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Results 451 - 500 of 2215
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Nie Yu-Qiang - - 2013
Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. Intracellular lipid content was ...
Stone Daniel - - 2013
Kinetics of CH2OO Criegee intermediate reactions with SO2, NO2, NO, H2O and CH3CHO and CH2I radical reactions with NO2 are reported as a function of pressure at 295 K. Measurements were made under pseudo-first-order conditions using flash photolysis of CH2I2-O2-N2 gas mixtures in the presence of excess co-reagent combined with ...
Liu Xinyu - - 2013
Pt alloy nanostructures show great promise as electrocatalysts for the oxygen reduction reaction (ORR) in fuel cell cathodes. Herein, three-dimensional (3D) Pt-Pd-Co trimetallic network nanostructures (TNNs) with a high degree of alloying are synthesized through a room temperature wet chemical synthetic method by using K2 PtCl4 /K3 Co(CN)6 -K2 PdCl4 ...
Tambara Koujiro - - 2013
The mechanism and thermodynamic functions of the self-assembly of a family of covalently linked oligomeric naphthalenediimides (NDIs) were investigated through variable-temperature NMR and CD studies. The NDIs were shown to self-assemble into helical supramolecular nanotubes via an isodesmic polymerisation mechanism, and regardless of the oligomer length a surprising entropy-enthalpy compensation ...
Nota Laura - - 2013
This study examines the importance of work in life of people with disability and then focuses on employer attitudes towards these people. In the light of Stone and Colella's model, the study examines the employer attitudes and the role of variables such as type of disability, employer experience in the ...
Koppel Jonathan - - 2013
The reminiscence bump refers to the disproportionate number of individualÅ› autobiographical memories which date from young adulthood. A similar bump is found in cultural life scripts: When people are asked to nominate and date major transitional events in a typical life course in their culture, a disproportionate number of the ...
Rolen S H - - 2013
Olfactory sensory neurons that express transient receptor potential channel M5 (TrpM5) or neurotrophin-3 (NT-3) project to defined clusters of glomeruli situated ventrally in the main olfactory bulb. Using genetically labeled mice, we investigated whether expression of NT-3-driven βgal and TrpM5-driven GFP marked overlapping sets of glomeruli and whether expression of ...
Lähteenmäki R - - 2013
We compared the efficacy of melatonin and placebo as adjuvants in the withdrawal of patients from long-term temazepam, zopiclone or zolpidem (here "BZD") use. A double-blind, placebo-controlled, randomised trial was conducted in a primary health care outpatient clinic. Ninety-two men or women (≥55 years) with primary insomnia and chronic BZD ...
Gouk Shiou-Wah - - 2013
In the present study, we investigated the effect of long-acyl chain SFA, namely palmitic acid (16 : 0) and stearic acid (18 : 0), at sn-1, 3 positions of TAG on obesity. Throughout the 15 weeks of the experimental period, C57BL/6 mice were fed diets fortified with cocoa butter, sal stearin (SAL), palm mid ...
Granatosky Michael C - - 2013
The presence of a stable thoracolumbar region, found in many arboreal mammals, is considered advantageous for bridging and cantilevering between discontinuous branches. However, no study has directly explored the link between osteological features cited as enhancing axial stability and the frequency of cantilevering and bridging behaviors in a terminal branch ...
Seabold Jason A - - 2013
A detailed understanding of doping level, electron diffusion length and coefficient, as well as light capture and charge separation efficiencies in nanoporous Mo-doped BiVO4 (Mo:BiVO4) photoanodes is obtained using photoelectrochemical techniques. Efficient water oxidation is achieved by doping with 1.8% Mo, resulting in a several-fold enhancement in photooxidation rate versus ...
Smolinska S - - 2013
Histamine is a biogenic amine with extensive effects on many cell types, mediated by the activation of its four receptors (H1R-H4R). Distinct effects are dependent on receptor subtypes and their differential expression. Within the gastrointestinal tract, histamine is present at relatively high concentrations, particularly during inflammatory responses. In this review, ...
Fergusson Rosalie J - - 2013
Heavy menstrual bleeding (HMB), which includes both menorrhagia and metrorrhagia, is an important cause of ill health in women. Surgical treatment of HMB often follows failed or ineffective medical therapy. The definitive treatment is hysterectomy, but this is a major surgical procedure with significant physical and emotional complications, as well ...
Wang Xia - - 2013
A novel multifunctional nanotheranostic agent with targeting, redox-responsive ultrasound imaging and ultrasound imaging-guided high-intensity focused ultrasound (HIFU) therapy (MSNC-PEG-HASS -PFH, abbreviated as MPHSS -PFH) capabilities is developed. The redox-responsive guest molecule release and ultrasound imaging functions can be both integrated in such a "smart" theranostic agent, which is accomplished by the redox-triggered ...
Hao Xiaojun - - 2013
We developed core-shell silica-coated dye nanoparticles as highly bright and ultrastable red-emitting fluorescent probes for long-term cellular imaging and ultrasensitive in vivo animal imaging.
Feng Lingling - - 2013
Cyanobacterial fructose-1,6/sedoheptulose-1,7-bisphosphatase (cy-FBP/SBPase) plays a vital role in gluconeogenesis and in photosynthetic carbon reduction pathway and is thus a potential enzymatic target for inhibition of harmful cyanobacterial blooms. Here, we describe the crystal structure of cy-FBP/SBPase in complex with adenosine monophosphate (AMP) and fructose-1,6-bisphosphate (FBP). The allosteric inhibitor AMP and ...
Liu Hsin-Yi - - 2013
Abstract Purpose: Powered seating functions (PSFs) provide powered wheelchair users an independent means to adjust posture dynamically. To facilitate the best use of PSFs in daily living, we conducted this structured interview study to develop a preliminary user guide to provide "take-home" information to powered wheelchair users. Method: An internally ...
Ha Yonghwang - - 2013
α-Synuclein oligomers can induce neurotoxicity and are implicated in Parkinson's disease etiology and disease progression. Many studies have reported α-synuclein oligomerization by dopamine (DA) and transition metal ions, but few studies provide insight into joint influences of DA and Cu(2+) . In this study, DA and Cu(2+) were coadministered aerobically ...
Moelans Cathy B - - 2013
Intratumor heterogeneity may lead to sampling bias and may present major challenges to personalized medicine and biomarker development. Despite many studies investigating genetic heterogeneity, epigenetic intratumor heterogeneity of promoter hypermethylation has only rarely been examined in breast cancer. To examine clonal intratumor heterogeneity of promotor hypermethylation, we performed methylation-specific multiplex ...
Gu Ning Yan - - 2013
Background and purpose An internet-based discrete choice experiment (DCE) was conducted to elicit preferences for a wide range of Dupuytren's contracture (DC)-related health states. An algorithm was subsequently developed to convert these preferences into health state utilities that can be used to assess DC's impact on quality of life and ...
Koeppen Veronika A - - 2013
Background and purpose The risk of atypical fracture of the femur is associated with bisphosphonate use. While characterizing atypical fractures from a previous nationwide study in radiographic detail, we had the impression that the fractures were located either in the subtrochanteric region or in the shaft. We determined whether there ...
Bekerom Michel P J van den - - 2013
Background Numerous papers have been published on the medium- and long-term results of hemiarthroplasties (HAs) after femoral neck fracture in the elderly. We were not aware of any articles that describe the outcome of HA until the patient dies. Methods Between 1975 and 1989, 307 bipolar hemiarthroplasties were performed in ...
Benz A - - 2013
The interaction between cavity modes and optical transitions leads to new coupled light-matter states in which the energy is periodically exchanged between the matter states and the optical mode. Here we present experimental evidence of optical strong coupling between modes of individual sub-wavelength metamaterial nanocavities and engineered optical transitions in ...
Xu Jin-Shi - - 2013
Revivals of quantum correlations in composite open quantum systems are a useful dynamical feature against detrimental effects of the environment. Their occurrence is attributed to flows of quantum information back and forth from systems to quantum environments. However, revivals also show up in models where the environment is classical, thus ...
Cuevas A - - 2013
Any practical realization of entanglement-based quantum communication must be intrinsically secure and able to span long distances avoiding the need of a straight line between the communicating parties. The violation of Bell's inequality offers a method for the certification of quantum links without knowing the inner workings of the devices. ...
Nache Vasilica - - 2013
Tetrameric cyclic nucleotide-gated (CNG) channels mediate receptor potentials in olfaction and vision. The channels are activated by the binding of cyclic nucleotides to a binding domain embedded in the C terminus of each subunit. Here using a fluorescent cGMP derivative (fcGMP), we show for homotetrameric CNGA2 channels that ligand unbinding ...
von Maltzahn Julia - - 2013
Wnt signaling has essential roles during embryonic development and tissue homoeostasis. Wnt proteins are post-translationally modified and the attachment of a palmitate moiety at two conserved residues is believed to be a prerequisite for the secretion and function of Wnt proteins. Here we demonstrate that a mammalian Wnt protein can ...
Angulo-Rojo Carla - - 2013
The Notch pathway is a highly conserved signaling system essential for modulating neurogenesis and promoting astrogenesis. Similarly, the cAMP signaling cascade can promote astrocytic commitment in several cell culture models, such as the C6 glioma cell line. These cells have the capacity to differentiate into oligodendrocytes or astrocytes, characteristics that ...
Zhai Shenyu S Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, - - 2013
The late phase of long-term potentiation (LTP) at glutamatergic synapses, which is thought to underlie long-lasting memory, requires gene transcription in the nucleus. However, the mechanism by which signaling initiated at synapses is transmitted into the nucleus to induce transcription has remained elusive. Here, we found that induction of LTP ...
Sköldenberg Olof - - 2013
Background and purpose Articular resurfacing metal implants have been developed to treat full-thickness localized articular cartilage defects. Evaluation of the fixation of these devices is mandatory. Standard radiostereometry (RSA) is a validated method for evaluation of prosthetic migration, but it requires that tantalum beads are inserted into the implant. For ...
Paulsen Aksel - - 2013
Background and purpose - The increased use of patient-reported outcomes (PROs) in orthopedics requires data on estimated minimal clinically important improvements (MCIIs) and patient-acceptable symptom states (PASSs). We wanted to find cut-points corresponding to minimal clinically important PRO change score and the acceptable postoperative PRO score, by estimating MCII and ...
Gregory Thomas - - 2013
Background and purpose It is difficult to evaluate glenoid component periprosthetic radiolucencies in total shoulder arthroplasties (TSAs) using plain radiographs. This study was performed to evaluate whether computed tomography (CT) using a specific patient position in the CT scanner provides a better method for assessing radiolucencies in TSA. Methods Following ...
Vahi Paul-Sander - - 2013
Background and purpose Failed closed treatment of carpal tunnel syndrome (CTS) is often followed by surgery. We investigated whether preoperative steroid injections could have a negative effect on the long-term outcome of the operation. Patients and methods 174 hands (164 patients) were operated on by a single surgeon at Tartu ...
Liu Haijun H Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, - - 2013
In photosynthetic organisms, photons are captured by light-harvesting antenna complexes, and energy is transferred to reaction centers where photochemical reactions take place. We describe here the isolation and characterization of a fully functional megacomplex composed of a phycobilisome antenna complex and photosystems I and II from the cyanobacterium Synechocystis PCC ...
Engelmann Bodil Elisabeth - - 2013
Abstract Objectives. Optimal management of colon cancer (CC) requires detailed assessment of extent of disease. This study prospectively investigates the diagnostic accuracy of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (PET/CT) for staging and detection of recurrence in primary CC. Material and methods. PET/CT for preoperative staging was performed in 66 prospectively ...
Miller Jonathan F JF Drexel University, Philadelphia, PA 19104, - - 2013
In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal ...
Panzarella Vera - - 2013
This retrospective study investigated, in two cohorts of subjects living in Southern Italy and awaiting treatment for oral squamous cell carcinoma (OSCC), the variables related to diagnostic delay ascribable to the patient, with particular reference to the cognitive and psychological ones. A total of 156 patients with OSCC (mean age: ...
Kong Leopold L Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, - - 2013
Hepatitis C virus (HCV), a Hepacivirus, is a major cause of viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV envelope glycoproteins E1 and E2 mediate fusion and entry into host cells and are the primary targets of the humoral immune response. The crystal structure of the E2 core bound to ...
Nelson Erik R ER Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, - - 2013
Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here, we show that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent growth and LXR-dependent metastasis in ...
Chung Mei - - 2013
Treatment of chronic pain conditions such as fibromyalgia is challenging due to limitations of drug therapies. An initial exploration into the relationships between self-reported alcohol consumption, symptom severity, and quality of life for individuals with fibromyalgia sheds new light on plausible hypotheses and potential mechanisms of action for future research. ...
Heller L - - 2013
Enhanced tumor delivery of plasmid DNA with electric pulses in vivo has been confirmed in many preclinical models. Intratumor electrotransfer of plasmids encoding therapeutic molecules has reached Phase II clinical trials. In multiple preclinical studies, a reduction in tumor growth, increased survival or complete tumor regression have been observed in ...
Yu Zuoren - - 2013
Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates the pRB protein and promotes G1/S cell-cycle progression and oncogenesis. Dicer is a central regulator of miRNA maturation, encoding an enzyme that cleaves double-stranded RNA or stem-loop-stem RNA into 20-25 nucleotide long small RNA, governing sequence-specific gene silencing and ...
Hussain Shobbir - - 2013
The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.
Deris J Barrett JB Department of Physics, University of California at San Diego, La Jolla, CA 92093-0374, - - 2013
To predict the emergence of antibiotic resistance, quantitative relations must be established between the fitness of drug-resistant organisms and the molecular mechanisms conferring resistance. These relations are often unknown and may depend on the state of bacterial growth. To bridge this gap, we have investigated Escherichia coli strains expressing resistance ...
Davies Jason M JM Department of Neurological - - 2014
The management of patients with locally recurrent or metastatic chordoma is a challenge. Preclinical disease models would greatly accelerate the development of novel therapeutic options for chordoma. The authors sought to establish and characterize a primary xenograft model for chordoma that faithfully recapitulates the molecular features of human chordoma. Chordoma ...
Adamala Katarzyna K Howard Hughes Medical Institute, Department of Molecular Biology, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, - - 2013
Efforts to recreate a prebiotically plausible protocell, in which RNA replication occurs within a fatty acid vesicle, have been stalled by the destabilizing effect of Mg(2+) on fatty acid membranes. Here we report that the presence of citrate protects fatty acid membranes from the disruptive effects of high Mg(2+) ion ...
Yeung C-Y CY Division of Gastroenterology and Nutrition, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Institute of Biotechnology and Department of Chemical Engineering, National Taipei University of Technology, Taipei, Taiwan; Department on Nursing, Mackay College of Medicine, Nursing and Management, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, - - 2014
A rapid identification of Salmonella, one of the most common foodborne pathogens worldwide, in clinical patients can enable better rational managements and prevent further outbreaks. The traditional immunochromatography using antibody-gold nanoparticles (Ab-AuNPs), such as the home pregnancy test, has been used for the Salmonella detection. In this study, we developed ...
Sun M H MH Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, - - 2014
The promising biocontrol isolate Clonostachys rosea 67-1 was investigated to clarify the effects of culture conditions on chlamydospore production in submerged fermentation. Culture conditions significantly affected both performance and types of C. rosea sporulation. C. rosea 67-1 was hard to generate chlamydospores under conventional conditions. However, the proportion of resistant ...
McLaughlin Nancy N Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, - - 2014
Value of care is emerging as a promising framework to restructure health care, emphasizing the importance of reporting multiple outcomes that encompass the entire care episode instead of isolated outcomes specific to care points during a patient's care. The authors assessed the impact of coordinated implementation of processes across the ...
Chan Louis K M LK Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA - - 2014
The rhodium-catalyzed methylation of ketones has been accomplished using methanol as the methylating agent and the hydrogen-borrowing method. The sequence is notable for the relatively low temperatures that are required and for the ability of the reaction system to form α-branched products with ease. Doubly alkylated ketones can be prepared ...
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