Search Results
Results 51 - 100 of 4133
1 2 3 4 5 6 7 8 9 10 >
Oben Jolien - - 2013
Abstract Objective - In this study we determine whether maternal cardiovascular profiling can detect first trimester differences between women with uncomplicated pregnancies (UP) and those who will develop gestational hypertensive disorders (GHD) or normotensive fetal growth retardation (FGR). Methods - Cardiac, arterial, and venous function were evaluated in 242 pregnant ...
Voruganti V Saroja - - 2013
Increased serum uric acid (SUA) or hyperuricemia, a risk factor for gout, renal and cardiovascular diseases, is caused by either increased production or decreased excretion of uric acid or a mix of both. The solute carrier protein 2 family, member 9 (SLC2A9) gene encodes a transporter that mediates urate flux ...
Singh Jay - - 2013
In this paper, we present results of the studies related to fabrication of a rare earth metal oxide based efficient biosensor using an interface based on hydrothermally prepared nanostructured thulium oxide (n-Tm2O3). A colloidal solution of prepared nanorods has been electrophoretically deposited (EPD) onto an indium-tin-oxide (ITO) glass substrate. The ...
- - 2013
Women admitted to hospital during pregnancy for reasons other than delivery have an increased risk of blood clots, according to a UK study.
Turner Steve - - 2013
Peter Cheese (Letters September 18) says zero-hours contracts can work for employers and employees. As chief executive of the Chartered Institute of Personnel and Development, he claims that zero-hours contracts have been 'unfairly demonised'.
Li J - - 2013
Increased expression of STMN1 has been observed in many tumor forms, but its expression and potential biological role in pancreatic cancer is still unknown. In this study, we demonstrated that STMN1 was expressed to a large extent in pancreatic cancer tissues and cell lines as compared to normal pancreatic tissues. Suppression of STMN1 ...
Yao Jiayun - - 2013
Exposure to forest fire smoke (FFS) is associated with a range of adverse health effects. The British Columbia Asthma Medication Surveillance (BCAMS) product was developed to detect potential impacts from FFS in British Columbia (BC), Canada. However, it has been a challenge to estimate FFS exposure with sufficient spatial coverage ...
Hara Toru - - 2013
Ultrabrilliant, femtosecond X-ray pulses from X-ray free-electron lasers (XFELs) have promoted the investigation of exotic interactions between intense X-rays and matters, and the observation of minute targets with high spatio-temporal resolution. Although a single X-ray beam has been utilized for these experiments, the use of multiple beams with flexible and ...
Esser Diederik - - 2013
Flavanol-enriched chocolate consumption increases endothelium-dependent vasodilation. Most research so far has focused on flow-mediated dilation (FMD) only; the effects on other factors relevant to endothelial health, such as inflammation and leukocyte adhesion, have hardly been addressed. We investigated whether consumption of regular dark chocolate also affects other markers of endothelial ...
Pietropolli Adalgisa - - 2013
Abstract This study reports a comparative analysis between results of transabdominal coelocentesis and traditional invasive procedure in order to assess the usefulness of coelocentesis as a source of fetal DNA for molecular and chromosomal analysis. A number of 28 women were included in the study. A successful sampling of coelomic ...
Martin-Hirsch Pierre Pl - - 2013
Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. Surgical treatments for CIN are commonly associated with blood loss. To assess the effectiveness and safety of interventions for preventing blood loss during the treatment of CIN. We searched the Cochrane Gynaecological Cancer Group Trials Register, MEDLINE, EMBASE and CENTRAL ...
Owen Michael - - 2013
Rachel Potter (Letters November 13) asks what should nurses do when they have reported instances of unsafe staffing to managers and their concerns have been ignored?
Chen Kuan Ling - - 2013
Neutron production is of concern for proton therapy, especially for passive scattering proton beam delivery methods. The levels of neutron dose equivalent vary significantly with system design and treatment parameters. The purpose of this study was to examine neutron dose equivalent per therapeutic dose (H/D) around the Mevion S250 proton ...
Song Lingjie - - 2013
Development of technologies for biomedical detection platform is critical to meet the global challenges of various disease diagnoses, especially for point-of-use applications. Due to its natural of simplicity, effectiveness and easy repeatability, random covalent-binding technique is widely adopted in antibody immobilization. However, its antigen-binding capacity is relatively low when compared ...
Curless Liam D - - 2013
In the presence of B(C6F5)3 five-membered heteroarenes undergo dehydrosilylation and hydrosilylation with silanes. The former, favoured on addition of a weak base, produces H2 as a by-product making the process catalytic in B(C6F5)3 but also enabling competitive heteroarene hydrogenation.
Sprinks Jennifer - - 2013
A mental health trust's pilot scheme to make some of its hospital grounds smoke free has reduced the incidence of violence among patients, according to the nurse who led the project.
Allen Daniel - - 2013
'Try to do at least four times more preparation than you think is enough,' says career strategist John Lees, author of How to Get a Job You'll Love.
Kuroshima S - - 2013
Administration of intermittent parathyroid hormone (PTH) promoted healing of tibial osseous defects and tooth extraction wounds and prevented the development of necrotic lesions in rats on a combined bisphosphonate and steroid regimen. Osteonecrosis of the jaw (ONJ) has emerged in association with antiresorptive therapies. The pathophysiology of ONJ is unknown ...
Allard Camille - - 2013
Hypothalamic glucose detection participates in maintaining glycemic balance, food intake, and thermogenesis. Although hypothalamic neurons are the executive cells involved in these responses, there is increasing evidence that astrocytes participate in glucose sensing (GS); however, it is unknown whether astroglial networking is required for glucose sensitivity. Astroglial connexins 30 and ...
Fuller N R - - 2013
Background:Due to the high prevalence of overweight and obesity there is a need to identify cost-effective approaches for weight loss in primary care and community settings.Objective:To evaluate the long-term cost-effectiveness of a commercial weight loss programme (Weight Watchers) (CP) compared with standard care (SC), as defined by national guidelines.Methods:A Markov ...
Deane Richard P RP Department of Obstetrics and Gynecology, Trinity College, University of Dublin, Coombe Women and Infants University Hospital, Dublin, - - 2013
Student attendance is thought to be an important factor in the academic performance of medical students, in addition to having important regulatory, policy, and financial implications for medical educators. However, this relationship has not been well evaluated within clinical learning environments. To evaluate the relationship between student attendance and academic ...
Leijtens Tomas - - 2013
The power conversion efficiency of hybrid solid-state solar cells has more than doubled from 7 to 15% over the past year. This is largely as a result of the incorporation of organometallic trihalide perovskite absorbers into these devices. But, as promising as this development is, long-term operational stability is just ...
Sloan Paul - - 2013
Chronic pain is frequently treated with our most potent analgesics, the opioids. While immediate-release opioids given every 3 - 4 h provide adequate analgesia for most patients with cancer pain and some patients with chronic nonmalignant pain, extended-release (ER) opioid formulations have been developed in the hope that patients with ...
Ortiz-Masiá D - - 2013
A defective induction of epithelial autophagy may have a role in the pathogenesis of inflammatory bowel diseases. This process is regulated mainly by extracellular factors such as nutrients and growth factors and is highly induced by diverse situations of stress. We hypothesized that epithelial autophagy is regulated by the immune ...
Tang Yue - - 2013
Abstract This study aims to develop oseltamivir phosphate (OP) liposomes as inhalation powders by spray-drying based on the single factor investigation, which was mainly composed of lactose, l-leucine and mannitol. It was found that the ratio of OP and liposomes (1:10), inlet temperature (110 °C) and airflow rate (2.3 mL/min) showed optimized ...
Li L - - 2013
Extranodal natural killer (NK)/T-cell lymphoma (ENKL) is an aggressive neoplasm with poor prognosis. Currently, there is no consensus on the optimal treatment of this disease. In this study, we report the efficacy of a pegaspargase (PEG-Asp)-based chemotherapy, a DDGP regimen (PEG-Asp, dexamethasone, cisplatin, gemcitabine), for the treatment of newly-diagnosed ENKL. From August ...
García-Vázquez V - - 2013
Intra-operative electron radiation therapy (IOERT) combines surgery and ionizing radiation applied directly to an exposed unresected tumour mass or to a post-resection tumour bed. The radiation is collimated and conducted by a specific applicator docked to the linear accelerator. The dose distribution in tissues to be irradiated and in organs ...
Huang Shouqiang - - 2013
Upconversion photocatalysts have the potential to absorb the near-infrared (NIR) light in solar energy and improve the photocatalytic performance. A hierarchical upconversion photocatalyst of BiVO4 (BVO)/CaF2:Er(3+), Tm(3+), Yb(3+) (CF) combined with the narrow-band semiconductor of BVO and the luminescence agent of CF to enhance upconversion properties was synthesized via the ...
Kusenda J - - 2013
In this review, we discuss methodological principles and clinical applications of minimal residual disease (MRD) assays based on multiparameter flow cytometry (MFC). The introduction of methods for MRD detection has revolutionized monitoring of treatment response in acute leukemia. Great progress has been made in the development of wide array of ...
Spieth P - - 2013
Mechanical ventilation may induce or aggravate lung injury - a phenomenon known as ventilator induced lung injury (VILI). On a macroscopic level, the effects of mechanical stress and strain on lung tissue are well described. Increased tidal volumes may lead to volutrauma, raised airway pressures may cause barotrauma and cyclic ...
Inesi Giuseppe G California Pacific Medical Center Research Institute, 475 Brannan Street, San Francisco, CA, 94107, USA, - - 2014
The Ca(2+) transport ATPase (SERCA) of sarcoplasmic reticulum (SR) plays an important role in muscle cytosolic signaling, as it stores Ca(2+) in intracellular membrane bound compartments, thereby lowering cytosolic Ca(2+) to induce relaxation. The stored Ca(2+) is in turn released upon membrane excitation to trigger muscle contraction. SERCA is activated ...
Nehring I - - 2013
Background/objective:Anorexia nervosa (AN) is a severe eating disorder with a high mortality rate. Treatment regimes show regional and global variation and are sometimes supported by enteral feeding (EF) via nasogastric tube, although risks and benefits are still unclear. We aimed to find out whether EF improves growth and AN recovery ...
Wang Lin - - 2013
We demonstrated, for the first time, that the short antimicrobial peptide Tet213 could be conjugated onto the silicon surface by Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC). The modified surface exhibited excellent antimicrobial activity against S. aureus and E. coli, and low cytotoxicity to rat bone mesenchymal stem cells (rBMSCs).
Martin-Hirsch Pierre Pl - - 2013
Cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion. Atypical squamous changes occur in the transformation zone of the cervix with mild, moderate or severe changes described by their depth (CIN 1, 2 or 3). Cervical intraepithelial neoplasia is treated by local ablation or lower morbidity excision techniques. Choice ...
Chen Li - - 2013
The Air Quality Health Index (AQHI) is an aggregate measure of outdoor air quality. We investigated associations between the AQHI and emergency department (ED) visits for acute ischemic stroke to validate the AQHI as a predictor of risk of morbidity from stroke. ED visits in Edmonton, Canada between 1998 and ...
Mooney Tracy - - 2013
Bell's palsy (idiopathic facial paralysis) is the most common cause of acute unilateral facial nerve paralysis. Although it is usually a self-limiting condition, it can be distressing for the patient. Many people who experience one-sided facial paralysis fear that it is a symptom of stroke. However, there are subtle differences ...
Döcker Dennis - - 2013
SATB2 is an evolutionarily highly conserved chromatin remodeling gene located on chromosome 2q33.1. Vertebrate animal models have shown that Satb2 has a crucial role in craniofacial patterning and osteoblast differentiation, as well as in determining the fates of neuronal projections in the developing neocortex. In humans, chromosomal translocations and deletions ...
O'Brien Robert V RV Department of Chemistry, Stanford University, Stanford, CA, - - 2014
The increasing availability of DNA sequence data offers an opportunity for identifying new assembly-line polyketide synthases (PKSs) that produce biologically active natural products. We developed an automated method to extract and consolidate all multimodular PKS sequences (including hybrid PKS/non-ribosomal peptide synthetases) in the National Center for Biotechnology Information (NCBI) database, ...
Curtis J Randall JR Harborview Medical Center, Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, Seattle2Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, - - 2013
Communication about end-of-life care is a core clinical skill. Simulation-based training improves skill acquisition, but effects on patient-reported outcomes are unknown. To assess the effects of a communication skills intervention for internal medicine and nurse practitioner trainees on patient- and family-reported outcomes. Randomized trial conducted with 391 internal medicine and ...
Eguren Manuel - - 2013
The E3-ubiquitin ligase APC/C-Cdh1 is essential for endoreduplication but its relevance in the mammalian mitotic cell cycle is still unclear. Here we show that genetic ablation of Cdh1 in the developing nervous system results in hypoplastic brain and hydrocephalus. These defects correlate with enhanced levels of Cdh1 substrates and increased ...
Ochs Christopher J - - 2013
We developed a computational model to predict oxygen levels in microfluidic plastic devices during cell culture. This model is based on experimental evaluation of oxygen levels. Conditions are determined that provide adequate oxygen supply to two cell types, hepatocytes and endothelial cells, either by diffusion through the plastic device, or ...
Kim Donghyuk - - 2013
Mesoporous silica nanoparticles are promising drug delivery agents; however, their interaction with various in vivo biological components is still under investigation. In this work, the impact of sub-50 nm diameter mesoporous silica nanoparticles on platelet function is investigated using a microfluidic platform to model blood vessel characteristics. Platelet adhesion and ...
Yang L - - 2013
Exposure to aflatoxins is strongly associated with hepatocellular carcinoma (HCC). Hepatic progenitor cells have been suggested to participate in the development of HCC. To further explore the molecular basis of aflatoxin-induced carcinogenesis, we utilized transcriptome profiles to examine the global gene expression alterations of malignant transformed rat hepatic stem-like cells. ...
- - 2013
Three quarters of UK lung cancer patients do not have regular access to 'vital' clinical nurse specialists, a new report reveals.
- - 2013
Courses, events, grants, and awards to progress your career.
Pedreira Denise A L - - 2013
Abstract Objective: To report our preliminary clinical experience in the antenatal correction of open spina bifida using a fetoscopic approach and a simplified closure technique. Methods: Four fetuses with lumbar-sacral defects were operated in utero from 25 to 27 weeks. Surgeries were performed percutaneously under general anesthesia using three trocars ...
Mei H - - 2013
Overexpression of anti-apoptotic Bcl-2 proteins is commonly observed in a variety of cancers and associated with resistance to conventional chemotherapeutic drugs. Targeting multiple anti-apoptotic proteins is now possible with the small molecule BH3 domain mimetics such as AT-101. Autophagy has been found to function as a resistance mechanism against apoptotic cell death. ...
Giuliani Anna Rita - - 2013
On 6 April 2009, the city of L'Aquila was hit by a violent earthquake that destroyed almost all of its medieval centre, and the surviving inhabitants were evacuated and relocated in temporary quarters or undamaged homes. The aim of this study was to investigate the perceived quality of life of ...
Bates Jane - - 2013
What is it about me and Friday afternoons? I am not superstitious, but it feels as though the most eagerly-awaited time of the working week for most of the population has become my nemesis.
Sim Michael W - - 2013
Introduction: Thyroid cancer represents over 90% of all endocrine malignancies, with medullary thyroid carcinoma (MTC) accounting for 5 - 9% of them. Patients with early-stage disease have a favorable prognosis, but once distant metastasis develops, survival drops to 50% or less. Although surgery remains effective for early-stage disease, patients with ...
1 2 3 4 5 6 7 8 9 10 >