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Results 351 - 400 of 4133
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Ahn Soon-Hyun - - 2013
Context:Special populations of cells that can efficiently initiate tumor growth have been characterized, and this feature supports the cancer stem cell theory. These cancer stem cell populations have been identified with CD44 and POU5F1. Most cancer stem cells express high levels of CD44 and low levels of CD24. In thyroid ...
Chan Rodman T H - - 2013
This study reports on the superior suitability of Polyhydroxybutyrate-polyethylene glycol hybrid polymers biosynthesised by Cupriavidus necator over PHB as biomaterials for tissue engineering. Incorporation of PEG106 (DEG) during PHB biosynthesis reduced crystallinity, molecular weight and hydrophobicity while improving mechanical properties. In vitro Olfactory Ensheathing cell (OEC) proliferation was enhanced by ...
Fox James G - - 2013
Since its discovery in 1982, the global importance of Helicobacter pylori-induced disease, particularly in developing countries, remains high. The use of rodent models, particularly mice, and the unanticipated usefulness of the gerbil to study H. pylori pathogenesis have been used extensively to study the interactions of the host, the pathogen, ...
Nguyen Huy Van - - 2013
In Vietnam, many medicine sellers serving pharmacies and retail outlets do not have adequate professional qualifications, and there has been a limited institutional control. The objective of this cross-sectional study was to examine the prevalence and determinants of self-medication among medicine sellers in Hanoi, Vietnam. Although 96.55% of medicine sellers ...
Laubner K - - 2013
We performed a comparative analysis of the use of long acting insulin (analogues) NPH, detemir (Det) and glargine (Gla), and quantified injection frequencies and daily insulin doses in patients with type 1 and 2 diabetes in daily practice. 51 964 patients from 336 centres in Germany and Austria with type ...
Bahr Melanie - - 2013
The potential of a pilot high rate algal pond (HRAP) interconnected via liquid recirculation with an external absorption column for the simultaneous removal of H2S and CO2 from biogas using an alkaliphilic microalgal-bacterial consortium was evaluated. A bubble column was preferred as external absorption unit to a packed bed column ...
Aksoy Mehmet - - 2013
We analysed the data in the medical records of six patients admitted for tetanus in the intensive care unit (ICU) of the anaesthesia department in the Medical Faculty of Ataturk University from 1 January 2010 to 31 December 2012. All patients received the generalized form of treatment for tetanus in ...
Aben Laurien - - 2013
and purpose. This study aims to determine the long-term effects of a new Memory Self-efficacy (MSE) training program for stroke patients on MSE, depression, and quality of life. . In a randomized controlled trial, patients were allocated to a MSE training or a peer support group. Outcome measures were MSE, ...
Rütgers Mark - - 2013
The vesicle inducing protein in plastids (VIPP1) is an essential protein for the biogenesis of thylakoids in modern cyanobacteria, algae, and plants. Although its exact function is still not clear, recent work has provided important hints to its mode of action. We believe that these data are consistent with a ...
Camaj Peter - - 2013
Pancreatic cancer aggressiveness is characterized by its high capacity for local invasion, ability to promote angiogenesis, and potential to metastasize. Hypoxia is known to represent a crucial step in the development of aggressive malignant features of many human cancers. However, micrometastatic tumors are not typically subjected to hypoxic events during ...
Dell'anna A - - 2013
Mild therapeutic hypothermia (MTH) has improved neurological outcome of comatose patients after cardiac arrest (CA). Since the first clinical studies performed in this setting, sedation has always been associated with cooling procedures. The use of sedative drugs during MTH is required because it allows faster achievement and better maintenance of ...
Valderrama J Andres - - 2013
Here we characterized the first known transcriptional regulator that accounts for carbon catabolite repression (CCR) control of the anaerobic catabolism of aromatic compounds in bacteria. The AccR response regulator of Azoarcus sp. CIB controls succinate-responsive CCR of the central pathways for the anaerobic catabolism of aromatics by this strain. Phosphorylation ...
Kawai Masanobu - - 2013
The circadian clock network is well known to link food intake and metabolic outputs. Phosphorus is a pivotal nutritional factor involved in energy and skeletal metabolisms, and possesses a circadian profile in the circulation; however, the precise mechanisms whereby phosphate metabolism is regulated by the circadian clock network remain largely ...
Falk Carl F - - 2013
Our research utilized two popular theoretical conceptualizations of implicit self-esteem: 1) implicit self-esteem as a global automatic reaction to the self; and 2) implicit self-esteem as a context/domain specific construct. Under this framework, we present an extensive search for implicit self-esteem measure validity among different cultural groups (Study 1) and ...
Asami Kazutaka - - 2013
One-electron oxidized salophen-type complexes, [Cu(salophen)](+) (H2salophen = N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-diaminobenzene), and its methoxy derivatives, [Cu(MeO-salophen)](+) and [Cu(salophen-(MeO)2)](+) (H2MeO-salophen = N,N'-bis(3-tert-butyl-5-methoxysalicylidene)-1,2-diaminobenzene, H2salophen-(MeO)2 = N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-diamino-4,5-dimethoxybenzene), have been synthesized and structurally characterized, and their reactivities have been investigated. The solid state structures of the one-electron oxidized forms of these complexes suggested that [Cu(salophen)](+) and [Cu(MeO-salophen)](+) ...
Cuzick Jack - - 2013
Background:Cervical screening consumes substantial resources, but little is known about utilization in the United States or compliance with guideline recommendations. Methods:To describe population screening coverage, utilization and outcomes and examine time trends from 2008 to 2011, cervical cytology reports from women residing in New Mexico (981,063 tests from 511,381 women) ...
Jardin Carla G M - - 2013
Although risk factors for torsade de pointes (TdP) are known, identifying hospitalized patients at greatest risk for QTcP who should receive cardiac monitoring is poorly defined. Describe the prevalence of risk for TdP in patients and associations between risk factors and QTc prolongation (QTcP) at a tertiary teaching hospital. This ...
Knoop U - - 2013
We report about a thirty-five-year-old male patient with miliary TB as first manifestation of HIV-infection.
Jackson Yves - - 2013
International migration has changed the global distribution of Chagas disease, with the emerging importance of non-endemic regions. We aimed at better documenting the Australia and New Zealand risk of Chagas disease and needs for interventions. We reviewed Chagas disease-related evidences, policies and practices in Australia and New Zealand and calculated ...
Eisenhower Abbey - - 2013
This study examined methodological concerns with standard approaches to measuring race and ethnicity using the federally defined race and ethnicity categories, as utilized in National Institutes of Health (NIH) funded research. Surveys were administered to 219 economically disadvantaged, racially and ethnically diverse participants at Boston Women Infants and Children (WIC) ...
Yanai Hideyuki H Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, - - 2013
High-mobility group box 1 (HMGB1) is a DNA-binding protein abundantly expressed in the nucleus that has gained much attention for its regulation of immunity and inflammation. Despite this, whether and how HMGB1 contributes to protective and/or pathological responses in vivo is unclear. In this study, we constructed Hmgb1-floxed (Hmgb1(f)(/f)) mice ...
Meads C C Health Economics Research Group, Brunel University, Middlesex, - - 2014
Positron emission tomography-computed tomography (PET-CT) is recommended to triage women for exenterative surgery and surveillance after treatment for advanced cervical cancer. To evaluate diagnostic accuracy of additional whole body PET-CT compared with CT/magnetic resonance imaging (MRI) alone in women with suspected recurrent/persistent cervical cancer and in asymptomatic women as surveillance. ...
See Isaac - - 2013
-Recent data on digoxin prescribing and adverse events are lacking but could help inform the management of digoxin in contemporary heart failure treatment. -We determined nationally-representative numbers and rates of emergency department (ED) visits for digoxin toxicity in the United States using 2005-2010 reports from the National Electronic Injury Surveillance ...
Karlin Bradley E - - 2013
Purpose of the Study: To promote mental health (MH) service access and quality for veterans with complex and chronic medical, social, and behavioral conditions, the U.S. Department of Veterans Affairs (VA) has integrated a full-time MH provider into each VA home-based primary care (HBPC) team. The goal of the current ...
Jang Hae Lin - - 2013
The synthesis of pure whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) has remained a challenge even though it is the second most abundant inorganic in living bone. Although a few reports about the precipitation of WH in heterogeneous phases have been published, to date, synthesizing WH without utilizing any effects of a buffer or ...
Qiu Wanzhi - - 2013
Graphene nanopores (GNPs) hold great promise as building blocks for electronic circuitry and sensors for biological and chemical sensing applications. Methods to design graphene nanopores that achieve desirable conduction performance and sensing characteristics have not been previously described. Here we present a study of the quantum transport properties of GNPs ...
Chan Matthew - - 2013
Gold-nanoparticles (AuNPs) are employed for cancer treatment, drug delivery, chemical analyses, and many other uses. As AuNP manufacture increases it is imperative that we understand the environmental fate of these nanomaterials. We investigated the transport and stability of AuNP under simulated groundwater conditions. Batch experiments indicated that 16 nm AuNP ...
Malpica Andreia - - 2013
Unlike other migratory hummingbirds in North America, the broad-tailed hummingbird (Selasphorus platycercus) exhibits both long-distance migratory behaviour in the USA and sedentary behaviour in Mexico and Guatemala. We examined the evolution of migration linked to its northward expansion using a multi-perspective approach. We analysed variation in morphology, mitochondrial and nuclear ...
Shah Manish I - - 2013
Abstract Objective. The objective of this guideline is to recommend evidence-based practices for timely prehospital pediatric seizure cessation while avoiding respiratory depression and seizure recurrence. Methods. A multidisciplinary panel was chosen based on expertise in pediatric emergency medicine, prehospital medicine, and/or evidence-based guideline development. The panel followed the National Prehospital ...
Cho Kyung-Bin - - 2013
The mechanism of the C-H bond activation of hydrocarbons by a nonheme chromium(IV) oxo complex bearing an N-methylated tetraazamacrocyclic cyclam (TMC) ligand, [Cr(IV)(O)(TMC)(Cl)](+) (2), has been investigated experimentally and theoretically. In experimental studies, reaction rates of 2 with substrates having weak C-H bonds were found to depend on the concentration ...
Zhao Bo - - 2013
Quantitative characterization of dynamic exchange between various conformational states provides essential insights into the molecular basis of many regulatory RNA functions. Here, we present an application of nucleic-acid-optimized carbon chemical exchange saturation transfer (CEST) and low spin-lock field R1ρ relaxation dispersion (RD) NMR experiments in characterizing slow chemical exchange in ...
Käß Martina - - 2013
Two novel tripodal ligands, (BIMPN(Mes,Ad,Me))(-) and (MIMPN(Mes,Ad,Me))(2-), combining two types of donor atoms, namely, NHC and phenolate donors, were synthesized to complete the series of N-anchored ligands, ranging from chelating species with tris(carbene) to tris(phenolate) chelating arms. The complete ligand series offers a convenient way of tuning the electronic and ...
Cakar Mustafa - - 2013
Pulse wave velocity (PWV), augmentation index (Aix), and central aortic pressure (CAP) are arterial stiffness markers of endothelial dysfunction (ED). We investigated the relationship between arterial stiffness parameters and asymmetric dimethylarginine (ADMA; a marker of ED), in newly diagnosed patients with hypertension (n = 101; 61 females). These patients were ...
Nicolo Michele - - 2013
The feasibility of accessing data in hospitalized patients to support a malnutrition diagnosis using the new Academy of Nutrition and Dietetics-American Society for Parenteral and Enteral Nutrition (AND-A.S.P.E.N.) consensus recommended clinical characteristics of malnutrition is largely unknown. We sought to characterize baseline practice to guide the development of appropriate interventions ...
Herrod Pjj - - 2013
BackgroundThe Hospital at Night system has been widely adopted to manage Out of Hours workload. However, it has the potential to introduce delays and corruption of information. The introduction of newer technologies to replace landlines, pagers, and paper may ameliorate these issues.AimTo establish if the introduction of a Hospital at ...
Shen Z - - 2013
Objective: This study investigated the expression and functional effects, and related molecular mechanisms, of microRNA-519a in laryngeal squamous cell carcinoma. Methods: MicroRNA-519a and HuR messenger RNA in laryngeal squamous cell carcinoma were measured using reverse transcription polymerase chain reaction. MicroRNA-519a effects on the growth of human epithelial type 2 cells ...
Shoqirat Noordeen - - 2013
The study examined the level of knowledge of health among hospital nurses in Jordan. Four focus group discussions were carried out with hospital nurses. The findings identified three themes: health as the freedom from illness, health as good social and psychological well-being, and health as a good environment to live ...
Markowski Alycia - - 2013
Abstract Background: Cupping, a classic Chinese medicine treatment, is a technique that applies suction cups over soft tissue. Cupping is gaining popularity in physical medicine because of the simplicity in application, minimal adverse effects, and reduction in pain and muscle tenderness. These factors also make it a cost-effective intervention. For ...
Knäbel Anja - - 2013
FOCUS models are used in European regulatory risk assessment to predict the frequency and magnitude of individual pesticide surface water concentrations. A recent study showed that these models are not protective in the prediction of insecticide concentrations in surface waters and sediments. Since fungicides differ with regard to their physicochemical ...
Bouzin Margaux - - 2013
Fluorophores useful for STimulated Emission Depletion (STED) spectroscopy must fulfill strict requirements on depletion efficiency and photo-stability. These parameters determine the effective resolution of STED imaging. Resolution is typically measured on 30-80 nm spheres heavily decorated with STED bright fluorophores, limiting the possibility to estimate the true resolution achievable on ...
Park Ji Eun - - 2013
Mammalian cells have two main types of proteasomes, the constitutive proteasome and the immunoproteasome, each containing a distinct set of three catalytic subunits. Recently, additional proteasome subtypes containing a non-standard mixture of catalytic subunits have gained increasing attention, especially due to their presence in cancer settings. However, practical methods for ...
Kelleher Cecily C - - 2013
In this paper we will review evidence on the early life and familial influences on childhood growth and development, with particular reference to the Lifeways cross-generation cohort study in the Republic of Ireland. The Lifeways cross-generation cohort study was established in 2001-2013 through two maternity hospitals in the Republic of ...
Crespillo Sara - - 2013
Immunotherapies and vaccines based on the induction of broadly neutralizing monoclonal antibodies (bNAb) have become outstanding strategies against HIV-1. Diverse bNAbs recognizing different regions of HIV-1 envelope have been identified and extensively studied. However, there is scarce information about the thermodynamics of binding of these bNAbs and their epitopes. We ...
Nobili V - - 2013
Hepatocellular carcinoma (HCC) may develop from non-alcoholic fatty liver disease (NAFLD) either in the presence or in the absence of established cirrhosis. Non-cirrhotic patients with NAFLD-related HCC are usually adult, male and obese. However, this association has not been reported yet in younger age groups. Objectives In the present study, ...
Tripsianes Konstantinos - - 2013
Many cellular processes are regulated by posttranslational modifications that are recognized by specific domains in protein binding partners. These interactions are often weak, thus allowing a highly dynamic and combinatorial regulatory network of protein-protein interactions. We report an efficient strategy that overcomes challenges in structural analysis of such a weak ...
Carter Helen E - - 2013
The incidence and severity of light leaf spot epidemics caused by the ascomycete fungus Pyrenopeziza brassicae on UK oilseed rape crops is increasing. The disease is currently controlled by a combination of host resistance, cultural practices and fungicide applications. We report decreases in sensitivities of modern UK P. brassicae isolates ...
Harrild David M - - 2013
Transcatheter pulmonary valve (TPV) replacement is an emerging therapy intended to restore pulmonary valve function in patients with right ventricular outflow tract conduit dysfunction; the impact of this technique on ventricular strain and synchrony is not known. Cardiac magnetic resonance and ECG data acquired at 1 center as part of ...
Mikati Abdul Ghani - - 2013
Hyperpermeability and iron deposition are 2 central pathophysiological phenomena in human cerebral cavernous malformation (CCM) disease. Here, we used 2 novel MRI techniques to establish a relationship between these phenomena. Subjects with CCM disease (4 sporadic and 17 familial) underwent MRI imaging using the dynamic contrast-enhanced quantitative perfusion and quantitative ...
Else Tobias - - 2013
Context:Adrenocortical carcinoma is a rare malignant endocrine neoplasia. Studies regarding outcome and prognostic factors rely on fairly small studies. Here we summarize the experience with patients with a diagnosis of adrenocortical carcinoma from a large tertiary referral center.Objective:To identify prognostic factors in patients with adrenocortical carcinoma and evaluate adjuvant treatment ...
Martin Gregory Gerald - - 2013
Although the human L-FABP T94A variant arises from the most commonly occurring SNP in the entire FABP family, there is a complete lack of understanding regarding the role of this polymorphism in human disease. It has been hypothesized that the T94A substitution results in complete loss of ligand binding ability ...
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