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Results 401 - 450 of 4133
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Hanaoka Hirofumi - - 2013
Abstract Carcinoembryonic antigen (CEA) is an attractive target molecule of radioimmunotherapy (RIT). To enhance RIT's therapeutic efficacy, the fractionation of radiolabeled antibody doses is an attractive strategy. In this study, a fully human anti-CEA monoclonal antibody (mAb) C2-45 was selected by virtue of its lack of immunogenicity, and the effectiveness ...
Sawyer Alyssa Cp - - 2013
Objective:To assess the screening accuracy of information obtained from parents of 4-5-year-old children for the purpose of identifying the children who have teacher-reported mental health problems when they are aged 6-7 years.Method:The study used data from the Longitudinal Study of Australian Children (LSAC) obtained when children were aged 4-5 years ...
Chen Yong - - 2013
DNA methylation plays an important role in the development of many types of cancer. Identifying differentially methylated loci between cancer and normal patients is one of the central tasks to understand the contributions of the methylation process on cancer development. Through investigation of the methylation measurements generated by the Illumina ...
Azimova Komola - - 2013
Depression is frequently associated with diabetes mellitus (DM) and may worsen DM-related morbidity and mortality. We determined the potential association of glucose levels with depression in Hispanic patients admitted to the Cardiovascular Intensive Care Unit. Patients were given the Center for Epidemiologic Studies-Depression scale survey within 24 hours of admission. ...
Shao Fang - - 2013
Varying-coefficient models have claimed an increasing portion of statistical research and are now applied to censored data analysis in medical studies. We incorporate such flexible semiparametric regression tools for interval censored data with a cured proportion. We adopted a two-part model to describe the overall survival experience for such complicated ...
Sibthorp Christopher - - 2013
The filamentous fungus Aspergillus nidulans has been a tractable model organism for cell biology and genetics for over 60 years. It is among a large number of Aspergilli whose genomes have been sequenced since 2005, including medically and industrially important species. In order to advance our knowledge of its biology ...
Yang Donghui - - 2013
The chemical system based on [SeMo6O21](4-) polyanion and carboxylate ligand has been investigated. According to the inherent nature of organic groups, a series of selenomolybdates with three architectures have been isolated through rational and deliberate synthetic routes by stereospecific addition of different carboxylic acids. Such an approach is potentially interesting ...
Rupanagudi Khader Valli - - 2013
Major histocompatibility complex (MHC) class II-mediated priming of T and B lymphocytes is a central element of autoimmunity in systemic lupus erythematosus (SLE) and lupus nephritis. The cysteine protease cathepsin S degrades the invariant peptide chain during MHC II assembly with antigenic peptide in antigen-presenting cells; therefore, we hypothesised that ...
Machu Christophe - - 2013
In budding yeast four mitotic cyclins (Clb1-4) cooperate in a partially redundant manner to bring about M-phase specific events, including the apical isotropic switch that ends polarized bud growth initiated at bud emergence. How exactly this morphogenetic transition is regulated by mitotic CDKs remains poorly understood. We have taken advantage ...
Kato-Noguchi Hisashi - - 2013
Ginkgo (Ginkgo biloba L.) has not changed over 121 million years. There may be unknown special strategy for the survival. Gingko litter inhibited the growth of weed species ryegrass (Lolium multiflorum L.). The inhibition was greater with the litter of the close position than that of the far position from ...
Kuznetsova Olga M - - 2013
In open-label studies, partial predictability of permuted block randomization provides potential for selection bias. To lessen the selection bias in two-arm studies with equal allocation, a number of allocation procedures that limit the imbalance in treatment totals at a pre-specified level but do not require the exact balance at the ...
Graindorge Matthieu - - 2013
The aromatic amino acids phenylalanine and tyrosine represent essential sources of high value natural aromatic compounds for human health and industry. Depending on the organism, alternative routes exist for their synthesis. Phenylalanine and tyrosine are synthesized either via phenylpyruvate/4-hydroxyphenylpyruvate, or via arogenate. In arogenate-competent microorganisms an aminotransferase is required for ...
Diago Maria P - - 2013
Flowers, flowering and fruit set are key determinants of grapevine yield. Currently, practical methods to assess the flower number per inflorescence, necessary for fruit-set estimation, are time and labour demanding. This work aims at developing a simple, cheap, fast, accurate and robust machine vision methodology to be applied to RGB ...
Townsend Jason M - - 2013
High-elevation ecosystems of the northeastern United States are vulnerable to deposition and environmental accumulation of atmospheric pollutants, yet little work has been done to assess mercury (Hg) concentrations in organisms occupying montane ecosystems. The authors present data on Hg concentrations in ground-foraging insectivorous songbirds, a terrestrial salamander, and forest floor ...
Conway Susan E - - 2013
Dabigatran is a novel oral anticoagulant for which a well-defined range of toxicity and proven antidote has not been established. The primary objective of this study was to characterize dabigatran exposures reported to poison centers by dose ingested, clinical effects, treatments used, and managment sites to gain a better understanding ...
Ahmed Imteaz - - 2013
A highly porous metal-organic framework (MOF), MIL-101 (Cr-benzenedicarboxylate), was synthesized in the presence of graphite oxide (GO) to produce GO/MIL-101 composites. The porosity of the composites increased remarkably in the presence of a small amount of GO (<0.5% of MIL-101); however, further increases in GO reduced the porosity. GO also ...
Jenkins Nathaniel D M - - 2013
The purpose of this exploratory study was to quantify the test-retest reliability, intertrial variability and correlations between variables calculated during voluntary and evoked muscle actions. During three separate trials of isometric leg extension muscle actions with 14 men [mean age (±SD) = 21·9 (±3·2) years; height = 179·2 (±8·0) cm; mass = 77·7 (±10·9) kg], peak torque (PTV ), ...
De Franco P - - 2013
Bifid median nerve is an anatomic variation that occurs in about 18% of patients with symptoms suggestive of carpal tunnel syndrome and in about 15% of symptom-free subjects. Reversed palmaris longus is a rare anatomic muscular variation. The simultaneous presence of a bifid median nerve and a reversed palmaris longus ...
Schnatter Wayne F K - - 2013
There are still some secrets left to this well-studied reaction. Previously unreported relationships discovered are as follows. The ordering of reactivities of C6H5X is the same as that of enthalpies of hydrogenation of the ring to the correspondingly substituted cyclohexane. The orientation of substitution (meta or ortho/para) is controlled by ...
Vucic Emily A - - 2013
Rationale: DNA methylation is an epigenetic modification that is highly disrupted in response to cigarette smoke and involved in a wide spectrum of malignant and non-malignant diseases, but surprisingly not previously assessed in small airways of patients with chronic obstructive pulmonary disease (COPD). Small airways are the primary sites of ...
Kanetada Naoya - - 2013
The adsorption and aggregation behaviors of the cationic porphyrin derivatives such as 5,10,15,20-tetrakis(4-pyridyl)porphyrin [TPyP], 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin [TMPyP], 5,10,15,20-tetrakis(N-ethyl-4-pyridyl)porphyrin [TEPyP], and 5,10,15,20-tetrakis(N-n-propyl-4-pyridyl)porphyrin [TPPyP] (hereafter called "TPyP derivatives") in the tungsten(VI) oxide (WO3) colloid aqueous solution at weak acidic pH were studied by UV-vis spectroscopy. The TPyP derivatives were strongly adsorbed as monolayer ...
Chen Shi - - 2013
Reproductive isolation is a fundamental requirement for speciation and includes several sequential stages. Few studies have determined the relative contributions of pre- and post-zygotic reproductive isolation in plants, especially between relative species with clear differentiation in flower form. To investigate the mechanisms responsible for reproductive isolation in sympatric Mussaenda pubescens ...
Hersey Peter - - 2013
Intralesional immunotherapy of melanoma has two complementary aims. One is to cause regression of the injected metastasis. The other is to incite or modulate systemic immune responses in such a way that non-injected metastases will also undergo regression. A number of phase 1 and phase II studies with cytokines, viral, ...
Horie Takahiro - - 2013
MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports have indicated that miR-33, which is located within the intron of sterol regulatory element-binding protein (SREBP) 2, controls cholesterol homoeostasis and may be a potential therapeutic target for the treatment ...
Li Qiaoli - - 2013
Context:Telomeres are specialized chromatin structures located at the ends of eukaryotic chromosomes, and telomere length plays a clear role in various diseases. However, it is not known whether telomere length is related to polycystic ovary syndrome (PCOS).Objective:We hypothesized that leukocyte telomere length (LTL) plays an important role in the pathophysiology ...
Nguyen Tung - - 2013
Carcinoembryonic antigen related cell adhesion molecule-1 (CEACAM1), a transmembrane protein, expressed on normal breast epithelial cells is down-regulated in breast cancer. Phosphorylation of Thr-457 on the short cytoplasmic domain isoform (CEACAM1-SF) that is predominant in normal epithelial cells is required for lumen formation in a 3D model that involves apoptosis ...
Deng Dongyan - - 2013
Because of its unique properties and capability of formation of well-dispersed aqueous colloids in aqueous phase, graphene oxide can be used for the efficient preconcentration of heavy metal ions prior to their determination. The complete collection of graphene oxide colloids from water has generally been considered to be insurmountable. Here, ...
Haggart Charles R - - 2013
Multiple cues have been suggested as the mechanical stimulus for the heart's hypertrophic response. Our work has previously suggested that the amount of cyclic shortening in cardiomyocytes controls myocyte shape and the amount of stretch controls myocyte size. To identify gene expression changes that occur in response to these mechanical ...
Perdigão J - - 2013
SUMMARY Objectives : To evaluate the effect of acid etching and application of a hydrophobic resin coat on the enamel/dentin bond strengths and degree of conversion (DC) within the hybrid layer of a universal adhesive system (G-Bond Plus [GB]). Methods : A total of 60 extracted third molars were divided ...
Yao Yu - - 2013
Graphene is emerging as a broadband optical material which can be dynamically tuned by electrostatic doping. However, direct application of grapheme sheets in optoelectronic devices is challenging due to its small thickness and the resultant weak interaction with light. By combining metal and graphene in a hybrid plasmonic structure, it ...
Bastiaans Jeroen - - 2013
Purpose: De-differentiation of retinal pigment epithelial (RPE) cells into mesenchymal cells (epithelial-mesenchymal transition; EMT) and associated collagen production contributes to development of proliferative vitreoretinopathy (PVR). In patients with PVR, intraocular coagulation cascade activation occurs and may play an important initiating role. Therefore we examined the effect of the coagulation proteins ...
Jia Hongxiao - - 2013
Phenomenological research indicates that disturbance of the basic sense of self may be a core phenotypic marker of schizophrenia spectrum disorders. Self-face recognition (SFR) is an experimental paradigm which can assess the basic sense of self. In this study, we used SFR to determine whether basic self-disturbance is present in ...
Zhao Yanchuan - - 2013
Fluorinated tungsten calix[4]arene imido complexes were synthesized and used as receptors to detect and differentiate neutral organic compounds. It was found that the binding of specific neutral organic molecules to the tungsten centers induces an upfield shift of the fluorine atom appended on the arylimido group, the extent of which ...
Likness Micah M MM State University of New York at Buffalo, Department of Otolaryngology, Buffalo, New York, - - 2014
A truly objective method of measuring disease severity in chronic rhinosinusitis (CRS) has only recently existed. We evaluated computed tomography (CT) scans of CRS patients using this novel objective 3D computerized system and compared results with a novel 2D computerized analysis of a single coronal slice through the osteomeatal complex ...
Pop Alexandra - - 2013
New organoselenium(ii) halides of the type [RSe](+)X(-) [R = 2,6-(Me2NCH2)2C6H3; X = Cl (), Br (), I ()] were prepared by cleavage of the Se-Se bond in R2Se2 () with SO2Cl2 followed by halogen exchange when organoselenium chloride was treated with NaBr or KI. The reaction between and R'2MCln resulted ...
Umemura Toshitaka - - 2013
Albuminuria, a marker of chronic kidney disease, is associated with an increased risk of incident stroke and unfavorable long-term outcomes. However, the association of albuminuria with short-term outcomes and change in infarct volume in patients with acute small subcortical infarction remains unknown. We retrospectively reviewed 85 consecutive patients with acute ...
Herndon Joseph M - - 2013
3,4-(±)-Methylenedioxymethamphetamine (MDMA) and 3,4-(±)-methylenedioxyamphetamine (MDA), a primary metabolite of MDMA, are phenylethylamine derivatives that cause serotonergic neurotoxicity. Although several phenylethylamine derivatives activate microglia, little is known about the effects of MDMA on glial cells, and evidence of MDMA-induced microglial activation remains ambiguous. We initially determined microglial occupancy status of the ...
Lai Yanqing - - 2013
This paper examines the relationships between firm size and employees' experience of work stress. We used a matched employer-employee dataset (Workplace Employment Relations Survey 2011) that comprises of 7182 employees from 1210 private organizations in the United Kingdom. Initially, we find that employees in small and medium-sized enterprises experience lower ...
Arias María Sol - - 2013
Abstract Oestrosis is one of the most prevalent parasitosis affecting the Iberian ibex, Capra pyrenaica. To date, both the diagnosis of oestrosis and the determination of the intensity of parasitism require the use of invasive methods (necropsy), which necessarily limit research posibilities. We analysed the immune humoral response (IgM and ...
Golub Eyal - - 2013
This study describes the novel hemin/G-quadruplex DNAzyme-catalyzed aerobic oxidation of thiols to disulfides and the respective mechanism. The mechanism of the reaction involves the DNAzyme-catalyzed oxidation of thiols to disulfides and the thiol-mediated autocatalytic generation of H2O2 from oxygen. The coupling of a concomitant H2O2-mediated hemin/G-quadruplex-catalyzed oxidation of Amplex Red ...
Hagen Ralf Matthias - - 2013
We evaluated the potential of Cryptosporidium spp. for intentional transmission as a terrorist tactic in asymmetric conflicts in terms of the recognised optimum conditions for biological warfare. Published and widely accepted criteria regarding the optimum conditions for the success of biological warfare based on experience from passive biological warfare research ...
Hemschemeier Anja - - 2013
In aerobes, anoxia impairs mitochondrial energy generation as well as biosynthesis and degradation of essential cell components. In a recent analysis we have shown that the unicellular green alga Chlamydomonas reinhardtii responds to anaerobiosis in the dark by significant changes of the transcriptome, which, in summary, were directed at saving ...
Sollinger Daniel - - 2013
Recent publications have shed new light on the role of the adaptive and the innate immune system in the pathogenesis of hypertension. However there are limited data whether receptors of the innate immune system may influence blood pressure. Toll-like receptor 4, a pattern recognition receptor, is a key component of ...
Tokuda Marcos - - 2013
Although well documented in matrilocal primate species, group fission is still a poorly known phenomenon among patrilocal primates. In this paper we describe in detail a group fission event in the population of northern muriquis at the Reserva Particular do Patrimônio Natural-Feliciano Miguel Abdala in Caratinga, Minas Gerais, Brazil, using ...
Davila Monica - - 2013
Tumor-derived TF activates coagulation in vitro and in vivo in an orthotopic model of human pancreatic cancer. Here, we further characterized tumor-derived TF in this model. Conditioned medium (CM) of L3.6pl human pancreatic tumor cells and plasma from nude mice bearing L3.6pl tumors were ultracentrifuged, and the pellets were filtered ...
Yoshihara K - - 2013
Among several functional monomers, 10-methacryloxydecyl dihydrogen phosphate (10-MDP) bonded most effectively to hydroxyapatite (HAp). However, more hydrolysis-resistant functional monomers are needed to improve bond durability. Here, we investigated the adhesive potential of the novel fluoro-carbon functional monomer 6-methacryloxy-2,2,3,3,4,4,5,5-octafluorohexyl dihydrogen phosphate (MF8P; Kuraray Noritake Dental Inc., Tokyo, Japan) by studying its ...
Yaqoob Parveen - - 2013
Influenza is a major cause of death in the over 65s. Increased susceptibility to infection and reduced response to vaccination are due to immunosenscence in combination with medical history and lifestyle factors. Age-related alterations in the composition of the gut microbiota have a direct impact on the immune system and ...
Knop Gabriel C - - 2013
Mammalian retinas comprise a variety of interneurons, among which amacrine cells represent the largest group, with more than 30 different cell types each exhibiting a rather distinctive morphology and carrying out a unique function in retinal processing. However, many amacrine types have not been studied systematically because, in particular, amacrine ...
Monshupanee Tanakarn - - 2013
Glycogen (GL) and lipids (LP) are efficient biofuel substrates whereas polyhydroxybutyrate (PHB) is a potent bio-degradable plastic. This study aimed to increase accumulation of these three compounds in Synechocystis sp. PCC 6803. Under autophototrophic growth, co-accumulation of the three compounds reached maximum level in a mid-stationary phase at 39.2% of ...
Lee P-Y - - 2013
Systemic candidiasis is the leading fungal bloodstream infection and its incidence has been on the rise. Recently, Candida parapsilosis has emerged as an increasingly prevalent fungal pathogen but little is known about its antigenic profile. Hence, the current work was performed to discover immunogenic proteins of C. parapsilosis using serological ...
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