Search Results
Results 251 - 300 of 2229
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Connaughton J - - 2013
Many people with mental health disorders experience fatigue, pain and poor sleep. In other patient groups, physical exercise has been shown to have positive effects on these symptoms. It is unknown whether day-to-day physical activity (not necessarily exercise) affects sleep quality or severity of pain or fatigue in those with ...
Ochoa-Cortes F - - 2013
Stress hormones can signal to colonic dorsal root ganglia (DRG) neurons and may play a role in sustained hyperexcitability of nociceptors. Mouse DRG neurons were exposed overnight to epinephrine (Epi) 5 nM and/or corticosterone (Cort) 1 μM or prior water-avoidance stress. Patch clamp recordings, visceromotor reflexes (VMRs) and molecular studies were conducted. ...
Lesko Lawrence J - - 2013
Heterogeneity of treatment effects in unselected patient populations has stimulated various strategic approaches to reduce variability and uncertainty and improve individualization of drug selection and dosing. The rapid growth of DNA sequencing and related technologies has ramped up progress in interpreting germline and somatic mutations and has begun to re-shape ...
Stone S F - - 2013
Hypersensitivity reactions including anaphylaxis have been reported for nearly all classes of therapeutic reagents and these reactions can occur within minutes to hours of exposure. These reactions are unpredictable, not directly related to dose or the pharmacological action of the drug and have a relatively high mortality risk. This review ...
Xu Mingze - - 2013
Reclaimable adsorbents have a critical application in the adsorption of radioactive materials. In this study, the novel bio-nanocomposites comprising fungi and titanate nanotubes are successfully synthesized by a simple and low-cost method. Morphological characterizations and composite mechanism analysis confirm that the composites are sufficiently stable to avoid dust pollution resulting ...
Badescu Alina - - 2013
Gastrointestinal Kaposi sarcoma (KS) is classical, but rare. The AKT signaling pathway plays a central role in G protein-coupled receptor, key protein of KS histogenesis, encoded by KSHV/HHV8. There is increasing evidence that rapamycin, acting on AKT pathway, may be useful in the treatment of KS, including in HIV patients. ...
Haarman Bartholomeus Benno Cm - - 2013
Existing and previously published datasets were examined for associations between illness and treatment characteristics and monocyte pro-inflammatory gene expression in patients with bipolar disorder (BD). We hypothesized a priori that increased monocyte pro-inflammatory gene expression would be found more frequently in patients with a lifetime history of psychotic symptoms. Monocyte ...
Suplicy H - - 2013
Context:No long-term studies have compared centrally acting drugs for treating obesity.Objective:To compare the efficacy and safety of diethylpropion (DEP), fenproporex (FEN), mazindol (MZD), fluoxetine (FXT), and sibutramine (SIB) in promoting weight loss.Design and Setting:A prospective, randomized, placebo (PCB)-controlled study conducted at a single academic institution.Patients:A total of 174 obese premenopausal ...
Boyer Nathan - - 2013
Initiation of enteral feeding is an important part of the best practice model for critically ill patients. Although nasogastric feeding is appropriate for the majority of patients requiring short-term nutrition support, certain patients benefit greatly from postpyloric feeding. To determine which of 2 specialized enteral tube systems achieved postpyloric placement ...
Wang Shuai - - 2013
No endogenous insulin-like peptides in parasitic flatworms have been reported. Insulin receptors from flukes and tapeworms have been shown to interact directly with the host-derived insulin molecule, which suggested the only exploitation of host-derived insulin. In this study, a combined strategy for genome-wide searches followed by comprehensive analyses of strictly ...
Singh Satyakam - - 2013
Multidrug resistance caused by ATP binding cassette transporter P-glycoprotein (P-gp) through extrusion of anticancer drugs from the cells is a major cause of failure in cancer chemotherapy. Previously, selenazole-containing cyclic peptides were reported as P-gp inhibitors and were also used for co-crystallization with mouse P-gp, which has 87 % homology to ...
Saeed Ayman Moustafa - - 2013
Summary Prenatal losses are a complex problem. Pregnancy requires orchestrated communication between the embryo and the uterus that includes secretions from the embryo to signal pregnancy recognition and secretion and remodelling from the uterine epithelium. Most of these losses are characterized by asynchronization between embryo and uterus. To better understand ...
Maeda-Uematsu Aya - - 2013
CCN2/connective tissue growth factor (CTGF) is a unique molecule that promotes both chondrocytic differentiation and proliferation through its matricellular interaction with a number of extracellular biomolecules. This apparently contradictory functional property of CCN2 suggests its certain role in basic cellular activities such as energy metabolism, which is required for both ...
Granatosky Michael C - - 2013
The presence of a stable thoracolumbar region, found in many arboreal mammals, is considered advantageous for bridging and cantilevering between discontinuous branches. However, no study has directly explored the link between osteological features cited as enhancing axial stability and the frequency of cantilevering and bridging behaviors in a terminal branch ...
Bundschu Karin - - 2013
Background: ATIPs (Angiotensin receptor type 2 (AT2) interacting proteins) are described as AT2 interacting protein variants, whereas their expression and functions during development are not known yet. Results: Here, we provide a detailed expression pattern of ATIP variants during mouse development by visualizing Mtus1 promotor activity, Mtus1 RNA, and subsequent ...
Cuevas A - - 2013
Any practical realization of entanglement-based quantum communication must be intrinsically secure and able to span long distances avoiding the need of a straight line between the communicating parties. The violation of Bell's inequality offers a method for the certification of quantum links without knowing the inner workings of the devices. ...
Laoutidis Zacharias G - - 2013
Akathisia is a common and distressing extrapyramidal side-effect, which usually results from the use of antipsychotic medication. Previous reviews and meta-analyses have demonstrated a lack of evidence for the effectiveness of treatment strategies, which are traditionally used against neuroleptic-induced akathisia (NIA), i.e. beta-blockers, anticholinergic agents and benzodiazepines. In the last ...
Stember Doron S - - 2013
Inflatable penile prosthesis (IPP) surgery is a successful therapeutic option for men with erectile dysfunction. Traditional placement of the reservoir in the retropubic space of Retzius is associated with the rare occurrence of significant complications including bladder, bowel, and vascular injury. An alternative site, posterior to the abdominal wall musculature, ...
Buratto Jérémie - - 2013
In the search of molecules that could recognize sizeable areas of protein surfaces, a series of ten helical aromatic oligoamide foldamers was synthesized on solid phase. The foldamers comprise three to five monomers carrying various proteinogenic side chains, and exist as racemic mixtures of interconverting right-handed and left-handed helices. Functionalization ...
Tang Ho Man - - 2013
The midribs of maize brown-midrib (bm) mutants exhibit a reddish-brown color associated with reductions in lignin concentration and alterations in lignin composition. Here, we report the mapping, cloning, and functional and biochemical analyses of the bm2 gene. The bm2 gene was mapped to a small region of chromosome 1 that ...
Davies Jason M JM Department of Neurological - - 2014
The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models would greatly accelerate the development of novel therapeutic options for chordoma. The authors sought to establish and characterize a primary xenograft model for chordoma that faithfully recapitulates the molecular features of human chordoma. Chordoma ...
Mosser Anna A - - 2013
Energetic balance is a central driver of individual survival and population change, yet estimating energetic costs in free and wide ranging animals presents a significant challenge. Animal-borne activity monitors (using accelerometer technology) present a promising method of meeting this challenge and opens new avenues for exploring energetics in natural settings. ...
Gaballah Marian - - 2013
Object The use of cerebral intraoperative angiography has been described in resection of arteriovenous malformations (AVMs) in adults. More recently, studies have described experiences with intraoperative angiography in a small number of children. However, data on the safety and clinical utility of intraoperative angiography in the pediatric population remains limited ...
Porta F - - 2013
To evaluate the feasibility and reproducibility of ultrasound elastography (UE) in the assessment of healthy patellar tendon and to describe its UE pattern. Twenty-two patellar tendons of 11 out of 16 healthy subjects who met the inclusion criteria were evaluated three times by ultrasound (US) and UE at their proximal, ...
Lercher Lukas - - 2013
Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.
Mouline Zineb - - 2013
Multivalent glycovesicle recognition over lectin layers emphasizes effects on the dynamic lateral fluidity of glycoside clusters upon multivalent binding at the bilayer surface and vice versa.
Welsh Patrick - - 2013
There is a long-standing interest in the relationship between patients affected by psychosis and their families. Previous research also suggests that perceived family dysfunction is a factor commonly associated with psychological problems in adolescence. The current study examined the role of self-reported family perceptions in the context of adolescents with ...
Tuckett Joel - - 2013
Background Sialocele and salivary fistula are common complications after parotidectomy. The purpose of the present study was to investigate whether extent of parotidectomy influences the incidence of these complications. Methods Prospective study of 66 consecutive parotidectomies. Cases undergoing skin or bone resection or flap reconstruction were excluded. Patients were divided ...
Paredes Igor - - 2013
Hirayama disease, or juvenile amyotrophy of distal upper extremity, is a benign, self-limiting cervical myelopathy consisting of selective unilateral weakness of the hand and forearm. The weakness slowly progresses until spontaneous arrest occurs within 5 years of onset. The condition predominantly affects Asian males and is thought to be secondary ...
Hansen Camilla P - - 2013
Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the use of these biomarkers may provide a ...
Moelans Cathy B - - 2013
Intratumor heterogeneity may lead to sampling bias and may present major challenges to personalized medicine and biomarker development. Despite many studies investigating genetic heterogeneity, epigenetic intratumor heterogeneity of promoter hypermethylation has only rarely been examined in breast cancer. To examine clonal intratumor heterogeneity of promotor hypermethylation, we performed methylation-specific multiplex ...
Jiang Jingjing - - 2013
Microwave absorption properties of core double-shell FeCo/C/(x)BaTiO3 nanocomposites were investigated in the 1-18 GHz frequency range. High resolution transmission electron microscopy studies reveal the core double-shell type nanocomposite with FeCo nanoparticles as the center, while carbon and BaTiO3 are the inside and the outside shells, respectively. Enhanced relative permittivity made ...
Bekerom Michel P J van den - - 2013
Background Numerous papers have been published on the medium- and long-term results of hemiarthroplasties (HAs) after femoral neck fracture in the elderly. We were not aware of any articles that describe the outcome of HA until the patient dies. Methods Between 1975 and 1989, 307 bipolar hemiarthroplasties were performed in ...
Kokubo Rinko - - 2013
Object Spinal subdural hematomas (SDHs) are rare and some are concomitant with intracranial SDH. Their pathogenesis and etiology remain to be elucidated although their migration from the intracranial space has been suggested. The authors postulated that if migration plays a major role, patients with intracranial SDH may harbor asymptomatic lumbar ...
Alan Nima - - 2013
Object The objective of this study was to assess whether preoperative anemia in patients undergoing elective cranial surgery influences outcomes in the immediate perioperative period (≤ 30 days). Methods The National Surgical Quality Improvement Program (NSQIP) was used to identify 6576 patients undergoing elective cranial surgery between 2006 and 2011. ...
Seabold Jason A - - 2013
A detailed understanding of doping level, electron diffusion length and coefficient, as well as light capture and charge separation efficiencies in nanoporous Mo-doped BiVO4 (Mo:BiVO4) photoanodes is obtained using photoelectrochemical techniques. Efficient water oxidation is achieved by doping with 1.8% Mo, resulting in a several-fold enhancement in photooxidation rate versus ...
Zhai Shenyu S Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, - - 2013
The late phase of long-term potentiation (LTP) at glutamatergic synapses, which is thought to underlie long-lasting memory, requires gene transcription in the nucleus. However, the mechanism by which signaling initiated at synapses is transmitted into the nucleus to induce transcription has remained elusive. Here, we found that induction of LTP ...
Loll-Krippleber Raphaël - - 2013
In response to genotoxic stress (GS), Candida albicans can undergo polarized growth and massive genome rearrangements including loss-of-heterozygosity (LOH) events. We evaluated the contribution of the CaRad53p and CaDun1p kinases of the DNA damage checkpoint (DDCP) in these processes. Characterization of C. albicans rad53ΔΔ and dun1ΔΔ mutants revealed that the ...
Parise Amelia - - 2013
Abstract The aim of this study was to incorporate a new naphthalenediimide derivative (AN169) with a promising anticancer activity into pegylated liposomes to an extent that allows its in vitro and in vivo testing without use of toxic solvent. AN169-loaded liposomes were prepared using the thin-film hydration method and characterized ...
McLaughlin Nancy N Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, - - 2014
Value of care is emerging as a promising framework to restructure health care, emphasizing the importance of reporting multiple outcomes that encompass the entire care episode instead of isolated outcomes specific to care points during a patient's care. The authors assessed the impact of coordinated implementation of processes across the ...
Huang Guoming - - 2013
This paper reports that iron carbide nanoparticles with high air-stability and strong saturation magnetization can serve as effective T2 contrast agents for magnetic resonance imaging. Fe5C2 nanoparticles (∼20 nm in diameter) exhibit strong contrast enhancement with an r2 value of 283.2 mM(-1) S(-1), which is about twice as high as ...
Kumsar Sükrü - - 2013
Women suffer from depression more frequently than men, which indicates that sex hormones might be involved in the etiology of this disease. The purpose of this study was to assess the relationship between testosterone and depression pathophysiology in depressive women along with sexual function. We also investigated whether antidepressant treatment ...
Deng Jie - - 2013
Studying how bacterial strains diverge over space and time and how divergence leads to ecotype formation is important for understanding structure and dynamics of environmental communities. Here we assess ecological speciation and temporal dynamics of a collection of Shewanella baltica strains from the redox transition zone of the central Baltic ...
Zhou Qing - - 2013
We report on the use of reconfigurable microfluidics for on-chip regeneration of aptasensors used for continuous monitoring of cell-secreted products.
Pérot Gaëlle - - 2013
The clinical relevance of accurately diagnosing pleomorphic sarcomas has been shown, especially in cases of undifferentiated pleomorphic sarcomas with myogenic differentiation, which appear significantly more aggressive. To establish a new smooth muscle differentiation classification and to test its prognostic value, 412 sarcomas with complex genetics were examined by immunohistochemistry using ...
Hines Eleanor E - - 2013
The Relative Risk Model (RRM) is a tool used to calculate and assess the likelihood of effects to endpoints when multiple stressors occur in complex ecological systems. In this study, a Bayesian network was used to calculate relative risk and estimate uncertainty (BN-RRM) in the Puyallup River Watershed. First, we ...
Shang Lu - - 2013
Graphene nanosheet-supported ultrafine metal nanoparticles encapsulated by thin mesoporous SiO2 layers were prepared and used as robust catalysts with high catalytic activity and excellent high-temperature stability. The catalysts can be recycled and reused in many gas- and solution-phase reactions, and their high catalytic activity can be fully recovered by high-temperature ...
Shen Shang-Hang - - 2013
Object The occurrence of hydrocephalic macrocephaly is uncommon. When the condition does occur, it is usually seen in infants and young children. Patients with this disorder have an excessively enlarged head and weak physical conditions. Various surgical techniques of reduction cranioplasty for the treatment of these patients have been reported. ...
Benz A - - 2013
The interaction between cavity modes and optical transitions leads to new coupled light-matter states in which the energy is periodically exchanged between the matter states and the optical mode. Here we present experimental evidence of optical strong coupling between modes of individual sub-wavelength metamaterial nanocavities and engineered optical transitions in ...
Tremolizzo L - - 2013
Objectives. The one-carbon metabolism, also known as methionine-homocysteine cycle, governs the dynamics of DNA methylation, epigenetically regulating gene expression, and has been reported altered in anorexia nervosa (AN) adult patients. The aim of this study consisted in assessing whole-blood DNA methylation in adolescent AN patients, assessing its significance in relationship ...
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