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Results 451 - 500 of 4133
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Nakamura Takashi - - 2013
Coordination-driven self-assembly utilizing labile capping ligands has been exploited as a novel strategy for metallo-cage containers. Herein, we report a tetrameric porphyrin barrel complex [C60⊂Zn814(H2O)4(OTs)12](OTs)4 (2) (OTs = p-CH3C4H6SO3) formed from a tetrakis(bipyridyl)porphyrin ligand 1, Zn(OTs)2, and a template guest, C60 fullerene. The tetrameric-barrel 2 contains two kinds of bis(bpy) ...
Erdem A - - 2013
SUMMARY This study compares the bond strength of resin cement and yttrium-stabilized tetragonal zirconia polycrystalline (Y-TZP) ceramic with different surface conditioning methods. Two hundred presintered Y-TZP ceramic specimens were prepared, sintered (4 × 4 × 4 mm), and randomly assigned to four equal groups as control (C, no conditioning); airborne ...
Mouton P le Fras N - - 2013
To elucidate the functional significance of the three distinct types of generation glands that have been identified among cordylid lizards, we mapped gland type to the terminal taxa in the most recent phylogenetic tree for the Cordylidae. We used the phylogenetic programme Mesquite and applied the principle of parsimony to ...
Kuklina Elena V - - 2013
Although the observed association between breastfeeding and cardiometabolic profile in childhood and adolescence in previous studies (refs) has biological plausibility, the precise mechanism and magnitude remains far from being fully understood.(1) Early nutrition and epigenetic programming(2), anti-inflammatory properties(3), and cardiorespiratory fitness(4) are among numerous hypotheses that are currently being actively ...
Bagchi Pritha - - 2013
The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. To address this deficiency, we have created and characterized a series of water-soluble monovalent copper ligands, MCL-1, MCL-2, and MCL-3, ...
Saavedra-Rodriguez K - - 2013
The mosquito Aedes aegypti is the main vector of Dengue and Yellow Fever flaviviruses. The organophosphate insecticide temephos is a larvicide that is used globally to control Ae. aegypti populations; many of which have in turn evolved resistance. Target site alteration in the acetylcholine esterase of this species has not ...
Luo Shan - - 2013
Abstract Polycystic ovary syndrome (PCOS) patients undergoing controlled ovarian stimulation and intrauterine insemination (COS/IUI) often face the risk of premature luteinization, which may result in lower pregnancy rate and higher miscarriage rate. This review was performed to identify if adjuvant treatment with GnRH antagonist (GnRH-ant) could effectively improve the clinical ...
Sherry Melissa K - - 2013
Currently, little is known about rates of death by cause and country among US travellers. Understanding the risk by cause and country is imperative to risk communication and the development of risk reduction strategies. Publicly available data on non-natural deaths of US citizens abroad were gathered from January 2003 to ...
Ahmed Shaimaa - - 2013
In this study, we used zinc finger nuclease-mediated knockout of the aryl hydrocarbon receptor (AHR) or AHR nuclear translocator (ARNT) in MCF7, and AHR knockout in MDA-MB-231 human breast cancer cells to investigate crosstalk among AHR, ARNT and ERα. Knockout of AHR or ARNT prevented the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-dependent induction of ...
Hock Sebastian J - - 2013
Twelve novel Re(i) acetonitrile complexes of the type [Re(CO)3(L)(MeCN)][WCA], with L being a chelating bis(NHC) ligand with alkylene-bridged and N-substituted bis(imidazolineylidene) moieties, and WCA (WCA = weakly coordinating anion) representing PF6(-) and [Al(OC(CF3)3)4](-), have been synthesized. 1D and 2D NMR spectroscopy as well as IR spectroscopy, elemental analysis and X-ray ...
Gok Gulcan - - 2013
Parotid fistula is a rare but very distressing sequelum of post-operative or traumatic injuries. The management of these injuries has been reported in the literature previously and techniques employed include pressure dressings, surgery and more recently botulinum toxin A (BTA) injections. We present a patient who developed a parotid fistula ...
Galluccio Elena - - 2013
Nitric oxide (NO) plays a key role in vascular homeostasis and is produced by endothelial NO synthase (eNOS), encoded by NOS3 gene. We previously reported the genetic association between NOS3 rs753482-A>C polymorphism on intron 19 and coronary artery disease (CAD). In the attempt of conferring functional implication to the rs753482-A>C ...
Zhao Lin - - 2013
Epigenetic modifications play a key role in the transcriptional regulation of stress-induced gene expression in plants. In this study, we showed that the overall acetylation levels of histone H3 lysine 9 (H3K9) and H4 lysine 5 (H4K5) in the genome were increased in maize seedlings after mannitol treatment (to mimic ...
Frazier-Bowers S A - - 2013
Autosomal dominant mutations in PTH1R segregate with primary failure of eruption (PFE), marked by clinical eruption failure of adult teeth without mechanical obstruction. While the diagnosis of PFE conveys a poor dental prognosis, there are no reports of PFE patients who carry PTH1R mutations and exhibit any other skeletal problems. ...
Pazderů Kateřina - - 2013
Plant integrity looks like a "very easy and expanded topic," but the reality is totally different. Thanks to the very high specialization of scientists, we are losing a holistic view of plants and are making mistakes in our research due to this drawback. It is necessary to sense a plant ...
M Cioran Ana - - 2013
The preparation of 3-4 nm and 10 nm gold nanoparticles capped with neutral carborane-based mercaptocarboranes, via two different preparative routes, is reported. The resulting boron-enriched nanomaterials exhibit complete dispersibility in water, opening the way for the use of these monolayer protected clusters (MPCs) in medical applications, such as boron neutron ...
Hasim Sahar S From the School of Biological Sciences - - 2014
Methylglyoxal is a cytotoxic reactive carbonyl compound produced by central metabolism. Dedicated glyoxalases convert methylglyoxal to d-lactate using multiple catalytic strategies. In this study, the DJ-1 superfamily member ORF 19.251/GLX3 from Candida albicans is shown to possess glyoxalase activity, making this the first demonstrated glutathione-independent glyoxalase in fungi. The crystal ...
Greenwald Eric C - - 2013
Scaffold proteins localize two or more signaling enzymes in close proximity to their downstream effectors. A-Kinase Anchoring Proteins (AKAPs) are a canonical family of scaffold proteins known to bind Protein Kinase A (PKA) and other enzymes. Several AKAPs have been shown to accelerate, amplify and specify signal transduction to dynamically ...
Shulman Eli - - 2013
There is compelling evidence that aminoglycoside (AG) antibiotics can induce the mammalian ribosome to suppress disease-causing nonsense mutations and partially restore the expression of functional proteins. However, prolonged AG treatment can cause detrimental side effects in patients, including most prominently, ototoxicity. Recent mechanistic discussions have considered the relative contributions of ...
Shen Chen-Tian - - 2013
The advent of biologically targeted agents and increased understanding of thyroid carcinogenesis have generated much interest in the development of biologically targeted therapy for thyroid cancer. Among them, sorafenib is the most commonly studied drug. The current meta-analysis was performed to estimate the efficacy and safety of sorafenib administered in ...
Malinova Irina - - 2013
Activity of the plastidial phosphorylase isozyme (PHS1) is elevated in leaves of two starch-related single knock-out mutants lacking either the cytosolic transglucosidase, DPE2 or the plastidial maltose transporter, MEX. In both mutants metabolism of starch-derived maltose is impaired but inhibition is effective at different subcellular sites. Two constitutive double knock-out ...
Ng Theodore W K - - 2013
Abnormal very-low-density lipoprotein (VLDL)-triglyceride (TG) metabolism underscores the hypertriglyceridemia in obese, insulin resistant men and contributes to increased cardiovascular disease (CVD) risk. Statins reduce CVD risk by decreasing low-density lipoprotein (LDL)-cholesterol but its effects on plasma TG-lowering are modest. Supplementing with high dose omega-3 fatty acid ethyl esters (ω-3 FAEEs) ...
Butler Karen M - - 2013
Secondhand smoke (SHS) is a leading cause of childhood illness and premature death, especially in rural areas. The study examined the relationship of having a smoke-free home, strength of smoke-free law (SFL) in the county of residence, having one or more minor children in the home, rural/urban location, and demographics. ...
Kim Ji-Yun - - 2013
Atopic dermatitis (AD) is a complicated skin condition influenced by genetic background and environmental factors. In this study, we applied Dermatophagoides farinae body extract (DfE) to the barrier-disrupted skin of NC/Nga mice twice a week for 8 weeks to identify the clinical and immunological factors in AD progression. Repeated application ...
Stone Melissa D - - 2013
The following case report details an in-flight medical emergency (IFME) that occurred during a trans-continental flight while the authors were en route to a medical conference. The report highlights the necessity for an improved approach to the prevention and management of IFMEs.
Foss Katherine A - - 2013
The number of adolescents, young adults, and senior citizens experiencing hearing loss has significantly increased over the last 30 years. Despite this prevalence, hearing loss receives little attention in popular and political discourse, except in its connection to aging. Thus, hearing loss and the use of hearing aids have been ...
Codd Rj - - 2013
The latest NBOCAP audit has identified our colorectal unit as an outlier with regard to the high permanent stoma rate. The aim of this study was to perform an audit of the rationale for stoma formation in patients undergoing rectal cancer resection in our unit. A review was conducted of ...
Ghosh Shishir - - 2013
Fe2(CO)4(μ-dppf)(μ-pdt) catalyses the conversion of protons and electrons into hydrogen and also the reverse reaction thus mimicing both types of binuclear hydrogenase enzymes.
Lee Robyn - - 2013
Onion (Allium cepa L.) is a biennial crop that in temperate regions is planted in the spring and, after a juvenile stage, forms a bulb in response to the lengthening photoperiod of late spring/summer. The bulb then overwinters and in the next season it flowers and sets seed. FLOWERING LOCUS ...
Jia Y - - 2013
Background:DAP3 is a member of the death-associated protein (DAP) family and is characterised by proapoptotic function. It is involved in both exogenous and endogenous apoptotic pathways. In our previous studies, apoptotic level was found to be correlated with the effectiveness of preoperative chemotherapy. The effectiveness of preoperative chemotherapy was also ...
Paloma-Castro Olga - - 2013
To validate the content of the NANDA-I nursing diagnosis of grieving in situations of perinatal loss. Using the Fehring's model, 208 Spanish experts were asked to assess the adequacy of the defining characteristics and other manifestations identified in the literature for cases of perinatal loss. The content validity index was ...
Park Meeyoung - - 2013
Mutations in the SO42-/Cl-/OH- exchanger Slc26a2 cause the disease diastrophic dysplasia (DTD), resulting in aberrant bone development and therefore skeletal deformities. DTD is commonly attributed to a lack of chondrocyte SO42- uptake and proteoglycan sulfation. However, the skeletal phenotype of patients with DTD is typified by reduction in cartilage and ...
Jugulam Mithila - - 2013
The phenoxy herbicides (e.g. 2,4-D and MCPA) are used widely in agriculture for the selective control of broadleaf weeds. In Western Australia, the reliance on phenoxy herbicides has resulted in the widespread evolution of phenoxy resistance in wild radish (Raphanus raphanistrum) populations. In this research the inheritance and mechanism of ...
Henderson Emily J - - 2013
Gait impairment is common in people with Parkinson's disease. There is a lack of effective interventions to target this debilitating complication and therefore a need to identify new therapeutic options. An underlying cholinergic deficit contributes to both the gait and cognitive dysfunction seen in Parkinson's disease. The combined impact of ...
Hsu Fu-Chiun - - 2013
Since the first study of hypoxic response in plants with cDNA microarray in 2002, the number of hypoxia-responsive genes has grown to more than 2000. However, to date, only small numbers of hypoxia-responsive genes are known to confer hypoxic resistance. Most investigations in this area have focused on identifying which ...
Bhattacharya Biswajit - - 2013
We report the synthesis, structural characterization and adsorption properties of three new porous coordination polymers {[Cu(Meazpy)0.5(glut)](H2O)}n (), {[Zn(azpy)0.5(terep)](H2O)}n (), and {[Zn(Meazpy)0.5(terep)]}n () [glut = glutarate, terep = terephthalate, azpy = N,N'-bis-(pyridin-4-ylmethylene)hydrazine and Meazpy = N,N'-bis-(1-pyridin-4-ylethylidene)hydrazine] composed of mixed linkers systems. Structure determination reveals that all three compounds have three-dimensional (3D) ...
Sublette M Elizabeth - - 2013
Dopaminergic function is thought to be altered in major depression and, in animal studies, is reduced in omega-3 polyunsaturated fatty acid (PUFA) deficiency states. Therefore we studied PUFAs and resting prolactin, a marker for dopaminergic tone, and cerebrospinal fluid homovanillic acid (HVA), the chief dopamine metabolite. In medication-free adults (n = 23) ...
Djurisic Maja M Bio-X, James H. Clark Center, Stanford University, Stanford, CA - - 2013
Experience-driven circuit changes underlie learning and memory. Monocular deprivation (MD) engages synaptic mechanisms of ocular dominance (OD) plasticity and generates robust increases in dendritic spine density on L5 pyramidal neurons. Here we show that the paired immunoglobulin-like receptor B (PirB) negatively regulates spine density, as well as the threshold for ...
Ding Rui - - 2013
Huperzine A, huperzine B and huperzine U are congeners isolated from the Chinese herbal Huperzia serrata (= Lycopodium serratum) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B and the first total synthesis of huperzine U have been achieved efficiently ...
Barr David A - - 2013
BACKGROUND:It is recommended that venous thromboembolism (VTE) prophylaxis be considered for patients receiving Outpatient Parenteral Antimicrobial Therapy (OPAT), but there is no published data to quantify VTE risk in this patient group.Aim and method:The aim of this retrospective cohort study was to establish VTE incidence in patients managed through an ...
Pinheiro José - - 2013
The statistical methodology for the design and analysis of clinical Phase II dose-response studies, with related software implementation, is well developed for the case of a normally distributed, homoscedastic response considered for a single timepoint in parallel group study designs. In practice, however, binary, count, or time-to-event endpoints are encountered, ...
Cox Kathryn - - 2013
Context:The focus of care in disorders of sex development (DSD) is often directed on issues related to sex and gender development. In addition, the molecular etiology remains unclear in the majority of cases.Objective:To report the range of associated conditions identified in the I-DSD Registry.Design, Setting & Patients:Anonymized data were extracted ...
Kim Young-Kyun - - 2013
Abstract This study prospectively evaluated the clinical prognoses of short implants (7 mm long) in the mandible. We investigated the clinical prognosis of short implants in 20 patients (46 implants) according to the installation technique (submerged or non-submerged), installation depth (5.5-mm depth, 7-mm depth), and crown/implant ratio. We investigated the ...
Gorochowski Thomas E - - 2013
Synthetic biology has developed numerous parts for the precise control of protein expression. However, relatively little is known about the burden these place on a host, or their reliability under varying environmental conditions. To address this, we made use of synthetic transcriptional and translational elements to create a combinatorial library ...
Zheng Zhitian - - 2013
Fimbrin is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. Its homologue Sac6p has been shown to play critical roles in endocytosis and diverse cellular processes in Saccharomyces cerevisiae. FgFim from the wheat scab pathogenic fungus Fusarium graminearum strain Y2021A, which is highly resistant to ...
Markey Charlotte N - - 2013
This special issue of the Journal of Personality focuses on the importance of considering both personality and relationship forces when examining physical and psychological health. The nine articles presented in this issue employed a variety of research designs, theoretical rationales, health outcomes, and advanced statistical methodologies in order to better ...
Rochester Lynn - - 2013
Spinocerebellar ataxia type 6 (SCA6) is an inherited ataxia with no established treatment. Gait ataxia is a prominent feature causing substantial disability. Understanding the evolution of the gait disturbance is a key step in developing treatment strategies. We studied 9 gait variables in 24 SCA6 (6 presymptomatic; 18 symptomatic) and ...
Sonpavde G - - 2013
To investigate the association of radiographic progression defined by Prostate Cancer Working Group (PCWG)-2 guidelines and overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC) PATIENTS AND METHODS: Two trials that employed PCWG-2 guidelines to define progression were analyzed: a randomized phase II trial (n=221) comparing first-line docetaxel-prednisone ...
Boyce Andrew Kj - - 2013
Pannexins (Panxs) are a multifaceted family of ion and metabolite channels that play key roles in a number of physiological and pathophysiological settings. These single membrane large-pore channels exhibit a variety of tissue, cell type, and subcellular distributions. The lifecycles of Panxs are complex, yet must be understood to accurately ...
Kubo Shoichi - - 2013
Inorganic semiconductor nanorods are regarded as the primary components of optical and electrical nanoscale devices. In this paper, we demonstrate the unidirectional alignment of monolayered and dispersed ZnO nanorods on a rubbed polyimide alignment layer, which was achieved by a conventional liquid crystal alignment technique. The outermost surfaces of the ...
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