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Hong Yoochan - - 2014
ABSTRACT. In this study, we describe the development of a cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance that enables recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on invasive cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using ...
Choi Jihye - - 2014
ABSTRACT. Biomarker-specific photothermal nanoparticles that can efficiently sense markers that are overexpressed in distinguished adenocarcinomas have attracted much interest in an aspect of efficacy increase of cancer treatment. We demonstrated a promising prospect of a smart photothermal therapy agent employing anti-epidermal growth factor receptor aptamer (AptEGFR)-conjugated polyethylene glycol (PEG) layted ...
Chang Minhyeok - - 2014
ABSTRACT. We present a single-molecule imaging platform that quantitatively explores the spatiotemporal dynamics of individual insulin receptors in living cells. Modified DNA aptamers that specifically recognize insulin receptors (IRs) with a high affinity were selected through the SELEX process. Using quantum dot-labeled aptamers, we successfully imaged and analyzed the diffusive ...
Kim Chang-Beom - - 2014
ABSTRACT. Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloid (Aβ) peptides. According to medical paradigmatic transition ...
Ha Sungji - - 2014
ABSTRACT. Stem cell therapy is a promising tool for the treatment of diverse conditions, including neurodegenerative diseases such as Alzheimer's disease (AD). To understand transplanted stem cell biology, in vivo imaging is necessary. Nanomaterial has great potential for in vivo imaging and several noninvasive methods are used, such as magnetic ...
Oh Eung Seok - - 2014
ABSTRACT. Parkinson's disease (PD) is characterized by progressive dopaminergic cell loss in the substantia nigra (SN) and elevated iron levels demonstrated by autopsy. Direct visualization of iron with live imaging techniques has not yet been successful. The aim of this study is to visualize and quantify the distribution of cellular ...
Thattiyaphong Aree - - 2014
The selling and importing of puffer fish species and their products was banned in Thailand in 2002, because of possible neurotoxic effects. However, the sale of their flesh is still happening in Thai markets. Standard methods for toxin quantification (HPLC and LC-MS) have significant limitations, therefore a lateral flow, immuno-chromatographic ...
Ashraf Sajjad - - 2014
To overcome and eliminate tuberculosis (TB), definitive, reliable, and rapid diagnosis is mandatory. Presently, the diagnostic potential of acute and latent stage TB specific antigens i.e., Rv3803c and Rv2626c was determined. Immunogenic recombinant genes of Rv3803c and Rv2626c antigens were cloned in bacterial expression vector pET23b and expressed product was ...
Alzoman Nourah Z - - 2014
This article describes, for the first time, a highly sensitive and specific enzyme-linked immunosorbent assay (ELISA) for therapeutic monitoring and pharmacokinetic studies of lenalidomide (LND), the potent drug for treatment of multiple myeloma (MM). The assay employed a polyclonal antibody that specifically recognizes LND with high affinity, and LND conjugate ...
Kumari G Lakshmi - - 2014
In steroid immunoassays, selection of right combination of antibody and enzyme-labeled antigen determine the sensitivity and specificity of ELISA. Antibodies raised against different positions of progesterone adopting heterologous systems were reported to provide better assays for progesterone. Four different antibodies developed against progesterone-11α-hemiglutarate-BSA (P-11-HG-BSA), progesterone-11α-hemisuccinate-BSA (P-11-HS-BSA), progesterone-3-O-carboxymethyloxime-BSA (P-3-CMO-BSA), and progesterone-3-O-carboxymethyloxime-ovalbumin ...
Zhou Peifu - - 2014
The transcriptional factor plays an important role in the regulation of gene expression and crucial to understand the biology of organisms. Mycobacterium tuberculosis, the causative agent of tuberculosis, harbors multiple transcriptional factors. Few transcriptional factors are well-documented antigens. Based on the screening of antigen with TB patients sera, a functional ...
Mu Alan Kang-Wai - - 2014
The main purpose of this article is to develop a new and reliable saliva-based clinical diagnostic method for the early detection of oral squamous cell carcinoma (OSCC). This study used an immunoproteomic approach which allowed the detection of immunogenic host proteins in patients' samples using pooled human antibodies. In an ...
Pata Supansa - - 2014
Couples in which both partners carry the α-thalassemia-1 trait have a 25% risk of hemoglobin Bart's hydrops fetalis in each pregnancy. Identification of α-thalassemia-1 trait is, therefore, necessary in order to control this severe form of α-thalassemia. We have generated monoclonal antibodies specific to the ζ-globin chain without cross reaction ...
Zhou Jianwei - - 2014
To date, the complete mechanism of rheumatoid arthritis (RA) remain unclear, T cells have been proposed to play an important role in the disease initiation and progression. Presently, some researchers have reported that there were skewed TCR Vβ in different samples of experimental animals or RA patients, such as in ...
Kumari G Lakshmi - - 2014
Enzyme-linked immunosorbent assays (ELISA's) reported for thyroxine (T4) and 3,5,3'-triiodothyronine (T3), involved coupling of the haptens through (i) carboxylic group to carrier protein for producing antibodies and (ii) amino group to detection labels. To improve the titer and specificity of antibodies, immunogens were prepared by coupling of carboxyl group to ...
Junker Klaus - - 2014
Malignant involvement of the trachea predominantly results from direct spread of neighboring tumors to the tracheal wall. Primary tracheal malignancies show a low incidence of approximately 0.1 in every 100,000 persons per year, squamous cell carcinomas and adenoid cystic carcinomas accounting for about two-thirds of adult primary tracheal tumors. The ...
Wiedemann Klaus - - 2014
Tracheobronchial surgery constitutes a challenge to the anesthetist because it involves the anatomic structures dedicated to bulk gas transport. Common approaches to airway management and gas exchange for extrathoracic and intrathoracic airway surgery are reviewed, with due regard to less common methods thought crucial for specific procedures. Tracheal surgery, beyond ...
Freitag Lutz - - 2014
For all cases of tracheal obstructions surgery should be considered first. Interventional endoscopic procedures can provide immediate relief. Intraluminally growing tumors can be resected with laser, argon-plasma coagulation, an electrosurgical knife or cryo-probe. Photodynamic therapy of smaller tracheal tumors can be curative. Narrowing from intramural tumor growth or wall destruction ...
Welter Stefan - - 2014
Tracheobronchial injuries (TBIs) are caused by blunt, penetrating injury or by iatrogenic damage. Most injuries are life threatening and need early and skillful airway management. Bronchoscopy remains the gold standard of diagnosis. Penetrating TBI always needs blunt trauma, and iatrogenic TBI sometimes needs surgical exploration and reconstruction, which is performed ...
Kugler Christian - - 2014
Tracheomalacia is excessive collapsibility of the trachea, typically during expiration. Congenital forms are associated with severe symptoms. Milder forms often present after the neonatal period. Adult malacia is mostly associated with chronic obstructive pulmonary disease. Functional bronchoscopy is still not standardized. Dynamic airway CT is a promising tool for noninvasive ...
Stoelben Erich - - 2014
Benign stenosis of trachea results mainly from tracheotomy, ventilation, or trauma. The combination of a defect of the mucosa or the tracheal wall and infection produce secondary scar tissue healing with shrinkage of the tracheal lumen or instability of the tracheal wall. Standard of treatment consists of resection of the ...
Zeeshan Ahmad - - 2014
Patients with tracheal stenosis can experience life-threatening dyspnea. When the stenosis is close to the larynx, management can be challenging. Non-definitive palliative measures should be kept to a minimum as they can make definitive management more complicated. Specialized techniques of resection and reconstruction of high tracheal lesions are available and ...
Behringer Dirk - - 2014
A patient identified with tracheal cancer benefits most from evaluation by an experienced center and an extensive effort to assess the possibility of a complete surgical resection as the most efficient treatment option for cure. Localized, nonoperable disease may still be controlled by combined modality using chemotherapy and concurrent radiation.
Weder Walter - - 2014
Carinal resection and sleeve pneumonectomy are rare procedures and challenging issues in thoracic surgery. In spite of the knowledge of the technique, the incidence of postoperative complications is higher compared with standard resections. Adequate patient selection, improved anesthetic management and surgical technique, and better postoperative management might reduce the rate ...
Hecker Erich - - 2014
There is no universally valid definition of the extent of tracheal resections that would be considered "extended." Underlying disease, necessary length of resection, anatomic localization, and chosen surgical approach account for a manifold interdependency. Existing data suggest a "cutoff margin" of 4 cm or more, referring to the likelihood of complications ...
Jungebluth Philipp - - 2014
No definitive solution has been discovered for replacing long segments or the entire trachea in humans. Most of this challenge stems from the specific function and mechanics that are almost impossible to replicate except in the setting of an allotransplantation, which requires lifelong immunosuppressive medication. Recently, tissue engineering provided significant ...
Leschber Gunda - - 2014
Complications in tracheal surgery are not uncommon but generally do not influence the final result. Most patients benefit from tracheal resections and mortality is low. Risk factors for complications are reoperations, preoperative tracheostomy, and lengthy resections. Precise information about the extent of the diseased tracheal part as well as thorough ...
Ota Naotoshi - - 2014
We compared the efficacies of ¹⁸F-fluoride positron emission tomography (¹⁸F-fluoride PET)/CT, ¹⁸F-fludeoxyglucose PET (¹⁸F-FDG PET)/CT, and ⁹⁹mTc bone scintigraphy [planar and single photon emission CT (SPECT)] for the detection of bone metastases in patients with differentiated thyroid carcinoma (DTC). We examined 11 patients (8 females and 3 males; mean age ...
Sipahi Ilke I Department of Cardiology, Acibadem University Medical School, Istanbul, Turkey2Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, - - 2014
Recent trials of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG) for multivessel disease were not designed to detect a difference in mortality and therefore were underpowered for this outcome. Consequently, the comparative effects of these 2 revascularization methods on long-term mortality are still unclear. In the absence ...
Stergiopoulos Kathleen K Division of Cardiovascular Medicine, Department of Medicine, State University of New York-Stony Brook School of Medicine, Stony - - 2014
Myocardial ischemia in patients with stable coronary artery disease (CAD) has been repeatedly associated with impaired survival. However, it is unclear if revascularization with percutaneous coronary intervention (PCI) to relieve ischemia improves outcomes compared with medical therapy (MT). The objective of this study was to compare the effect of PCI ...
Jang Sung-Soo - - 2014
For many years, brain ischemia has been known to be a leading cause of adult neurological disorder. In particular, many reports have shown that hyperexcitability of neurons and inflammatory response of the glia induced by ischemic reperfusion (I/R) determine the fate of cells in the ischemic core and the penumbra ...
Labbé Daniel - - 2014
The digastric corset is a new concept for open neck contouring, indicated in the treatment of difficult necks. We described a retaining ligament between the anterior belly of the digastric muscle and the mylo-hyoid muscle. After suprahyoid fat lipectomy, a digastric corset can be performed as a running suture between ...
Gonzalez Raul - - 2014
Lateral plication of the platysma can substitute medial plication in all cases, no matter the severity of the case, with several advantages. This article presents a useful method, called lateral overlapping plication of the platysma (LOPP). In addition to the simplicity of the procedure, it has other advantages over medial ...
Bjermer Leif - - 2014
This review provides an update on the importance of the peripheral 'small' airways in asthma. As the small airways account for less than 10% of total airway resistance, thus having little impact on standard lung function measures such as forced expiratory volume and peak flow, they have been referred to ...
Compalati Enrico - - 2014
The aim is to review recent literature up to July 2013 concerning the effect of allergen-specific immunotherapy (AIT) on asthma. AIT, effective in combined allergic rhinitis and asthma, was previously described as a convenient approach able to improve clinical outcomes and reduce bronchial hyperresponsiveness. In addition, long-term and preventive effects ...
Matarasso Alan - - 2014
Isolated surgery of the neck without a facelift is increasingly in demand and a satisfying option for patients concerned with the aging appearance of the neck. It seems to be requested frequently in men and women and in patients who are satisfied with nonsurgical rejuvenation of the midface or who ...
Weyand Cornelia M - - 2014
With progressive age, the immune system and the propensity for abnormal immunity change fundamentally. Individuals greater than 50 years of age are not only more susceptible to infection and cancer, but also at higher risk for chronic inflammation and immune-mediated tissue damage. The process of immunosenescence is accelerated in rheumatoid ...
Ramirez Oscar M - - 2014
Correction of aesthetic and anatomic deformities of the neck due to aging is a complex proposition, and the planning and approach depends on the findings during your initial examination. More than any area of the body, an in-depth knowledge of the anatomy is mandatory. The surgery can be very simple ...
Ristow Brunno - - 2014
This article addresses specific questions posed to the author by the editor to elucidate his 40-years experience with neck lift. Surgery of the neck has been, in the author's hands, for all practical purpose, problem free. However, one needs to understand the issues and apply the proper techniques. By far, ...
Ellenbogen Richard - - 2014
After a visit to Bruce Connell in 1975, I realized I had seen the ultimate answer to neck correction in facelifts-the treatment of the muscles, the removal of fat both superficial and deep, and the skin tightening. I devised a neck-only lift using his principles. These consisted of submental incision, ...
Paul Malcolm D - - 2014
There are many surgical solutions for the aging neck, from closed liposuction, closed or minimal access thread suspension, to open minimally and moderately aggressive approaches with oral sedation and analgesia or with general anesthesia. However, procedures performed under local anesthesia with oral sedation and analgesia can provide a safe, efficient, ...
Schroeder Stephen M - - 2014
Perioperative management of diabetic patients involves optimizing glycemic control and negotiating comorbidities to help reduce complications and obtain results on par with nondiabetics. These goals are usually achievable in the elective surgical setting, but they can be more difficult to control in urgent or emergent situations. Understanding and recognizing the ...
Shalaby Sherif Y - - 2014
The diabetic population is increasing worldwide at a staggering rate. Diabetic foot ulcers are a major contributor to nontraumatic lower limb amputations and peripheral arterial disease is one of main contributing pathophysiologic causes of diabetic ulcers. The dire need to reduce complication and wound healing recovery period of the chronic ...
Fridman Robert - - 2014
Complications from diabetic foot infections are a leading cause of nontraumatic lower-extremity amputations. Nearly 85% of these amputations result from an infected foot ulcer. Osteomyelitis is present in approximately 20% of diabetic foot infections. It is imperative that clinicians make quick and successful diagnoses of diabetic foot osteomyelitis (DFO) because ...
Sagray Bryan A - - 2014
Treatment of the patient with a diabetic foot infection and underlying osteomyelitis is currently an evolving process, often complicated by neuropathy, peripheral vascular disease, and renal insufficiency. Understanding which patients require hospitalization, intravenous antibiotic therapy, and urgent operative intervention may ultimately prevent the spread of infection or major limb amputation. ...
McCartan Brant L - - 2014
The diabetic foot is more susceptible than the non-diabetic foot to collapse. This frequently leads to bony prominences followed by ulceration. Offloading of areas of increased pressure is paramount to ulcer prevention and healing. Several devices and accommodations can aid practitioners in saving patients' extremities and allow them to ambulate. ...
Cook Emily A - - 2014
Bioengineered alternative tissues (BATs) are heterogeneous processed materials used to aid in wound closure of diabetic foot ulcers. There has been significant progress in the development and clinical use of BATs in the last decade. BATs may be derived from an autograft, allograft, or xenograft source. They may be a ...
Boffeli Troy J - - 2014
Lower extremity infections are a common yet unfortunate complication of diabetes-related ulcers often requiring surgical intervention. The main goals of surgical treatment consist of selecting the appropriate procedure to effectively eradicate nonsalvageable tissue, achieve primary healing, and maximize subsequent dynamic functionality. An overview of each partial foot amputation procedure is ...
Blume Peter A - - 2014
The goal of wound healing is to obtain the best closure through the least morbid means. In the surgical treatment of the diabetic foot and ankle, the reconstructive foot and ankle surgeon is tasked with the challenge of repairing a variety of tissue defects. The decision for wound closure depends ...
Blume Peter A - - 2014
This article reviews current literature discussing the etiology, pathophysiology, diagnosis and imaging, and conservative and surgical treatment of Charcot osteoarthropathy. The treatment of Charcot osteoarthropathy with concurrent osteomyelitis is also discussed.
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