Search Results
Results 251 - 300 of 4089
< 1 2 3 4 5 6 7 8 9 10 11 >
Bosch Calero Cristina - - 2013
Large-conductance Ca (2+)-activated (BK) channels, expressed in a variety of tissues, play a fundamental role in regulating and maintaining arterial tone. We recently demonstrated that the slow voltage indicator DiBAC 4(3) does not depend, as initially proposed, on the β 1 or β 4 subunits to activate native arterial smooth ...
Di Lorenzo C - - 2013
The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin sisters, whose high-frequency migraine improved during ...
Pileggi Claudia - - 2013
Human-papillomavirus (HPV) DNA testing has been proposed as an alternative to primary cervical cancer screening using cytological testing. Review of the evidence shows that available data are conflicting for some aspects. The overall goal of the study is to update the performance of HPV-DNA as stand-alone testing in primary cervical ...
Crespillo Sara - - 2013
Immunotherapies and vaccines based on the induction of broadly neutralizing monoclonal antibodies (bNAb) have become outstanding strategies against HIV-1. Diverse bNAbs recognizing different regions of HIV-1 envelope have been identified and extensively studied. However, there is scarce information about the thermodynamics of binding of these bNAbs and their epitopes. We ...
Di Fabio Roberto - - 2013
To date, there exist no data reporting the level of suitability of requests for electromyography examinations (EMGs) in Rome. The records of 1,220 consecutive patients (age: 57.6±15.0 years; 400 M, 820 F) in two neurophysiology laboratories were collected and analyzed. In total, 1,317 EMGs were requested, mainly by general practitioners ...
Mielgo-Ayuso Juan - - 2013
The aim of the present study was to examine the effects of green tea epigallocatechin-3-gallate (EGCG) on changes in body composition, energy and substrate metabolism, cardiometabolic risk factors and liver function enzymes after an energy-restricted diet intervention in obese women. In the present randomised, double-blind, placebo-controlled study, eighty-three obese (30 kg/m2>BMI < 40 kg/m2) ...
Kitsche Andreas - - 2013
Testing for or against a qualitative interaction is relevant in randomized clinical trials that use a common primary factor treatment and have a secondary factor, such as the centre, region, subgroup, gender or biomarker. Interaction contrasts are formulated for ratios of differences between the levels of the primary treatment factor. ...
Lethaby Anne - - 2013
Metal pins are used to apply skeletal traction or external fixation devices in the management of orthopaedic fractures. These percutaneous pins protrude through the skin, and the way in which they are treated after insertion may affect the incidence of pin site infection. This review set out to summarise the ...
Sewell Mary Anne - - 2013
Ocean acidification (OA), the reduction of seawater pH as a result of increasing levels of atmospheric CO2, is an important climate change stressor in the Southern Ocean and Antarctic. We examined the impact of OA on fertilization success in the Antarctic sea urchin Sterechinus neumayeri using pH treatment conditions reflective ...
Lee Marietta Ywt - - 2013
DNA polymerase δ (Pol δ) is a key enzyme in eukaryotic DNA replication. Human Pol δ is a heterotetramer whose subunit Pol δ is degraded in response to DNA damage, leading to the in vivo conversion of Pol δ4 to Pol δ3. Two E3 ubiquitin ligases, RNF8 and CRL4(Cdt2), participate ...
Valderrama J Andres - - 2013
Here we characterized the first known transcriptional regulator that accounts for carbon catabolite repression (CCR) control of the anaerobic catabolism of aromatic compounds in bacteria. The AccR response regulator of Azoarcus sp. CIB controls succinate-responsive CCR of the central pathways for the anaerobic catabolism of aromatics by this strain. Phosphorylation ...
Brioche T - - 2013
The aim of our study was to elucidate the role of growth hormone (GH) replacement therapy in three of the main mechanisms involved in sarcopenia: alterations in mitochondrial biogenesis, increase in oxidative stress, and alterations in protein balance. We used young and old Wistar rats that received either placebo or ...
Graindorge Matthieu - - 2013
The aromatic amino acids phenylalanine and tyrosine represent essential sources of high value natural aromatic compounds for human health and industry. Depending on the organism, alternative routes exist for their synthesis. Phenylalanine and tyrosine are synthesized either via phenylpyruvate/4-hydroxyphenylpyruvate, or via arogenate. In arogenate-competent microorganisms an aminotransferase is required for ...
Jang Hae Lin - - 2013
The synthesis of pure whitlockite (WH: Ca18Mg2(HPO4)2(PO4)12) has remained a challenge even though it is the second most abundant inorganic in living bone. Although a few reports about the precipitation of WH in heterogeneous phases have been published, to date, synthesizing WH without utilizing any effects of a buffer or ...
Alikhasi Marzieh - - 2013
Accurate recording of implant location is required in every implant-supported prostheses. Implant angulation, which is inevitable in various clinical situations, could affect the impression accuracy. The purpose of this in vitro study was to compare the transfer accuracy of straight and tilted implants of All-on-4 protocol with implant or abutment ...
Christensen Caspar Elo - - 2013
Accumulating evidence suggest that the pyridine nucleotide NAD has far wider biological functions than its classical role in energy metabolism. NAD is used by hundreds of enzymes that catalyse substrate oxidation and as such it plays a key role in various biological processes such as aging, cell death and oxidative ...
Yip Yan Y - - 2013
Dynamic microtubule changes following a cell stress challenge are required for cell survival and adaptation. Stathmin (STMN), a cytoplasmic microtubule-destabilizing phosphoprotein, regulates interphase microtubules during cell stress but the signalling mechanisms involved are poorly defined. In this study, through the ectopic expression of single alanine-substituted phospho-resistant mutants demonstrated that STMN ...
Juul Tina - - 2013
This study investigates the reliability of muscle performance tests using cost- and time-effective methods similar to those used in clinical practice. When conducting reliability studies, great effort goes into standardising test procedures to facilitate a stable outcome. Therefore, several test trials are often performed. However, when muscle performance tests are ...
Hanberger L - - 2013
To study whether monthly variations in type 1 diabetes incidence are related to monthly glycated haemoglobin (HbA1c) levels at diagnosis and if high HbA1c at diagnosis is related to certain clinical variables at diagnosis and during the clinical course of the disease. Data from 4,430 boys and 3,590 girls registered ...
Rajan Sreekanth - - 2013
The malarial parasites currently remain one of the most dreadful parasites, which show increasing trend of drug resistance to the currently available antimalarial drugs. Thus, the need to identify and characterize new protein targets in these parasites can aid to design novel therapeutic strategies to combat malaria. Recently, the conserved ...
Park Eun-Jung - - 2013
In previous studies, (R)-2-isobutyl 3-methyl 3,4-dihydro-1H-pyrido[3,4-b]indole-2,3(9H)-dicarboxylate (1), a callophycin A derivative, was found to strongly inhibit nitrite production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, while (R)- or (S)-callophycin A showed only weak inhibition. We currently report additional studies to define the mechanisms underlying the inhibitory action of 1. Expression of ...
Hock Sebastian J - - 2013
Twelve novel Re(i) acetonitrile complexes of the type [Re(CO)3(L)(MeCN)][WCA], with L being a chelating bis(NHC) ligand with alkylene-bridged and N-substituted bis(imidazolineylidene) moieties, and WCA (WCA = weakly coordinating anion) representing PF6(-) and [Al(OC(CF3)3)4](-), have been synthesized. 1D and 2D NMR spectroscopy as well as IR spectroscopy, elemental analysis and X-ray ...
Maalcke Wouter J - - 2013
Nitric oxide (NO) is an important molecule in all domains of life with significant biological functions in both pro- and eukaryotes. Anaerobic ammonium-oxidizing (anammox) bacteria that contribute substantially to the release of fixed nitrogen into the atmosphere use the oxidizing power of NO to activate inert ammonium into hydrazine (N2H4). ...
Knop Gabriel C - - 2013
Mammalian retinas comprise a variety of interneurons, among which amacrine cells represent the largest group, with more than 30 different cell types each exhibiting a rather distinctive morphology and carrying out a unique function in retinal processing. However, many amacrine types have not been studied systematically because, in particular, amacrine ...
Paloma-Castro Olga - - 2013
To validate the content of the NANDA-I nursing diagnosis of grieving in situations of perinatal loss. Using the Fehring's model, 208 Spanish experts were asked to assess the adequacy of the defining characteristics and other manifestations identified in the literature for cases of perinatal loss. The content validity index was ...
Chen Yu - - 2013
Photonic crystal nanobeam cavities with high quality factors are very sensitive to the changes of the dielectric properties of their surroundings. Utilizing this high sensitivity and by applying chemical functionalization, an ultrasensitive chemical sensor for gases based on a nanobeam cavity was demonstrated. Limit of detection of 1.5 parts-per-billion (ppb) ...
Gharaibeh Almutez - - 2013
Traumatic hyphema is the entry of blood into the anterior chamber (the space between the cornea and iris) subsequent to a blow or a projectile striking the eye. Hyphema uncommonly causes permanent loss of vision. Associated trauma (e.g. corneal staining, traumatic cataract, angle recession glaucoma, optic atrophy, etc.) may seriously ...
Krupka Christina - - 2013
Antibody-based immunotherapy represents a promising strategy to target and eliminate chemoresistant leukemic cells. Here, we evaluated the CD33/CD3-bispecific BiTE® antibody (AMG 330) for its suitability as therapeutic agent in AML. We first assessed CD33 expression levels by flow cytometry and found expression in >99% of patient samples (n=621). CD33 was ...
Landry Marie-Claude - - 2013
It is believed that mitochondrial dynamics is coordinated with endosomal traffic rates during cytoskeletal remodeling, but the mechanisms involved are largely unknown. The adenovirus early region 4 ORF4 protein (E4orf4) subverts signaling by Src-family kinases (SFK) to perturb cellular morphology, membrane traffic and organellar dynamics and to trigger cell death. ...
Chen Zhuo - - 2013
Energy transfer along a non-conjugated polymer chain is studied with a polystyrene based copolymer of oligo(phenylene-ethynylene) (OPE) donor and thiophene-benzothiadiazole (TBT) acceptor pendants. The graft copolymers are prepared from reversible adition-fragmentation transfer polymerization (RAFT) and copper(I)-catalyzed azide-alkyne "click" reaction. The singlet energy transfer from donor to accept is studied via ...
Greenwald Eric C - - 2013
Scaffold proteins localize two or more signaling enzymes in close proximity to their downstream effectors. A-Kinase Anchoring Proteins (AKAPs) are a canonical family of scaffold proteins known to bind Protein Kinase A (PKA) and other enzymes. Several AKAPs have been shown to accelerate, amplify and specify signal transduction to dynamically ...
Su Bo - - 2013
Appropriate mitochondrial transport and distribution are essential for neurons because of the high energy and Ca2+ buffering requirements at synapses. Brain-derived neurotrophic factor (BDNF) plays an essential role in regulating synaptic transmission and plasticity. However, whether and how BDNF can regulate mitochondrial transport and distribution is still unclear. Here, we ...
Kikuchi Ryo - - 2013
In the mammalian cell cycle, both cyclin A and cyclin B are required for the entry into mitosis, and their elimination is also essential to complete the process. During mitosis, cyclin A and cyclin B are ubiquitylated by the anaphase promoting complex/cyclosome (APC/C) and then subjected to proteasomal degradation. However, ...
Liang Cheng-Qin - - 2013
Three new triterpenoids, kadcotriones A-C (1-3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds ...
Kawai Masanobu - - 2013
The circadian clock network is well known to link food intake and metabolic outputs. Phosphorus is a pivotal nutritional factor involved in energy and skeletal metabolisms, and possesses a circadian profile in the circulation; however, the precise mechanisms whereby phosphate metabolism is regulated by the circadian clock network remain largely ...
Chung Hwa Hwa - - 2013
The identification of lysine acetylation of steroid hormone receptors has previously been based on the presence of consensus motif K/RXKK. This study reports the discovery by mass spectrometry of a novel progesterone receptor acetylation site at K183 that is not in the consensus motif. In vivo acetylation and mutagenesis experiments ...
Boonk S E - - 2013
Patients with mycosis fungoïdes (MF) tumor stage IIB disease show considerable variation in the number of tumors and time interval between each tumor occasion. To quantify the extent of tumor formation in MF stage IIB patients and correlation with survival. The variability in tumor development of 46 MF patients with ...
Goldspiel Barry R - - 2013
Pharmacogenetics (PG) examines gene variations for drug disposition, response, or toxicity. At the National Institutes of Health Clinical Center (NIH CC), a multidepartment Pharmacogenetics Testing Implementation Committee (PGTIC) was established to develop clinical decision support (CDS) algorithms for abacavir, carbamazepine, and allopurinol, medications for which human leukocyte antigen (HLA) variants ...
McKinlay James B - - 2013
When starved for nitrogen, non-growing cells of the photosynthetic bacterium Rhodopseudomonas palustris continue to metabolize acetate and produce H2, an important industrial chemical and potential biofuel. The enzyme nitrogenase catalyzes H2 formation. The highest H2 yields are obtained when cells are deprived of N2 and thus use available electrons to ...
Farnworth Mj - - 2013
To compare the use and provision of analgesia to cats undergoing gonadectomy by a sample of veterinarians in New Zealand, Australia and the United Kingdom (UK). Small animal veterinarians' views and practices on provision of analgesia to cats at three different time phases (pre/intra-operatively, post-operatively and post-discharge) were gathered using ...
Zhang Yuyuan - - 2013
UV-pump/broadband-mid-IR-probe transient absorption (TA) experiments and ab initio quantum mechanical (QM) calculations were used to investigate the photophysics in heavy water of the neutral and acid forms of guanosine 5'-monophosphate (GMP and GMPD(+), respectively). Excited GMP undergoes ultrafast internal conversion (IC) and returns to the electronic ground state in less ...
Pan Cong - - 2013
Magnesium is widely used to control calcium carbonate deposition in the shell of pearl oysters. Matrix proteins in the shell are responsible for nucleation and growth of calcium carbonate crystals. However, there is no direct evidence supporting a connection between matrix proteins and magnesium. Here, we identified a novel acidic ...
Le Hoa T - - 2013
Oxidative stress induced by reactive oxygen species (ROS) is associated with various neurological disorders including aging, neurodegenerative diseases, as well as traumatic and ischemic insults. Astrocytes have an important role in the anti-oxidative defense in the brain. The gap junction protein connexin43 (Cx43) forms intercellular channels as well as hemichannels ...
Dorman Susan E - - 2013
Rationale: Interferon gamma release assays (IGRAs) are alternatives to tuberculin skin testing (TST) for diagnosis of latent tuberculosis infection. Limited data suggest IGRAs may not perform well for serially testing healthcare workers (HCWs). Objective: Determine performance characteristics of IGRAs vs. TST for serially testing HCWs. Methods: A longitudinal study involving ...
Andersson Peter - - 2013
Full-arch clearances of compromised teeth and placement of implant-supported prostheses is one solution for the prosthetic rehabilitation of partially dentate patients. To retrospectively evaluate treatment outcomes after full clearance, immediate placement, and early loading of full-arch fixed bridges. Fifty-five patients subjected to full clearance and placement of 284 Neoss implants ...
Nguyen Tung - - 2013
Carcinoembryonic antigen related cell adhesion molecule-1 (CEACAM1), a transmembrane protein, expressed on normal breast epithelial cells is down-regulated in breast cancer. Phosphorylation of Thr-457 on the short cytoplasmic domain isoform (CEACAM1-SF) that is predominant in normal epithelial cells is required for lumen formation in a 3D model that involves apoptosis ...
Park Meeyoung - - 2013
Mutations in the SO42-/Cl-/OH- exchanger Slc26a2 cause the disease diastrophic dysplasia (DTD), resulting in aberrant bone development and therefore skeletal deformities. DTD is commonly attributed to a lack of chondrocyte SO42- uptake and proteoglycan sulfation. However, the skeletal phenotype of patients with DTD is typified by reduction in cartilage and ...
Gieseg Ma - - 2013
To determine if cats anaesthetised with alfaxalone have different recoveries to cats anaesthetised with a combination of ketamine and diazepam. Anaesthesia for ovariohysterectomy was induced in cats with either alfaxalone (n=23) or a combination of ketamine and diazepam (n=22). All cats were premedicated with combinations of acepromazine and morphine. Recoveries ...
Shulman Eli - - 2013
There is compelling evidence that aminoglycoside (AG) antibiotics can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, prolonged AG treatment can cause detrimental side effects in patients, including most prominently, ototoxicity. Recent mechanistic discussions have considered the relative contributions of ...
Montalli Victor Angelo - - 2013
The morphological criteria for identification of intercalated duct lesions (IDLs) of salivary glands were recently defined. It has been hypothesized that IDL could be a precursor of basal cell adenoma (BCA). BCAs show a variety of histological patterns and the tubular variant is the one that presents stronger resemblance with ...
< 1 2 3 4 5 6 7 8 9 10 11 >