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Tarini Beth A BA FAAP, Child Health Evaluation and Research Unit, University of Michigan, 300 North Ingalls St, Room 6D19, Ann Arbor, MI 48109-5456. - - 2013
The family history has been called the first genetic test; it was a core element of primary care long before the current wave of genetics technologies and services became clinically relevant. Risk assessment based on family history allows providers to personalize and prioritize health messages, shifts the focus of health ...
Real Eusebio E University of Cantabria, Dep. TEISA, Photonics Engineering Group, Avda. Los Castros S/N, 39005 Santander, - - 2013
Optical coherence tomography images of human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall. These disorders can be employed as indicators for wall degradation and, therefore, become a hallmark for diagnosis of risk of aneurysm under intraoperative ...
Marcus Erin N EN From the Miller School of Medicine, University of Miami, Miami, and Indian River State College, Fort Pierce, - - 2013
To explore breast cancer beliefs among a cohort of low-income, urban, English-speaking women in Miami, Florida, who had undergone screening mammography. Four focus groups of 34 women were conducted. Discussions were transcribed verbatim and transcripts were analyzed separately by two investigators using an immersion-and-crystallization approach. Common risk factors were identified ...
Lu Jian J Johns Hopkins University, Bloomberg School of Public Health, Department of Biochemistry and Molecular Biology, Baltimore, Maryland, - - 2013
Mediator of DNA-damage checkpoint 1 (MDMDC1) has a central role in repair of DNA double-strand breaks (DSBs) by both homologous recombination and nonhomologous end joining, and its function is regulated by post-translational phosphorylation, ubiquitylation and sumoylation. In this issue, a new study by Watanabe et al. reveals that methylation of ...
Bookman M A MA University of Arizona Cancer Center, Tucson, - - 2013
Treatment options for patients with high-risk advanced-stage ovarian cancer continue to evolve, including consideration of neoadjuvant chemotherapy (NACT), timing of cytoreductive surgery, utilization of intraperitoneal (IP) chemotherapy, adoption of dose-dense weekly paclitaxel (Taxol), addition of maintenance chemotherapy, and incorporation of bevacizumab. Overall, the proportion of patients with suboptimal residual disease ...
Singh Khuraijam Dhanachandra KD Department of Bioinformatics, Alagappa University, Karaikudi - 630 004, Tamil Nadu, - - 2013
Both endothelin ETA receptor antagonists and angiotensin AT1 receptor antagonists lower blood pressure in hypertensive patients. A dual AT1 and ETA receptor antagonist may be more efficacious antihypertensive drug. In this study we identified the mode and mechanism of binding of imidazole series of compounds as dual AT1 and ETA ...
Tan Yan Y Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, - - 2013
Aptamers are oligonucleic acid or peptide molecules that bind to a specific target molecule in cells, thus may act as effective vehicles for drug or siRNA delivery. In this study we investigated the DNA aptamers that target human glioblastoma multiforme (GBM) cells overexpressing epidermal growth factor receptor variant III (EGFRvIII), ...
Radke Elizabeth G EG From the Department of Epidemiology and Emerging Pathogens Institute and the Department of Medicine, University of Florida, Gainesville, and the University of Maryland School of Medicine, - - 2013
Ciguatera is a foodborne illness that causes severe gastrointestinal and neurologic symptoms, but the risk factors for illness are not well established. In St Thomas, US Virgin Islands, we performed a case-control study for ciguatera, enrolling 47 patients primarily through the emergency department and 141 age- and sex-matched controls identified ...
Dassie Justin P JP Department of Internal Medicine, University of Iowa, 375 Newton Rd, 5202 MERF, Iowa City, IA 52242, - - 2013
Exploiting the power of the RNAi pathway through the use of therapeutic siRNA drugs has remarkable potential for treating a vast array of human disease conditions. However, difficulties in delivery of these and similar nucleic acid-based pharmacological agents to appropriate organs or tissues, remains a major impediment to their broad ...
Pazol Karen - - 2013
Since 1969, CDC has conducted abortion surveillance to document the number and characteristics of women obtaining legal induced abortions in the United States. 2010. Each year, CDC requests abortion data from the central health agencies of 52 reporting areas (the 50 states, the District of Columbia, and New York City). ...
Dhanda Ashwin D AD Ashwin D Dhanda, Peter L Collins, C Anne McCune, Department of Liver Medicine, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8HW, United - - 2013
Acute alcoholic hepatitis (AAH) is characterised by deep jaundice in patients with a history of heavy alcohol use, which can progress to liver failure. A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other ...
Lupberger Joachim J Joachim Lupberger, Stephanie Schaedler, Eberhard Hildt, Department of Medicine II, University of Freiburg, D-79106 Freiburg, - - 2013
To characterize the nuclear import of hepatitis B virus (HBV) polymerase (P) and its relevance for the viral life cycle. Sequence analysis was performed to predict functional motives within P. Phosphorylation of P was analyzed by in vitro phosphorylation. Phosphorylation site and nuclear localization signal (NLS) were destroyed by site ...
Zanini Barbara B Barbara Zanini, Federica Benini, Marie Graciella Pigozzi, Alberto Lanzini, Department of Clinical and Experimental Sciences, Gastroenterology Unit, University and Spedali Civili of Brescia, I-25123 Brescia, - - 2013
To assess the acceptance, safety and efficacy of care and treatment for chronic hepatitis C (CHC) in drug addicts. We designed a multidisciplinary, phase IV prospective cohort study. All illicit drug users (IDUs) visited a Territorial Addiction Service (SerT) in the District of Brescia, and hepatitis C antibody (HCVAb) testing ...
Karargyris Alexandros A Alexandros Karargyris, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, United - - 2013
To evaluate the three-dimensional (3-D) representation performance of 4 publicly available Shape-from-Shading (SfS) algorithms in small-bowel capsule endoscopy (SBCE). SfS techniques recover the shape of objects using the gradual variation of shading. There are 4 publicly available SfS algorithms. To the best of our knowledge, no comparative study with images ...
Khanafer Nagham N Nagham Khanafer, Philippe Vanhems, Laboratory of Epidemiology and Public Health, CNRS UMR 5558, University of Lyon, 69 373 Lyon, - - 2013
To describe and analyse factors associated with Clostridium difficile infection (CDI) severity in hospitalised medical intensive care unit patients. We performed a retrospective cohort study of 40 patients with CDI in a medical intensive care unit (MICU) at a French university hospital. We include patients hospitalised between January 1, 2007 ...
Kianička Bohuslav B Bohuslav Kianička, 2 Clinic of Internal Medicine, Department of Gastroenterology, St. Anne's University Hospital Brno, 656 91 Brno, Czech - - 2013
To evaluate single balloon enteroscopy in diagnostic and therapeutic endoscopic retrograde cholangiography (ERC) in patients with Roux-en-Y hepaticojejunoanastomosis (HJA). The study took place from January 2009 to December 2011 and we retrospectively assessed 15 patients with Roux-en-Y HJA who had signs of biliary obstruction. In total, 23 ERC procedures were ...
Soletti Rossana C RC Rossana C Soletti, Kelly Z Alves, João C Machado, Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-972, - - 2013
To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy (eUBM) to track the progression of mouse colonic lesions. Ten mice were treated with a single azoxymethane intraperitoneal injection (week 1) followed by seven days of a dextran sulfate sodium treatment in their drinking water (week 2) to induce ...
Garip Gokhan G Gokhan Garip, Ekrem Kaya, Department of Surgery, Uludag University School of Medicine, 16059 Gorukle-Bursa, - - 2013
To evaluate the effects of disease severity and necrosis on organ dysfunctions in acute pancreatitis (AP). One hundred and nine patients treated as AP between March 2003 and September 2007 with at least 6 mo follow-up were included. Patients were classified according to severity of the disease, necrosis ratio and ...
Shang Jing-Juan JJ Jing-Juan Shang, Hui Xu, Rong-Zhu Tang, Yue-Bin Dong, Division of Gastroenterology, Shanghai Seventh People's Hospital, Shanghai 200137, - - 2013
To evaluate the therapeutic effect of Shugan-decoction (SGD) on visceral hyperalgesia and colon gene expressions using a rat model. Ninety-six adult male Wistar rats were randomized into six equal groups for assessment of SGD effects on psychological stress-induced changes using the classic water avoidance stress (WAS) test. Untreated model rats ...
Qin Jian-Ping JP Jian-Ping Qin, Ming-De Jiang, Wen Tang, Xiao-Ling Wu, Xin Yao, Wei-Zheng Zeng, Hui Xu, Department of Digestion, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, - - 2013
To determine the clinical effects and complications of transjugular intrahepatic portosystemic shunt (TIPS) for portal hypertension due to cirrhosis. Two hundred and eighty patients with portal hypertension due to cirrhosis who underwent TIPS were retrospectively evaluated. Portal trunk pressure was measured before and after surgery. The changes in hemodynamics and ...
Wang Zi-Jing ZJ Zi-Jing Wang, Jiang-Yan Lou, Jie Chen, Cong Liu, Lian-Di Guo, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, Department of Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, - - 2013
To investigate H2B monoubiquitination (uH2B) and H3K4 di- and tri-methylation (H3K4-2me, H3K4-3me) levels and their clinical significance in gastric cancer (GC). Immunohistochemistry (IGC) was used to detect the differential levels of uH2B, H3K4-2me and H3K4-3me modifications in GC specimens from chemo/radiotherapy-naïve patients who underwent potentially curative surgical resection (n = ...
Chen Wen W Wen Chen, Department of Educational Administration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, - - 2013
To investigate the clinical usefulness of interferon-gamma release assays (IGRAs) in the differential diagnosis of intestinal tuberculosis (ITB) from Crohn's disease (CD) by meta-analysis. A systematic search of English language studies was performed. We searched the following databases: Medline, Embase, Web of Science and the Cochrane Library. The Standards for ...
Seong Hyeonjin H Hyeonjin Seong, Jin Il Kim, Hyun Jeong Lee, Hyun Jin Kim, Hyung Joon Cho, Hye Kang Kim, Dae Young Cheung, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 150-713, South - - 2013
An 85 year male patient complaining epigastric discomfort was admitted. From the esophagogastroduodenoscopy, three early gastric cancer (EGCa) lesions had been identified and these were diagnosed as adenocarcinoma with poorly differentiated cell type. The patient underwent operation. From the post-operative mapping, however, additional 4 EGCa lesions were found, and the ...
Jo Jae-Min JM Jae-Min Jo, Yoo-kyung Cho, Ji-Young Rhee, Jung-Mi Kwon, Woo-Kun Kim, Sang-Hoon Han, Department of Internal Medicine, Jeju National University Hospital, Jeju-si 890-716, Jeju Self-Governing Province, South - - 2013
An 80-year-old woman presenting with chest pain was found to have a large, lobulated soft tissue mass in the liver and nearby tissues on abdominal computed tomography (CT). The tumor had invaded the common hepatic artery and main portal vein. Jaundice developed 4 wk later, at which point, a pancreas ...
Yu Lin L Lin Yu, Jian Wang, Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai 200032, - - 2013
Paragangliomas typically develop in the extra-adrenal sites along the sympathetic and/or the parasympathetic chain. Occasionally, the tumors may arise in some exotic sites, including the head and neck region and the urogenital tract. Paraganglioma presenting as a primary rectal neoplasm has not been well described in the literature. Here, we ...
Yao Deng-Hua DH Deng-Hua Yao, Xue-Feng Luo, Biao Zhou, Xiao Li, Department of Gastroenterology and Hepatology, Institution of Intervention Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, - - 2013
Ileal conduit stomal varices are rare, and may result in bleeding. The standard treatment modality for management of this type of hemorrhage has not been established. We present the case of a 70-year-old woman with progressive ileal conduit stomal variceal bleeding which was successfully managed by endovascular embolization via the ...
Song Xiu-Guang XG Xiu-Guang Song, Li-Xian Ma, Department of Infectious Diseases, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, - - 2013
To investigate the expression of the hepatitis B virus (HBV) 1.3-fold genome plasmid (pHBV1.3) in an immortalized mouse hepatic cell line induced by SV40 T-antigen (SV40T) expression. Mouse hepatic cells were isolated from mouse liver tissue fragments from 3-5 d old Kunming mice by the direct collagenase digestion method and ...
Cosme Angel A Angel Cosme, Nerea Borda, Luis Bujanda, Department of Gastroenterology, Hospital de Donostia-Instituto Biodonostia, Centro de Investigaciones Biomédicas en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco UPV/EHU, 20014 San Sebastián, - - 2013
To study the prognosis (recurrence and mortality) of patients with ischemic colitis (IC). This study was conducted in four Spanish hospitals, participants in the Ischemic Colitis in Spain study We analyzed prospectively 135 consecutive patients who met criteria for definitive or probable IC according to Brandt criteria, and follow up ...
Fu Jian-Fei JF Jian-Fei Fu, Yan-Qin Huang, Jiao Yang, Cheng-Hao Yi, Hai-Long Chen, Shu Zheng, Key Laboratory of Cancer Prevention and Intervention, Chinese Ministry of Education, Hangzhou 310009, Zhejiang Province, - - 2013
To explore the clinical characteristics and prognosis of young patients with colorectal cancer patients in Eastern China. A total of 1335 patients with colorectal cancer treated from December 1985 to December 2005 at the Second Affiliated Hospital of Zhejiang University School of Medicine were studied retrospectively. The patients were divided ...
Lei Jian-Yong JY Jian-Yong Lei, Wen-Tao Wang, Lu-Nan Yan, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, - - 2013
To validate the "Metroticket" predictor using a large cohort of liver transplantation (LT) patients with hepatocellular carcinoma (HCC) in China. In total, 230 cases of LT for HCC treatment at our center, from July 2000 to August 2008, were included in the present study. The predicted 1-, 3- and 5-year ...
Zhou Dong D Dong Zhou, Jie Yang, Wei-Dong Huang, Jun Wang, Qiang Zhang, Department of General Surgery, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang 441000, Hubei Province, - - 2013
To determine the effects of RNAi-mediated inhibition of the growth hormone receptor (GHR) gene on tumors and colon cancer cells in vivo. Construction of a eukaryotic vector for human GHR expression, the pcDNA6.2-GW/EmGFP-small interfering RNAs (siRNAs)-GHR plasmid, was used to inhibit GHR expression. Thirty-six BALB/c nude mice were randomly divided ...
Xiong Jun-Jie JJ Jun-Jie Xiong, Chun-Lu Tan, Neng-Wen Ke, Si-Ming Xie, Xun Ran, Hao Zhang, Yong-Hua Chen, Xu-Bao Liu, Department of Hepato-Biliary-Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, - - 2013
To conduct a meta-analysis comparing laparoscopic total gastrectomy (LTG) with open total gastrectomy (OTG) for the treatment of gastric cancer. Major databases such as Medline (PubMed), Embase, Academic Search Premier (EBSCO), Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library were searched ...
Clouatre Dallas L DL Dallas L Clouatre, Glykon Technologies Group, LLC, Seattle, WA 98109, United - - 2013
Garcinia cambogia extract (GC) with its active component consisting of hydroxycitric acid (HCA) is widely utilized for weight loss. Various HCA salts are available, including calcium, magnesium, potassium and mixtures of these. Experimentally, these salts exhibit different properties with some, but not all, improving glucose tolerance and blood pressure. Recently, ...
Myers Lynnea Heather - - 2013
With national projections indicating the need for more RNs to meet the health care workforce demands, innovative strategies to recruit high school students into the profession of nursing must be utilized. This article describes an innovative strategy aimed at high school students through a Summer Institute of Nursing-a 5-day, 4-night, ...
Jun Won Hee - - 2013
The 5E learning cycle model has shown a positive effect on student learning in science education, particularly in courses with theory and practice components. Combining problem-based learning (PBL) with the 5E learning cycle was suggested as a better option for students' learning of theory and practice. The purpose of this ...
Koo Laura Warnock - - 2013
Interdisciplinary collaboration and interprofessional education (IPE) are essential for transforming health care. Students in nurse practitioner (NP) programs have limited exposure to IPE. Simulated clinical experiences, based on social learning theory, provide a safe and realistic environment to expose NP students to interdisciplinary collaboration as a step toward developing IPE. ...
Hickman Susan E - - 2013
This report describes the use of team-based learning concepts in an undergraduate nursing applied ethics course using established reporting guidelines. Team-based learning relies on actively engaging students in the learning process through small-group activities that facilitate the development of skills, including concept analysis, critical thinking, and problem solving. Students are ...
Holzmann R - - 2014
Acne in the adult female often presents as a chronic condition that can have a considerable negative psychological, social and emotional impact on the affected individual. Estimated prevalence rates of adult female acne vary widely according to study type. Case reports and clinical examinations estimate the prevalence of clinical acne ...
Sieber M A - - 2014
Acne is a common skin disorder that can be problematic for adults as well as for adolescents. It has several key pathophysiological features such as follicular hyperkeratosis, elevated Propionibacterium acnes proliferation, and reactive inflammation, all of which should be targeted for an optimal outcome. Azelaic acid (AzA) has profound anti-inflammatory, ...
Vargas-Diez E - - 2014
Acne, one of the most common skin problems in dermatological practice, is a condition that affects not only adolescents but also adults. While approximately 80% of cases occurring in adulthood are persistent from teenage years, around 20% are described as 'late-onset' disease, appearing for the first time in adulthood. The ...
Shen Chao-Tang - - 2013
Give me a B: A stepwise chloride abstraction of [Cp*BCl2 (IMes)] resulted in the linear di-substituted boron dication [Cp*B(IMes)](2+) . The hypercoordinated boron dication, stabilized in the pentagonal pyramidal [C5 B](2+) cluster, reacts with superhydride to yield the N-heterocyclic carbene-stabilized borabenzene, [C5 Me5 B(IMes)].
Nakashima Takuya - - 2013
Herein, we designed chiral photoresponsive tetra(2-phenylthiazole)s, which induce a diastereoselective 6π-electrocyclization reaction in a helically folded structure to freeze the conformational interconversions. The folding conformation with one helical turn of tetra(2-phenylthiazole)s was supported by multiple intramolecular noncovalent interactions including vicinal S⋅⋅⋅N interheteroatom interactions and CH-π and π-π stacking interactions between ...
Pavlidou Efterpi - - 2013
Epilepsy following febrile seizures (FS) has been estimated between 2% and 7%. It concerns a prospective study in a large sample of children with a long-term follow-up. The aim of this study is to identify the prognostic factors that can lead children with FS to epilepsy. Children with a first ...
Lin Jack J - - 2013
Neurobehavioral comorbidities are common in pediatric epilepsy with enduring adverse effects on functioning, but their neuroanatomic underpinning is unclear. Striatal and thalamic abnormalities have been associated with childhood-onset epilepsies, suggesting that epilepsy-related changes in the subcortical circuit might be associated with the comorbidities of children with epilepsy. We aimed to ...
Vignoli Aglaia - - 2013
Prevalence and long-term outcome of epilepsy in tuberous sclerosis complex (TSC) is reported to be variable, and the reasons for this variability are still controversial. We reviewed the clinical characteristics of patients with TSC who were regularly followed since 2000 at the San Paolo Multidisciplinary Tuberous Sclerosis Centre in Milan, ...
An Dongmei - - 2013
Simultaneous electroencephalography/functional magnetic resonance imaging (EEG/fMRI) recording can noninvasively map in the whole brain the hemodynamic response following an interictal epileptic discharge. EEG/fMRI is gaining interest as a presurgical evaluation tool. This study aims to determine how hemodynamic responses related to epileptic activity can help predict surgical outcome in patients ...
Wiebke Jonas - - 2013
Putting the bite on argon: Ab initio Monte Carlo simulations of superheated argon crystals at up to 100 GPa suggest that theory can provide a more accurate picture of high-pressure melting than modern diamond-anvil cell experiments.
Wallbaum Jan - - 2013
Four at one stroke: A quadruple domino carbopalladation reaction gives access to highly substituted dibenzopentafulvalenes and the complete pentafulvalene backbone is constructed in only one synthetic step. Structural and electronic properties have been evaluated by X-ray crystallography and cyclovoltammetry.
Giannerini Massimo - - 2013
Elegant like a butterfly, stings like a lithium reagent: Mono- and di-ortho-substituted aryllithium reagents were coupled through palladium catalysis with hindered aryl bromides to form highly congested tri- and tetra-ortho-substituted biaryls. The reaction allows the use of easily accessible ortho-functionalized aryllithium compounds. The high reactivity of organolithium reagents facilitates a ...
Martí-Rujas Javier - - 2013
Bis(I2 ) adducts of hexamethonium dihalides are pre-organized to respond dynamically to heating and reach a functional structure that favors the formation of the poorly stable and virtually unknown [I2 Br2 ](2-) and [I2 Cl2 ](2-) tetrahalides which could not be obtained in solution. The cavity-directed reactivity affords new opportunities ...
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