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Ortiz-Masiá D - - 2013
A defective induction of epithelial autophagy may have a role in the pathogenesis of inflammatory bowel diseases. This process is regulated mainly by extracellular factors such as nutrients and growth factors and is highly induced by diverse situations of stress. We hypothesized that epithelial autophagy is regulated by the immune ...
Bacher P - - 2013
Foxp3(+) regulatory T cells (Treg) have a central role for keeping the balance between pro- and anti-inflammatory immune responses against chronically encountered antigens at mucosal sites. However, their antigen specificity especially in humans is largely unknown. Here we used a sensitive enrichment technology for antigen-reactive T cells to directly compare ...
Xu J B - - 2013
This article aimed to investigate the value of α-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC) and to evaluate the relationship between AFP and various clinical variables of HCC comprehensively. A retrospective study of postoperative patients diagnosed with liver neoplasm from two Chinese centers was enrolled in our study.A ...
Sheng H - - 2013
Transmembrane protease, serine 4 (TMPRSS4), is a novel type of II transmembrane serine protease that is highly expressed in multiple cancers. However the expression pattern and clinical significance of TMPRSS4 in gastric cancer (GC) remain unclear. We aimed to investigate the clinical and prognostic importance of TMPRSS4 in GC. We performed ...
Mei H - - 2013
Overexpression of anti-apoptotic Bcl-2 proteins is commonly observed in a variety of cancers and associated with resistance to conventional chemotherapeutic drugs. Targeting multiple anti-apoptotic proteins is now possible with the small molecule BH3 domain mimetics such as AT-101. Autophagy has been found to function as a resistance mechanism against apoptotic cell death. ...
Yang Z - - 2013
The WW domain-containing oxidoreductase (WWOX) gene is a candidate tumor suppressor gene. However, its exact mechanism is unclear. This study aimed to investigate the role of the WWOX gene in the development of nasopharyngeal carcinoma (NPC). Tissues were collected from 65 NPC patients. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry ...
Liang D - - 2013
The Piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal in diverse organisms. However, data on the function of Hiwi gene (a human homologue of Piwi family) in cancer stem cells remains obscure. The aim of this study was to investigate the role ...
Zhang H - - 2013
Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapy. In present study, we identified a subpopulation of cells isolated from the A549 cell line with marker CD133. In vivo results showed that A549 CD133+ cells displayed high ...
Kusenda J - - 2013
In this review, we discuss methodological principles and clinical applications of minimal residual disease (MRD) assays based on multiparameter flow cytometry (MFC). The introduction of methods for MRD detection has revolutionized monitoring of treatment response in acute leukemia. Great progress has been made in the development of wide array of ...
Luo Guan-Zheng - - 2013
Integrative Short Reads NAvigator (ISRNA) is an online toolkit for analyzing high-throughput small RNA sequencing data. Besides the high-speed genome mapping function, ISRNA provides statistics for genomic location, length distribution and nucleotide composition bias analysis of sequence reads. Number of reads mapped to known microRNAs and other classes of short ...
Liu Hai-Xia - - 2013
We report herein the designed synthesis of four silver(i)- or gold(i)-bridged flexible metalla-macrocycles (MMCs) and their distinct performance in the surface modification of gold nanoparticles (AuNPs). The resulting gold(i)-MMCs-modified AuNPs were found to be resistant to pH variation and capable of binding with metal ions.
Koyama D - - 2013
The Notch signaling pathway has been recognized as a key player for the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL), because of the high incidence of activating mutations of Notch1. Notch inhibition could serve as a new treatment strategy for T-ALL; however, the attempts to perturb Notch signaling pathways have ...
Valentine M C - - 2013
Infant leukemia (IL) is a rare sporadic cancer with a grim prognosis. While most cases are accompanied by MLL-rearrangements and harbor very few somatic mutations; less is known about the genetics of the cases without MLL translocations. We performed the largest exome sequencing study to date on matched non-cancer DNA ...
Pietropolli Adalgisa - - 2013
Abstract This study reports a comparative analysis between results of transabdominal coelocentesis and traditional invasive procedure in order to assess the usefulness of coelocentesis as a source of fetal DNA for molecular and chromosomal analysis. A number of 28 women were included in the study. A successful sampling of coelomic ...
Song Lingjie - - 2013
Development of technologies for biomedical detection platform is critical to meet the global challenges of various disease diagnoses, especially for point-of-use applications. Due to its natural of simplicity, effectiveness and easy repeatability, random covalent-binding technique is widely adopted in antibody immobilization. However, its antigen-binding capacity is relatively low when compared ...
Martin-Hirsch Pierre Pl - - 2013
Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. Atypical squamous changes occur in the transformation zone of the cervix with mild, moderate or severe changes described by their depth (CIN 1, 2 or 3). Cervical intraepithelial neoplasia is treated by local ablation or lower morbidity excision techniques. Choice ...
Chilajwar Sai V - - 2013
Introduction: Recently, Nanotechnology is receiving considerable acknowledgment due to its potential to combine features that are difficult to achieve by making use of a drug alone. Cyclodextrin-based nanosponges are yet another contemporary approach for highlighting the advancements which could be brought about in a drug delivery system. Statistical analyses have ...
Kitajima Akiko - - 2013
A new monitoring system has been established to assess low-level radioactive caesium in Fukushima waters directly using caesium adsorbents: plastic containers, U8 containers, and a germanium (Ge) detector container packed with nanoparticle-Prussian blue (PB) immobilized on a polymer. The results show that the calibration coefficient for a flow rate of ...
Tereza Ulmannova - - 2013
Abstract Objective Diabetes in pregnancy is associated with increased risks of maternal as well as foetal complications. Methods Retrospective data on 96 women and 96 their newborns were anonymously statistically analysed to assess pregnancies of T1D women managed in our hospital in past nine years. The outcomes of the neonates ...
Crespo Cuaresma Jesús - - 2013
The effect of changes in age structure on economic growth has been widely studied in the demography and population economics literature. The beneficial effect of changes in age structure after a decrease in fertility has become known as the "demographic dividend." In this article, we reassess the empirical evidence on ...
Chen Li - - 2013
The Air Quality Health Index (AQHI) is an aggregate measure of outdoor air quality. We investigated associations between the AQHI and emergency department (ED) visits for acute ischemic stroke to validate the AQHI as a predictor of risk of morbidity from stroke. ED visits in Edmonton, Canada between 1998 and ...
Gayoso Carmen María - - 2013
Desiccation tolerance contributes to the maintenance of bacterial populations in hospital settings and may partly explain its propensity to cause outbreaks. Identification and relative quantitation of proteins involved in bacterial desiccation tolerance was made using label free quantitation and iTRAQ labelling. Under desiccating conditions, the population of the Acinetobacter baumannii ...
Yao Jiayun - - 2013
Exposure to forest fire smoke (FFS) is associated with a range of adverse health effects. The British Columbia Asthma Medication Surveillance (BCAMS) product was developed to detect potential impacts from FFS in British Columbia (BC), Canada. However, it has been a challenge to estimate FFS exposure with sufficient spatial coverage ...
Pugh Thomas - - 2013
The three-coordinate iron(ii) NHC complexes [(IPr)Fe(N'')2] () and [(I(t)Bu)Fe(N'')2] () (N'' = N(SiMe3)2) react with PhSeH or LiSePh to give the iron(ii) selenolates [(IPr)Fe(N'')(SePh)] () and [I(t)Bu(H)][(aI(t)Bu)Fe(SePh)3], [I(t)Bu(H)][], with complex containing an abnormal NHC ligand.
Giuliani Anna Rita - - 2013
On 6 April 2009, the city of L'Aquila was hit by a violent earthquake that destroyed almost all of its medieval centre, and the surviving inhabitants were evacuated and relocated in temporary quarters or undamaged homes. The aim of this study was to investigate the perceived quality of life of ...
Park Katya J - - 2013
White matter sparing after traumatic brain injury (TBI) is an important predictor of survival and outcome. Blood vessels and axons are intimately associated anatomically and developmentally. Neural input is required for appropriate vascular patterning, and vascular signaling is important for neuron development and axon growth. Owing to this codependence between ...
Allard Camille - - 2013
Hypothalamic glucose detection participates in maintaining glycemic balance, food intake, and thermogenesis. Although hypothalamic neurons are the executive cells involved in these responses, there is increasing evidence that astrocytes participate in glucose sensing (GS); however, it is unknown whether astroglial networking is required for glucose sensitivity. Astroglial connexins 30 and ...
Sahmay S - - 2013
Abstract Objectives: A significant number of individuals have high serum follicle-stimulating hormone (FSH) level but do not meet the criteria for diagnosis of premature ovarian insufficiency (POI) due to ongoing menstruation. We compared a group of women with elevated FSH levels (EFSH) and POI with a control group in terms ...
Famakin Bolanle M - - 2013
To better understand the role of downstream Toll-like receptor (TLR) signaling during acute cerebral ischemia, we performed cDNA microarrays, on brain RNA, and cytokine arrays, on serum, from wild type (WT), MyD88-/- and TRIF-mutant mice, at baseline and following permanent middle cerebral artery occlusion (pMCAO). The acute stress response pathway ...
Chen F-P - - 2013
Abstract Objective: To explore the effect and pathway of phytoestrogens on the growth of breast cancer cell line MCF-7. Methods: MCF-7 cells (human estrogen -receptor-positive and progesterone-receptor-positive breast cancer cells) were cultured in serum-free medium for 24 h and then treated with genistein, resveratrol, and quercetin (10(-10) to 10(-4) M). After ...
Curless Liam D - - 2013
In the presence of B(C6F5)3 five-membered heteroarenes undergo dehydrosilylation and hydrosilylation with silanes. The former, favoured on addition of a weak base, produces H2 as a by-product making the process catalytic in B(C6F5)3 but also enabling competitive heteroarene hydrogenation.
Gobrogge Kyle L - - 2013
Prairie voles (Microtus ochrogaster) are a rodent species that display socially monogamous pair-bonds, a behavior illustrated by several types of social interactions such as mating-induced partner preference, selective aggression toward conspecific strangers, and bi-parental care. Therefore, this species has provided an excellent opportunity for the study of pair-bonding and its ...
Hirota-Takahata Yuki - - 2013
In the course of our screening for inhibitors of lipopolysaccharide (LPS) binding to cellular receptor CD14, potent inhibitory activity was detected in the cultured broth of Pedobacter sp. SANK 72003. Three active compounds, pedopeptin A, B and C, were isolated from the broth and their structures were elucidated by physicochemical ...
O'Brien Robert V - - 2013
The increasing availability of DNA sequence data offers an opportunity for identifying new assembly-line polyketide synthases (PKSs) that produce biologically active natural products. We developed an automated method to extract and consolidate all multimodular PKS sequences (including hybrid PKS/non-ribosomal peptide synthetases) in the National Center for Biotechnology Information (NCBI) database, ...
Tian Xiaoyu - - 2013
Recent studies have shown the feasibility of estimating patient dose from a CT exam using CTDIvol-normalized-organ dose (denoted as h), DLP-normalized-effective dose (denoted as k), and DLP-normalized-risk index (denoted as q). However, previous studies were limited to a small number of phantom models. The purpose of this work was to ...
Siegrist M - - 2013
Objective:Childhood obesity is associated with an impaired retinal microcirculation. The aim of the study was to investigate the association between specific obesity-related biomarkers, physical fitness and retinal vessel diameters in school children.Design and Subjects:We studied 381 children aged 10 to 11 years (body mass index: 19.3±3.7 kg/m(2)) in a school-based setting.Measurements:Anthropometric ...
Fuller N R - - 2013
Background:Due to the high prevalence of overweight and obesity there is a need to identify cost-effective approaches for weight loss in primary care and community settings.Objective:To evaluate the long-term cost-effectiveness of a commercial weight loss programme (Weight Watchers) (CP) compared with standard care (SC), as defined by national guidelines.Methods:A Markov ...
Lamart Stephanie - - 2013
Following cancer radiotherapy, reconstruction of doses to organs, other than the target organ, is of interest for retrospective health risk studies. Reliable estimation of doses to organs that may be partially within or fully outside the treatment field requires reliable knowledge of the location and size of the organs, e.g., ...
Liu M - - 2013
Co-evolution of fungal pathogens with their host species during the domestication of modern crop varieties has likely affected the current genetic divergence of pathogen populations. The objective of this study was to determine if the evolutionary history of the obligate rust pathogen on wheat, Puccinia triticina, is correlated with adaptation ...
Samarajeewa Sandani - - 2013
Electrostatic interaction-mediated enzymatic-hydrolysis of poly(lactide)-containing nanoscale assemblies is described. At physiological pH, degradable core-shell morphologies with charged shells can readily attract or repel enzymes carrying opposite or similar charges, respectively.
Yanai Anat - - 2013
Transplantation of photoreceptor precursor cells (PPCs) differentiated from human embryonic stem cells (hESCs) is a promising approach to treat common blinding diseases such as age-related macular degeneration and retinitis pigmentosa. However, existing PPC generation methods are inefficient. To enhance differentiation protocols for rapid and high-yield production of PPCs, we focused ...
Degrolard-Courcet Emilie - - 2013
Fanconi anaemia (FA) is characterized by progressive bone marrow failure, congenital anomalies, and predisposition to malignancy. In a minority of cases, FA results from biallelic FANCD1/BRCA2 mutations that are associated with early-onset leukaemia and solid tumours. Here, we describe the clinical and molecular features of a remarkable family presenting with ...
Coppin Lucie - - 2013
The identification of Von Hippel-Lindau (VHL) mosaic mutations by conventional Sanger sequencing requires a labour-intensive enrichment step, thus explaining that mosaicism occurrence is underestimated in patients. Nowadays, it is possible to detect mutation in cell sub-populations by next-generation sequencing (NGS). Here, we described a diagnosis strategy using NGS with high ...
Dreesen Jos - - 2013
Preimplantation genetic diagnosis (PGD) for monogenic disorders currently involves polymerase chain reaction (PCR)-based methods, which must be robust, sensitive and highly accurate, precluding misdiagnosis. Twelve adverse misdiagnoses reported to the ESHRE PGD-Consortium are likely an underestimate. This retrospective study, involving six PGD centres, assessed the validity of PCR-based PGD through ...
Petersen Bent Ole - - 2013
Complex mixtures of carbohydrates pose distinct challenges in routine and high-throughput analysis, so that only a few carbohydrate components are routinely resolved and identified in biofluids, extracts, foods and other complex mixtures. Here, we conduct precise measurements of (1)H and (13)C anomeric chemical shifts to construct a reference library of ...
Chen Kuan Ling - - 2013
Neutron production is of concern for proton therapy, especially for passive scattering proton beam delivery methods. The levels of neutron dose equivalent vary significantly with system design and treatment parameters. The purpose of this study was to examine neutron dose equivalent per therapeutic dose (H/D) around the Mevion S250 proton ...
Spieth P - - 2013
Mechanical ventilation may induce or aggravate lung injury - a phenomenon known as ventilator induced lung injury (VILI). On a macroscopic level, the effects of mechanical stress and strain on lung tissue are well described. Increased tidal volumes may lead to volutrauma, raised airway pressures may cause barotrauma and cyclic ...
Ochs Christopher J - - 2013
We developed a computational model to predict oxygen levels in microfluidic plastic devices during cell culture. This model is based on experimental evaluation of oxygen levels. Conditions are determined that provide adequate oxygen supply to two cell types, hepatocytes and endothelial cells, either by diffusion through the plastic device, or ...
Forbes Dorothy - - 2013
This is an update of our previous 2008 review. Several recent trials and systematic reviews of the impact of exercise on people with dementia are reporting promising findings.  OBJECTIVES: Primary: Do exercise programs for older people with dementia improve cognition, activities of daily living (ADLs), challenging behaviour, depression, and mortality ...
Zhong S - - 2013
Background/Objectives:Epidemiologic findings concerning the association between coffee consumption and prostate cancer risk yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies.Subjects/Methods:We searched PubMed, Web of Science and EMBASE for studies published up to July 2013. We calculated the summary relative risk (RR) ...
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