Search Results
Results 201 - 250 of 3165
< 1 2 3 4 5 6 7 8 9 10 >
Marshall Natalie C - - 2013
Introduction: Causative agents of pneumonia, gastroenteritis, typhoid fever, and plague all utilize a type III secretion inhibitors (T3SS) to directly inject proteins into human cells and cause disease. These bacterial pathogens are frequently resistant to antibiotics and novel treatment options are needed. The T3SS is essential for virulence and can ...
Uehara Thiers Massami - - 2013
The understanding of the interactions between small molecules and magnetic nanoparticles is of great importance for many areas of bioapplications. Although a large array of studies in this area have been performed, aspects involving the interaction of magnetic nanoparticles with phospholipids monolayers, which can better mimic biological membranes, have not ...
Marze Sébastien - - 2013
The digestion of lipophilic nutrients and micronutrients requires numerous and simultaneous processes of chemical, physical and biological nature. Studying these processes experimentally is challenging, explaining why there is only little information about the mechanisms and interactions involved. Nevertheless, the bioaccessibility of lipophilic micronutrients is poorly understood so new investigation approaches ...
Smid Ida - - 2013
Proteins from higher fungi have attracted interest because of their exceptional characteristics. Macrocypins, cysteine protease inhibitors from the parasol mushroom Macrolepiota procera, were evaluated for their adverse effects and their mode of action on the major potato pest Colorado potato beetle (CPB, Leptinotarsa decemlineata Say). They were shown to reduce ...
Wang Haiyang - - 2013
The ordered, aligned fibrillar morphology at multiple scales of a donor-acceptor (D-A) conjugated copolymer of 3,6-bis-(thiophen-2-yl)-N,N'-bis(2-octyl-1-dodecyl)-1,4-dioxo-pyrrolo[3,4-c]pyrrole and thieno[3,2-b]thiophene (PDBT-TT) was prepared via blending with flexible polymers (PS13.7k, PDBT-TT/PS = 1/10 w/w) followed by chloroform (CF) solvent vapor annealing (SVA) for 24 h. The aligned fibrillar bundles were of about 500 ...
Krentz Hartmut B - - 2013
Antiretroviral drug resistance (ARV) limits choices often necessitating the selection of drugs with less desirable pill burdens, toxicity profiles, drug interactions, dosing schedules, and may increase cost. We examine the impact of resistance on the cost of HIV care. All adult HIV-positive individuals newly referred for HIV care from 1/1/2007-1/1/2011 ...
Mhizha Samson - - 2013
The present study sought to explore the relationship between street childhood and adolescent religious-spiritual self-image. In Zimbabwe, there has been a rise in street children population in the urban centres. The current study investigated whether adolescent street children live and work in an eco-developmentally risky context for the development of ...
Malikiwi Andra - - 2013
Vasopressin is emerging as a therapeutic adjunct option towards treatment of shock states in the pediatric population. Its effects on pulmonary vasculature are less well understood. This report describes a 5-month-old infant with nitric oxide-unresponsive pulmonary hypertension, oxygenation failure, and systemic hypotension. Vasopressin therapy improved oxygenation and blood pressure and ...
Zakharova Maria V - - 2013
A series of asymmetrically substituted sulfonium derivatives of nido-carborane [9-R(Me)S-nido-7,8-C2B9H11] (R = Et, Pr, Bu, Bn, CH[double bond, length as m-dash]CH2, CH2CH[double bond, length as m-dash]CH2, CH2C[triple bond, length as m-dash]CH, CH[double bond, length as m-dash]C[double bond, length as m-dash]CH2) were prepared by alkylation of the 9-methylthio-nido-7,8-carborane. The synthesized compounds ...
Hakan Nilay - - 2013
We aimed to determine reference values of perfusion index (PI) in healthy newborns during the early neonatal period. Preductal (right hand) and postductal (foot) PI values were assessed during the first 5 days of life by using a new generation pulse oximetry. A total of 241 newborn infants (196 [81.3 %] term ...
Karadag-Oncel Eda - - 2013
Myiasis involving the eyelid is uncommon. Herein, we present an 8-year-old boy who was diagnosed with preseptal cellulitis, yet a single larva was eventually extracted from his eyelid.
Edwards Emily Sj - - 2013
The role of CD4(+) T cells in the control of infectious pathogens is highly complex with a myriad of functions but how these T cells acquire differential functional potentiality remains poorly defined. Here we show that human cytomegalovirus (CMV)-specific CD4(+) T cells directed towards different viral antigens expressed predominantly TNF-α ...
Karaman Maja - - 2013
Abstract Crude extracts of two edible and two medicinal lignicolous mushroom species: Meripilus giganteus, Agrocybe aegerita, Fomes fomentarius and Xylaria polymorpha, growing wild in Serbia, were analyzed for their antioxidative and antibacterial potentials. Free radical scavenging capacity (RSC) on DPPH(•) and (•)OH was evaluated both by spectrophotometer and by Electron ...
Westhorpe Clare L V - - 2013
Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype predict subclinical atherosclerosis in virologically suppressed HIV-positive ...
Pan Ke - - 2013
Generation of functional dendritic cells (DCs) with boosted immunity after the withdrawal of initial activation/maturation conditions remains a significant challenge. In this study, we investigated the impact of a newly developed maturation cocktail consisting of OK-432 and interferon-gamma (IFN-γ) on the function of human monocyte-derived DCs (MoDCs). We found that ...
Jiang L - - 2013
Objectives:Many complex mechanisms responsible for the pathogenesis of pressure ulcers (PUs) currently remain poorly understood. The objective of this study was to discover the major roles for inflammatory cytokines, growth factors and several apoptosis-related signal molecules in chronic PU wound.Methods:We investigated expression of inflammatory cytokines, growth factors and their corresponding ...
Guy S - - 2013
Study design:Systematic review and effectiveness analysis.Objectives:Assess the effectiveness of anticonvulsants for the management of post spinal cord injury (SCI) neuropathic pain.Setting:Studies from multiple countries were included.Methods:CINAHL, Cochrane, EMBASE and MEDLINE were searched up to April 2013. Quality assessment was conducted using the Jadad and the Downs and Black tools. Effect ...
Rush Ryan A - - 2013
The present study examines how discussion between individuals regarding a shared memory affects their subsequent individual memory reports. In three experiments pairs of participants recalled items from photographs of common household scenes, discussed their recall with each other, and then recalled the items again individually. Results showed that after the ...
Noriega Daniela Briceno - - 2013
Autism spectrum disorder (ASD) is a common and severe neuro-developmental disorder in early childhood which is defined by social and communication deficits and repetitive and stereotypic behaviours. The aetiology of ASD remains poorly understood. Susceptibility to development of ASD has significant environmental components, in addition to the profound genetic heritability. ...
Park Hee-Jung - - 2013
The stem wood of Machilus japonica Siebold & Zucc were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, five procyanidins, procyanidin A1 (1), procyanidin A2 (2), procyanidin B7 (3), cinnamtannin B1 (4), and aesculitannin ...
Gallagher Thomas H - - 2013
Important changes are occurring in how the medical profession approaches assessing and maintaining competence. Physician support for such changes will be essential for their success. To describe physician attitudes towards assessing and maintaining competence. Cross-sectional internet survey. Random sample of 1,000 American College of Physicians members who were eligible to ...
Fan Jiangli - - 2013
, a Nile Blue based NIR fluorescent dye was reported. is highly effective in specifically labeling lysosomes with low concentration and good photostability in various kinds of live cells. It was first successfully used to observe the disappearance and reproduction of lysosomes during cell division.
Chopra Kanwaljit - - 2013
Introduction: An apparent clinical relationship between pain and depression has long been recognized, which makes an enormous impact on the individual health care. At present, the practical implication of such overlapping symptomatology between pain and depression is not clear, but the prevalence estimates for depression are substantially inflated among patients ...
Selleslagh Margot - - 2013
Globus is a topic of interest for many specialties including otorhinolaryngology, gastroenterology and psychiatry/psychosomatic medicine, but, although many hypotheses have been suggested, key questions about its aetiology remain. This Review provides an overview of the extensive literature concerning this topic and discusses the quality of the evidence to date. Globus ...
Starks Tyrel J - - 2013
Previous research has found secure adult attachment to be associated positively with dimensions of main partner relationship quality and negatively with sexual risk taking and sex with casual partners among heterosexuals in primary relationships. Potential associations between adult attachment and aspects of relationship functioning have received limited attention among gay ...
Zheng Yan-Zhen - - 2013
There has been a rapid expansion in the use of molecular magnets for both low- and ultra low-temperature cooling applications in recent years, and here we review the chemical variation and magnetothermal properties of reported molecular coolers, structuring the review by structural dimensions, metal-ions involved and ligands employed. This review ...
Shibutani Shusaku T - - 2013
Autophagy is a bulk degradation system induced by cellular stresses such as nutrient starvation. Its function relies on the formation of double-membrane vesicles called autophagosomes. Unlike other organelles that appear to stably exist in the cell, autophagosomes are formed on demand, and once their formation is initiated, it proceeds surprisingly ...
Bird Elizabeth R - - 2013
Women with a history of childhood sexual abuse (CSA) experience dissociative symptoms and sexual difficulties with greater frequency than women without a history of CSA. Current models of sexual dysfunction for sexual abuse survivors suggest that dissociation may mediate the relationship between CSA and sexual arousal difficulties. Dissociation, however, is ...
Yang Peiguo - - 2013
Autophagy involves the sequestration of a portion of the cytosolic contents in an enclosed double-membrane autophagosomal structure and its subsequent delivery to lysosomes for degradation. Autophagy activity functions in multiple biological processes during Caenorhabditis elegans development. The basal level of autophagy in embryos removes aggregate-prone proteins, paternal mitochondria and spermatid-specific ...
Huang Ruiwang - - 2013
Many previous studies suggested that both short-term and long-term motor training can modulate brain structures. However, little evidence exists for such brain anatomical changes in top-level gymnasts. Using diffusion-weighted and structural magnetic resonance images of the human brain, we applied voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) as well ...
Harris Lara - - 2013
Prior neuropsychological evidence suggests that semantic and phonological components of short-term memory (STM) are functionally and neurologically distinct. The current paper examines proactive interference (PI) from semantic and phonological information in two STM-impaired patients, DS (semantic STM deficit) and AK (phonological STM deficit). In Experiment 1 probe recognition tasks with ...
Jia Deshui - - 2013
We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal amplicon, 1q24.1-24.2, targets the MPZL1 gene in HCC. Notably, there is a positive correlation between the expression levels of MPZL1 and intrahepatic ...
Cieplik Fabian - - 2013
The aim of this study was to demonstrate that the periodontal pathogen Aggregatibacter actinomycetemcomitans (AA) can be killed by irradiation with blue light derived from a LED light-curing unit due to its endogenous photosensitizers. Planktonic cultures of AA and Escherichia coli were irradiated with blue light from a bluephase® C8 ...
Ferranti E J S - - 2013
Quantifying the sources of fugitive dusts on complex industrial sites is essential for regulation and effective dust management. This study applied two recently-patented Directional Passive Air Samplers (DPAS) to measure the fugitive dust contribution from a Metal Recovery Plant (MRP) located on the periphery of a major steelworks site. The ...
Lu Rong-Li - - 2013
Mutation of epidermal growth factor receptor (EGFR) gene has been reported to be present in lung adenocarcinoma (LAC). In this study, we extensively investigated the impact of patients' biological characteristics on EGFR mutation and the impact of EGFR mutation subtypes on targeted therapy of advanced LAC. We examined EGFR exons18to21status ...
Fukushima Kenji - - 2013
Posthepatectomy liver failure (PHLF) is a major complication after hepatectomy. As there was no standardized definition, the International Study Group of Liver Surgery (ISGLS) defined PHLF as increased international normalized ratio and hyperbilirubinemia on or after postoperative day 5 in 2010. We evaluated the impact of the ISGLS definition of ...
Mehta Urvakhsh Meherwan - - 2013
We aimed to assess the relationship between social cognition, neurocognition, negative symptoms and functional status in a homogeneous schizophrenia patient group remitted from positive symptoms. Sixty patients underwent assessments of social and neurocognition dimensions recommended by expert panels. A blind rater assessed their functional status. Second order theory of mind ...
Kute Vivek B - - 2013
Abstract Background: Kidney paired donation (KPD) is a rapidly growing modality for facilitating living donor kidney transplantation (LDKTx) for patients who are incompatible with their healthy, willing and living donor. The impact of donor-recipient age difference on long and short-term graft and patient survivals in LDKTx is still uncertain. Methods: ...
Freeman Daniel - - 2013
Persecutory delusions are one of the key problems seen in psychotic conditions. The aim of the study was to assess for the first time the levels of psychological well-being specifically in patients with current persecutory delusions. One hundred and fifty patients with persecutory delusions in the context of a diagnosis ...
Tsang Walter Y - - 2013
The benefit of an operation to remove the primary tumor among patients with synchronous stage IV colorectal cancer is controversial. This study analyzed the survival benefits associated with primary tumor resection among chemotherapy-treated stage IV colorectal cancer patients. The study analyzed 11,716 chemotherapy-treated stage IV colorectal cancer patients in the ...
Omori Takeshi - - 2013
The intracorporeal anastomosis is one of the most difficult procedures in single-incision laparoscopic gastrectomy for gastric cancer. We describe a simple technique for intracorporeal triangular Billroth I anastomosis in transumbilical single-port surgery. After adequate lymphadenectomy, the stomach and duodenum were staple-transected. Small incisions were made to the remnant stomach and ...
Wang Ling-Jia - - 2013
We are reporting first successful intrahepatic autologous islet transplantation after total pancreatectomy in a patient with chronic pancreatitis and primary sclerosing cholangitis. Total pancreatectomy and subsequent islet autotransplantation were performed in a 16-year-old boy with intractable pain due to chronic pancreatitis in the setting of ulcerative colitis and primary sclerosing ...
Mygatt J - - 2013
Background:To determine whether prostate cancers detected in the anterior vs posterior zones impact clinicopathological features and patient outcomes. This information could potentially affect clinical management.Methods:A retrospective pathological review of 1528 radical prostatectomy specimens submitted between 1989 and 2011 was completed. Specimens were characterized as anterior zone vs posterior zone based ...
Saetan Natthaphon - - 2013
Recent evidence suggests that angiogenesis and inflammation contribute to the development and progression of osteoarthritis (OA). The purpose of this study was to investigate vascular endothelial growth factor (VEGF) levels in plasma and synovial fluid of patients with knee OA and to determine the relationship of VEGF levels with disease ...
Mauffrey Cyril - - 2013
Once the privilege of few clinical scholars in the field of orthopaedics, medical writing has become a must for career advancement. The number of papers submitted and published yearly has increased steadily, and with the development of the Internet, manuscript and journals have become easily accessible. Medical writing has risen ...
Xue Youdi - - 2013
Treatment of talar neck fractures is challenging. Various surgical approaches and fixation methods have been documented. Clinical outcomes are often dissatisfying due to inadequate reduction and fixation with high rates of complications. Obtaining satisfactory clinical outcomes with minimum complications remains a hard task for orthopaedic surgeons. In the period from ...
Luo Qing - - 2013
Abdominal organs segmentation of magnetic resonance (MR) images is an important but challenging task in medical image processing. Especially for abdominal tissues or organs, such as liver and kidney, MR imaging is a very difficult task due to the fact that MR images are affected by intensity inhomogeneity, weak boundary, ...
Gao Yan - - 2013
Objective: Although cisplatin combined with 5-fluorouracil is a common first-line regimen for advanced nasopharyngeal carcinoma (NPC), there are no standard regimens for refractory or relapsed patients. A study of DXD regimen [cisplatin (D), capecitabine (X) and docetaxel (D)] was conducted to evaluate the efficacy and toxicity for patients with refractory ...
Magdaleno Anahí - - 2013
Toxicity of cadmium, copper and zinc was tested on four green algal species (Ankistrodesmus fusiformis, Chlorella ellipsoidea, Monoraphidium contortum and Scenedesmus acuminatus) isolated from a highly polluted river (Matanza-Riachuelo River, Buenos Aires, Argentina). The relative abundance of these species in river waters showed that C. ellipsoidea was the most abundant ...
Martins André F - - 2013
In an effort towards the visualization of β-amyloid (Aβ) plaques by T 1-weighted magnetic resonance imaging for detection of Alzheimer's disease, we report the synthesis and characterization of stable, noncharged Gd(3+) complexes of three different 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid monoamide derivatives conjugated to Pittsburgh compound B, a well-established marker of Aβ plaques. The ...
< 1 2 3 4 5 6 7 8 9 10 >