiency of the procedure relies on the use of readily available silyl-protected alkynylphosphine-boranes, which were subjected to desilylation with TBAF followed by copper-catalyzed azide-alkyne-cycloaddition in one pot. Subsequent treatment with DABCO afforded the targeted triazolylphosphines in ...
Ebe Hiroshi H Department of Internal Medicine, Faculty of Medicine, University of Tsukuba , Tsukuba , - - 2014
Objective. To define the clinical features of IgG4-related disease (IgG4-RD) complicated with perivascular lesions. Methods. The clinical features of seven patients with IgG4-RD and perivascular lesions diagnosed at the University of Tsukuba Hospital between October 2008 and October 2013, were analyzed, including clinical background, results of imaging studies, satisfaction of ...
Mora Marylú M Laboratorio de Neurobiología, Centro de Investigaciones Biomédicas, Instituto Venezolano de Investigaciones Científicas (IVIC), Hospital Universitario de Maracaibo, 9no Piso, Maracaibo, 4002, Estado Zulia, - - 2014
The toxicity caused by high concentrations of manganese (Mn) could be due to a production of free radicals. Minocycline is an effective antioxidant with a high potential to capture free radicals. We investigated the effect of minocycline in the activities of superoxide dismutase (SOD) and catalase, and in the concentrations ...
Nakagishi Yasuo Y Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children's Hospital , Kobe, Hyogo , - - 2014
Macrophage activation syndrome (MAS) is a severe and potential life-threatening complication of childhood systemic inflammatory disorders. Corticosteroids are commonly used as the first-line therapy for MAS. We report four patients with MAS who were successfully treated with dexamethasone palmitate (DexP), a liposome-incorporated dexamethasone, much more efficient than free corticosteroids. DexP ...
Betts Aaron M AM Department of Radiology, University of Cincinnati Medical Center, 234 Goodman St., Cincinnati, OH, 45267, USA, - - 2014
Computed tomography (CT) is widely used in the initial evaluation of patients with craniofacial trauma. Due to anatomical proximity, craniofacial trauma often involves concomitant injury to the eye and orbit. These injuries may have devastating consequences to vision, ocular motility, and cosmesis. CT imaging provides a rapid and detailed evaluation ...
Nakhleh Afif A Department of Internal Medicine A, Bnai Zion Medical Center, Faculty of Medicine , Technion, Haifa , - - 2014
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans histiocytosis with heterogeneous clinical manifestations. The most common presentation is bone pains typically involving the long bones. Approximately 75% of the patients develop extraskeletal involvement. Cardiac involvement is seen in up to 45% of the patients, and although, pericardial involvement is ...
Yuan Peng P Department of Pain Management, Tangdu Hospital, The Fourth Military Medical University, Xi'an, - - 2014
The functional abnormality of circadian regulation genes is involved in the development and progression of HCC. However, the association between functional SNPs in circadian gene NPAS2 and the overall survival of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE) has never been investigated. Six functional SNPs in NPAS2 ...
Stępiński Dariusz D Department of Cytophysiology, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143, 90-236, Łódź, Poland, - - 2014
Nucleoli are nuclear domains present in almost all eukaryotic cells. They not only specialize in the production of ribosomal subunits but also play roles in many fundamental cellular activities. Concerning ribosome biosynthesis, particular stages of this process, i.e., ribosomal DNA transcription, primary RNA transcript processing, and ribosome assembly proceed in ...
Serrão José Eduardo JE Departamento de Biologia Geral, Universidade Federal de Viçosa, Av. P.H. Rolfs, s/n, 36570-000, Viçosa, Minas Gerais, Brazil, - - 2014
Nectar used by bees as a food source is collected and stored in the crop, where it is transported and converted into honey. The production of honey involves water uptake from nectar. However, the crop is a portion of the insect foregut that has been characterized solely as a food ...
Chinn Danielle C DC Division of Hematology/Oncology, UC Davis Cancer Center, 4501 X Street, Suite 3016, Sacramento, CA, 95817, - - 2014
Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and chromosomal instability, a contributor to tumorigenesis. MK-5108 is a potent inhibitor of Aurora A kinase that has shown preclinical potent activity in malignancies of breast, cervical, colon, ovarian, and pancreatic origin. We sought to ...
Wang Guang-Zhi GZ Department of Intervention Radiology, Zhongshan Hospital Fudan University, No. 180 Fenglin Road, Xuhui, Shanghai, - - 2014
Arsenic trioxide (ATO) has been found effective in several types of cancer cells, including acute promyelocytic leukemia, and recently in hepatocellular carcinoma (HCC). In this study, we investigated the role of ATO in regulating the invasive activity of HCC after transarterial embolization (TAE). Cell migration and invasion were observed using ...
Kovač Branka B Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia. - - 2014
The photoionization of three stable nitroxyl radicals has been studied in the valence and core regions using synchrotron radiation. We observed different variations of the relative band intensities with the photon energy for two pyrrolidine nitroxyls (nitroxyl8 and nitroxyl9) in the valence ionization region. This is due to strong intramolecular ...
Coelho A A Department of Experimental Biology, Faculty of Medicine, University of Porto, Portugal; IBMC, Instituto for Molecular and Cell Biology, University of Porto, - - 2014
Botulinum toxin A (Onabot/A) has been shown to have an antinociceptive effect. This might be due to an impairment of sensory nerves not only in the peripheral but also in the central nervous system. In this work, we analysed both systems by studying the effect of intrathecal (i.t.) administration of ...
Mostafa Nael M NM Research and Development, AbbVie Inc., One N. Waukegan Road, North Chicago, IL, 60064, USA, - - 2014
A pharmacokinetic substudy was conducted within a phase 3 clinical trial that evaluated the efficacy and safety of two leuprolide acetate 3-month depot formulations in children with central precocious puberty (CPP), where the pharmacokinetics of leuprolide and the exposure-response relationship between leuprolide concentration and the probability of luteinizing hormone (LH) ...
Mao Guo-Jiang GJ Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China. xbzhang@hnu.edu.cn - - 2014
A novel coumarin-based fluorescent probe, , for quantitative detection of nitroxyl (HNO) was developed. exhibits a selective response to HNO over other biological reductants and was also applied for quantitative detection of HNO in bovine serum with satisfactory results.
Wang Yuqing - - 2014
Membrane transporter PhT2 (SLC15A3), which belongs to the proton-coupled oligopeptide transporter family, mediates the transport of di/tripeptides and histidine utilizing an inwardly-directed proton gradient and negative membrane potential. The aim of this study was to elucidate the molecular expression of PhT2 in macrophages and mouse tissues, and to explore the ...
Kelly-Hughes Denise H DH a Health in Action: Stress Research Group, Department of Psychology, Faculty of Health and Life Sciences , Northumbria - - 2014
Abstract Previous research investigating the influence of Type D personality on cardiovascular reactivity to stress in healthy young adults is somewhat mixed. The present study sought to investigate this question using an ecologically valid laboratory stressor. Beat-to-beat blood pressure and heart rate were measured in 77 healthy young adults during ...
Shen Xiao X Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032 (P. R. - - 2014
Unlike the facile synthesis of β-monofluoromethyl alcohols by nucleophilic monofluoromethylation of epoxides, the synthesis of β-difluoromethyl alcohols by nucleophilic difluoromethylation of epoxides still remains a challenge. Herein, studies on tackling this problem with PhSO(NTBS)CF2 H (2; TBS=tert-butyldimethylsilyl) are reported. The preorganization of 2 and epoxides with BF3 ⋅Et2 O was ...
Zhao Fei F Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, - - 2014
The aim of this study was to assess the effectiveness of adding viral vector-mediated gene therapy with herpes simplex virus thymidine kinase (HSV-tk) to standard treatment, in comparison with standard treatment alone to treat patients with high-grade gliomas (HGGs). A literature search of the databases PubMed, Embase, the Cochrane Library, ...
Hsieh Wen-Tsong WT Department of Pharmacology, School of Medicine, China Medical University, Taichung, - - 2014
Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor characterized by its rapid infiltration to surrounding tissues during the early stages. The fast spreading of GBM obscures the initiation of the tumor mass making the treatment outcome undesirable. Endothelin-1 is known as a secretory protein ...
Calışkan Cüneyt C Department of Emergency and Disaster Management, Canakkale Onsekiz Mart University, Canakkale, - - 2014
Emergency and core ambulance personnel work under all environmental conditions, including severe weather condtions. We evaluated emergency medical personnel in Çanakkale, Turkey, for their degree of preparedness. A descriptive study was conducted in Çanakkale, Turkey, within 112 emergency service units and their 17 district stations. Surveys were developed to measure ...
Gozalpour Elnaz - - 2014
Digitalis-like compounds (DLCs) such as digoxin, digitoxin and ouabain, also known as cardiac glycosides, are among the oldest pharmacological treatments of heart failure. The compounds have a narrow therapeutic window, while at the same time DLC pharmacokinetics is prone to drug-drug interactions at the transport level. Hepatic transporters Organic Anion ...
Hosonaga Mari M Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinano-machi, 160-8582, Shinjuku-ku, Tokyo, Japan; Department of Breast Oncology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, 160-0023, Shinjuku-ku, Tokyo, - - 2014
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is treated with HER2-targeted agents, such as trastuzumab and lapatinib, that suppress signaling by phosphatidylinositol 3-kinase (PI3K)-Akt and MAPK pathways. However, resistance to HER2-targeted therapy remains a major clinical problem. Overexpression of CD24 has been detected in many cancers and is ...
Ryken Timothy Charles TC Department of Neurosurgery, Iowa Spine and Brain Institute, Waterloo, IA, USA, - - 2014
Should patients with previously diagnosed malignant glioma who are suspected of experiencing progression of the neoplasm process undergo repeat open surgical resection? These recommendations apply to adults with previously diagnosed malignant glioma who are suspected of experiencing progression of the neoplastic process and are amenable to surgical resection. Repeat cytoreductive ...
Goszczynski D E DE Plant Protection Research Institute, Agricultural Research Council, Private Bag X134, Queenswood, Pretoria, 0121, South Africa, - - 2014
A new genetic variant of grapevine virus A (GVA) of phylogenetic group I was identified during comparative analysis of the viruses infecting two sibling grapevines cv. Shiraz. The grapevines were propagated from a single mother plant. One of them become infected with Shiraz disease (SD), which is highly destructive on ...
Ghosh Mimi M Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, Washington, DC, - - 2014
The mucosal microenvironment of the female reproductive tract (FRT) is rich in secreted endogenous antimicrobials that provide the first line of defense against pathogens. This review focuses on the spectrum of secreted antimicrobials found in the FRT that have anti-HIV functions and are regulated by the natural hormonal changes in ...
Liao Qinfeng Q Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian district, Beijing, 100193, People's Republic of - - 2014
A novel goose calicivirus (GoCV) was sequenced. The 8013-nt-long genome was organized into two open reading frames that were in the same frame and separated by 3 nucleotides. This feature is similar to what has been observed in turkey calicivirus (TuCV). Comparison of GoCV with other caliciviruses showed that it ...
Dong Bo B Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, 130062, - - 2014
In this study, we investigated an acute outbreak of porcine hemagglutinating encephalomyelitis on a farm of 127 pigs in Jilin province, China. Porcine hemagglutinating encephalomyelitis virus (PHEV) was detected in suckling and weaning pigs by RT-PCR assays. Coronavirus-like particles were observed by electron microscopy. The virus isolate was designated PHEV-JT06. ...
Liu Juan J Beijing Institute of Radiation Medicine, Beijing Key Laboratory of New Molecular Diagnosis Technologies for Infectious Diseases, 27 Taiping Road, Haidian District, Beijing, 100850, People's Republic of - - 2014
Enterovirus 71 (EV71) is a highly infectious virus that is a major cause of hand, foot, and mouth disease (HFMD), which can lead to severe neurological complications. Currently, there is no effective therapy against EV71. Five antisense oligodeoxynucleotides targeting the 5'-terminal conserved domain of the viral genome were designed using ...
Holz Nathalie E NE Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, - - 2014
Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity ...
Zhang Yang Y State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People's Republic of China. zyhou@ciac.ac.cn - - 2014
In this paper, well defined GdOF:Yb(3+)/Er(3+), Tm(3+), Ho(3+) nano/submicrocrystals with multiform morphologies were prepared via the urea-based precipitation method without using any surfactants. The morphologies of the GdOF products, including spindles and spheres with different sizes (30-550 nm), could be easily modulated by changing the fluorine sources, and the possible ...
Tian Xin X Molecular Oncology Department of Cancer Research Institute, the First Affiliated Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, - - 2014
Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a molecular chaperone involved in multi-drug resistance and antiapoptosis in some human tumors, but its regulatory mechanisms have not been revealed in esophageal squamous cell carcinoma. In this study, 138 specimens of esophageal squamous cell carcinoma (ESCC) were analyzed. TRAP1 was overexpressed ...
Papavasiliou A A Sport Injuries Laboratory, Department of Physical Education and Sport Sciences, Aristotle University of Thessaloniki, Thermi, 54124, Thessaloniki, Greece, - - 2014
Specific patterns of developmental adaptation of the proximal femur have been recognized in some sports. Gymnastics are characterized by repetitive axial loading and hip rotations in combination with extreme hip positions. It is unknown how and if these forces can affect an immature skeleton in the long term. We sought ...
Pearl Rebecca L RL a Department of Psychology . Yale University , New Haven , CT - - 2014
Abstract Objective: The objective of this research was to compare the effects of different causal attributions for overweight and obesity, among individuals with overweight and obesity, on weight-related beliefs, stigmatizing attitudes, and policy support. Design: In Study 1, an online sample of 95 U.S. adults rated the extent to which ...
Rao K D M KD Chemistry & Physics of Materials Unit and Thematic Unit of Excellence in Nanochemistry, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore 560064, India. - - 2014
A transparent conductor which can generate high temperatures finds important applications in optoelectronics. In this article, a wire network made of Au on quartz is shown to serve as an effective high temperature transparent heater. The heater has been fabricated by depositing Au onto a cracked sacrificial template. The highly ...
Raja R R Central Rice Research Institute, Cuttack, 753 006, Odisha, - - 2014
An experiment was conducted to assess the effect of fly ash deposition without and with (0.25, 0.50, 1.0 and 1.5 g m(-2 )day(-1)) foliar dusting on the photosynthesis, stomatal conductance, transpiration, leaf temperature, albedo and productivity of rice. Dusting of 0.5 g m(-2 )day(-1) fly ash and above significantly reduced the photosynthesis, stomatal conductance, transpiration and ...
Austin A W AW Montreal Behavioural Medicine Centre, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada; Department of Exercise Science, Concordia University, Montreal, Quebec, Canada; Research Centre, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, - - 2014
To examine the associations of depressive symptoms with insulin resistance, evaluating somatic and cognitive depressive symptoms separately. A total of 328 individuals (mean age 60 years) referred for exercise stress testing, taking part in the Mechanisms and Outcomes of Silent Myocardial Ischemia study, completed the Beck Depression Inventory II. A ...
Gholampour Akbar A Department of Environmental Health Engineering, School of Public Health, Tabriz University of Medical Sciences, Tabriz, Iran, - - 2014
Atmospheric particulate matter (PM) was measured concurrently from September, 2012, to June, 2013, at two sites, urban and industrial suburban, in Tabriz, Iran. The annual average concentration of total suspended particulates (TSP), PM10, PM2.5, and PM1 at the urban site were 142.2 ± 76.3, 85.3 ± 43.9, 39 ± 19.1, and 28.4 ± 14.9 µg/m(3) (mean ± SD), respectively. A total ...
Nagy Emese E School of Psychology, University of Dundee, - - 2014
Imitation in human neonates, unlike imitation in young infants, is still regarded as controversial. Four studies with 203 newborns are presented to examine the imitation of index finger, two- and three-finger movements in human neonates. Results found differential imitations of all three modelled gestures, a left-handed pattern, and a rapid ...
Tekin Neslihan N Department of Chemistry, Biochemistry Division, Faculty of Arts and Science, Aksaray University, Aksaray, Turkey, - - 2014
We evaluated the effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex ([Au(dppz)Cl2]Cl) on apoptosis during chemically induced hepatocellular carcinoma. 48 male Spraque-Dawley rats were divided into six groups; group I (control), group II [Dimethyl sulfoxide (DMSO)], group III ([Au(dppz)Cl2]Cl), group IV [diethylnitrosamine + Phenobabital (DEN + PB)], group V (DEN + PB + [Au(dppz)Cl2]Cl (2nd week)), and group ...
Willrodt Christian C Laboratory of Chemical Biotechnology, Department of Biochemical and Chemical Engineering, TU Dortmund University, Emil-Figge-Stra&e 66, 44227 Dortmund, - - 2014
The efficiency and productivity of cellular biocatalysts play a key role in the industrial synthesis of fine and bulk chemicals. This study focuses on optimizing the synthesis of (S)-limonene from glycerol and glucose as carbon sources using recombinant E. coli. The cyclic monoterpene limonene is extensively used in the fragrance, ...
Ye Xianqing X Key Laboratory of Modern Toxicology, Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, 211166, Nanjing, - - 2014
Current treatments of breast cancer, a common malignancy in human females, are less than satisfactory because of high rates of metastasis. Glabridin (GLA), which acts through the FAK/ROS signaling pathway, has been used as an antioxidant and anti-metastatic agent. However, little is known regarding the effect of microRNAs (miRNAs) on ...
Ma Yun Y School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin, - - 2014
A data set of phytoplankton community and environmental parameters in a hydrological integrity period, i.e. a poor water term, a medium term and a rich water term of North Temperate Zone climate, was analyzed in order to describe seasonal variation of phytoplankton community and its relationship with environmental variables in ...
Hur Hyuk H Department of Neurosurgery, Chonnam National University Medical School and Research Institute of Medical Sciences, 671, Jebongno, Dong-gu, Gwangju, 501-757, Republic of - - 2014
The goal of this study was to evaluate the results and feasibility of primary anterior cervical discectomy and fusion (ACDF) with plating for unstable traumatic spondylolisthesis of the axis, the so-called hangman's fracture, via the standard anterior retropharyngeal approach. The clinical and radiological records of 17 patients (14 males and ...
Pithwa Yogesh K YK Spine Surgery, HOSMAT Hospital, Bangalore, India, - - 2014
To evaluate difference in accuracy of pedicle screw insertion in thoracic and lumbosacral spine using a straight pedicle probe vis-à-vis a curved one. Prospective, comparative, non-randomized, single-blind study. Straight and curved pedicle probes used on opposite sides of same vertebra in patients undergoing thoracolumbar pedicle screw fixation for various indications. ...
Nugent M M Cappagh National Orthopaedic Hospital, Finglas, Dublin 11, Ireland, - - 2014
Fluoroscopy is frequently used in orthopaedic surgery, particularly in a trauma setting. Exposure of patients and staff to ionising radiation has been studied extensively; however, little work has been done to evaluate current knowledge and practices among orthopaedic trainees. This study aimed to investigate the knowledge and practices of Irish ...
Gutman Gabriel G Department of Orthopedic Surgery, Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel, - - 2014
Demonstrative case report of two different evolutions in developmental spondylolisthesis. To our knowledge spontaneous sacral doming reconstruction and healing has never been previously reported. Presentation of two cases with developmental spondylolisthesis and no sacral dome that had at the beginning a similar presentation and finally evolved in different ways. Initially, ...
Yazdanfar Iraj I Laser Dental Clinic, Kermanshah, Iran, - - 2014
At the present time, evidence-based, best practices have yet to be established for maintaining the vitality of teeth by managing caries-associated pulp exposure in permanent teeth. In terms of biomechanical and esthetic considerations, pulp capping has proven to be more effective than root-canal therapy. Given the low success rate of ...
Rasmus Stacy M SM Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, P.O. Box 757000, Fairbanks, AK, 99775, USA, - - 2014
The process that community based participatory research (CBPR) implementation takes in indigenous community contexts has serious implications for health intervention outcomes and sustainability. An evaluation of the Elluam Tungiinun (Towards Wellness) Project aimed to explore the experience of a Yup'ik Alaska Native community engaged within a CBPR process and describe ...
Winston Jincy J Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, - - 2014
Facioscapulohumeral muscular dystrophy 1 (FSHD1) is caused by a contraction in the number of D4Z4 repeats on chromosome 4, resulting in relaxation of D4Z4 chromatin causing inappropriate expression of DUX4 in skeletal muscle. Clinical severity is inversely related to the number of repeats. In contrast, FSHD2 patients also have inappropriate ...
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