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Results 301 - 350 of 4133
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Shi Nianmin - - 2013
To evaluate the safety, immunogenicity and batch consistency of Aleph inactivated split influenza vaccine, 3308 healthy Chinese people more than 3 years old were enrolled in a randomized, controlled, blinded study and divided into four age groups: 3-10 years, 11-17 years, 18-54 years, and more than 55 years. Each age ...
Mohsen-Kanson Tala - - 2013
Identification of molecular mechanisms involved in generation of different types of adipocytes is progressing substantially in mice. However, much less is known regarding characterization of brown and white adipocyte progenitors (APs) in humans, highlighting the need for an in vitro model of human adipocyte development. Here we report a procedure ...
Voshaar Thomas - - 2013
Abstract Background: Inhaler mishandling is a common issue among patients suffering from asthma and is associated with poor clinical outcomes and greater consumption of health-care resources. Ease of use can improve inhaler technique and, possibly, patients' preference for their inhaler device, which in turn may lead to better adherence to ...
Bonanomi Sara - - 2013
Collections of historical tissue samples from fish (e.g. scales and otoliths) stored in museums and fisheries institutions are precious sources of DNA for conducting retrospective genetic analysis. However, in some cases only external tags used for documentation of spatial dynamics of fish populations have been preserved. Here we test the ...
Schou Morten - - 2013
Renal dysfunction is associated with a variety of cardiac alterations including left ventricular (LV) hypertrophy, LV dilation, and reduction in systolic and diastolic function. It is common and associated with an increased mortality risk in heart failure (HF) patients. This study was designed to evaluate whether severe diastolic dysfunction contribute ...
Suntornsaratoon Panan - - 2013
During lactation, the osteoclast-mediated bone resorption and intestinal calcium hyperabsorption help provide extra calcium for lactogenesis. Since the suckling-induced surge of pituitary prolactin (PRL) rapidly stimulates calcium absorption in lactating rats, it is hypothesized that pre-suckling oral calcium supplementation should be an efficient regimen to shift the calcium source from ...
Li Changli - - 2013
Large-scale and high-quality Cu2O microcrystalline films with high photoactivity are synthesized using a novel and low-cost method. The enhanced photoactivity is achieved through the formation of Cu2O microcrystalline films having well-defined crystal facets and porous structure. Cu2O microcrystalline films are fabricated by decomposing previously synthesized Cu(OH)2 nanowires on a Cu ...
Wang Yangmeng - - 2013
CHIP (the carboxyl terminus of Hsc70-interacting protein, also named Stub1), a U-box containing E3 ubiquitin ligase, is involved in degradation of certain oncogenic proteins. Recent studies indicated that CHIP suppresses tumor progression in human cancers by targeting Src-3, HIF-1α, NF-κB, ErbB2 and c-Myc. Here, we report that CHIP was down-regulated, ...
Carroll Patrick - - 2013
This letter to the editor concerns the reply by C. M. Braüner and J. Attermann to comments by J. Brind and P. Carroll published on-line on September 2013 (1), following previous correspondence an earlier issue (2) regarding the article of Braüner and co-workers (3). The reply by C M Braüner and ...
Seo Jeongsuk - - 2013
The size dependence of the oxygen reduction reaction activity was studied for TaOx nanoparticles electrodeposited on carbon black for application to polymer electrolyte fuel cells (PEFCs). Compared with a commercial Ta2O5 material, the ultrafine oxide nanoparticles exhibited a distinctively high onset potential different from that of the bulky oxide particles.
Solazzo Caroline - - 2013
Deamidation of glutamine (Q) and asparagine (N) has been recognized as a marker of degradation and aging in ancient proteins. Using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-ToF-MS) to study deamidation in wool textiles, we identified eight peptides from α-keratin proteins in sheep wool that could potentially be used to assess ...
Kise Drew P - - 2013
We report a continuous-flow, microfluidic mixer utilizing mid-infrared hyperspectral imaging detection, with an experimentally determined, submillisecond mixing time. The simple and robust mixer design has the microfluidic channels cut through a polymer spacer that is sandwiched between two IR transparent windows. The mixer hydrodynamically focuses the sample stream with two ...
Hartsough Edward J EJ 1Departments of Pathology and Ophthalmology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, - - 2013
Activation of vascular endothelial growth factor receptor-2 (VEGFR-2), an endothelial cell receptor tyrosine kinase, promotes tumor angiogenesis and ocular neovascularization. We report the methylation of VEGFR-2 at multiple Lys and Arg residues, including Lys(1041), a residue that is proximal to the activation loop of the kinase domain. Methylation of VEGFR-2 ...
Garciaz Sylvain - - 2013
Patients with relapsed or refractory Hodgkin lymphoma (RR-HL) have poor outcomes. Brentuximab vedotin (BV), an antibody-drug conjugate comprising an anti-CD30 antibody conjugated to the potent anti-microtubule agent, monomethyl auristatin E, induces high tumour responses with moderate adverse effects. In a retrospective study, we describe objective response rates and subsequent allogeneic ...
Khatri A - - 2013
Background:Gemcitabine is used for the treatment of several solid tumours and exhibits high inter-individual pharmacokinetic variability. In this study, we explore possible predictive covariates on drug and metabolite disposition.Methods:Forty patients were enrolled. Gemcitabine and dFdU concentrations in the plasma and dFdCTP concentrations in peripheral blood mononuclear cell were measured to ...
Sewell Mary Anne - - 2013
Ocean acidification (OA), the reduction of seawater pH as a result of increasing levels of atmospheric CO2, is an important climate change stressor in the Southern Ocean and Antarctic. We examined the impact of OA on fertilization success in the Antarctic sea urchin Sterechinus neumayeri using pH treatment conditions reflective ...
Marconato Laura - - 2013
Active immunotherapy is a promising antitumoral strategy; however its use in combination with chemotherapy in dogs with large B-cell lymphoma (DLBCL) remains largely untested. Heat shock proteins (HSPs) bind the small peptides they chaperone (HSPPCs), allowing for immunization of the host against a large repertoire of tumor-associated antigens. Hydroxylapatite (HA) ...
Phillips David - - 2013
To report the implementation and outcomes of a routine opt-out HIV testing policy in an acute medical unit (AMU) of a district general hospital in an area of high diagnosed HIV prevalence. Since July 2011, all patients aged 16-79 years attending AMU were offered an HIV test as a hospital ...
Samanta Soumen Kumar - - 2013
A family of supramolecular 4-component nano¬rotors was quantitatively self-assembled from two different zinc(II) porphyrins one representing the stator and the other the rotator, DABCO as an interconnecting axle and copper(I) ions. Rotational spinning in ROT-1΄ occurs at 97000 s-1 at 25 °C but is virtually stopped at -75 °C. The ...
Shihadeh Alan - - 2013
In recent years, a class of products marketed as "tobacco-free" alternatives for the "health conscious user" has become widely available for waterpipe (hookah, narghile, or shisha) smoking. Their adoption may be in part driven by regulations banning tobacco smoking in public places and by an increasing awareness of the hazards ...
Walters Matthew S - - 2013
As the multipotent progenitor population of the airway epithelium, human airway basal cells (BC) replenish the specialized differentiated cell populations of the mucociliated airway epithelium during physiological turnover and repair. Cultured primary BC divide a limited number of times before entering a state of replicative senescence, preventing the establishment of ...
Eskandari-Nasab Ebrahim - - 2013
The protective immune response against Brucella involves T cell-mediated immunity. T lymphocyte receptors, CD28 and Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), bind the same ligands, CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APCs) and regulate T cell activation. CD28 delivers stimulatory while CTLA-4 provides inhibitory signals for T cell activation. ...
Arafah Mohamed - - 2013
The Centralized pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS) survey evaluated the attainment of low-density lipoprotein cholesterol (LDL-C) goals among patients on lipid-lowering drugs (LLDs) according to the updated National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP-III) guideline. The survey was conducted in 6 Arabian Gulf countries. Patients ...
Li Weili - - 2013
A carboxyethyl substituted azacrown ether (CSAE) derivative was intercalated as a second host into a parent host of layered gadolinium hydroxides (LGdH) by an anion-exchange reaction. The influence of intercalation temperature and starting material ratios of CSAE/LRH on the structures and compositions of CSAE-LRH nanocomposites were investigated. Higher temperature and ...
Arya V B - - 2013
Hepatocyte nuclear factor 4α (HNF4A) is a member of the nuclear receptor family of ligand-activated transcription factors. HNF4A mutations cause hyperinsulinaemic hypoglycaemia in early life and maturity-onset diabetes of the young. Regular screening of HNF4A mutation carriers using the oral glucose tolerance test has been recommended to diagnose diabetes mellitus ...
Tang Yuanjiao - - 2013
We report a rare case of a 5-year-old patient with a toothpick in the knee joint resulting in septic arthritis. The toothpick was detected in the joint by sonography and was confirmed at surgery. A wooden foreign body is an uncommon cause of arthritis. This case report is followed by ...
Chen Zhuo - - 2013
Energy transfer along a non-conjugated polymer chain is studied with a polystyrene based copolymer of oligo(phenylene-ethynylene) (OPE) donor and thiophene-benzothiadiazole (TBT) acceptor pendants. The graft copolymers are prepared from reversible adition-fragmentation transfer polymerization (RAFT) and copper(I)-catalyzed azide-alkyne "click" reaction. The singlet energy transfer from donor to accept is studied via ...
Wong Sze Ling - - 2013
Recent literature has suggested an association between autoimmune thyroiditis and papillary thyroid cancer. The aims of this study were to evaluate if positive thyroid antibodies are associated with thyroid carcinoma and to examine the role of thyroid antibodies in the management of thyroid nodules. This is a database study of ...
Zeng Teng - - 2013
Dissolved organic matter (DOM) represents the major pool of organic precursors for harmful disinfection byproducts, such as haloacetic acids (HAAs), formed during drinking water chlorination, but much of it remains molecularly uncharacterized. Knowledge of model precursors is thus a prerequisite for understanding the more complex whole water DOM. The utility ...
Wang Yuzhong - - 2013
In contrast to stable phosphorus oxides such as P4O6 and P4O10 that possess iconic adamantane-like cage structures, highly reactive phosphorus oxides such as PO, PO2, and P2Ox (x = 1-5) only have been studied in the gas phase or by matrix isolation techniques. Elusive diphosphorus tetroxide, the long sought phosphorus ...
Lu Hong-Liang - - 2013
We report photoconductivity of an insulating LaAlO3-SrTiO3 (LAO-STO) heterointerface. Persistent photocurrent induced by a 514 nm laser at room temperature is significant, which is attributed to carriers trapped by a built-in potential well at the interface. Further studies of photoconductivity of the insulating LAO-STO interface performed with a monochrometer demonstrate ...
Bossou Annick D - - 2013
Insecticide resistance in sub-Saharan Africa and especially in Benin is a major public health issue hindering the control of the malaria vectors. Each Anopheles species has developed a resistance to one or several classes of the insecticides currently in use in the field. Therefore, it is urgent to find alternative ...
Earla Ravinder R School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri (R.E., A.A., A.K., S.K.); and Department of Oral and Craniofacial Science, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri - - 2014
Smoking is approximately three times more prevalent in HIV-1-positive than HIV-negative individuals in the United States. Nicotine, which is the major constituent of tobacco, is rapidly metabolized mainly by cytochrome P450 (CYP2A6) to many metabolites. In this study, we developed a simple, fast, and sensitive electrospray ionization liquid chromatography-tandem mass ...
Yang Yi-Xin - - 2013
Silica nanoparticles (NPs) have been widely used in food products as an additive; however, their toxicity and safety to the human body and the environment still remain unclear. As a food additive, silica NPs firstly enter the human gastrointestinal tract along with food, thus their gastrointestinal toxicity deserves thorough study. ...
Halbron M - - 2013
To evaluate if a single inpatient education training programme can achieve individualized therapeutic targets. Patients with Type 1 diabetes participating in a flexible intensive therapy programme were consecutively included in a prospective monocentric study. They all participated in the same education programme which had a patient-centred approach. Before the intervention, ...
Xiao Zheming - - 2013
A metal-free, photo-induced C-O bond formation methodology was developed to construct tetrahydroxanthones. This mild and efficient methodology was based on intramolecular oxygen trapping of the reactive species produced by photolytic activation of a C-Cl bond. We believe this method could be used in the synthesis of related xanthone-type natural products.
Saneyoshi Hisao - - 2013
A series of triphenylphosphinecarboxamide (TPPc) derivatives were designed and synthesized as alternative reagents to triphenylphosphine for the facile reduction of azides. The TPPc derivatives performed as efficient reducing agents for the synthesis of primary amines without the need for an additional hydrolysis procedure. The TPPc derivatives were also applied to ...
Gieseg Ma - - 2013
To determine if cats anaesthetised with alfaxalone have different recoveries to cats anaesthetised with a combination of ketamine and diazepam. Anaesthesia for ovariohysterectomy was induced in cats with either alfaxalone (n=23) or a combination of ketamine and diazepam (n=22). All cats were premedicated with combinations of acepromazine and morphine. Recoveries ...
Barkana Yaniv - - 2013
Change in intraocular pressure (IOP) is known to occur with body posture. Previous studies have reported markedly different estimations of this change. The Icare Pro is a new device that is designed to measure IOP with the subject supine. We compared the measurement of postural change in IOP obtained with ...
Quinkler Marcus - - 2013
The discovery of Cortisone by Hench, Kendall and Reichstein in the late 1940's was the turning point for the deadly disease adrenal insufficiency (AI), effectively rendering it a treatable chronic disorder. For many decades endocrinologists assumed that corticosteroid replacement therapy resulted in a normal life expectancy (1). However, recent outcome ...
Chailertvanitkul P - - 2013
To compare the treatment outcomes when calcium hydroxide and mineral trioxide aggregate are used for partial pulpotomy in cariously-exposed young permanent molars in a randomized control trial. Eighty-four teeth in 80 volunteers (aged 7-10 years) with reversible pulpitis and carious pulp exposures were randomly divided into two groups. Exposed pulps ...
Juarez-Colunga Elizabeth - - 2013
Many clinical trials are designed to study outcome measures recorded as the number of events occurring during specific intervals, called panel data. In such data, the intervals are specified by a planned set of follow-up times. As the collection of panel data results in a partial loss of information relative ...
Park Sunyoung - - 2013
While emissions of halogenated compounds in East Asia have been known to make up a significant fraction of the total global emissions, both with respect to ozone depletion potential (ODP) and global warming potential (GWP), the actual sources of these emissions are relatively poorly understood. High-precision in situ measurements of ...
Leshem Eyal - - 2013
Current guidelines recommend continuation of atovaquone-proguanil (AP) malaria prophylaxis for 7 days after leaving Plasmodium falciparum endemic areas. Evidence from clinical studies suggests that discontinuation of AP 1 day after exposure ends may be safe and effective. Our objective was to assess the effectiveness of short-course AP prophylaxis among travelers ...
Ruddat I - - 2013
SUMMARY A collection of Salmonella Typhimurium isolates obtained from sporadic salmonellosis cases in humans from Lower Saxony, Germany between June 2008 and May 2010 was used to perform an exploratory risk-factor analysis on antimicrobial resistance (AMR) using comprehensive host information on sociodemographic attributes, medical history, food habits and animal contact. ...
Chen Congying - - 2013
Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) are highly heritable traits that are used clinically to evaluate risk for cardiovascular disease in humans. In this study, we applied a genome-wide association study (GWAS) in 1,075 pigs from two populations and ...
Verkhratsky Alexei - - 2013
Astroglia are the homoeostatic cells of the central nervous system that control a normal function of synaptically connected neuronal networks and contribute to brain defense. Recent advances in comprehension of pathological potential of astroglia indicate that astrocytes are fundamental for most (if not all) neurological diseases. Neuropathological and neuroimaging studies ...
Hong Shouhai - - 2013
With the wide-spread and application of acupuncture and moxibustion, the demand of its standardization construction is increasingly prominent. On the basis of further investigation into the standards of acupuncture and moxibustion in China, this paper summarize the research status of Chinese standardization of acupuncture and moxibustion, analyze some problems existing ...
Guha Neela - - 2013
We conducted a random-effects meta-analysis of 50 publications assessing the relationship between oral/oropharyngeal cancer and chewing betel quid, with (BQ+T) or without added tobacco (BQ-T), a common practice in many parts of Asia and globally among Asian immigrants. Exposure-response, by daily amount and years of BQ chewed, was assessed using ...
Szweykowska-Kulińska Zofia - - 2013
Many of the plant microRNA (miRNA) genes contain introns. The miRNA-containing hairpin loop structure is predominantly located within the first exon of such pri-miRNAs. We have shown that the downstream intron and its splicing are important for the regulation of the processing of these pri-miRNAs. The 5' splice site in ...
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