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Results 301 - 350 of 2227
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Nurden Alan T - - 2013
Genetic defects of platelets constitute rare diseases that include bleeding syndromes of autosomal dominant, recessive or X-linked inheritance. They affect platelet production, resulting in a low circulating platelet count and changes in platelet morphology, platelet function, or a combination of both with altered megakaryopoiesis and a defective platelet response. As ...
Goodman Jarid - - 2013
Extensive evidence indicates that mammalian memory is organized into multiple brains systems, including a 'cognitive' memory system that depends on the hippocampus and a stimulus-response 'habit' memory system that depends on the dorsolateral striatum. Dorsal striatal-dependent habit memory may in part influence the development and expression of some human psychopathologies, ...
Brown T N - - 2013
A group contribution-based quantitative structure-property relationship (QSPR) for the hexadecane-air equilibrium partition coefficients (L) of organic chemicals is developed using the iterative fragment selection (IFS) approach. This new QSPR includes in its training and external validation data sets L values for a large number of structurally complex chemicals measured by ...
Reeves Wendy - - 2013
Background In the simple ascidian chordate Ciona the signaling pathways and gene regulatory networks giving rise to initial notochord induction are largely understood and the mechanisms of notochord morphogenesis are being systematically elucidated. The notochord has generally been thought of as a non-compartmentalized or regionalized organ that is not finely ...
Chou Sheng-Lung - - 2013
The photodissociation of gaseous molecular nitrogen has been investigated intensively, but the corresponding knowledge in a solid phase is lacking. Irradiation of pure solid nitrogen at 3 K with vacuum-ultraviolet light from a synchrotron produced infrared absorption lines of product l-N3 at 1657.8 and 1652.6 cm(-1) . The threshold wavelength ...
Ravi P R - - 2013
Abstract Intranasal thermosensitive gel for rasagiline mesylate (RM) was developed for effective treatment of Parkinson's disease. Intranasal gels were prepared by combination of poloxamer 407 and poloxamer 188 (1:1) with mucoadhesive polymers (carbopol 934 P and chitosan). The formulations were evaluated for sol-gel transition temperature, in-vitro drug release and in-vivo mucociliary ...
Li Jihong - - 2013
Sweet sorghum is regarded as a very promising energy crop for ethanol production because it not only supplies grains and sugar, but also offers lignocellulosic resource. Cost-competitive ethanol production requires bioconversion of all carbohydrates in stalks including of both sucrose and lignocellulose hydrolyzed into fermentable sugars. However, it is still ...
Canfrán-Duque Alberto - - 2013
Exosomes/microvesicles are originated from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of curcumin, a polyphenol, on exosomes/microvesicles secretion in different cells lines, using U18666A as a model of intracellular cholesterol trafficking impairment. In both HepG2 hepatocarcinoma ...
Yoshizumi Tomoharu - - 2013
Limit of donor age, graft size and model for end-stage liver disease (MELD) score has not been apparent in living donor liver transplantation (LDLT). Our team has developed the following formula for predicting graft survival after living donor liver transplantation (LDLT): predictive score = 0.011 × graft weight (%) - ...
Jancke Georg - - 2013
Abstract Objective. This study aimed to evaluate the impact of experience in transurethral resection of bladder tumour (TURBT) on recurrence and progression in primary Ta/T1 urinary bladder cancer. Material and methods. Clinical and pathological characteristics of patients with primary Ta/T1 urinary bladder cancer were recorded prospectively from 1992 to 2007 ...
Jia Ling-Yi - - 2013
The mutualism between fig trees and their wasp pollinators is a model system for many ecological and evolutionary studies. However, the immature stages of pollinating fig wasps have rarely been studied. We monitored developing fig wasps of known ages and performed a series of dissections at 24 h intervals to identify ...
Maroto Enrique E - - 2013
A complete stereocontrol of 1,3-dipolar cycloaddition of N-metalated azomethine ylides onto endohedral fullerene H2@C60 is reported for the first time. The stereodivergent synthesis of either the cis or the trans endohedral cycloadduct is achieved with excellent diastereo- and enantioselectivities.
Pinheiro Vanessa Alves - - 2013
Abstract With the aim of reducing system absorption and consequently, the side effects, and simultaneously select a penetration enhancing, three topical formulations with 0.5% ciclopirox olamine (CO) and 15% of propylene glycol (PG), ethoxydiglycol or oleic acid were developed and evaluated regarding the skin penetration and cutaneous retention of the ...
Lückhoff Marlize - - 2013
Suicide risk behavior is a significant contributor to the mortality and morbidity of schizophrenia. We previously reported affected sibship status in a Xhosa schizophrenia or schizoaffective disorder sample to be protective in nature; given the counterintuitive nature of this finding, we expanded the sample size to seek further clarification. Subjects ...
Riley Sean P - - 2013
Bacteria of the genus Rickettsia are transmitted from arthropod vectors and primarily infect cells of the mammalian endothelial system. Throughout this infectious cycle, the bacteria are exposed to the deleterious effects of serum complement. Using Rickettsia conorii, the etiologic agent of Mediterranean spotted fever (MSF), as a model rickettsial species, ...
Park Jonghyuck - - 2013
Acrolein, an α,β-unsaturated aldehyde and a reactive product of lipid peroxidation, has been suggested as a key factor in neural post-traumatic secondary injury in SCI, mainly based on in vitro and ex vivo evidence. Here we demonstrate an increase of acrolein up to 300%; the elevation lasted at least two ...
Kami Chitose - - 2013
Phototropism allows plants to orient their photosynthetic organs towards the light. In Arabidopsis, phototropins 1 and 2 sense directional blue light with phot1 triggering phototropism in response to low fluence rates, while both phot1 and phot2 mediate this response in higher light. Phototropism results from asymmetric growth in the hypocotyl ...
Ochoa-Cortes F - - 2013
Stress hormones can signal to colonic dorsal root ganglia (DRG) neurons and may play a role in sustained hyperexcitability of nociceptors. Mouse DRG neurons were exposed overnight to epinephrine (Epi) 5 nM and/or corticosterone (Cort) 1 μM or prior water-avoidance stress. Patch clamp recordings, visceromotor reflexes (VMRs) and molecular studies were conducted. ...
Rhieu Steve Y - - 2013
Non-invasive and real-time analysis of cellular redox processes has been greatly hampered by lack of suitable measurement techniques. Here we describe an in-cell nuclear magnetic resonance (NMR) based method for measuring the intracellular glutathione redox potential by direct and quantitative measurement of isotopically labeled glutathione introduced exogenously into living yeast. ...
Shang Lu - - 2013
Graphene nanosheet-supported ultrafine metal nanoparticles encapsulated by thin mesoporous SiO2 layers were prepared and used as robust catalysts with high catalytic activity and excellent high-temperature stability. The catalysts can be recycled and reused in many gas- and solution-phase reactions, and their high catalytic activity can be fully recovered by high-temperature ...
Ozalvo Rachel - - 2013
The responses of two closely related members of Arabidopsis 13-lipoxygenase (13-LOX)- LOX3 and LOX4-to infection by the sedentary nematodes root-knot nematode (Meloidogyne javanica) and cyst nematode (Heterodera schachtii) were analyzed in transgenic Arabidopsis seedlings. Tissue localization of LOX3 and LOX4 gene expression using β-glucuronidase (GUS) reporter gene constructs showed local ...
Prestage Garrett - - 2013
Use of erectile dysfunction medications (EDMs) is relatively common among gay and bisexual men and has been associated with human immunodeficiency virus sexual risk behavior. We aimed to determine what factors were related to EDM use on occasions when participants engaged in protected anal intercourse (PAIC) and when they engaged ...
Lesko Lawrence J - - 2013
Heterogeneity of treatment effects in unselected patient populations has stimulated various strategic approaches to reduce variability and uncertainty and improve individualization of drug selection and dosing. The rapid growth of DNA sequencing and related technologies has ramped up progress in interpreting germline and somatic mutations and has begun to re-shape ...
Westneat David F - - 2013
Plasticity in life history characteristics can influence many ecological and evolutionary phenomena, including how invading organisms cope with novel conditions in new locations or how environmental change affects organisms in native locations. Variation in reaction norm attributes is a critical element to understanding plasticity in life history, yet we know ...
Suhm Martin A - - 2013
"…︁ Which is the most stable molecular structure of the sum formula C6 H12 O6 ? Nobody really knows yet, but for sure it is not glucose …︁ The winners-and there is just one for every reasonable sum formula-might be termed 'Guinness molecules' …︁" Read more in the Editorial by ...
Nyyssönen Virva - - 2013
Abstract Objective. The aim of this study was to investigate the difference in subjective cure rate and patient satisfaction between tension-free vaginal tape (TVT) and transobturator tape (TOT) surgical methods in the treatment of stress and mixed urinary incontinence. Material and methods. From January 2004 to November 2006, a total ...
Esposito Fabienne - - 2013
Objective: Apathy, defined as a reduction in voluntary goal-directed behaviors (GDBs), is common in aging, but the processes underlying apathy are still unclear. Self-efficacy beliefs are likely to play a key role in GDBs, by influencing goal setting, perceived difficulty, and the necessary amount of effort to achieve goals. The ...
Saeed Ayman Moustafa - - 2013
Summary Prenatal losses are a complex problem. Pregnancy requires orchestrated communication between the embryo and the uterus that includes secretions from the embryo to signal pregnancy recognition and secretion and remodelling from the uterine epithelium. Most of these losses are characterized by asynchronization between embryo and uterus. To better understand ...
S Pujari - - 2013
The present study focuses on the effects of nanoscale porosity on inflammatory response in vitro and in vivo. Nanoporous alumina membranes with different pore sizes, 20 and 200nm in diameter, were used. We first evaluated cell/alumina interactions in vitro by observing adhesion, proliferation, and activation of a murine fibroblast and ...
Gaile Daniel P - - 2013
There are still many open questions in data-analytic research pertaining to biomarker development in the era of personalized/precision medicine and big data. Among them is the question of what constitutes best practice for the extraction of prioritized lists of candidate biomarkers from smaller studies that are 'hypothesis generating' in nature. ...
Zheng Xingliang - - 2013
Constructing biaryls through direct aromatic CH functionalization of unactivated arenes has become a popular topic in organic chemistry. Many efficient methods have been developed. In this Communication, a direct arylation of unactivated arenes with a broad range of aryl iodides is reported. This reaction proceeds through a new type of ...
Lerner Nataly - - 2013
Background: The ADA 2010 guidelines added HbA1c ≥ 6.5% as a criterion for diagnosing diabetes mellitus type 2. Objective: To evaluate the HbA1c test in predicting type 2 diabetes in a high risk population. Methods: A community-based historic cohort study was conducted including 10 201 patients, who had not been ...
Wrubel David M - - 2013
Object Quality assessment measures have not been well developed for pediatric neurosurgical patients. This report documents the authors' experience in extracting information from an administrative database to establish the rate of return to system within 30 days of pediatric neurosurgical procedures. Methods Demographic, socioeconomic, and clinical characteristics were prospectively collected ...
Shirokane Kenji - - 2013
A chemoselective approach for the total synthesis of (±)-gephyrotoxin has been developed. The key to success was the utilization of N-methoxyamides, which enabled the direct coupling of the amide with an aldehyde and selective reductive nucleophilic addition to the amide in the presence of a variety of sensitive and electrophilic ...
Dahl Cecilie - - 2013
The aim of this study was to investigate relations between cadmium, lead, and aluminum in municipality drinking water and the incidence of hip fractures in the Norwegian population. A trace metals survey in 566 waterworks was linked geographically to hip fractures from hospitals throughout the country (1994-2000). In all those ...
Shen Shang-Hang - - 2013
Object The occurrence of hydrocephalic macrocephaly is uncommon. When the condition does occur, it is usually seen in infants and young children. Patients with this disorder have an excessively enlarged head and weak physical conditions. Various surgical techniques of reduction cranioplasty for the treatment of these patients have been reported. ...
Manna Uttam - - 2013
I'm stuck on you: Droplet-based liquid crystal (LC) chemical sensors can be immobilized on living cells. The decorated cells can report in real time on the presence of toxins in surrounding culture media. The approach provides new principles for the design of droplet-based LC sensors as well as methods for ...
Bateman Grant A - - 2013
Object It is known that CSF diversion in neonatal hydrocephalus can significantly increase cerebral blood flow, suggesting that a rapidly reversible elevation in vascular resistance underlies this disorder. Various sites of vascular compression have been described in the literature, from the arterioles to the capillary bed to the venules and ...
Di Mauro Antonio - - 2013
Autoantibody-related congenital heart block (CHB) is an autoimmune condition in which trans placental passage of maternal autoantibodies cause damage to the developing heart conduction system of the foetus. We report a case of an Italian 31--year-old woman, in a good clinical status, referred to our Centre at 26 weeks of ...
Goeminne Pieter C - - 2013
Non-cystic fibrosis bronchiectasis (NCFB) is characterized by a vicious cycle of airway infection, inflammation and structural damage with inappropriate mucus clearance. Our aim was to relate the value of proteolytic enzymes, proteolytic enzyme activity and inflammatory markers to disease severity and symptoms in patients with NCFB. Sputum induction in NCFB ...
Broda Henning - - 2013
New iron dinitrogen complexes are crucial to a catalytic ammonia synthesis in homogeneous solution and establish new structural motifs related to the iron-molybdenum cofactor of the enzyme nitrogenase (see scheme; BAr(F) = B[3,5-(CF3 )2 C6 H3 ]4 ). These findings are put into the context of 50 years of synthetic ...
McLaughlin Nancy - - 2013
Object Value of care is emerging as a promising framework to restructure health care, emphasizing the importance of reporting multiple outcomes that encompass the entire care episode instead of isolated outcomes specific to care points during a patient's care. The authors assessed the impact of coordinated implementation of processes across ...
Tang Ho Man - - 2013
The midribs of maize brown-midrib (bm) mutants exhibit a reddish-brown color associated with reductions in lignin concentration and alterations in lignin composition. Here, we report the mapping, cloning, and functional and biochemical analyses of the bm2 gene. The bm2 gene was mapped to a small region of chromosome 1 that ...
Moore Jason S - - 2013
Currently, kinetic data is either collected under steady-state conditions in flow or by generating time-series data in batch. Batch experiments are generally considered to be more suitable for the generation of kinetic data because of the ability to collect data from many time points in a single experiment. Now, a ...
Alan Nima - - 2013
Object The objective of this study was to assess whether preoperative anemia in patients undergoing elective cranial surgery influences outcomes in the immediate perioperative period (≤ 30 days). Methods The National Surgical Quality Improvement Program (NSQIP) was used to identify 6576 patients undergoing elective cranial surgery between 2006 and 2011. ...
Kivipelto Leena - - 2013
Object The object of this study was to describe the authors' institutional experience in the treatment of complex middle cerebral artery (MCA) aneurysms necessitating bypass and vessel sacrifice. Methods Cases in which patients with MCA aneurysms were treated with a combination of bypass and parent artery sacrifice were reviewed retrospectively. ...
Froeding Ligita Paskeviciute - - 2013
Radical vaginal trachelectomy (RVT) offers low complication rate, good survival, and possibility for future childbearing for young women with early stage cervical cancer. However, the literature on quality of life (QOL) and sexual functioning in patients undergoing RVT is scarce. The aims of this study were to prospectively assess sexual ...
Barcellos Christovam - - 2013
To examine the spatial and temporal patterns of the recent expansion of dengue transmission area in Brazil (2001-2012) with the aim to identify pathways and constraints to dengue diffusion. Synthetic indicators were calculated to characterise timing (year of first dengue outbreak), permanence (number of years with dengue outbreaks) and intensity ...
Davies Jason M - - 2013
Object The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models would greatly accelerate the development of novel therapeutic options for chordoma. The authors sought to establish and characterize a primary xenograft model for chordoma that faithfully recapitulates the molecular features of human chordoma. ...
Cao Nan - - 2013
Well-dispersed core-shell Ru@M (M=Co, Ni, Fe) nanoparticles (NPs) supported on carbon black have been synthesized via a facile in situ one-step procedure under ambient condition. Core-shell Ru@Co NPs were synthesized and characterized for the first time. The as-synthesized Ru@Co and Ru@Ni NPs exhibit superior catalytic activity in the hydrolysis of ...
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