Search Results
Results 201 - 250 of 4133
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Tripsianis G - - 2013
Presented study was conducted to investigate the prognostic significance of the coexpression of serum interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) in breast cancer, by correlating their presence with clinicopathological characteristics indicative of tumor progression and the overall survival of breast cancer patients. One hundred twelve consecutive patients with primary ...
Wu P - - 2013
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which has long been believed to be highly selective in inducing apoptosis in cancer cells, has turned out to be a molecule that induces a far more diverse range of effects. The aim of this study was to investigate whether or not ERK1/2 pathway is involved ...
Park Katya J - - 2013
White matter sparing after traumatic brain injury (TBI) is an important predictor of survival and outcome. Blood vessels and axons are intimately associated anatomically and developmentally. Neural input is required for appropriate vascular patterning, and vascular signaling is important for neuron development and axon growth. Owing to this codependence between ...
Dreesen Jos - - 2013
Preimplantation genetic diagnosis (PGD) for monogenic disorders currently involves polymerase chain reaction (PCR)-based methods, which must be robust, sensitive and highly accurate, precluding misdiagnosis. Twelve adverse misdiagnoses reported to the ESHRE PGD-Consortium are likely an underestimate. This retrospective study, involving six PGD centres, assessed the validity of PCR-based PGD through ...
Imai H - - 2013
The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with non-small cell lung cancer (NSCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), or tumor response could be valid surrogate endpoints for OS after first-line chemotherapies in advanced NSCLC by using ...
Valentine M C - - 2013
Infant leukemia (IL) is a rare sporadic cancer with a grim prognosis. While most cases are accompanied by MLL-rearrangements and harbor very few somatic mutations; less is known about the genetics of the cases without MLL translocations. We performed the largest exome sequencing study to date on matched non-cancer DNA ...
- - 2013
Twelve months ago this week, England's chief nurse Jane Cummings launched the 6Cs, her flagship policy setting out the core values that underpin excellent nursing care. In this week's issue, we look at how the policy is working in practice and speak to nurses who have made fundamental changes as ...
Coghill Yvonne - - 2013
November was the NHS awards season, hot on the heels of October's Black History Month, which celebrated the achievements and contribution to society of people of African origin.
Koyama D - - 2013
The Notch signaling pathway has been recognized as a key player for the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), because of the high incidence of activating mutations of Notch1. Notch inhibition could serve as a new treatment strategy for T-ALL; however, the attempts to perturb Notch signaling pathways have ...
- - 2013
Nursing Central is a comprehensive mobile and web-aligned American app providing detailed information on diseases, tests, procedures, medicines and access to a range of evidence-based nursing journals and resources.
von Bornstädt Daniel - - 2013
Ambient particulate matter (PM) pollution is estimated to be responsible for 3.2 million deaths annually worldwide. Although many studies have demonstrated PM as a serious risk factor for cardiovascular diseases, less is known on its association with cerebrovascular events. Over the last decade, however, an increasing number of studies have ...
- - 2013
Patient safety must be transformed within the NHS, health secretary Jeremy Hunt told hundreds of senior nurses last week.
Li Nan - - 2013
Adaptive radiation therapy (ART) can reduce normal tissue toxicity and/or improve tumor control through treatment adaptations based on the current patient anatomy. Developing an efficient and effective re-planning algorithm is an important step toward the clinical realization of ART. For the re-planning process, manual trial-and-error approach to fine-tune planning parameters ...
Van Zundert T - - 2013
Background: Extraglottic airway devices (EADs) are frequently used airway devices, yet often they seal poorly, resulting in a functionally unacceptable leak. Optimal size selection of the EAD is therefore critical to the safe and effective use of an EAD. This review is designed to delineate the sizing recommendations of EADs ...
Shufaro Yoel - - 2013
Abstract The maternal age at the first and repeated deliveries constantly rises in developed countries due to current social trends that favor values of personal achievements upon procreation. Assisted reproduction technologies (ART) and especially the availability of oocyte donation programs extend the age of fecundity to the fifth and sixth ...
Kameyama Hiroki - - 2013
Adult male mice were continuously treated with bromodeoxyuridine (BrdU) for 1, 2, or 4 weeks by an osmotic pump. To detect BrdU-label-retaining cells (LRCs), putative progenitor/stem cells, other animals were continuously treated with BrdU for 2 weeks, and were then kept without any treatments for 2, 6, or 18 months. ...
Gayoso Carmen María - - 2013
Desiccation tolerance contributes to the maintenance of bacterial populations in hospital settings and may partly explain its propensity to cause outbreaks. Identification and relative quantitation of proteins involved in bacterial desiccation tolerance was made using label free quantitation and iTRAQ labelling. Under desiccating conditions, the population of the Acinetobacter baumannii ...
- - 2013
Nurses should care for patients in the same way they would a member of their own family, Northern Ireland's chief nurse has said.
Newnham David - - 2013
I like grocery shopping. Does that make me weird? Then I might as well tell the whole truth - I actually enjoy pushing a trolley round a supermarket, even on a Saturday morning. Phew. I feel better for getting that off my chest.
Lamart Stephanie S Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, - - 2013
Following cancer radiotherapy, reconstruction of doses to organs, other than the target organ, is of interest for retrospective health risk studies. Reliable estimation of doses to organs that may be partially within or fully outside the treatment field requires reliable knowledge of the location and size of the organs, e.g., ...
Coppin Lucie - - 2013
The identification of Von Hippel-Lindau (VHL) mosaic mutations by conventional Sanger sequencing requires a labour-intensive enrichment step, thus explaining that mosaicism occurrence is underestimated in patients. Nowadays, it is possible to detect mutation in cell sub-populations by next-generation sequencing (NGS). Here, we described a diagnosis strategy using NGS with high ...
Tsirigotis Konstantinos - - 2013
The objective of this study is to examine the gender (sex) differentiation of indirect self-destructiveness and its manifestations as well as its relationships with suicide attempt methods in females and males. The study was conducted among 147 persons (114 females, 33 males) who attempted suicide. The research instrument was the ...
Xu J B - - 2013
This article aimed to investigate the value of α-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC) and to evaluate the relationship between AFP and various clinical variables of HCC comprehensively. A retrospective study of postoperative patients diagnosed with liver neoplasm from two Chinese centers was enrolled in our study.A ...
Pourpoint Frédérique - - 2013
We show how (27)Al-(13)C proximities in the microporous metal-organic framework MIL-100(Al) can be probed using advanced (27)Al-(13)C NMR methods boosted by Dynamic Nuclear Polarization.
Warner David O DO Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota3American Board of Anesthesiology, Raleigh, North - - 2013
Substance use disorder (SUD) among anesthesiologists and other physicians poses serious risks to both physicians and patients. Formulation of policy and individual treatment plans is hampered by lack of data regarding the epidemiology and outcomes of physician SUD. To describe the incidence and outcomes of SUD among anesthesiology residents. Retrospective ...
Amenabar Iban - - 2013
Mid-infrared spectroscopy is a widely used tool for material identification and secondary structure analysis in chemistry, biology and biochemistry. However, the diffraction limit prevents nanoscale protein studies. Here we introduce mapping of protein structure with 30 nm lateral resolution and sensitivity to individual protein complexes by Fourier transform infrared nanospectroscopy (nano-FTIR). ...
Gabbay-Benziv Rinat - - 2013
Abstract Objective: To determine the association between decision to delivery interval and short term perinatal outcome in cases of suspected placental abruption delivered by cesarean section (CS). Study Design: A retrospective cohort study of all cases of placental abruption delivered by CS (2010-2012) in a single university affiliated tertiary center. ...
Bacher P - - 2013
Foxp3(+) regulatory T cells (Treg) have a central role for keeping the balance between pro- and anti-inflammatory immune responses against chronically encountered antigens at mucosal sites. However, their antigen specificity especially in humans is largely unknown. Here we used a sensitive enrichment technology for antigen-reactive T cells to directly compare ...
Rummel Christian - - 2013
We report on oxygenation changes noninvasively recorded by multichannel continuous-wave near infrared spectroscopy (CW-NIRS) during endovascular neuroradiologic interventions requiring temporary balloon occlusion of arteries supplying the cerebral circulation. Digital subtraction angiography (DSA) provides reference data on the site, timing, and effectiveness of the flow stagnation as well as on the ...
Rooijers Koos - - 2013
Mitochondria are essential cellular organelles for generation of energy and their dysfunction may cause diabetes, Parkinson's disease and multi-systemic failure marked by failure to thrive, gastrointestinal problems, lactic acidosis and early lethality. Disease-associated mitochondrial mutations often affect components of the mitochondrial translation machinery. Here we perform ribosome profiling to measure ...
Hata M - - 2013
Extramammary Paget's disease (EMPD) is a relatively rare malignancy, and there are few reports related to radiation therapy. In the present study, we investigated the outcome of radiation therapy for EMPD. Forty-one patients with EMPD in the genitalia underwent radiation therapy with curative intent. Fifteen patients had regional lymph node ...
Weinrich Michael - - 2013
Inhalation anesthetics have been in clinical use for over 160 years, but the molecular mechanisms of action continue to be investigated. Direct interactions with ion channels received much attention after it was found that anesthetics do not change the structure of homogeneous model membranes. However, it was recently found that ...
Kim Young-Woong YW Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, - - 2014
Despite the damaging effect on tissues at a high concentration, it has been gradually established that oxidative stress plays a positive role during angiogenesis. In adults, physiological or pathological angiogenesis is initiated by tissue demands for oxygen and nutrients, resulting in a hypoxia/reoxygenation cycle, which, in turn promotes the formation ...
McKinlay James B - - 2013
When starved for nitrogen, non-growing cells of the photosynthetic bacterium Rhodopseudomonas palustris continue to metabolize acetate and produce H2, an important industrial chemical and potential biofuel. The enzyme nitrogenase catalyzes H2 formation. The highest H2 yields are obtained when cells are deprived of N2 and thus use available electrons to ...
Zhou Jian-Qiao - - 2013
The objective of this study was to compare the sampling efficiency of ultrasound-guided fine-needle aspiration (FNA) and fine-needle capillary (FNC) sampling in thyroid nodules, in which the authors specifically analyzed the influence of nodule size. This study included 280 thyroid nodules in 275 consecutive patients. The nodules were divided into ...
Backenson Erica M - - 2013
Children with specific learning disabilities (SLD) have deficits in the basic psychological processes that interfere with learning and academic achievement, and for some SLD subtypes, these deficits can also lead to emotional and/or behavior problems. This study examined psychosocial functioning in 123 students, aged 6 to 11, who underwent comprehensive ...
McIntyre Brendan A S - - 2013
Production of human embryonic stem cell (hESC)-derived lung progenitors has broad applicability for drug screening and cell therapy; however, this is complicated by limitations in demarcating phenotypic changes with functional validation of airway cell types. In this paper, we reveal the potential of hESCs to produce multipotent lung progenitors using ...
Nanayakkara Charith E - - 2013
The surface photochemistry of nitric acid (HNO3) adsorbed on hematite (α-Fe2O3) particle surfaces under various environmental conditions has been investigated. Surface product formation and photochemistry of adsorbed nitrate studied using X-ray photoelectron spectroscopy (XPS). Adsorbed nitrate resulted from gas phase nitric acid adsorption showed a N1s peak at 407.4 eV. ...
Nagarajan Sangeetha - - 2013
The biosynthesis of metal nanoparticles by marine resources is thought to be clean, nontoxic, and environmentally acceptable "green procedures". Marine ecosystems are very important for the overall health of both marine and terrestrial environments. The use of natural sources like Marine biological resources essential for nanotechnology. Seaweeds constitute one of ...
Tan Binbin - - 2013
To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement ...
Chiêm Jean-Christophe - - 2013
Various elderly case management projects have been implemented in Belgium. This type of long-term health care intervention involves contextual factors and human interactions. These underlying complex mechanisms can be usefully informed with field experts' knowledge, which are hard to make explicit. However, computer simulation has been suggested as one possible ...
Yeh Yi-Chen - - 2013
Pulmonary neuroendocrine tumors have a prognostic spectrum including typical carcinoid (TC), atypical carcinoid (AC), small cell carcinoma (SCLC), and large cell neuroendocrine carcinoma (LCNEC). We conducted a retrospective study to compare their clinicopathological characteristics, immunophenotype, preoperative biopsy and frozen section diagnoses, and prognosis. Ninety cases of surgically treated pulmonary neuroendocrine ...
James-Martin G - - 2013
While advanced cancer is often associated with weight loss, curative cancer treatment is often associated with weight gain. Weight gain during treatment may be associated with greater risk of cancer recurrence and development of lifestyle diseases. Currently, limited resources are available to cancer patients focussed on weight control. This study ...
Zhuang Shendong - - 2013
The visible-light-driven photocatalytic activities of graphene-semiconductor catalysts have recently been demonstrated, however, the transfer pathway of photogenerated carriers especially where the role of graphene still remains controversial. Here we report graphene-SnO2 aerosol nanocomposites that exhibit more superior dye adsorption capacity and photocatalytic efficiency compared with pure SnO2 quantum dots, P25 ...
Sánchez-García N - - 2013
One of the fish species with the highest potential for aquaculture is the sharpsnout seabream, Diplodus puntazzo Cetti. Among other aspects, the development of new fish cultures requires studies of potential pathogens that may compromise survival of the fish in captivity. Moreover, both cultured and wild fish can act as ...
Coldman A J - - 2013
Background:Cancers not detected by breast screening are commonly assumed to have poorer prognosis.Methods:We examined the survival experience of all women aged 50-74 years diagnosed with a first breast cancer between 1998 and 2006 in British Columbia, Canada and determined their screening experience. Disease-specific survival rates were calculated and, for cases ...
Venkatesan C - - 2013
A sandwich enzyme-linked immunosorbent assay (ELISA) was developed to detect the venom of Indian cobra (Naja naja naja) in various tissues (brain, heart, lungs, liver, spleen, blood, kidneys, and tissue at the site of injection) of mice after cobra venom injected at different time intervals (0, 2, 4, 6, 8, ...
Patten S B - - 2013
In MS, transitions between working and not-working status may occur in association with depression. This can complicate patients' ability to promptly obtain disability support due to an expectation that their functioning will improve after the depression resolves, a viewpoint that sees depression assuming a role as a causal determinant of ...
Dal Molin Alberto - - 2013
To analyze the predictive validity and reliability of the Blaylock Risk Assessment Screening Score (BRASS) Index in a large group of patients. Prospective multicenter observational study was conducted in six Italian hospitals. Data were collected in three phases. Seven hundred eleven patients were recruited. The mean length of hospitalization for ...
Wu Chao-Yi - - 2013
Radiation therapy (RT) kills cancer cells by causing DNA damage, and stimulates a systemic antitumor immune response by releasing tumor antigen and endogenous adjuvant within the tumor microenvironment. However, RT also induces the recruitment of immunosuppressive myeloid cells, which can interfere with the antitumor immune responses elicited by apoptotic tumor ...
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