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Results 451 - 500 of 3164
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Comoglu Tansel - - 2013
Abstract Orally fast disintegrating tablets (FDTs or ODTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy ...
Estevez Ana - - 2013
Pathological gambling has severe consequences for adolescents and their families and friends. Despite its high prevalence, pathological gambling in adolescents has been insufficiently studied. Sensation seeking and impulsivity are two variables that are related to the appearance and maintenance of pathological gambling. However, few studies have determined the role these ...
Yang C-A - - 2013
Objectives: An elevated interleukin (IL)-1β response in peripheral blood mononuclear cells (PBMCs) has been observed in systemic juvenile idiopathic arthritis (sJIA), suggesting a role for inflammasomes in the pathogenesis of JIA. We aimed to determine whether genetic polymorphisms of the NLRP3 inflammasome components confer risk for oligoarticular and polyarticular JIA ...
Madhaiyan Munusamy - - 2013
A pink-pigmented, Gram negative, aerobic, facultatively methylotrophic bacterium, strain BL44(T), was isolated from bamboo leaves and identified as a member of the genus Methylobacterium. Phylogenetic analysis based on 16S rRNA gene sequences showed similarity values of 98.7-97.0 % with closely related type strains and showed highest similarity to Methylobacterium zatmanii DSM ...
Mi Liwei - - 2013
In this study, novel hierarchical rose-like Cu1.8Se microspheres with a porous three-dimensional (3D) framework were successfully synthesized by using a one-pot in situ growth method at low temperature (60 °C). The Cu1.8Se microspheres covered the surface of the 3D porous framework. The formation mechanism was investigated in detail by adjusting ...
Luo Cheng - - 2013
Prostate carcinoma is one of the leading causes of cancer-related morbidity and mortality in males in western countries. Curcumin exhibits growth-suppressive activity against several cancers, including prostate cancer, but it has poor bioavailability. The purpose of this study was to evaluate the anticancer potency and mechanism of a curcumin analogue, ...
Haynes Aveni - - 2013
The aim of this study was to investigate the association between maternal smoking during pregnancy and type 1 diabetes in the offspring, using complete population data sources available in Western Australia. A prospective cohort study was undertaken with cases defined as children born in Western Australia between 1998 and 2008 ...
Harish T Shilpa - - 2013
We report the interactions of a mesogenic molecule, 4'-octyl-4-biphenyl-carbonitrile (8CB), with some cations (Na(+), Cu(2+), Ni(2+), La(3+) and Al(3+)) dissolved in the aqueous subphase. Surface manometry studies show that the di- (Ni(2+) and Cu(2+)) and trivalent (La(3+)) ions promote condensation in the area per molecule and enhance the stability of ...
Rahman Shahidur - - 2013
The present manuscript provides a detailed physicochemical and thermodynamic characterization of 9-aminocamptothecin (9AC) which can be used as a tool to develop novel formulation strategies for optimum pharmacological activity. The pK a of 9AC was determined to be 2.43 at 37°C, while the basicity of quinoline nitrogen of 9AC was ...
Linda Anna - - 2013
This study was undertaken to evaluate whether magnetic resonance (MR) imaging is able to rule out malignancy in the case of BI-RADS 3 microcalcifications, providing a sufficient negative predictive value (NPV) for early work-up, and to reduce unnecessary stereotactically guided vacuum-assisted biopsy (SVAB) procedures. We prospectively enrolled consecutive women with ...
Capalbo Emanuela - - 2013
This study was performed to determine the type and incidence of complications of fine-needle aspiration biopsy (FNAB) and core biopsy (CNB) performed under computed tomography (CT) guidance to characterise lung lesions, and assess the diagnostic accuracy of the two techniques. In 2009-2011, we performed 124 lung biopsies (66 CNB and ...
Rydberg Patrik - - 2013
Introduction: The cytochrome P450 enzymes (CYPs) metabolize many drug compounds. They catalyze a wide variety of reactions, and potentially, a large number of different metabolites can be generated. Density functional theory (DFT) has, over the past decade, been shown to be a powerful tool to rationalize and predict the possible ...
Takeuchi Hajime - - 2013
To observe a case of congenital extrahepatic portosystemic shunt and discuss it from the embryological and clinical viewpoints. An 85-year-old female cadaver was employed for a dissection course at Aichi Medical University in 2009. There was no evidence of liver cirrhosis macroscopically or microscopically. A portosystemic shunt was observed that ...
Reis Henning - - 2013
Steatosis in donor livers is an accepted adverse prognostic factor after liver transplantation. While its semiquantitative assessment shows varying reproducibility, it is questioned as a standard method. Additionally, the influence of hepatic steatosis on ischemia/reperfusion injury (I/R injury) has not been evaluated in biopsies after reperfusion. We compared different staining ...
Wang Yun - - 2013
The organic-inorganic hybrid perovskite CH3NH3PbI3 is a novel light harvester, which can greatly improve the solar-conversion efficiency of dye-sensitized solar cells. In this article, a first-principle theoretical study is performed using local, semi-local and non-local exchange-correlation approximations to find a suitable method for this material. Our results, using the non-local ...
Govi Silvia - - 2013
ABSTRACT Indolent lymphomas primarily involving the skeleton (iPBL) represent <1% of all primary bone lymphomas. The management and prognosis have not been previously described. Patients with primary and secondary iPBL were selected from an international database of 499 patients with a histopathological diagnosis of non-Hodgkin lymphoma and skeleton involvement, and ...
Tortella-Feliu Miquel - - 2013
Attentional network functioning in emotionally neutral conditions and self-reported attentional control (AC) were analysed as predictors of the tendency to engage in dysfunctional emotion regulation strategies. Diminished attentional orienting predicted an increased tendency to engage in brooding rumination, and enhanced alertness predicted a greater chance of suppression, beyond trait anxiety ...
Veltri Andrea - - 2013
The study was done to analyse the results of a series of radiofrequency ablation (RFA) procedures performed on hepatic metastases (METS) from breast cancer in order to evaluate the clinical impact of this therapy. We analysed 45 patients (mean age 55 years) with 87 METS (mean size 23 mm), in terms of ...
Ierardi Anna Maria - - 2013
The aim of our study was to review our experience and long-term follow-up in the treatment of iatrogenic renal vascular injuries using transcatheter embolisation. Our retrospective analysis of cases collected in two interventional centres consists of a total of 21 patients who underwent renal arterial embolisation (RAE) for iatrogenic arterial ...
Clauser Paola - - 2013
This study was done to assess the feasibility of three-dimensional ultrasonography (3D-US) for volume calculation of solid breast lesions. The volumes of 36 malignant lesions were measured using conventional 2D-US, 3D-US and magnetic resonance imaging (MRI) and compared with that obtained with histology (standard of reference). With 2D Ultrasouns, volume ...
Collins Sheila - - 2013
Almost 20 years ago, the protein encoded by the ob locus in mice was identified as an adipocyte-secreted hormone, now termed leptin, which functions as a peripheral signal to communicate the organism's energy reserve-and thereby protects against starvation due to insufficient caloric resources. Additional peripheral factors have since been identified ...
Eggers Sander M - - 2013
Despite its popularity, few studies have assessed the temporal stability and cross-lagged effects of the Theory of Planned Behavior factors: Attitude, subjective norms and self-efficacy. For this study, 298 adolescent learners from KwaZulu-Natal, South Africa, filled out a Theory of Planned Behavior questionnaire on teenage pregnancy at baseline and after ...
Bartolotta Tommaso Vincenzo - - 2013
This study was undertaken to compare the imaging findings of focal nodular hyperplasia (FNH) in men and women, as seen on multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS). Two radiologists reviewed 195 imaging studies (17 MDCT, 81 MRI and 97 CEUS examinations) pertaining to 111 ...
Cazzola Mario - - 2013
Introduction: Indacaterol is a β2-agonist with a rapid onset of action and a bronchodilating effect that lasts for 24 h. Areas covered: This review considers indacaterol in chronic obstructive pulmonary disease patients, in whom it is rapidly absorbed into the systemic circulation with serum levels measurable after 5 min and ...
Magnavita Nicola - - 2013
Scientific data have amply demonstrated that work stress increases the risk of cardiovascular disease. However, less attention has been given to the association between stress and metabolic syndrome. In this study, our aim was to investigate the relationship between work stress and metabolic syndrome in a population of radiologists. Radiologists ...
Jennings Paul C - - 2013
Density functional theory calculations are performed on 38 and 79 metal atom truncated octahedron clusters to study oxygen dissociation as a model for the initial stage of the oxygen reduction reaction. Pure platinum and alloyed platinum-titanium core-shell systems are investigated. It is found that barrierless oxygen dissociation occurs on the ...
Snyder Hannah R - - 2013
People constantly face the need to choose one option from among many, such as when selecting words to express a thought. Selecting between many options can be difficult for anyone, and can feel overwhelming for individuals with elevated anxiety. The current study demonstrates that anxiety is associated with impaired selection ...
Cino Elio - - 2013
Linear Motifs (LMs) are protein-protein interaction sites, typically consisting of ~4-20 amino acid residues that are often found in disordered proteins or regions, and function largely independent from other parts of the proteins they are found in. These short sequence patterns are involved in a wide spectrum of biological functions ...
Giribabu Lingamallu - - 2013
'Axial-bonding'-type hetero trimers have been constructed by employing a simple 'inorganic' reaction such as axial bond formation of main group element containing phosphorus corrole. The approach is simple and modular in nature. The architecture of these hetero trimers such that, while a phosphorus(V)corrole forms the basal scaffolding unit, either two ...
Yadavi Marzieh - - 2013
An bis(2-aminoethyl)-2-(9-fluorenyl)malonamide as fluorophore ligand was immobilized onto mesoporous silica type SBA-15 via post synthesis grafting. The obtained material was characterized by small and wide angle X-ray diffraction, N2 adsorption-desorption, Fourier transform infrared spectroscopy, Raman spectroscopy and thermogravimetric analysis that indicate the successful immobilization of the ligand on the surface ...
Shimamoto Seiko - - 2013
FKBP38 (FK506-binding protein 38), a membrane-anchored, tetratricopeptide repeat (TPR)-containing immunophilin, regulates signaling pathways such as cell survival, apoptosis, proliferation, and metastasis. However, the mechanisms that regulate the activity of FKBP38 are, at present, poorly understood. We previously reported that Ca2+/S100 proteins directly associate with the TPR-proteins, such as Hsp70/Hsp90-organizing protein ...
Liao Kang-Ling - - 2013
We consider a two-patch model for a single species with dispersal and time delay. For some explicit range of dispersal rates, we show that there exists a critical value τ c for the time delay τ such that the unique positive equilibrium of the system is locally asymptotically stable for ...
Hosokawa Seiki - - 2013
Scanning timing for multi-detector row computed tomography during thoracic aortography (MDCT-TA) was explored for depiction of arteries responsible for hemoptysis. The mean time (MT) from contrast medium (CM) injection to peak enhancement (PE) in the descending aorta at the level of the diaphragm on thoracic aortography was investigated. The MT ...
Mullen Lisa - - 2013
Introduction: The use of cytokines as therapeutic agents is important, given their potent biological effects. However, this very potency, coupled with the pleiotropic nature and short half-life of these molecules, has limited their therapeutic use. Strategies to increase the half-life and to decrease toxicity are necessary to allow effective treatment ...
Crowther Carol - - 2013
Hepatitis B virus (HBV) is hyperendemic to southern Africa and parts of Asia, but licensed antivirals have little effect on limiting life-threatening complications of the infection. Although RNA interference- (RNAi-) based gene silencing has shown therapeutic potential, difficulties with delivery of antiHBV RNAi effecters remain an obstacle to their clinical ...
Knott Lauren M - - 2013
In this study, we examined the role of mood-congruency and retention interval on the false recognition of emotion laden items using the Deese/Roediger-McDermott (DRM) paradigm. Previous research has shown a mood-congruent false memory enhancement during immediate recognition tasks. The present study examined the persistence of this effect following a one-week ...
Niederle Bruno - - 2013
This "consensus statement" aims to summarise the current evidence-based knowledge as to "timing" and planning the "extent" of thyroid surgery in terms of an optimal balance between the prevention of thyroid malignancy (involving metastasis) and the risks associated with more extended surgery (permanent hypoparathyroidism, permanent paralysis of the recurrent laryngeal ...
Tan Kuan-Boone - - 2013
Aim: The aim of this work was to develop a liposomal formulation to facilitate delivery of a synergistic safingol/C2-ceramide combination in the treatment of acute myeloid leukemia (AML). Materials & methods: Liposomes were prepared using the extrusion method and the bioactive lipids were encapsulated passively. Drug concentrations were determined by ...
Ryoo Soyoon - - 2013
Avascular necrosis of the femoral head (ANFH) is commonly observed in patients treated with excessive glucocorticoid (GC). Single administration of lipopolysaccharide (LPS) has shown to induce immune stimulatory factors. However, the effect of repeated administration of LPS on GC-induced ANFH has not been studied. Thus the purpose of this study ...
Ayora-Talavera G - - 2013
In influenza A H1 virus, amino acids at position 190 and 225 of HA affect replication and transmission. In this study, we show that the mutation D190Y in the HA of influenza AH1N1pdm09 virus reduces the affinity of the virus for sialic acid receptors expressed at the surface of red ...
Kuhrt Katy - - 2013
Abstract Objective Accurate prediction of spontaneous preterm birth (sPTB) is essential to target interventions. Fetal fibronectin (fFN) is a leading predictor. A quantitative fFN (qfFN) test has improved prediction, based on high vaginal swabs (HVS). It is not known how endocervical (ECS) fFN levels compare, or which has the best ...
Martínez-Paz Pedro - - 2013
Small heat shock proteins constitute the most diverse and least conserved group within the large family of heat shock proteins, which play a crucial role in cell response to environmental insults. Chironomus riparius larvae are widely used in environmental research for testing pollutant toxicity in sediments and freshwater environments. Different ...
Tado Masahiro - - 2013
In order to clarify the role of vascular endothelial growth factor (VEGF) in the formation of contusion edema and necrosis after traumatic brain injury, we examined the time course of changes in the VEGF expression (Enzyme-Linked ImmunoSorbent Assay), cerebrovascular permeability (extravasation of Evans blue) and water content (dry-wet weight method) ...
Grayson Scott M - - 2013
The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masses across the mass range examined, ...
Satomura Yoshihiro - - 2013
Recently, there has been growing emphasis on enhancing subjective quality of life (QOL), in addition to treating symptoms or extending one's life. However, the neurobiological basis of subjective QOL is unknown. To illuminate the neural substrates that inform subjective QOL, the association between prefrontal function and subjective QOL was explored ...
Wills Rebecca H - - 2013
Non-ribosomal peptides are bio synthesized using a range of enzymes that allow much more structural variability compared with "normal" peptides. Deviations from the standard amino acid structures are common features of this diverse class of natural products, making sequencing a challenging process. FTICR mass spectrometry, specifically the complementary tandem mass ...
Todorova Roumiana - - 2013
Ewing`s sarcoma (ES) family of tumors (ESFTs) are round cell tumors of bone and soft tissues, afflicting children and young adults. This review summarizes the present findings about ES cancer stem cell (CSC) targeted therapy: prognostic factors, chromosomal translocations, initiation, epigenetic mechanisms, candidate cell of ES origin (Mesenchymal stem cells ...
Moura Bárbara Baêsso - - 2013
Ozone (O3) is a toxic secondary pollutant able to cause an intense oxidative stress that induces visual symptoms on sensitive plant species. Controlled fumigation experiment was conducted with the aim to verify the O3 sensibility of three tropical species: Piptadenia gonoachanta (Mart.) Macbr. (Fabaceae), Astronium graveolens Jacq. (Anacardiaceae), and Croton ...
Drosos Marios - - 2013
A fractionation technique, combining dialysis removal of metal and ash components with hydrofluoric acid and pH 10 citrate buffer followed by chromatography of dialysis permeate on XAD-8 resin at decreasing pH values, has been applied to lignite humic acid (lignite-HA) and soil humic acid (soil-HA). H-binding data and non ideal ...
Emonds Griet - - 2013
When people are confronted with social dilemmas, their decision-making strategies tend to be associated with individual social preferences; prosocials have an intrinsic willingness to cooperate, while proselfs need extrinsic motivators signaling personal gain. In this study, the biological roots for the proselfs/prosocials concept are explored by investigating the neural correlates ...
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