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Bäck Jennie - - 2013
Patients with systemic lupus erythematosus (SLE) have persistent platelet activation and an increased risk of thrombotic events, which cannot be accounted for by traditional cardiovascular risk factors. Factor (F)XII has a potentially important role in thrombus formation and is triggered by activated platelets. We therefore asked whether the contact system ...
Iwabuchi Masahiro - - 2013
Ubiquitylation is a posttranslational protein modification that modulates various cellular processes of key significance, including protein degradation and DNA damage repair. In animals subjected to transient cerebral ischemia, ubiquitin-conjugated proteins accumulate in Triton-insoluble aggregates. Although this process is widely considered to modulate the fate of postischemic neurons, few attempts have ...
Hirota-Takahata Yuki - - 2013
In the course of our screening for inhibitors of lipopolysaccharide (LPS) binding to cellular receptor CD14, potent inhibitory activity was detected in the cultured broth of Pedobacter sp. SANK 72003. Three active compounds, pedopeptin A, B and C, were isolated from the broth and their structures were elucidated by physicochemical ...
Smith Marissa N - - 2013
To fully understand the potentially harmful effects of prenatal stress exposure impacts, it is necessary to quantify long-term and episodic stress exposure during pregnancy. There is a strong body of research relating psychological stress to elevated cortisol levels in biomarkers. Recently, maternal hair has been used to measure cortisol levels, ...
- - 2013
Health unions warned last week that any proposals to change nurses' pay, terms and conditions under an independent Scotland would require staff-side negotiations.
Stovicek Jan - - 2013
Abstract Objective. Neurological complications of inflammatory bowel diseases (IBDs) are not rare but are under-diagnosed; some are probably immune-mediated. Several previous studies have suggested a higher incidence of demyelinating diseases such as multiple sclerosis in IBD patients. In this single-center, prospective, observational study, the authors focus on T2 focal white-matter ...
Liang D - - 2013
The Piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal in diverse organisms. However, data on the function of Hiwi gene (a human homologue of Piwi family) in cancer stem cells remains obscure. The aim of this study was to investigate the role ...
- - 2013
Matrons at Epsom and St Helier University Hospitals NHS Trust in Surrey have had their working hours extended to oversee care this winter.
Chambers Stuart M - - 2013
The neural crest (NC) is a transient population of multipotent cells giving rise to the peripheral nervous system, skin pigmentation, heart, and facial mesenchyme. The broad cell fate potential of NC makes it an attractive cell fate to derive from human pluripotent stem cells (hPSCs) for exploring embryonic development, modeling ...
Beck Tim - - 2013
To facilitate broad and convenient integrative visualization of and access to GWAS data, we have created the GWAS Central resource (http://www.gwascentral.org). This database seeks to provide a comprehensive collection of summary-level genetic association data, structured both for maximal utility and for safe open access (i.e., non-directional signals to fully preclude ...
Wu Lina - - 2013
Advanced methods are urgently needed to determine the identity and viability of trace amount of pathogenic bacteria in a short time. Existing approaches either fall short in the accurate assessment of microbial viability or lack of specificity in bacterial identification. Bacteriophages (or phages for short) are viruses that exclusively infect ...
Crespo Cuaresma Jesús - - 2013
The effect of changes in age structure on economic growth has been widely studied in the demography and population economics literature. The beneficial effect of changes in age structure after a decrease in fertility has become known as the "demographic dividend." In this article, we reassess the empirical evidence on ...
Woo Jacky - - 2013
Targeting the CD20 antigen has been a successful therapeutic intervention in the treatment rheumatoid arthritis (RA). However, in some patients with an inadequate response to anti-CD20 therapy, a persistence of CD20- plasmablasts are noted. The strong expression of CD319 on CD20- plasmablast and plasma cell populations in RA synovium led ...
Liu M - - 2013
Co-evolution of fungal pathogens with their host species during the domestication of modern crop varieties has likely affected the current genetic divergence of pathogen populations. The objective of this study was to determine if the evolutionary history of the obligate rust pathogen on wheat, Puccinia triticina, is correlated with adaptation ...
Arif Zeba - - 2013
In last month's long-awaited response to the Francis report, the government committed to introducing mandatory reporting of ward staff numbers.
Kalhapure Rahul S - - 2013
Abstract Dendrimers are a relatively new class of monodisperse polymers, which have tree-like spherical structures with well-defined sizes and shapes. Their unique structure has a significant impact on their physical and chemical properties. Research on dendrimers is of significant interest to scientists from all areas and their utility in various ...
Kitajima Akiko - - 2013
A new monitoring system has been established to assess low-level radioactive caesium in Fukushima waters directly using caesium adsorbents: plastic containers, U8 containers, and a germanium (Ge) detector container packed with nanoparticle-Prussian blue (PB) immobilized on a polymer. The results show that the calibration coefficient for a flow rate of ...
Nagaosa Naoto - - 2013
Magnetic skyrmions are particle-like nanometre-sized spin textures of topological origin found in several magnetic materials, and are characterized by a long lifetime. Skyrmions have been observed both by means of neutron scattering in momentum space and microscopy techniques in real space, and their properties include novel Hall effects, current-driven motion ...
Nelson M D - - 2013
Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide NLP-22 is a regulator of ...
- - 2013
Surgeons who are involved in major surgical complications often feel guilt and other emotions that can negatively effect their practice.
Liu Hai-Xia - - 2013
We report herein the designed synthesis of four silver(i)- or gold(i)-bridged flexible metalla-macrocycles (MMCs) and their distinct performance in the surface modification of gold nanoparticles (AuNPs). The resulting gold(i)-MMCs-modified AuNPs were found to be resistant to pH variation and capable of binding with metal ions.
Tereza Ulmannova - - 2013
Abstract Objective Diabetes in pregnancy is associated with increased risks of maternal as well as foetal complications. Methods Retrospective data on 96 women and 96 their newborns were anonymously statistically analysed to assess pregnancies of T1D women managed in our hospital in past nine years. The outcomes of the neonates ...
Sibbing D - - 2013
Oral anticoagulants and platelet receptor blockers are widely used in clinical practice with the aim of reducing the risk of thrombotic complications in patients with cardiovascular diseases. Their regular intake and adequate antithrombotic action is vital and this is way numerous assays have been developed for laboratory testing and monitoring ...
Tian Xiaoyu - - 2013
Recent studies have shown the feasibility of estimating patient dose from a CT exam using CTDIvol-normalized-organ dose (denoted as h), DLP-normalized-effective dose (denoted as k), and DLP-normalized-risk index (denoted as q). However, previous studies were limited to a small number of phantom models. The purpose of this work was to ...
Starmer Amy J AJ Division of General Pediatrics, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts2Doernbecher Children's Hospital, Oregon Health and Science University, - - 2013
Handoff miscommunications are a leading cause of medical errors. Studies comprehensively assessing handoff improvement programs are lacking. To determine whether introduction of a multifaceted handoff program was associated with reduced rates of medical errors and preventable adverse events, fewer omissions of key data in written handoffs, improved verbal handoffs, and ...
- - 2013
Many patients with epilepsy control their seizures by taking antiepileptic drugs (AEDs) that may accelerate bone loss and increase the risk of osteoporotic fractures.
Buchan James - - 2013
The news that one in three NHS trusts in England has recruited nurses from abroad says as much about the state of Europe as it does about the NHS.
Li Neng - - 2013
We have investigated the mechanism of densification of a nearly perfect continuous random network (CRN) model of amorphous SiO2 (a-SiO2) glass with 1296 atoms and periodic boundary conditions. The model has no under- or over-coordinated atoms and small bond length and bond angle distributions. This near-perfect model is systematically densified ...
Imura Takayuki - - 2013
Leucocytozoon caulleryi, a haemosporidian parasite of the chicken (Gallus gallus domesticus), can be highly pathogenic and often fatal. Although this parasite is extremely relevant to veterinary science, knowledge of its genomic features is limited. To gain information applicable to developing novel control methods for the parasite, we analyzed the apicoplast ...
Gillen Sally - - 2013
England's most senior nurse has urged all hospitals to publish a range of information each month that will 'shine a light' on the care they provide.
Kalimeris K - - 2013
Background: Sevoflurane exerts effects on pulmonary cells that could protect against lung injury. We evaluated the potential of pretreatment with sevoflurane to attenuate lipopolysaccharide (LPS)-induced lung injury. Methods: LPS was administered intratracheally in Wistar rats to induce lung injury. Sevoflurane was administered for 30 min at 0.25, 0.5 or 1.0 ...
Chilajwar Sai V - - 2013
Introduction: Recently, Nanotechnology is receiving considerable acknowledgment due to its potential to combine features that are difficult to achieve by making use of a drug alone. Cyclodextrin-based nanosponges are yet another contemporary approach for highlighting the advancements which could be brought about in a drug delivery system. Statistical analyses have ...
Wang Meng - - 2013
High-temperature superconductivity in iron pnictides occurs when electrons and holes are doped into their antiferromagnetic parent compounds. Since spin excitations may be responsible for electron pairing and superconductivity, it is important to determine their electron/hole-doping evolution and connection with superconductivity. Here we use inelastic neutron scattering to show that while ...
List Tricia - - 2013
During the final week of my community placement, I accompanied my mentor to see an elderly lady who was reaching the end of her life. I will call her Ann.
Sarcher Christian - - 2013
Gold(i) complexes ligated by phosphines with N-heterocycles in the periphery were prepared. First the synthesis of the ligands N-(diphenylphosphino)-4-(pyridin-2-yl)pyrimidin-2-amine (Hpypya) and N-(diphenylphosphino)-4-phenylpyrimidin-2-amine (Hphpya) are reported. These two compounds together with the related but earlier published ligands 3-(2-(diphenylphosphino)phenyl)-1H-pyrazole (Hph3py) and 5-(4-(diphenylphosphino)phenyl)-1H-pyrazole (Hph5py) were reacted with [(tht)AuCl] and [Au(tht)2]ClO4 to give the ...
Li X - - 2013
Though the overall incidence of gastric cancer was decreasing in the developed countries in the past decades, it is still a serious threat to human health throughout the world. The molecular mechanisms underlying development of gastric cancer remains unclear. Though accumulating evidences shed a light on the implications of mitochondrial tumor suppressor ...
- - 2013
Rates of testosterone therapy have increased markedly in the United States over the past decade, with annual prescriptions reaching 5.3 million in 2011.
Benjamin Caroline - - 2013
This is the seventh article in a series examining how nurses can develop confidence and competence in genetics and genomics health care. This article focuses on identifying the nurse's awareness of genetic and genomic issues and the effect this has on his or her practice. It considers the importance of ...
Sheng H - - 2013
Transmembrane protease, serine 4 (TMPRSS4), is a novel type of II transmembrane serine protease that is highly expressed in multiple cancers. However the expression pattern and clinical significance of TMPRSS4 in gastric cancer (GC) remain unclear. We aimed to investigate the clinical and prognostic importance of TMPRSS4 in GC. We performed ...
Gillen Sally - - 2013
Health secretary Jeremy Hunt's announcement that every hospital patient is to have the name of their nurse placed above their bed came as a surprise to many especially those who for years have been doing just that.
Delancey Marian - - 2013
The government's response to the Francis report (Editorial, News and Analysis November 27) sounds promising, but does this mean that yet more administration staff will need to be employed to ascertain and publish the figures and data on staffing levels?
Martins Ana M - - 2013
Biomimetic calcium phosphate coating (CaP) methodology mimics the natural biomineralization process of bone, which involves two phases: nucleation and growth. In this chapter we present a successful method to coating biodegradable natural-origin materials with biomimetic CaP layer as a strategy to incorporate enzymes with the main aim of controlling and ...
Yousuf Seema - - 2013
We evaluated the neuroprotective effects of delayed progesterone (PROG) treatment against ischemic stroke-induced neuronal death, inflammation, and functional deficits. We induced transient focal cerebral ischemia in male rats and administered PROG (8 mg/kg) or vehicle intraperitoneally at 3, 6, or 24 hours post occlusion, subcutaneously 5 hours later and then every 24 hours for ...
- - 2013
Peter Wing reflects on his interesting and somewhat dysfunctional life working as cabin crew, nurse and charity worker, inviting us on a journey through the highs and lows of his professional and personal life.
Gemming L - - 2013
Background/Objectives:The most recent New Zealand Adult Nutrition Survey 2008/09 (ANS 08/9) revealed a decrease in reported energy intakes (EIs) compared with the previous 1997 National Nutrition Survey (NNS97). Conversely, measured body weights increased over the same period. We conducted an analysis on the ANS 08/9 data sets to evaluate reported ...
Arcau Julià - - 2013
The synthesis and characterization of three propynyloxycoumarins are reported in this work together with the formation of three different series of gold(i) organometallic complexes. Neutral complexes are constituted by water soluble phosphines (PTA and DAPTA) which confer water solubility to them. The X-ray crystal structure of 7-(prop-2-in-1-yloxy)-1-benzopyran-2-one and its corresponding ...
Bodmann Eva-Lisa - - 2013
Some G‑protein‑coupled receptors regulate biological processes via Gα12/13‑ or Gαq/11‑mediated stimulation of Rho guanine nucleotide exchange factors (RhoGEFs). p63RhoGEF is known to be specifically activated by Gαq/11 and mediates a major part of the acute response of vascular smooth muscle cells to Angiotensin II treatment. In order to gain information ...
Sahmay S - - 2013
Abstract Objectives: A significant number of individuals have high serum follicle-stimulating hormone (FSH) level but do not meet the criteria for diagnosis of premature ovarian insufficiency (POI) due to ongoing menstruation. We compared a group of women with elevated FSH levels (EFSH) and POI with a control group in terms ...
- - 2013
A ward sister who improved older people's care by changing the ward culture has become RCN Wales's nurse of the year.
Evans Roger - - 2013
The London-based College of Health Care Chaplains is a multi-faith, interdenominational organisation open to paid and voluntary healthcare chaplaincy staff and those with an interest in this area. It is a professional section of Unite, the UK's largest trades union.
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