Search Results
Results 401 - 450 of 3165
< 4 5 6 7 8 9 10 11 12 13 14 >
Pompe Manca Tekavčič - - 2013
The purpose of this study was to investigate chromatic visual evoked potential (cVEP) response characteristics during the first year of life and to collect as large database of healthy baby responses as possible. This study also complements our previous studies on cVEP in schoolchildren and preschool children. Forty-four healthy babies ...
Xie Xi - - 2013
Introduction: Rheumatoid arthritis (RA) demonstrates a high heterogeneity in clinical responses to treatment. Although the efficacy of biological therapy has undoubtedly been established, the response differs considerably between individuals. This variability between individuals has aroused the research for biomarkers predictive of treatment response. Pharmacogenomics underlying individual responses to drugs is ...
Singh Ramandeep - - 2013
To evaluate the feasibility and short-term outcome of 23-gauge vitrectomy in children for various vitreoretinal conditions. A retrospective chart review was conducted of consecutive children younger than 14 years who underwent 23-gauge transconjunctival sutureless vitrectomy for various vitreoretinal conditions from January 2008 to December 2011 at a tertiary care center. ...
Rasmussen Anna Julie - - 2013
During the education of scientists at the university level the students become more and more specialized. The specialization of the students is a consequence of the scientific research becoming specialized as well. In the interdisciplinary field of nanoscience the importance of specialization is also emphasized throughout the education. Being an ...
Wang Zhenmin - - 2013
This study aims to explore the probable mechanism of better result of dural reconstruction by CO2 laser soldering and the effect of exogenous basic fibroblast growth factor (bFGF) or transforming growth factor-beta1(TGFβ1) on wound healing. In part I of the study, ten minipigs were randomized into two equal groups, and ...
Chen Yang - - 2013
To investigate the influence of different actuator materials and nozzle designs on the electrostatic charge properties of a series of solution metered dose inhaler (pMDI) aerosols. Actuators were manufactured with flat and cone nozzle designs using five different materials from the triboelectric series (Nylon, Polyethylene terephthalate, Polyethylene-High density, Polypropylene copolymer ...
Shah Lipa - - 2013
Although neuro-active peptides are highly potent as central nervous system (CNS) therapeutics, their systemic delivery across the blood-brain barrier (BBB) is limited due to lack of permeability in the brain and rapid systemic metabolism. In this study, we aimed at enhancing the brain delivery and stability of chemically modified [D-Arg(2), ...
Ramasamy Thiruganesh - - 2013
To investigate the effect of polyelectrolytes on the formation and physicochemical properties of chitosan nanoparticles (CS-NPs) used for the delivery of an anticancer drug, doxorubicin (DOX). Three DOX-loaded CS-NPs were formulated with tripolyphosphate (CS-TP/DOX NPs), dextran sulfate (CS-DS/DOX NPs), and hyaluronic acid (CS-HA/DOX NPs) by using ionotropic gelation or complex ...
Caddeo Carla - - 2013
To develop quercetin-loaded phospholipid vesicles, namely liposomes and PEVs (Penetration Enhancer-containing Vesicles), and to investigate their efficacy on TPA-induced skin inflammation. Vesicles were made from a mixture of phospholipids, quercetin and polyethylene glycol 400 (PEG), specifically added to increase drug solubility and penetration through the skin. Vesicle morphology and self-assembly ...
Jain Amit K - - 2013
The present work reports rationalized development and characterization of solidified self-nanoemulsifying drug delivery system for oral delivery of combinatorial (tamoxifen and quercetin) therapeutic regimen. Suitable oil for the preparation of liquid SNEDDS was selected based on the maximum saturation solubility of both the drugs while surfactant and co-surfactant were selected ...
Azadi Ali - - 2013
To evaluate the effect of surgical instruments handling on polypropylene mesh using scanning electron microscopy (SEM). We applied different surgical instruments, including a few robotic ones, to pieces of polypropylene mesh. SEM was used to evaluate the morphological changes with this intervention. Straight hemostat, laparoscopic atraumatic grasper, laparoscopic needle driver, ...
Hyakutake Momoe Tina - - 2013
In recent years, pelvic floor surgeons have increasingly repaired pelvic organ prolapse around an intact uterus. Uterine conservation and hysteropexy have been driven by patient preference, less risk of mesh erosion, shorter operative time, and decreased blood loss and postoperative pain. We present a case series of patients with cervical ...
Cuellar-Rodriguez J - - 2013
It is unclear whether blood culture samples should be obtained through one or multiple catheter lumens. We measured how frequently drawing blood cultures from all the lumens from a multilumen catheter resulted in discordant results and how often these caused medical interventions. We performed a retrospective review of the microbiology ...
Wojcik Pawel Jerzy - - 2013
An efficient mathematical strategy in the field of solution processed electrochromic (EC) films is outlined as a combination of experiment work, modelling and information extraction from massive computational data via statistical software. This paper describes a case study in which Design of Experiment (DOE) for mixtures was used for statistical ...
Yoshida Masao - - 2013
Carbon dioxide (CO2) insufflation reduces abdominal pain and discomfort after endoscopic procedures; however, there is no previous study focusing the safety of CO2 insufflation for patients with obstructive ventilatory disturbance. Here, we investigated the safety of CO2 insufflation during colorectal endoscopic submucosal dissection (ESD) for patients with obstructive disturbance. Between ...
Domoto Satoru - - 2013
Systolic anterior motion (SAM) of the mitral apparatus is a relatively frequent complication of mitral valve repair. When significant SAM persists despite intraoperative medical therapies, a second repair is generally required. We describe a rare case of SAM due to a hypertrophic septum in a patient who underwent mitral valve ...
Watanabe Jun - - 2013
Although obesity is considered as a risk factor for postoperative morbidity in abdominal surgery, its effect on the outcomes of laparoscopic-assisted colectomy (LAC) is still unclear. The technical difficulty and risk factor for postoperative complication in LAC are thought to be influenced by visceral obesity. The aim of this prospective ...
Macilvaine W Rodman - - 2013
To assess the impact of community service on personal wellbeing in a mid-west church-based population. A prospective survey evaluating: self-reported community service, the perceived benefit of the service and its association to personal wellbeing. 309 participants were included of whom 92 % were employed full or part time, homemakers or students. ...
Kim Jae Hoon - - 2013
Cisternal irrigation with thrombolytic agents was used to prevent post-SAH vasospasm, but its role remained inconclusive. To verify effectiveness of papaverine (PPV) in preventing vasospasm, we studied relationship between inflammatory biologic markers and vasospasm. This prospective study included 121 patients with clipped anterior circulation aneurysms that had ruptured, and 372 ...
Wiener Zev - - 2013
Current data suggest that up to 60 % of patients presenting to the ED with syncope leave the hospital without a defined etiology. Although a relationship between syncope and substance abuse has been described, no study to date has looked at the relationship between syncope of unknown etiology and substance abuse ...
Hesser Hugo - - 2013
Whether handicap due to tinnitus-sound(s) in the ears and/or in the head in the absence of an external auditory source-is best conceived as dimensional or categorical remains an unanswered empirical question. The objective was to investigate whether tinnitus severity was best conceptualized as qualitatively distinct subtypes, quantitative differences varying along ...
Ruiz-Ibán Miguel Angel - - 2013
Long-bone segmental defects caused by infection, fracture, or tumour are a challenge for orthopaedic surgeons. Structural allografts are sometimes used in their treatment but their poor biological characteristics are a liability. The objective of this study was to determine whether the addition of recombinant vascular endothelial growth factor-A (VEGF) to ...
Kircher Jörn - - 2013
This manuscript describes the successful treatment of a steroid-induced avascular necrosis of the humeral head using arthroscopically assisted retrograde drilling of a stage II lesion using a guiding device. At the final follow-up 19 month post-operatively, the patient presented pain-free without functional limitations although the osteonecrosis had not been fully healed.
Mäkikangas Anne - - 2013
The purpose of this quantitative diary study was to investigate daily vigor and exhaustion using a person-centered approach. The study also investigated whether and how experiences of vigor and exhaustion relate to a state of being recovered. A total of 256 Finnish employees filled in a diary questionnaire during five ...
Maclary Emily - - 2013
The X-inactivation center is a hotbed of functional long noncoding RNAs in eutherian mammals. These RNAs are thought to help orchestrate the epigenetic transcriptional states of the two X-chromosomes in females as well as of the single X-chromosome in males. To balance X-linked gene expression between the sexes, females undergo ...
De Prá Samira D T - - 2013
Mutations in the tyrosine aminotransferase gene have been identified to cause tyrosinemia type II which is inherited in an autosomal recessive manner. Studies have demonstrated that an excessive production of ROS can lead to reactions with macromolecules, such as DNA, lipids, and proteins. Considering that the L-tyrosine may promote oxidative ...
Mostafavi S - - 2013
A study of genome-wide gene expression in major depressive disorder (MDD) was undertaken in a large population-based sample to determine whether altered expression levels of genes and pathways could provide insights into biological mechanisms that are relevant to this disorder. Gene expression studies have the potential to detect changes that ...
Balata Gehan - - 2013
Abstract Context: Propolis has traditionally been used in curing infections and healing wounds and burns. Objective: The aim of this study is to formulate pluronic lecithin organogel of propolis to improve its availability and antimicrobial activity. Materials and methods: Different organogels were prepared by using soybean lecithin, isopropyl palmitate, pluronic ...
Jokela M - - 2013
The hypothesis of metabolically healthy obesity posits that adverse health effects of obesity are largely avoided when obesity is accompanied by a favorable metabolic profile. We tested this hypothesis with depressive symptoms as the outcome using cross-sectional data on obesity, metabolic health and depressive symptoms. Data were extracted from eight ...
Morel C - - 2013
Smoking is the most important preventable cause of morbidity and mortality worldwide. Recent genome-wide association studies highlighted a human haplotype on chromosome 15 underlying the risk for tobacco dependence and lung cancer. Several polymorphisms in the CHRNA3-CHRNA5-CHRNB4 cluster coding for the nicotinic acetylcholine receptor (nAChR) α3, α5 and β4 subunits ...
Verdoia Monica - - 2013
Periprocedural myocardial infarction (PMI) represents a frequent complication in patients undergoing percutaneous coronary revascularization. Despite great attention focused on pharmacological prevention of periprocedural damage, very little is known about using biomarkers to potentially predict the risk of PMI. Larger platelets have been associated with enhanced reactivity, increased cardiovascular risk, and ...
Yang Zuyao - - 2013
Resistance and aerobic exercises are both recommended as effective treatments for people with type 2 diabetes. However, the optimum type of exercise for the disease remains to be determined to inform clinical decision-making and facilitate personalized exercise prescription. Our objective was to investigate whether resistance exercise is comparable to aerobic ...
Park Sang-Kyu - - 2013
Fpr3 and Fpr4 of Saccharomyces cerevisiae are nuclear FK506-binding proteins each containing an extended acidic domain in addition to the conserved FK506-binding/peptidylprolyl isomerase (PPIase) domain. Previous studies have shown that the PPIase domain regulates histone H3 methylation, while the acidic domain facilitates histone deposition and may regulate rDNA silencing. To ...
Zhang Wenji - - 2013
Abstract Objective: For better treatment of circadian cardiovascular events, a novel Propranolol hydrochloride (PNH) delayed-release osmotic pump capsule was developed. Methods: The capsule body was designed of asymmetric membrane and the capsule cap was made impermeable. The physical characteristics of capsule body walls and membrane permeability were compared among different ...
Suzuki Azusa - - 2013
A novel environmentally sensitive fluorescent (ESF) purine nucleoside, , was synthesized and its photophysical properties were investigated. The base-modified fluorescent nucleoside exhibited remarkable solvatochromicity and environmentally sensitive dual fluorescence. By using , we have developed highly thymine (T) selective fluorescent DNA probes that can sense the corresponding T in a ...
Luhtanen Anne-Mari - - 2013
In search for sea ice bacteria and their phages from the Baltic Sea ice, two ice samples were collected from land-fast ice in a south-west Finland coastal site in February and March 2011. Bacteria were isolated from the melted sea ice samples and phages were screened from the same samples ...
Sullan Ruby May A - - 2013
Although bacterial pili are known to mediate cell adhesion to a variety of substrates, the molecular interactions behind this process are poorly understood. We report the direct measurement of the forces guiding pili-mediated adhesion, focusing on the medically important probiotic bacterium Lactobacillus rhamnosus GG (LGG). Using non-invasive single-cell force spectroscopy ...
Steiner Kristina L - - 2013
Older adults' memories of events that occurred in adolescence and early adulthood are over-represented compared to other lifetime periods. Prior research on this reminiscence bump has focused on qualities of individual memories. The present study used a novel interview method to examine the potential role played by mental representations of ...
Feng Miao - - 2013
To realize their practical and operable applications as a potential optical limiting (OL) material, quantum dots (QDs) need to have good processability by incorporating them into optical-quality matrices. This work reports a facile route for the room-temperature preparation of large, stable transparent monolithic CdS nanocomposites which can be easily extended ...
Haya Luisa - - 2013
The development of new antioxidants with enhanced activity constitutes a very active research field as it can contribute to the improvement of human health. Although the antioxidant activity occurs through different mechanisms, usually most of the antioxidant molecules present a unique active center which is able to react following a ...
Fischer James H - - 2013
Labetalol is frequently prescribed for the treatment of hypertension during pregnancy; however, the influence of pregnancy on labetalol pharmacokinetics is uncertain, with inconsistent findings reported by previous studies. This study examined the population pharmacokinetics of oral labetalol during and after pregnancy in women receiving labetalol for hypertension. Data were collected ...
Roscioni Sara S - - 2013
The renin-angiotensin-aldosterone system (RAAS) has a key role in the regulation of blood pressure, sodium and water balance, and cardiovascular and renal homeostasis. In diabetic nephropathy, excessive activation of the RAAS results in progressive renal damage. RAAS blockade using angiotensin-converting-enzyme inhibitors or angiotensin-receptor blockers is the cornerstone of treatment of ...
Oldehinkel Marianne - - 2013
Concurring with the shift from linking functions to specific brain areas towards studying network integration, resting state FMRI (R-FMRI) has become an important tool for delineating the functional network architecture of the brain. Fueled by straightforward data collection, R-FMRI analysis methods as well as studies reporting on R-FMRI have flourished, ...
Schuurmans-Stekhoven James Benjamin - - 2013
Previously published path models apparently confirm the belief-as-benefit perspective that spirituality boosts well-being via social support. The broad acceptance of such findings has motivated recommendations that clinical psychologists and psychiatrists routinely assess their patients' spiritual status. Skeptics retort that past findings are statistically confounded and that numinous beliefs and well-being ...
Wiegerinck Johannes I - - 2013
Calcaneal apophysitis, or Sever's disease, is a traction apophysitis. It is a frequent cause of heel pain in children. Knowledge about the exact incidence of calcaneal apophysitis in the general population, however, is lacking. Cross-sectional study. From 34 general practices, records of patients between 6 and 17 years old, visiting the ...
Jo Ah-Ram - - 2013
The purpose of this study was to investigate the mechanism(s) of interleukin (IL)-8 suppression by Treponema denticola, one of the major periodontal pathogens, in gingival epithelial cells. Immortalized human gingival epithelial HOK-16B cells were infected with wild-type (WT), dentilisin-deficient (K1) or flagellin-deficient (flgE) T. denticola in the presence or absence ...
Strauss Bernhard Michael - - 2013
Abstract Objective: Two patient-focused long-term research projects performed in the German outpatient psychotherapy system are focused on in this article. The TK (Techniker Krankenkasse) project is the first study to evaluate a quality assurance and feedback system with regard to its practical feasibility in German routine care. The other study ...
Alavizadeh S A - - 2013
Objectives:The present study was conducted to determine the prevalence of T-score discordance and its risk factors in a group of patients with spinal cord injury in a university teaching hospital in the Iranian capital of Tehran.Methods:This cross-sectional study was conducted on paraplegic men undergoing bone density testing in an outpatient ...
He Liyu - - 2013
Abstract Imbalance of Th1/Th2 pro-inflammatory cytokines plays an important role in the development and progression of IgA nephropathy (IgAN). Clinical development and exacerbation of IgAN are frequently preceded by episodes of upper respiratory tract infection, and palatine tonsils represent the predominant immunocompetent tissue of the upper respiratory tract. This study ...
Ribeiro António P - - 2013
Abstract Objectives: We understand ambivalence as a cyclical movement between two opposing parts of the self. The emergence of a novel part produces an innovative moment, challenging the current maladaptive self-narrative. However, the novel part is subsequently attenuated by a return to the maladaptive self-narrative. This study focused on the ...
< 4 5 6 7 8 9 10 11 12 13 14 >