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Usmani Hadi - - 2013
Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. These drugs seem to ...
Pietrzak R H - - 2013
Post-traumatic stress disorder (PTSD) in response to the World Trade Center (WTC) disaster of 11 September 2001 (9/11) is one of the most prevalent and persistent health conditions among both professional (e.g. police) and non-traditional (e.g. construction worker) WTC responders, even several years after 9/11. However, little is known about ...
Zhu Leize - - 2013
Earth-abundant and nontoxic pyrite iron disulfide (FeS2) is very promising for photovoltaic applications but the phase purity and the morphology of iron pyrite nanocrystals (NCs) have a significant impact on the solar cell performance. In this work, we systematically investigated reaction conditions and the local chemical environment on the phase ...
Dambacher Franziska - - 2013
The ability to inhibit action tendencies is vital for adaptive human behaviour. Various paradigms are supposed to assess action inhibition and are often used interchangeably. However, these paradigms are based on different conceptualizations (action restraint vs. action cancellation) and the question arises as to what extent different conceptualizations of inhibitory ...
Matsugi Akira - - 2013
Vibrationally excited species have been considered to play significant roles in H2/F2 reaction systems. In the present study, in order to obtain further understanding of the chain-reaction mechanism in the combustion of mixtures containing H2 and F2, burning velocities for H2/F2/O2/N2 flames were measured and compared to that obtained from ...
Derlet Flavie - - 2013
Abstract Aldosterone levels are increased in primary aldosteronism (PA) and might be triggered in several cardiovascular disorders. The aim of our study was to assess the analytical validity of a novel automated aldosterone immunoassay. Method comparison was also performed with a reference radioimmunoassay. We report for the first time the ...
Balamurugan A - - 2013
A triple-action π-conjugated polymer chemosensor is developed for sensing temperature, selective detection of copper(ii) metal-ion and biological species - amino acids, in two wavelength optical switches based on red-fluorescent and blue-fluorescent molecular probes.
Jo Mi Ru - - 2013
A nano-Si/FeSi2Ti hetero-structure has been synthesized for highly reversible Li-ion batteries by using a simple melt-spinning method. We demonstrate that this composite has a very peculiar core/shell structure in which the FeSi2Ti alloy plays various pivotal roles as a mechanically supporting backbone and as an electronic pathway for the active ...
de Lima C R A - - 2013
Respiratory viral infections are frequent causes of morbidity in transplant patients. We screened symptomatic adult transplant recipients for respiratory viruses in a cohort of patients attending a referral medical center in Brazil. The duration of viral shedding and the prevalence of viral codetections were also determined. During a 1-year period ...
Dai Kai - - 2013
Surface-fluorinated TiO2 (F-TiO2) nanosheets with exposed (001) facets were synthesized from a scalable hydrothermal treatment assisted by a specific stabilization effect of fluorine ions on the (001) facets. Assembly of F-TiO2 on graphene oxide (GO) sheets into GO/F-TiO2 hybrid in aqueous solution was further achieved by making use of the ...
Erzengin Mahmut - - 2013
Abstract The antipsychotic drugs currently used to treat schizophrenia can be divided into two distinct classes, typical and atypical antipsychotics. Many drug molecules are enzyme inhibitors that bind reversibly or irreversibly to their target through intermolecular interactions. That's why enzyme inhibition studies are an important issue for drug design and ...
Angeli R D - - 2013
Background: The tensor tympani muscle is the largest muscle within the middle ear. Its voluntary contraction is a very unusual event. Only a few papers have documented its audiometric effects. Objective: To report an unusual case of voluntary tensor tympani muscle contraction and describe its audiometric effects. Case report: A ...
Stewart J I - - 2013
Without proper treatment, the mortality of pulmonary mucormycosis is nearly 100%. Although the diagnosis is often made histologically, it can be suspected when patients have a reverse halo sign on computed tomography (CT) of the chest, along with the right clinical findings. We describe the case of a woman 7 months ...
Kumar Ashok - - 2013
A long standing problem related to the capping of carbon nanotubes (CNT) by inorganic materials at high temperature has been solved. In situ dynamic response of Pb(Zr0.52Ti0.48)O3 (PZT) nanocrystals attached to the wings of the outer surface of PZT/CNT hybrid-nanostructure has been demonstrated under a constant-energy high-resolution transmission electron microscopy ...
Nascimento M M - - 2013
Alkali production by oral bacteria via the arginine deiminase system (ADS) increases the pH of oral biofilms and reduces the risk for development of carious lesions. This study tested the hypothesis that increased availability of arginine in the oral environment through an exogenous source enhances the ADS activity levels in ...
Borges Ab - - 2013
SUMMARY Purpose : The aim of this study was to investigate the staining behavior of demineralized enamel infiltrated by low-viscosity resin. Methods and Materials : Bovine enamel/dentin cylindrical samples (3 × 2 mm) were assigned into four groups (n=45) according to the enamel treatment: sound enamel (control), demineralization + artificial ...
de Paula Ab - - 2013
SUMMARY Objectives : The aim of this in vitro study was to investigate the effect of chemical degradation on the surface roughness (Ra) and hardness (Knoop hardness number [KHN]) of nano restorative materials. Methods : Disc-shaped specimens (5-mm diameter; 2-mm thick) of Filtek Z350 and TPH Spectrum composites and the ...
García-Fortea Pedro - - 2013
Abstract Objective: The relationship between labor physiology and the onset of lactation leads to assess the potential correlation between oxytocin administration during labor and duration of breast-feeding. Methods: This study was designed as a retrospective cohort study where patients given synthetic oxytocin during labor induction were considered as the exposed ...
Saiki K - - 2013
Outer membrane protein PG27 is essential for secretion/maturation of conserved C-terminal domain (CTD) proteins such as gingipains, HagA, and PG0026. To determine the binding partner(s) of PG27, we used a Porphyromonas gingivalis mutant strain, 83K48, which expressed functional histidine-tagged PG27. Purification of histidine-tagged PG27 from 83K48 found that 136-kDa and ...
Suárez Dimas - - 2013
Computational methods can help in the design of new bioorganometallic compounds. However, the presence of multihapto or σ/π metal-ligand bonding still precludes the direct application of either pure molecular mechanics (MM) or hybrid quantum mechanics-MM methods to study the flexibility of biomolecules in complex with organometallics. Herein, we present a ...
Song Jing-Ru - - 2013
Two new 2D COFs were synthesized from triformylcyclotrianisylene, which show not only thermal stability but also hydrolytic stability. CTV-COF-1 with smaller pore size stored a high hydrogen level of 1.3 wt% at low pressure, while CTV-COF-2 with larger pore size showed superior carbon dioxide uptake, up to 250 cm(3) g(-1) ...
Osmonov D - - 2013
Isolated left ventricular non-compaction is a rare genetic disorder manifesting mainly with heart failure, ventricular arrhythmias and systemic embolism. Isolated ventricular tachycardia originating from the right ventricular outflow tract is an arrhythmia that can be treated medically and/or by radiofrequency catheter ablation. Here, we report a case of an asymptomatic ...
Rafaeli-Yehudai Tal - - 2013
Abstract Objectives: To determine the effect of cervical cerclage on obstetrical complications and perinatal outcomes of patients following conization. Design: A retrospective population based cohort study Setting: Tertiary academic medical center that covers all the deliveries of the region Population: All patients with previous cervical conization who delivered between the ...
De-Jian Sun - - 2013
China used to be one of the most heavily endemic countries for lymphatic filariasis (LF) in the world. There were 864 endemic counties/cities in 16 provinces/autonomous regions/municipalities (P/A/M) with a total population of 330 million at risk of infection. Since the founding of the People's Republic of China in 1949, ...
Noueiri Soubra Balsam - - 2013
Dental trauma is a major problem in oral health in childhood especially if the result is a tooth avulsion. Subsequently, an appropriate management is essential to preserve the avulsed tooth. The goal of this study is to evaluate the knowledge of children concerning dental trauma and to highlight the importance ...
Qiao Na - - 2013
Increase of belowground C allocation by plants under global warming or elevated CO2 may promote decomposition of soil organic carbon (SOC) by priming and strongly affects SOC dynamics. The specific effects by priming of SOC depend on the amount and frequency of C inputs. Most previous priming studies have investigated ...
Hall A C - - 2013
Objective: To assess management of epistaxis at a tertiary ENT referral hospital against a recently published standard of best practice. Methods: Fifty consecutive cases of acute epistaxis that required admission to Guy's Hospital in 2009 were evaluated. Epistaxis education sessions were held to introduce our algorithm of best practice in ...
Matcham Faith - - 2013
The National Health Service (NHS) Stop Smoking Service (SSS) is an extremely cost-effective method of enabling smoking cessation. However, the SSS is only used by a minority of smokers. Developing interventions to maintain service attendance may help to increase the number of quitters. This study pilots an intervention aimed at ...
Bieri Franziska A - - 2013
With more than two billion people infected worldwide, soil-transmitted helminths (STH) are the most widespread infections. To date, STH control efforts rely predominantly on recurrent mass drug administration (MDA), which does not prevent reinfection. Additional public health measures including novel health educational tools are required for more sustained integrated control ...
Hamilton D W - - 2013
Background: The Cumberland Infirmary, Carlisle, serves a largely remote, rural population of 330 000. The aim of this study was to report the treatment and survival figures for patients treated for laryngeal cancer at this centre. Methods: The study included 209 consecutive patients with squamous cell carcinoma of the larynx ...
Boumans Nicolle P G - - 2013
This study compared the work-related experiences and personal health status of double-duty caregivers with those of caregivers who do not provide informal care to a family member or close friend in need. The interest in providing informal care alongside employment is growing. However, little attention has been paid to the ...
Zhi Wen-Hong - - 2013
Simvastatin (SV) is reported to improve cognition and slow the progression of Alzheimer's disease (AD). This study explored the mechanisms underlying the antiamnesic effect of SV in AD using behavior tests, histological examination, western blot analysis, and electrophysiological recording technique in AD model mice created by intracerebroventricular injection (i.c.v.) of ...
Lee Manhee - - 2013
Coalescence of two kinds of pre-processed droplets is necessary to perform chemical and biological assays in droplet-based microfluidics. However, a robust technique to accomplish this does not exist. Here we present a microfluidic device to synchronize the reinjection of two different kinds of droplets and coalesce them, using hydrostatic pressure ...
Jansson M - - 2013
One problem in modern dogs is a high occurrence of physical diseases, defects and disorders. Many breeds exhibit physical problems that affect individual dogs throughout life. A potential cause of these problems is inbreeding that is known to reduce the viability of individuals. We investigated the possible correlation between recent ...
Rizzello Loris - - 2013
Despite the current advancement in drug discovery and pharmaceutical biotechnology, infection diseases induced by bacteria continue to be one of the greatest health problems worldwide, afflicting millions of people annually. Almost all microorganisms have, in fact, an intrinsic outstanding ability to flout many therapeutic interventions, thanks to their fast and ...
Labs Sabrina - - 2013
The miscibility behavior of the USiO<sub>4</sub> - ThSiO<sub>4</sub> system was investigated. The end members and ten solid solutions U<sub>x</sub>Th<sub>(1-x)</sub>SiO<sub>4</sub> with x = 0.12 - 0.92 were successfully synthesized, without formation of other secondary uranium or thorium phases. Lattice parameters of the solid solutions evidently follow Vegard's Law. Investigation of the ...
Ramakrishnan Sathish Kumar - - 2013
Engineering shape-controlled bionanomaterials requires comprehensive understanding of interactions between biomolecules and inorganic surfaces. We explore the origin of facet-selective binding of peptides' adsorbed onto Pt(100) and Pt(111) crystallographic facets. Using molecular dynamics simulations we show that upon adsorption the peptides adopt a predictable conformation. We compute the binding energies of ...
Wang Kaiying - - 2013
Hollow nanoarchitectured materials with straight channels play a crucial role in the fields of renewable energy, environment and biotechnology due to their one-dimensional morphology and extraordinary properties. The current challenge is the difficulty on tailoring hollow nanoarchitectures with well-controlled morphology at a relatively low cost. As a conventional technique, electrochemistry ...
Wang Zheng - - 2013
Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons. In this study, we have investigated the molecular mechanisms ...
Redden George - - 2013
Flow columns containing regions of urease immobilized on silica gel were used to examine how calcium carbonate precipitation and strontium partitioning are distributed along the flow path when calcium, strontium and urea are present in the influent. Bicarbonate ion was generated in situ by urea hydrolysis. Under constant hydraulic head ...
Jin Changyun - - 2013
Olmesartan medoxomil inhibits the vasoconstrictor effects of angiotensin II. Hydrochlorothiazide (HCTZ) promotes sodium excretion, resulting in a reduction of plasma volume and peripheral resistance. A combination of these agents is known to have a greater effect for the treatment of hypertension than monotherapy with either one of these components. Objective: ...
Yang Weihong - - 2013
Background: Gender differences in pharmacokinetics have been reported to have important clinical consequences; however, no information about differences in the pharmacokinetics of the cholesterol-lowering drug simvastatin lactone and its metabolite, simvastatin hydroxy acid, in males and females is available. Objective: The aim of this study was to investigate the effect ...
Tfelt-Hansen Peer C - - 2013
Introduction: The development of sumatriptan, more than 20 years ago, added substantially to the characterization of 5-hydroxytryptamine (5-HT) receptors and their relevance to acute migraine therapy. Recently, 5-HT1F receptor agonists, with no vascular effects, have shown efficacy in the treatment of migraines. Areas covered: This evaluation reviews the recent advances ...
Chen Peng - - 2013
We review the rare cancer cell sorting technologies, with a focus on multiscale immunomagnetic approaches. Starting from the conventional magnetic activated cell sorting system, we derive the scaling laws of immunomagnetic assay and justify the recent trend of using downscaled systems for CTC studies. Furthermore, we introduce recent work on ...
Koutsoukas Alexios - - 2013
Chemical diversity is a widely applied approach to select structurally diverse subsets of molecules, often with the aim of maximizing the number of hits in biological screening. While many methods exist in the area, few systematic comparisons using current descriptors in particular with the objective of assessing diversity in bioactivity ...
Wang Rong - - 2013
A previously healthy young female, presenting with nausea, vomiting, diarrhea, anemia, thrombocytopenia, and acute renal failure, was admitted to our hospital. Her clinical and histological features were consistent with both hemolytic uremic syndrome and IgA nephropathy, and she responded to steroid treatment, plasma transfusion, and gamma globulin therapy and did ...
Ferri Francesca - - 2013
Request and emblematic gestures, despite being both communicative gestures, do differ in terms of social valence. Indeed, only the former are used to initiate/maintain/terminate an actual interaction. If such a difference is at stake, a relevant social cue, i.e. eye contact, should have different impacts on the neuronal underpinnings of ...
Zhao Yan - - 2013
Isoelectric focusing (IEF) is a powerful and widely used technique for protein separation and purification. There are many embodiments of microscale IEF that use capillary or microfluidic chips for the analysis of small sample volumes. Nevertheless, collecting the separated sample volumes without causing remixing remains a challenge. Herein, we describe ...
Tran Thai Hoa - - 2013
Children with Down syndrome (DS) are at high risk of infectious toxicity when treated with acute lymphoblastic leukemia chemotherapy protocols optimized in children without DS. Our objective was to determine if children with DS and acute myeloid leukemia (AML) have a different risk of infection when treated with chemotherapy protocols ...
Ishibashi Akira - - 2013
A novel free radical scavenger, edaravone, has been demonstrated to exert a neuroprotective effect and improve outcomes in acute ischemic stroke, but there have been few clinical studies. Therefore, we investigated retrospectively whether the administration of edaravone at the acute stage of ischemic stroke can improve outcomes of the disease ...
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