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Hagen Ralf Matthias - - 2013
We evaluated the potential of Cryptosporidium spp. for intentional transmission as a terrorist tactic in asymmetric conflicts in terms of the recognised optimum conditions for biological warfare. Published and widely accepted criteria regarding the optimum conditions for the success of biological warfare based on experience from passive biological warfare research ...
Gok Gulcan - - 2013
Parotid fistula is a rare but very distressing sequelum of post-operative or traumatic injuries. The management of these injuries has been reported in the literature previously and techniques employed include pressure dressings, surgery and more recently botulinum toxin A (BTA) injections. We present a patient who developed a parotid fistula ...
Chan Matthew - - 2013
Gold-nanoparticles (AuNPs) are employed for cancer treatment, drug delivery, chemical analyses, and many other uses. As AuNP manufacture increases it is imperative that we understand the environmental fate of these nanomaterials. We investigated the transport and stability of AuNP under simulated groundwater conditions. Batch experiments indicated that 16 nm AuNP ...
Yan Ya - - 2013
Well-defined ultrathin MoS2 nanoplates are developed by a facile solvent-dependent control route from single source precursor for the first time. The obtained ultrathin nanoplate with a thickness of ~5nm features high density of basal edges and abundant unsaturated active S atoms. The multistage growth process is investigated and the formation ...
Banerjee Manish - - 2013
Treatment of tetrakis(diethylamido)zirconium(iv); [Zr(NEt2)4] with a series of β-ketoimines ({[RHN]C(CH3)[double bond, length as m-dash]C(H)C(CH3)[double bond, length as m-dash]O} where R is a functionalized side-chain; 4-(2-methoxyethylamino)pent-3-en-2-one, Hmeap; 4-(3-methoxypropylamino)pent-3-en-2-one, Hmpap; 4-(2-(dimethylamino)ethylamino)pent-3-en-2-one, Hdeap; 4-(3-(dimethylamino)propylamino)pent-3-en-2-one, Hdpap) leads to an amine substitution reaction that yielded novel monomeric heteroleptic mixed amido-ketoiminato complexes of the type bis(4-(2-methoxyethylamino)pent-3-en-2-onato)bis(diethylamido)zirconium(iv) ...
Hsu Fu-Chiun - - 2013
Since the first study of hypoxic response in plants with cDNA microarray in 2002, the number of hypoxia-responsive genes has grown to more than 2000. However, to date, only small numbers of hypoxia-responsive genes are known to confer hypoxic resistance. Most investigations in this area have focused on identifying which ...
Cerqueira Mariana - - 2013
Split-thickness autografts still are the current gold standard to treat skin, upon severe injuries. Nonetheless, autografts are dependent on donor site availability and often associated to poor quality neoskin. The generation of dermal-epidermal substitutes by tissue engineering is seen as a promising strategy to overcome this problematic. However, solutions that ...
Cunha Lucas Leite - - 2013
Immune responses against thyroid carcinomas have long been demonstrated and associations between inflammatory microenvironment and thyroid carcinomas repeatedly reported. This scenario warranted scientists throughout the world to unveil how the inflammatory microenvironment is established in thyroid tumors and what is its influence on the outcome of patients with thyroid carcinomas. ...
Shen Chen-Tian - - 2013
The advent of biologically targeted agents and increased understanding of thyroid carcinogenesis have generated much interest in the development of biologically targeted therapy for thyroid cancer. Among them, sorafenib is the most commonly studied drug. The current meta-analysis was performed to estimate the efficacy and safety of sorafenib administered in ...
Onodera Yoshiaki - - 2013
NRF2 (nuclear factor erythroid 2-related factor 2) is an important transcriptional activator involved in the cellular defense mechanisms against electrophilic and oxidative stress. Recent studies have demonstrated that NRF2 protein is up-regulated in several human malignancies and is associated with worse prognosis of these patients. However, pathological and clinical significance ...
Rodrigues Giseli Capaci - - 2013
Today there are approximately 8 million cases of Chagas disease only in the Southern Cone and about 100 million people living with the risk of becoming infected. The present pharmacotherapy is sometimes ineffective and has serious side effects. Here we report a series of 4,5-dihydroisoxazoles incorporating hydroxamate moieties, which act ...
Azmi Fazren - - 2013
Peptide-based subunit vaccines are of great interest in modern immunotherapy as they are safe, easy to produce and well defined. However, peptide antigens produce a relatively weak immune response, and thus require the use of immunostimulants (adjuvants) for optimal efficacy. Developing a safe and effective adjuvant remains a challenge for ...
Hemschemeier Anja - - 2013
In aerobes, anoxia impairs mitochondrial energy generation as well as biosynthesis and degradation of essential cell components. In a recent analysis we have shown that the unicellular green alga Chlamydomonas reinhardtii responds to anaerobiosis in the dark by significant changes of the transcriptome, which, in summary, were directed at saving ...
Nakamura Takashi - - 2013
Coordination-driven self-assembly utilizing labile capping ligands has been exploited as a novel strategy for metallo-cage containers. Herein, we report a tetrameric porphyrin barrel complex [C60⊂Zn814(H2O)4(OTs)12](OTs)4 (2) (OTs = p-CH3C4H6SO3) formed from a tetrakis(bipyridyl)porphyrin ligand 1, Zn(OTs)2, and a template guest, C60 fullerene. The tetrameric-barrel 2 contains two kinds of bis(bpy) ...
Deng Dongyan - - 2013
Because of its unique properties and capability of formation of well-dispersed aqueous colloids in aqueous phase, graphene oxide can be used for the efficient preconcentration of heavy metal ions prior to their determination. The complete collection of graphene oxide colloids from water has generally been considered to be insurmountable. Here, ...
Jing Changcheng - - 2013
A Rh2(OAc)4-catalyzed diazo decomposition reaction of diazo esters with 2-aminophenyl ketones is reported. A series of 3-hydroxy-2,2,3-trisubstituted indolines are produced in good yields with excellent diastereoselectivities via an intramolecular aldol-type trapping of ammonium ylides with ketone units.
Zhou Jian-Qiao - - 2013
The objective of this study was to compare the sampling efficiency of ultrasound-guided fine-needle aspiration (FNA) and fine-needle capillary (FNC) sampling in thyroid nodules, in which the authors specifically analyzed the influence of nodule size. This study included 280 thyroid nodules in 275 consecutive patients. The nodules were divided into ...
Sjøberg Kim A - - 2013
The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was ...
Ren Shunlin - - 2013
Intracellular lipid accumulation, inflammatory responses, and subsequent apoptosis are the major pathogenic events of metabolic disorders, including atherosclerosis and nonalcoholic fatty-liver diseases. Recently, a novel regulatory oxysterol, 5-cholesten-3b, 25-diol 3-sulfate (25HC3S) has been identified and hydroxysterol sulfotransferase 2B1b (SULT2B1b) has been elucidated as the key enzyme for its biosynthesis from ...
Knudsen Sine H - - 2013
Satiety and satiety-regulating gut hormone levels are abnormal in hyperglycemic individuals. We aimed to determine whether these abnormalities are secondary to hyperglycemia. Ten healthy overweight/obese subjects (age: 56±3 y, BMI: 30.3±1.2 kg/m(2)) received three equicaloric meals at T = 0, 4, and 8-hours in the absence (control trial) and presence ...
Kusumoto Shuhei - - 2013
Unprecedented direct acceptorless dehydrogenation of C-C single bonds adjacent to functional groups to form α,β-unsaturated compounds has been accomplished by using a new class of group 9 metal complexes. Metal-ligand cooperation operated by the hydroxycyclopentadienyl ligand was proposed to play a major role in the catalytic transformation.
Dankel Simon N - - 2013
Repeated attempts to lose weight by temporary dieting may result in weight cycling, eventually further gain of body fat, and possible metabolic adaptation. We tested this by a controlled experiment in C57BL/6J mice subjected to four weight cycles (WC), continuous hypercaloric feeding (HF), or low-fat feeding (LF). To search for ...
Kogan A - - 2013
Severe lung injury with the development of acute respiratory distress syndrome (ARDS) is a serious complication of cardiac surgery. The aim of this study was to determine the incidence, risk factors, and mortality of ARDS following cardiac surgery. We retrospectively analyze data in the period between January 2005 and March ...
White Heather M - - 2013
In this study, we used lentiviral-delivered shRNA to generate a clonal line of 3T3-F442A preadipocytes with stable silencing of Hepatocyte Growth Factor (HGF) expression, and examined the long-term consequence of this modification on fat pad development. HGF mRNA expression was reduced 94%, and HGF secretion 79% (P<0.01), compared to preadipocytes ...
Ariza Lorena - - 2013
Canine adenovirus type 2 vectors (CAV-2) are promising tools to treat global central nervous system (CNS) disorders due to their preferential transduction of neurons and efficient retrograde axonal transport. Here we tested the potential of a helper-dependent CAV-2 vector expressing ß-glucuronidase (HD-RIGIE) in a mouse model of mucopolysaccharidosis type VII ...
Porcelijn Leendert - - 2013
The performance of a newly developed Luminex bead-based platelet (PLT) antibody detection method (PAKLx) was compared with the monoclonal antibody immobilization of PLT antigens (MAIPA) assay and the LifeScreen Deluxe Luminex bead-based HLA Class I antibody detection method (LMX). Six sera containing anti-human PLT antigen (HPA)-1a (n = 2), HPA-1b, HPA-2b, HPA-3a, ...
Malinova Irina - - 2013
Activity of the plastidial phosphorylase isozyme (PHS1) is elevated in leaves of two starch-related single knock-out mutants lacking either the cytosolic transglucosidase, DPE2 or the plastidial maltose transporter, MEX. In both mutants metabolism of starch-derived maltose is impaired but inhibition is effective at different subcellular sites. Two constitutive double knock-out ...
Gosselin-Badaroudine Pascal - - 2013
Nav 1.5 dysfunctions are commonly linked to rhythms disturbances that include type 3 long QT syndrome (LQT3), Brugada syndrome (BrS), sick sinus syndrome (SSS) and conduction defects. Recently, this channel protein has been also linked to structural heart diseases such as dilated cardiomyopathy (DCM).
Cui Zhi-Ping - - 2013
In weak acid medium, aluminum(III) can react with chlorophosphonazo III [CPA(III), H8 L] to form a 1:1 coordination anion [Al(OH)(H4 L)](2-) . At the same time, proteins such as bovine serum albumin (BSA), lysozyme (Lyso) and human serum albumin (HSA) existed as large cations with positive charges, which further combined ...
Figueroa Arturo - - 2013
Obesity and reduced muscle strength are associated with increased blood pressure (BP). We examined the impact of milk proteins and combined exercise training (CET) on BP, arterial function, and muscle strength (one-repetition maximum (1-RM)). Thirty-three obese sedentary women (age = 30±1 years; body mass index = 35.2±0.9kg/m(2); systolic BP (SBP) ...
Wang Jinliang - - 2013
Many plants and some animal species are polyploids. Non-disomically inherited markers (e.g. microsatellites) in such species cannot be analysed directly by standard population genetics methods developed for diploid species. One solution is to transform the polyploid codominant genotypes to pseudo diploid dominant genotypes, which can then be analysed by standard ...
Sparke Alison - - 2013
Cervical immobilisation is commonly applied following trauma, particularly blunt head injury, but current methods of immobilisation are associated with significant complications. Semi-rigid disposable cervical collars are known to cause pressure ulcers, and impede effective airway management. These collars may also exacerbate a head injury by increasing intracranial pressure as a ...
Antiñolo Maria - - 2013
The relative importance in the atmosphere of UV photolysis of perfluoropropionaldehyde, CF3CF2CHO, and reaction with hydroxyl (OH) radicals has been investigated in this work. Firstly, the forbidden n-π* transition of the carbonyl chromophore was characterized between 230 and 380 nm as a function of temperature (269 - 298 K) and ...
Backenson Erica M - - 2013
Children with specific learning disabilities (SLD) have deficits in the basic psychological processes that interfere with learning and academic achievement, and for some SLD subtypes, these deficits can also lead to emotional and/or behavior problems. This study examined psychosocial functioning in 123 students, aged 6 to 11, who underwent comprehensive ...
Saidi Wissam A - - 2013
The optical properties, including UV-vis spectra and resonance Raman profiles, of pristine and defected single-walled carbon nanotubes (SWCNTs) are computed using state-of-the-art time-dependent density functional theory (TDDFT) as implemented using the Liouville-Lanczos approach to linear-response TDDFT. The CNT defects were of the form of Stone-Wales and diatom-vacancies. Our results are ...
Knäbel Anja - - 2013
FOCUS models are used in European regulatory risk assessment to predict the frequency and magnitude of individual pesticide surface water concentrations. A recent study showed that these models are not protective in the prediction of insecticide concentrations in surface waters and sediments. Since fungicides differ with regard to their physicochemical ...
Rocha Natália Pessoa - - 2013
Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and ...
Ng Theodore W K - - 2013
Abnormal very-low-density lipoprotein (VLDL)-triglyceride (TG) metabolism underscores the hypertriglyceridemia in obese, insulin resistant men and contributes to increased cardiovascular disease (CVD) risk. Statins reduce CVD risk by decreasing low-density lipoprotein (LDL)-cholesterol but its effects on plasma TG-lowering are modest. Supplementing with high dose omega-3 fatty acid ethyl esters (ω-3 FAEEs) ...
Zang Huidong - - 2013
Photoinduced hole transfer from a CdSe/ZnS quantum dot to a conjugated polymer is tuned by varying the quantum dot core size. Hole transfer affects the photoluminescence blinking of the quantum dot, increasing the duration of the on-states and decreasing that of the off-states.
Maruyama Osamu - - 2013
Protein complexes are basic cellular entities that carry out the functions of their components. It can be found that in databases of protein complexes of yeast like CYC2008, the major type of known protein complexes is heterodimeric complexes. Although a number of methods for trying to predict sets of proteins ...
Chunju Lv - - 2013
Porous TiO2 nanowire microspheres with greatly decreasing agglomeration were successfully prepared by spray drying of hydrothermal reaction suspension, followed by calcination at 350°C. The as-obtained nanowire microspheres with TiO2 -B structure reach an initial discharge capacity 210 mAh g(-1) with an irreversible capacity 25 mAh g(-1) at a current density ...
Perdigão J - - 2013
SUMMARY Objectives : To evaluate the effect of acid etching and application of a hydrophobic resin coat on the enamel/dentin bond strengths and degree of conversion (DC) within the hybrid layer of a universal adhesive system (G-Bond Plus [GB]). Methods : A total of 60 extracted third molars were divided ...
Jensen Roxanne E - - 2013
The use of electronic patient-reported outcomes (PRO) systems is increasing in cancer clinical care settings. This review comprehensively identifies existing PRO systems and explores how systems differ in the administration of PRO assessments, the integration of information into the clinic workflow and electronic health record (EHR) systems, and the reporting ...
McMenamin Mary - - 2013
The authors previously demonstrated that lysing samples with glacial acetic acid (GAA) before human papillomavirus (HPV) testing does not adversely affect HPV detection with the cobas 4800 HPV Test. However, the long-term impact of GAA on HPV DNA was not explored in that study, and inherent cell loss with the ...
Tripsianes Konstantinos - - 2013
Many cellular processes are regulated by posttranslational modifications that are recognized by specific domains in protein binding partners. These interactions are often weak, thus allowing a highly dynamic and combinatorial regulatory network of protein-protein interactions. We report an efficient strategy that overcomes challenges in structural analysis of such a weak ...
Pinnamaneni Kranthi - - 2013
We sought to determine the effects of brief exposures to low concentrations of tobacco secondhand smoke (SHS) on arterial flow-mediated dilation (FMD, a nitric oxide-dependent measure of vascular endothelial function), in a controlled animal model never before exposed to smoke. In humans, SHS exposure for 30min impairs FMD. It is ...
Quinkler Marcus - - 2013
The discovery of Cortisone by Hench, Kendall and Reichstein in the late 1940's was the turning point for the deadly disease adrenal insufficiency (AI), effectively rendering it a treatable chronic disorder. For many decades endocrinologists assumed that corticosteroid replacement therapy resulted in a normal life expectancy (1). However, recent outcome ...
Cazzo Everton - - 2013
Abstract Background: Metabolic syndrome (MetS) is a complex association of clustering metabolic factors that increase risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Surgical treatment has become an important tool to achieve its control. The aim of this study was to evaluate the impact of Roux-en-Y gastric bypass ...
Li Changli - - 2013
Large-scale and high-quality Cu2O microcrystalline films with high photoactivity are synthesized using a novel and low-cost method. The enhanced photoactivity is achieved through the formation of Cu2O microcrystalline films having well-defined crystal facets and porous structure. Cu2O microcrystalline films are fabricated by decomposing previously synthesized Cu(OH)2 nanowires on a Cu ...
Naganaboina Ram Tilak - - 2013
BF3·etherate-mediated carbon-carbon bond formation by the Friedel-Crafts arylation of 2-hydroxybenzoxazine derivatives with various electron-rich arenes is reported. The current protocol provides an easy access for the synthesis of a series of densely substituted 2-aryl-1,4-benzoxazine derivatives under mild conditions.
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