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Results 251 - 300 of 2047
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González-Martín A - - 2013
Approximately 75% of patients with advanced ovarian cancer will have a recurrence of their disease within the first 3 years after upfront surgery and paclitaxel-carboplatin-based chemotherapy. An optimal choice of treatment of patients with a recurrence is an important issue, and several factors should be taken into account in this ...
Craig A D - - 2013
A homeostatic energy model of awareness proposes that the anterior insular cortex engenders feelings that provide an amodal valuation of homeostatic energy utilization in an opponent, bivalent emotional control system. Feelings are the "common currency" which enable optimal utilization in the physical and mental behavior of a highly social primate. ...
Gutierrez Amparo - - 2013
Duchenne muscular dystrophy (DMD) is the most common neuromuscular disease affecting boys. Advances in their care can delay the progression of DMD-related disability and prolong survival. The administration of glucocorticoids is among these advances. Glucocorticoid therapy, however, is associated with a myriad of potential adverse effects, and treating physicians as ...
Perry M Scott - - 2013
Nearly one third of patients with epilepsy become medically intractable, and the likelihood of achieving seizure freedom decreases with each additional medication trial. For appropriately chosen patients, epilepsy surgery affords the opportunity to achieve seizure freedom and potentially wean off medications. Epilepsy surgery, as with medical management, is not without ...
Buchheit Martin - - 2013
To examine the time course of changes in wellness and health status markers before and after episodes of sickness in young soccer players during a high-altitude training camp (La Paz, 3600 m). Wellness and fatigue were assessed daily on awakening using specifically-designed questionnaires and resting measures of heart rate and ...
Xie Si-Tian - - 2013
Although the appropriate management of condylar process fractures after miniplate or microplate fixation has been described, there has been no comparative analysis of these plating systems. A retrospective review of patients who underwent open reduction and internal fixation (ORIF) of condylar head or neck fractures at our institution from January ...
Sky Karen - - 2013
Antitumor necrosis factor alpha agents are known to increase the risk for severe and atypical infections. Numerous atypical organisms have been reported previously, however, there is a paucity of reports of Salmonella as a complication of these therapies. We report a case of a 69-year-old female who developed Salmonella septic ...
Rajput Sandeep K - - 2013
Despite several decades since the birth of the first test tube baby and the first calf derived from an in vitro-fertilised embryo, the efficiency of assisted reproductive technologies remains less than ideal. Poor oocyte competence is a major factor limiting the efficiency of in vitro embryo production. Developmental competence obtained ...
Hu S - - 2013
Nucleoporin 155 (NUP155) is a major component of the nuclear pore complex involved in the cellular nucleo-cytoplasmic transport. NUP155 knockout in mice leads to atrial fibrillation and early sudden cardiac death. Due to the small size of the heart, functional electrophysiology is problematic in transgenic mice. Large transgenic animal models ...
Matsuda H - - 2013
In beef cattle, 20 to 44% embryonic loss occurs during the early stages of pregnancy (Humblot et al. 2001). However, the mechanism of early and late embryonic death is not clear. We investigated occurrence of embryonic death by monitoring ovarian hormones dynamics and checking for the presence of the conceptus ...
Cassee Flemming R - - 2013
Abstract Particulate matter (PM) is regulated in various parts of the world based on specific size cut offs, often expressed as 10 or 2.5 µm mass median aerodynamic diameter. This pollutant is deemed one of the most dangerous to health and moreover, problems persist with high ambient concentrations. Continuing pressure to ...
Okudaira Y - - 2013
In human, bovine, mouse, and rat sperm, translation of RNA to proteins in the mitochondrial ribosome during capacitation has been reported to be important for fertilization. The objective of this study was to examine effect of protein synthesis inhibitor (ribosome inhibitor) on boar sperm capacitation and IVF. Sperm from an ...
McGill J - - 2013
Compared with other domestic species, embryo technologies are least developed for the dog. This is mainly due to difficulties in producing mature oocytes in vitro. Canine oocytes contain exceptionally high amounts of lipid. High lipid content increases the chilling sensitivity of oocytes and embryos. Mechanical and chemical reductions of the ...
Soper David E - - 2013
Maternal cytomegalovirus (CMV) is the cause of the most frequent congenital infection in America; however, pregnant women are not routinely screened. Primary CMV infection is associated with a high maternal-to-child transmission rate (40%); up to 15% of these infected neonates will be symptomatic at birth and develop permanent sequelae that ...
Haynes Amber K - - 2013
Background. Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in young children globally, with the highest burden in low- and middle-income countries where the association between RSV activity and climate remains unclear. Methods. Monthly laboratory-confirmed RSV cases and associations with climate data were assessed for respiratory surveillance ...
Bonato Mario - - 2013
The cognitive impairments shown by brain-damaged patients emphasize the role of task difficulty as a major determinant for performance. We discuss the proposal of Kurzban et al. in light of our findings on right-hemisphere-damaged patients, who show increasing awareness deficits for the contralesional hemispace when engaged with resource-consuming dual tasks. ...
Westbrook John Andrew - - 2013
If cognitive effort indexes opportunity costs, it should be investigated like other cost factors including risk and delay. We discuss recent methodological advances in behavioral economics and neuroeconomics, highlighting our own work in measuring the subjective (economic) value of cognitive effort. We discuss the implications of Kurzban et al.'s proposal ...
Johnson Natasha L - - 2013
Ocular graft-versus-host disease (GVHD) is a common complication that occurs after allogeneic transplantation. It can cause severe dry eyes that are described as having a burning, gritty, and painful sensation. Ocular GVHD can affect quality of life by causing pain and photophobia, limiting activities of daily living (e.g., reading, watching ...
Hsieh Ching-Hua - - 2013
Despite the rare incidence, occult chronic thrombosis of peroneal veins of the fibula graft during the flap harvest presents a challenge to produce a successful reconstruction. In this article, we present a case of a 54-year-old man with chronic thrombosis of peroneal veins found during the harvest of the free ...
Ascherio Alberto - - 2013
Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within families, the changes in MS risk that occur with migration can be explained only by changes in the environment. The strongest known risk factor for MS is infection with Epstein-Barr virus (EBV). Compared with uninfected individuals, the hazard ...
Saul Robert A - - 2013
A colloquium on genetic literacy in pediatric primary care sponsored by the Health Resources and Services Administration Maternal and Child Health Bureau was held at the American Academy of Pediatrics headquarters on October 2-3, 2012. The overarching goal of the colloquium was to provide context for delivery of genetics-related services ...
Morishita Naoki - - 2013
A 48-year-old man with locally advanced pancreatic cancer underwent combined treatment with gemcitabine and proton radiation therapy. Because of subsequent obstruction of the common bile duct, a metallic biliary stent was placed and he received further gemcitabine chemotherapy. During chemotherapy, he developed an acute abdomen with a sudden-onset of tarry ...
Toishibekov M M - - 2013
This work evaluated different methods: vitrification (V) and super-cooling ultra-rapid vitrification (SCURV). The goat morulae were cryopreserved into the High Security Vitrification (HSV) Kit (Cryo Bio System, Paris, France). The vitrification method was applied according to the method described by Vajta et al. (1998). Both treatments used a vitrification solution ...
Satué K - - 2013
Several studies in cows have shown that plasma levels of chloride are positively correlated with the diameter of the preovulatory follicle (FD), establishing at the same time a significant positive association between plasma levels and intraoviducal concentration of this electrolyte (Hugentobler et al. 2007). These relationships may reflect the influence ...
Cabezas J - - 2013
Adult mesenchymal stem cells had been isolated from various tissues of different species, including endometrial tissue of humans, mice, and pigs, but not from cattle. The aim of our work was to identify such cells in the bovine endometrium and to establish a model system in which to test inducers ...
Desaulniers A T - - 2013
Unlike the native form of gonadotropin-releasing hormone (GnRH-I), the second isoform of GnRH (GnRH-II) is highly conserved throughout evolution and is ubiquitously expressed. The pig represents one of the few species possessing coding sequence for a functional receptor specific to GnRH-II (GnRHR-II). Binding of GnRH-II to its receptor has been ...
Wright Tiffany N - - 2013
We compared outcomes among pediatric patients managed with minimally invasive (MI) packing techniques with those managed with traditional packing techniques for drainage of subcutaneous abscesses. After institutional review board approval, medical records of children requiring drainage of subcutaneous abscesses between January 2010 and June 2011 were reviewed. Data were collected ...
Boppana Suresh B - - 2013
Congenital cytomegalovirus (CMV) infection is a leading cause of hearing loss and neurologic disabilities in children worldwide. Infants with symptomatic congenital CMV infection at birth are at significantly increased risk for developing adverse long-term outcomes. The vast majority of infants with congenital CMV infection have no clinical findings at birth ...
Wu Xi-Li - - 2013
To study the effects and possible underlying mechanism of Qufeng Tongluo Prescription (, QFTL) on the regulation of mesangial cells (MCs) proliferation and apoptosis. The MCs used in this experiment have undergone five passages induced by lipopolysaccharide (LPS). Changes in the proliferation, apoptosis, cell cycle regulatory proteins and mRNA expression ...
Mammen Andrew L - - 2013
This article reviews the most important muscle toxins, many of which are widely prescribed medications. Particular emphasis is placed on statins, which cause muscle symptoms in a relatively large proportion of the patients who take them. As with other toxic myopathies, most cases of statin-associated myotoxicity are self-limited and subside ...
Farrar John T - - 2013
Appropriate measurement of any state of health or disease depends on several factors. First and foremost is the scientific question to be answered, which can range from basic science to clinical processes to societal impact. Questions primarily address either the current state of the patient or are designed to measure ...
Kip Kevin E - - 2013
Therapies for post-traumatic stress disorder (PTSD) endorsed by the Department of Defense and Veterans Administration are relatively lengthy, costly, and yield variable success. We evaluated Accelerated Resolution Therapy (ART) for the treatment of combat-related psychological trauma. A randomized controlled trial of ART versus an Attention Control (AC) regimen was conducted ...
Nelson D Alan - - 2013
No evidence-based mechanism currently exists to inform U.S. Army clinicians of soldiers at risk of being found "Medically Not Ready" for combat duty. Historically, musculoskeletal conditions represent high-frequency medical problems among Army soldiers. We explored the feasibility of using centrally archived medical and administrative data on Army soldiers in the ...
Kobayashi M - - 2013
Transgenic (Tg) pigs expressing a fluorescent protein are extremely useful for research into transplantation and regenerative medicine. This study aimed to create Tg pigs expressing monomeric Plum (mPlum), a far-red fluorescent protein with a longer wavelength than enhanced green fluorescent protein (EGFP) and humanized Kusabira Orange (huKO), the two fluorescent ...
Matshaba B - - 2013
The cryopreservation process is one of the most crucial factors that affect the post-thaw quality of frozen goat semen. The aim of this study was to compare 4 different semen diluents (Tris-BSA, Tris-yolk, Bioxcell(®), and Ovixcell(®)). A total of 5 indigenous bucks were used as semen donors. Semen was evaluated ...
Bogliotti Y S - - 2013
During pre-implantation development, substantial epigenetic changes occur that are thought to play key roles in achieving embryonic genome activation and totipotency. Embryonic genome activation occurs at the 8- to 16-cell stage in cattle and, although it is a crucial step of development, the specific mechanisms involved are still poorly understood. ...
Baldoceda L - - 2013
Mitochondria play an important role during early mammalian embryo development through their diverse cellular functions, in particular creating balance between production of ATP by electron transport chain and oxidative stress. Embryonic mitochondria are inherited maternally and independently of the nuclear genome. They show limited activity during the early developmental stages ...
Ferguson Matthew D - - 2013
Abstract Airborne particulate matter (PM) is one of the six criteria air pollutants currently regulated by the U.S. Environmental Protection Agency (EPA), with existing ambient standards for PM2.5 and PM10. Currently there are no health-based regulations for the size fraction between 2.5 and 10 µm, commonly known as the coarse fraction ...
Waheed M M - - 2013
A series of 4 factorial-arranged experiments were conducted to study the effect of oocyte quality and different in vitro maturation (IVM) media supplements on IVM, cleavage, and embryo development of buffalo (Bubalus bubalis) oocytes. Buffalo ovaries were collected at a local abattoir in a warm (32-35°C) saline (0.9% NaCl), and ...
Choi Y - - 2013
Toxicity is generally referred to as the degree to which a substance can damage an organism. According to numerous reports, determination of toxicity through an in vitro system is an economical and ethical method, compared with an in vivo system using animals. The hES cells can differentiate into three germ ...
Cohen Daniel B - - 2013
We argue that maximising utility does not promote survival. Hence, there is no reason to expect people to modulate effort according to a task's opportunity costs. There is also no reason why our evaluation of the marginal opportunity costs of tasks should predictably rise with repetition. Thus, the opportunity cost ...
Llewellyn Sue - - 2013
This article argues that rapid eye movement (REM) dreaming is elaborative encoding for episodic memories. Elaborative encoding in REM can, at least partially, be understood through ancient art of memory (AAOM) principles: visualization, bizarre association, organization, narration, embodiment, and location. These principles render recent memories more distinctive through novel and ...
Gendolla Guido H E - - 2013
We welcome the development of a new model on effort and performance and the critique on existing resource-based models. However, considering the vast evidence for the significant impact of experienced task demand on resource allocation, we conclude that Kurzban et al.'s opportunity cost model is only valid for one performance ...
Winkeljohn Debra - - 2013
Management of immune thrombocytopenia (ITP) requires accurate assessment and evaluation, appropriate treatment strategies, and timely nursing interventions (e.g., monitoring, bleeding prevention, patient education). The overview of ITP in the current article reviews its etiology and provides updates about medical management and key components of nursing care.
Mazher Saeed - - 2013
Objective: To evaluate the outcome of management of intraventricular lesions operated by an open transcortical (nonendoscopic) approach. Study Design: Case series. Place and Duration of Study: Department of Neurosurgery, Dow University of Health Sciences and Civil Hospital, Karachi, from January 2009 to December 2011, with six months follow-up. Methodology: All ...
Lin Yi-Han - - 2013
Embryonic stem cells (ESCs) are pluripotent cells that can differentiate into various cell types, including keratinocyte-like cells, within suitable microniches. In this study, we aimed to investigate the effects of culture media, cell coculture, and a tissue-engineering biocomposite on the differentiation of mouse ESCs (MESCs) into keratinocyte-like cells and applied ...
Kaye Celia - - 2013
Since the sequencing of the human genome was completed, progress toward understanding the genetic contributions to both rare and common disorders has accelerated dramatically. That understanding will lead to new approaches to diagnosis and management, which will be incorporated into day-to-day medical practice. Moreover, the mindset with regard to genetic ...
Tatsumi Kenji - - 2013
The present study investigated the long-term outcomes of restorative proctocolectomy in pediatric patients with ulcerative colitis (UC). We report a series of 25 patients who underwent total proctocolectomy with ileal pouch-anal canal anastomosis (IACA). Surgery was performed for medically intractable colitis and severe colitis in 14 and 11 patients, respectively. ...
Chung J - - 2013
The high mobility group AT-hook 2 (HMGA2) protein has been shown to be a crucial gene for cell growth, proliferation, and apoptosis; HMGA2 is also a strong biological candidate for growth, because mutations in this gene alter body size in mice and humans. Compared with wild-type controls, adult mice lacking ...
Fernandes C A C - - 2013
In most Brazilian farms, the management of embryo recipients is done exclusively under grazing systems. Thus, the seasonal variation of grass availability can affect the energy balance and reduce weight gain, and consequently affects the rate of pregnancy. The aim of the present study was to evaluate the effect of ...
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