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Results 401 - 450 of 4089
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Fox James G - - 2013
Since its discovery in 1982, the global importance of Helicobacter pylori-induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to study the interactions of the host, the pathogen, ...
Means John C - - 2013
Infection of the lepidopteran insect Trichoplusia ni with the baculovirus Autographa californica M nucleopolyhedrovirus (AcMNPV) by the oral route stimulates activation of host matrix metalloproteases (MMP) and effector caspases, a process dependent on expression of the viral fibroblast growth factor (vFGF). This pathway leads to tracheal cell basal lamina remodeling, ...
Rochester Lynn - - 2013
Spinocerebellar ataxia type 6 (SCA6) is an inherited ataxia with no established treatment. Gait ataxia is a prominent feature causing substantial disability. Understanding the evolution of the gait disturbance is a key step in developing treatment strategies. We studied 9 gait variables in 24 SCA6 (6 presymptomatic; 18 symptomatic) and ...
Saidenberg Elianna - - 2013
Previous studies have indicated that medical trainees receive inadequate instruction in transfusion medicine and that this translates into insufficient transfusion knowledge throughout medical practice. We undertook to assess transfusion knowledge among internal medicine trainees in a single institution using a standardized oral examination case. A case of an adult with ...
Dan Sorin - - 2013
Since the early 1990s, major reform in healthcare has been adopted in former communist countries in Central and Eastern Europe. More than 20 years after, reform in healthcare still draws much interest from policy makers and academics alike. One of the dynamic components of reform has been the reform of payment ...
Galluccio Elena - - 2013
Nitric oxide (NO) plays a key role in vascular homeostasis and is produced by endothelial NO synthase (eNOS), encoded by NOS3 gene. We previously reported the genetic association between NOS3 rs753482-A>C polymorphism on intron 19 and coronary artery disease (CAD). In the attempt of conferring functional implication to the rs753482-A>C ...
Södersten Per - - 2013
In 1936, Eugen Steinach and colleagues published a work that brought steroid biochemistry to the study of sexual behavior and, using synthetic androgens and estrogens, foreshadowed by an astonishing four decades the discovery of the central role of estrogen in the sexual behavior of male rats. We offer an English ...
Losasso Carmen - - 2013
Abstract Objective: This study describes an effective educational program to improve children's knowledge about characteristics of microorganisms and food contamination, and their personal hygiene behaviors. Materials and Methods: Between November 2011 and March 2012, a health campaign, targeted at fifth-grade students of 12 public primary compulsory schools, was conceived. Participants ...
Shao Chunhong - - 2013
We have previously demonstrated that rat islets express high density of Angiotensin type 2 receptors (AT2R) and that activation of this receptor evokes insulinotropic effect. In this study, we evaluated the protective effects of Compound 21 (C21), a nonpeptide AT2R agonist, on islets in streptozotocin (STZ)-induced diabetes. Rats were assigned ...
Gan Yujun - - 2013
Growth hormone (GH) signals through GH receptor (GHR), a cytokine receptor linked to JAK2. GH activates STAT5, causing expression of genes including insulin-like growth factor-1 (IGF-1). IGF-1 binds IGF-1 receptor (IGF-1R), a heterotetrameric (α2-β2) tyrosine kinase growth factor receptor similar to insulin receptor (IR). In addition to this GH -> ...
Nanayakkara Charith E - - 2013
The surface photochemistry of nitric acid (HNO3) adsorbed on hematite (α-Fe2O3) particle surfaces under various environmental conditions has been investigated. Surface product formation and photochemistry of adsorbed nitrate studied using X-ray photoelectron spectroscopy (XPS). Adsorbed nitrate resulted from gas phase nitric acid adsorption showed a N1s peak at 407.4 eV. ...
Mizumoto Hiroyuki - - 2013
In tomato plants, Pepper mild mottle virus (PMMoV) cannot replicate because the tm-1 protein inhibits RNA replication. The resistance of tomato plants to PMMoV remains durable both in the field and under laboratory conditions. In this study, we constructed several mutant PMMoVs and analyzed their abilities to replicate in tomato ...
Krieger Christine C - - 2013
Excess production of hyaluronan (hyaluronic acid, HA) in the retro-orbital space is a major component of Graves' ophthalmopathy and regulation of HA production by orbital cells is a major research area. In most previous studies, HA was measured by ELISAs that used HA binding proteins (HABP) for detection and rooster ...
Jardin Carla G M - - 2013
Although risk factors for torsade de pointes (TdP) are known, identifying hospitalized patients at greatest risk for QTcP who should receive cardiac monitoring is poorly defined. Describe the prevalence of risk for TdP in patients and associations between risk factors and QTc prolongation (QTcP) at a tertiary teaching hospital. This ...
Tsampalieros A - - 2013
This prospective study evaluated changes in dual energy X-ray absorptiometry (DXA) whole body bone mineral content (WB-BMC) and spine areal bone mineral density (spine-BMD), and tibia quantitative computed tomography (QCT) trabecular and cortical volumetric BMD and cortical area in 56 children over 12 months following renal transplantation. At transplant, spine-BMD ...
Willett Kristine C - - 2013
To evaluate the appropriate dosing of enoxaparin as a venous thromboembolism (VTE) prophylaxis in hospitalized obese patients. Literature articles were accessed through MEDLINE (1946 to August week 1, 2013) and EMBASE (1980 to 2013 week 33) searches using the terms enoxaparin, obesity, and thromboprophylaxis. All articles that involved human subjects ...
Juarez-Colunga Elizabeth - - 2013
Many clinical trials are designed to study outcome measures recorded as the number of events occurring during specific intervals, called panel data. In such data, the intervals are specified by a planned set of follow-up times. As the collection of panel data results in a partial loss of information relative ...
Arakaki Richard F - - 2013
To compare efficacy and safety of two, once-daily basal insulin formulations (insulin lispro protamine suspension [ILPS] versus insulin glargine [glargine]) added to oral antihyperglycaemic medications (OAMs) and exenatide BID in suboptimally-controlledtype 2 diabetes (T2D) patients. This 24-week, open-label, multicentre trial randomised patients to bedtime ILPS (n = 171) or glargine (n = 168). Non-inferiority ...
Ferreira Valerie - - 2013
Cellular immune responses to adeno-associated viral (AAV) vectors used for gene therapy have been linked to attenuated transgene expression and loss of efficacy. The impact of such cellular immune responses on the clinical efficacy of alipogene tiparvovec (Glybera®, AAV1-LPLS447X, uniQure, Amsterdam, the Netherlands), a gene-therapy consisting of intramuscular administration of ...
Lu Wen-Jing - - 2013
Hepatocellular carcinoma (HCC) is the fifth most lethal malignancy worldwide with no curative therapies. To discover potentially novel therapeutic targets for HCC, we previously studied the gene expression profiles of HCC patients, and identified that significant up-regulation of N-Myc downstream regulated gene 1 (NDRG1) is associated with more aggressive phenotypes ...
Ghinescu Minerva - - 2013
Aging is affecting health care all over Europe, but it is expected to have a much greater impact in Eastern Europe. Reliable data on various indicators of health of older adults in Eastern Europe are lacking. The objectives of the present study were to describe the health of older Romanian ...
Wang Yangmeng - - 2013
CHIP (the carboxyl terminus of Hsc70-interacting protein, also named Stub1), a U-box containing E3 ubiquitin ligase, is involved in degradation of certain oncogenic proteins. Recent studies indicated that CHIP suppresses tumor progression in human cancers by targeting Src-3, HIF-1α, NF-κB, ErbB2 and c-Myc. Here, we report that CHIP was down-regulated, ...
Bultman Scott J - - 2013
Gene-environment interactions underlie cancer susceptibility and progression. Yet we still have limited knowledge of which environmental factors are important and how they function during tumorigenesis. In this respect, the microbial communities that inhabit our gastrointestinal tract and other body sites have been unappreciated until recently. However, our microbiota are environmental ...
Iwaki Ryuma - - 2013
Repair of a postinfarction ventricular septal defect (VSD) is a challenging procedure with a high risk of postoperative residual shunt and subsequent mortality. This retrospective study aimed to assess a modified infarct exclusion technique with a biventricular approach. Nineteen consecutive patients who underwent the infarct exclusion procedure for VSD between ...
Bouzin Margaux - - 2013
Fluorophores useful for STimulated Emission Depletion (STED) spectroscopy must fulfill strict requirements on depletion efficiency and photo-stability. These parameters determine the effective resolution of STED imaging. Resolution is typically measured on 30-80 nm spheres heavily decorated with STED bright fluorophores, limiting the possibility to estimate the true resolution achievable on ...
Viljakka T - - 2013
Radial shortening osteotomy (RSO) as treatment for Kienböck's disease usually improves patient symptoms for several years. Four small series have also shown that the effect may last for decades, but only two studies have used a patient-based assessment. We examined 16 patients, with a mean age at operation of 32 ...
Al-Qattan M M - - 2013
Isolated familial non-syndromic brachydactyly is interesting from the embryological point of view because the phenotypes of isolated brachydactyly are frequently overlapping, yet they are caused by different gene mutations and the ring finger is frequently relatively preserved. We review the embryology of isolated familial brachydactyly with special attention to these ...
Stiver Corey - - 2013
Diastolic dyssynchrony has correlated with pulmonary capillary wedge pressures in patients with normal cardiac anatomy. No data exist in single right ventricle (sRV) patients. Goal of this study was to determine if diastolic dyssynchrony in sRV patients correlates with ventricular end-diastolic pressures (VEDP). Tissue Doppler imaging (TDI) and strain rate ...
Usami S - - 2013
This fingertip reconstruction study retrospectively compared sensory recovery and active range of motion outcomes in neurovascular island advancement and reverse digital artery island flaps. Seventeen oblique triangular flaps and 14 reverse digital artery island flaps were performed for nail bed level fingertip amputations (Ishikawa subzone II). There was no significant ...
Loporcaro Christina G - - 2013
Annually, the sudden death of thousands of young people remains inadequately explained despite medicolegal investigation. Postmortem genetic testing for channelopathies/cardiomyopathies may illuminate a potential cardiac mechanism and establish a more accurate cause and manner of death and provide an actionable genetic marker to test surviving family members who may be ...
Tokuda Marcos - - 2013
Although well documented in matrilocal primate species, group fission is still a poorly known phenomenon among patrilocal primates. In this paper we describe in detail a group fission event in the population of northern muriquis at the Reserva Particular do Patrimônio Natural-Feliciano Miguel Abdala in Caratinga, Minas Gerais, Brazil, using ...
Lloyd A - - 2013
Collaborative goal setting (between patient and professional) confers benefits within stroke and neurological rehabilitation, and is recommended in clinical guidelines. However, evidence suggests that patient participation in rehabilitation goal setting is not maximized, particularly within the hospital setting. The purpose of this study was to investigate physiotherapists' perceptions about their ...
Filipović Nenad R - - 2013
In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N'-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the ...
Demiroglu Ilker - - 2013
Considering 105 ZnO polymorphs we use many body GW and density functional based calculations to probe how the band gap is affected by nanoporosity. Within a reasonable range of energetic stability, we predict that nanoporosity can induce band gap increases of up to ∼1.5 eV relative to wurtzite ZnO. Our ...
Cutini Pablo Hernán - - 2013
Medroxyprogesterone acetate (MPA) is a synthetic progestin commonly used in hormone replacement therapy (HRT). The aim of this work was to study and compare the effect of progesterone (Pg) and MPA, on the regulation of cellular events associated with vascular homeostasis and disease. Platelet adhesion to endothelial cells (ECs), nitric ...
Matos Samantha M - - 2013
Our aims were to evaluate the neurocognitive performance in adolescents with congenital heart disease (CHD) and to determine whether parameters of fetal development evaluated in neonates, such as head circumference, length, weight, and Apgar scores, are somehow related to their neurocognitive performance. We evaluated 77 CHD patients (43 males) aged ...
Nguyen Huy Van - - 2013
In Vietnam, many medicine sellers serving pharmacies and retail outlets do not have adequate professional qualifications, and there has been a limited institutional control. The objective of this cross-sectional study was to examine the prevalence and determinants of self-medication among medicine sellers in Hanoi, Vietnam. Although 96.55% of medicine sellers ...
Park Sunyoung - - 2013
While emissions of halogenated compounds in East Asia have been known to make up a significant fraction of the total global emissions, both with respect to ozone depletion potential (ODP) and global warming potential (GWP), the actual sources of these emissions are relatively poorly understood. High-precision in situ measurements of ...
Bouricha Mehdi - - 2013
Suspicion of contagious disease on commercial ships tends to be poorly managed, as there is little capacity to confirm a case on board except for malaria. Here we implemented a point-of-care (POC) laboratory on one container ship and one cruise ship for the rapid syndrome-based diagnosis of infectious diseases on ...
Zhu Yanlin - - 2013
Amlodipine is a commonly prescribed calcium channel blocker for the treatment of hypertension and ischemic heart disease. The drug is slowly cleared in human primarily via dehydrogenation of its dihydropyridine moiety to a pyridine derivative (M9) followed by M9 further oxidation. Results from clinical drug-drug interaction studies suggest that CYP3A4/5 ...
Yanagi Masahide - - 2013
Purpose:Wider retinal venular caliber is shown to be associated with an increased risk of stroke, while smoking is associated with a wider retinal venular caliber. However, the impact of smoking cessation on the retinal vessels has not been previously reported. We examined this issue in an adult cohort of atomic ...
Mouton P le Fras N - - 2013
To elucidate the functional significance of the three distinct types of generation glands that have been identified among cordylid lizards, we mapped gland type to the terminal taxa in the most recent phylogenetic tree for the Cordylidae. We used the phylogenetic programme Mesquite and applied the principle of parsimony to ...
Ahmed Mohammed - - 2013
Raman spectroscopy in combination with multivariate curve resolution (Raman-MCR) is used to explore the interaction between water and various kosmotropic and chaotropic anions. Raman-MCR of aqueous Na-salt (NaI, NaBr, NaNO3, Na2SO4, and Na3PO4) solutions provides solute correlated Raman spectra (SC-spectra) of water. The SC-spectra predominantly bear the vibrational characteristics of ...
Bastiaans Jeroen - - 2013
Purpose: De-differentiation of retinal pigment epithelial (RPE) cells into mesenchymal cells (epithelial-mesenchymal transition; EMT) and associated collagen production contributes to development of proliferative vitreoretinopathy (PVR). In patients with PVR, intraocular coagulation cascade activation occurs and may play an important initiating role. Therefore we examined the effect of the coagulation proteins ...
Li Xing - - 2013
Recently, a great variety of aggregation-induced emission (AIE)-active molecules have been utilized to design bioprobes for label-free fluorescent turn-on aptasensing with high sensitivity. However, due to nonspecific binding interaction between aptamer and AIE probe, these AIE-based aptasensors have nearly no selectivity, thereby significantly limiting the development. In this work, a ...
Robciuc Alexandra - - 2013
Purpose: Since homeostasis at the ocular surface requires a delicate balance between numerous factors, and the external environment contributes as an unpredictable component, we aimed to understand the role that various lipids and their regulators play in the complex process that maintains a healthy corneal surface. Methods: Through basic proteomics, ...
Laubner K - - 2013
We performed a comparative analysis of the use of long acting insulin (analogues) NPH, detemir (Det) and glargine (Gla), and quantified injection frequencies and daily insulin doses in patients with type 1 and 2 diabetes in daily practice. 51 964 patients from 336 centres in Germany and Austria with type ...
Qin Yan-Ru - - 2013
Esophageal Squamous Cell Carcinoma (ESCC), the major histological form of esophageal cancer, is a heterogeneous tumor displaying a complex variety of genetic and epigenetic changes. Aberrant RNA editing of adenosine-to-inosine (A-to-I) as it is catalyzed by adenosine deaminases (ADARs) represents a common post-transcriptional modification in certain human diseases. In this ...
Kovatchev Boris P - - 2013
Abstract Background: Laboratory hemoglobin A1c (HbA1c) assays are typically done only every few months. However, self-monitored blood glucose (SMBG) readings offer the possibility for real-time estimation of HbA1c. We present a new dynamical method tracking changes in average glycemia to provide real-time estimation of A1c (eA1c). Materials and Methods: A ...
Ma Yuting - - 2013
The therapeutic efficacy of anthracyclines relies, at least partially, on the induction of a dendritic cell (DC)- and T lymphocyte-dependent anticancer immune response. Here, we show that anthracycline-based chemotherapy promotes the recruitment of functional CD11b+CD11c+Ly6ChighLy6G-MHCII+ DC-like antigen-presenting cells (APCs) into the tumor bed, but not into lymphoid organs. Accordingly, draining ...
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