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Results 451 - 500 of 2216
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Hansen Camilla P - - 2013
Previous studies have suggested that the intake of trans-fatty acids (TFA) plays a role in the development of obesity. The proportions of adipose tissue fatty acids not synthesised endogenously in humans, such as TFA, usually correlate well with the dietary intake. Hence, the use of these biomarkers may provide a ...
George Leni - - 2013
Abstract Background: Mycophenolate mofetil (MMF) is increasingly being used by dermatologists to treat various skin conditions, but limited evidence exists regarding its efficacy. Objective: To evaluate safety and efficacy of MMF in the treatment of dermatological conditions. Methods: A retrospective chart review of all the dermatology patients treated with MMF ...
Maeda-Uematsu Aya - - 2013
CCN2/connective tissue growth factor (CTGF) is a unique molecule that promotes both chondrocytic differentiation and proliferation through its matricellular interaction with a number of extracellular biomolecules. This apparently contradictory functional property of CCN2 suggests its certain role in basic cellular activities such as energy metabolism, which is required for both ...
Lalubin Fabrice - - 2013
In disease ecology, there is growing evidence that environmental quality interacts with parasite and host to determine host susceptibility to an infection. Most studies of malaria parasites have focused on the infection costs incurred by the hosts and few have investigated the costs on mosquito vectors. The interplay between the ...
Johnston A - - 2013
Poor quality medicines present a serious public health problem, particularly in emerging economies and developing countries, and may have a significant impact on the national clinical and economic burden. Attention has largely focused on the increasing availability of deliberately falsified drugs, but substandard medicines are also reaching patients because of ...
Sonabend Adam M - - 2013
Object Central nervous system (CNS) hemangiopericytomas are relatively uncommon and unique among CNS tumors as they can originate from or develop metastases outside of the CNS. Significant difference of opinion exists in the management of these lesions, as current treatment paradigms are based on limited clinical experience and single-institution series. ...
Porta F - - 2013
To evaluate the feasibility and reproducibility of ultrasound elastography (UE) in the assessment of healthy patellar tendon and to describe its UE pattern. Twenty-two patellar tendons of 11 out of 16 healthy subjects who met the inclusion criteria were evaluated three times by ultrasound (US) and UE at their proximal, ...
Fujiwara Kenshu - - 2013
Pectenotoxin-2 (PTX2) is a shellfish toxin and has a non-anomeric spiroacetal, which is not stabilized by an anomeric effect. The selective construction of the non-anomeric spiroacetal has been a major problem in the synthesis of PTX2. Described herein is the stereoselective total synthesis of PTX2 via the isomerization of anomeric ...
Jin Guoxiang - - 2013
The tumor suppressor promyelocytic leukaemia protein (PML) is predominantly localized in the nucleus, where it is essential for the formation and stabilization of the PML nuclear bodies (PML-NBs). PML-NBs are involved in the regulation of numerous cellular functions, such as tumorigenesis, DNA damage and antiviral responses. Despite its nuclear localization, ...
Anastassov Ivan - - 2013
Our recent studies have shown that endogenous zinc, co-released with glutamate from the synaptic terminals of vertebrate retinal photoreceptors, provides a feedback mechanism that reduces calcium entry and the concomitant vesicular release of glutamate. We hypothesized that zinc feedback may serve to protect the retina from glutamate excitotoxicity, and conducted ...
Majdi Nabil - - 2013
Predator effects on ecosystems can extend far beyond their prey and are often not solely lethally transmitted. Change in prey traits in response to predation risk can have important repercussions on community assembly and key ecosystem processes (i.e., trait-mediated indirect effects). In addition, some predators may themselves alter habitat structure ...
Batailler Martine - - 2013
Neural stem and precursor cells persist postnatally throughout adulthood and are capable of responding to numerous endogenous and exogenous signals by modifying their proliferation and differentiation. While adult neurogenesis has been extensively studied in the dentate gyrus of the hippocampal formation and in the subventricular zone adjacent to the wall ...
Kumsar Sükrü - - 2013
Women suffer from depression more frequently than men, which indicates that sex hormones might be involved in the etiology of this disease. The purpose of this study was to assess the relationship between testosterone and depression pathophysiology in depressive women along with sexual function. We also investigated whether antidepressant treatment ...
Kauscher Ulrike - - 2013
This article describes light-responsive vesicles that can release their contents in response to a light-sensitive molecular trigger. To this end, liposomes were equipped with amphiphilic β-cyclodextrin that was covalently labeled with azobenzene. Using dye encapsulation and confocal laser scanning microscopy, we show that the permeability of these vesicles strongly increases ...
Gattass Ricardo - - 2013
Area V4 has numerous, topographically organized connections with multiple cortical areas, some of which are important for spatially-organized visual processing, and others of which seem important for spatial attention. Although the topographic organization of V4's connections with other cortical areas has been established, the detailed topography of its connections with ...
Yang Jing - - 2013
Recent genome-wide association studies have shown associations between variants at five loci (TNS1, GSTCD, HTR4, AGER and THSD4) and chronic obstructive pulmonary disease (COPD) or lung function. However, their association with COPD has not been proven in Chinese Han population, nor have COPD-related phenotypes been studied. The objective of this ...
Martijn Lucie - - 2013
This study aimed to perform a structural analysis of determinants of risk of critical incidents in care for women with a low risk profile at the start of pregnancy with a view on improving patient safety. We included 71 critical incidents in primary midwifery care and subsequent hospital care in ...
Nie Yu-Qiang - - 2013
Accumulating evidence supports the role of miR-122 in fatty liver disease. We investigated miR-122 expression in a steatotic hepatocyte model, the effect of miR-122 over-expression and inhibition in the pathogenesis. Human hepatic cell line L02 was induced with oleic acid to establish the steatotic hepatocyte model. Intracellular lipid content was ...
Stone Daniel - - 2013
Kinetics of CH2OO Criegee intermediate reactions with SO2, NO2, NO, H2O and CH3CHO and CH2I radical reactions with NO2 are reported as a function of pressure at 295 K. Measurements were made under pseudo-first-order conditions using flash photolysis of CH2I2-O2-N2 gas mixtures in the presence of excess co-reagent combined with ...
Liu Xinyu - - 2013
Pt alloy nanostructures show great promise as electrocatalysts for the oxygen reduction reaction (ORR) in fuel cell cathodes. Herein, three-dimensional (3D) Pt-Pd-Co trimetallic network nanostructures (TNNs) with a high degree of alloying are synthesized through a room temperature wet chemical synthetic method by using K2 PtCl4 /K3 Co(CN)6 -K2 PdCl4 ...
Tambara Koujiro - - 2013
The mechanism and thermodynamic functions of the self-assembly of a family of covalently linked oligomeric naphthalenediimides (NDIs) were investigated through variable-temperature NMR and CD studies. The NDIs were shown to self-assemble into helical supramolecular nanotubes via an isodesmic polymerisation mechanism, and regardless of the oligomer length a surprising entropy-enthalpy compensation ...
Nota Laura - - 2013
This study examines the importance of work in life of people with disability and then focuses on employer attitudes towards these people. In the light of Stone and Colella's model, the study examines the employer attitudes and the role of variables such as type of disability, employer experience in the ...
Koppel Jonathan - - 2013
The reminiscence bump refers to the disproportionate number of individualÅ› autobiographical memories which date from young adulthood. A similar bump is found in cultural life scripts: When people are asked to nominate and date major transitional events in a typical life course in their culture, a disproportionate number of the ...
Rolen S H - - 2013
Olfactory sensory neurons that express transient receptor potential channel M5 (TrpM5) or neurotrophin-3 (NT-3) project to defined clusters of glomeruli situated ventrally in the main olfactory bulb. Using genetically labeled mice, we investigated whether expression of NT-3-driven βgal and TrpM5-driven GFP marked overlapping sets of glomeruli and whether expression of ...
Lähteenmäki R - - 2013
We compared the efficacy of melatonin and placebo as adjuvants in the withdrawal of patients from long-term temazepam, zopiclone or zolpidem (here "BZD") use. A double-blind, placebo-controlled, randomised trial was conducted in a primary health care outpatient clinic. Ninety-two men or women (≥55 years) with primary insomnia and chronic BZD ...
Gouk Shiou-Wah - - 2013
In the present study, we investigated the effect of long-acyl chain SFA, namely palmitic acid (16 : 0) and stearic acid (18 : 0), at sn-1, 3 positions of TAG on obesity. Throughout the 15 weeks of the experimental period, C57BL/6 mice were fed diets fortified with cocoa butter, sal stearin (SAL), palm mid ...
Granatosky Michael C - - 2013
The presence of a stable thoracolumbar region, found in many arboreal mammals, is considered advantageous for bridging and cantilevering between discontinuous branches. However, no study has directly explored the link between osteological features cited as enhancing axial stability and the frequency of cantilevering and bridging behaviors in a terminal branch ...
Seabold Jason A - - 2013
A detailed understanding of doping level, electron diffusion length and coefficient, as well as light capture and charge separation efficiencies in nanoporous Mo-doped BiVO4 (Mo:BiVO4) photoanodes is obtained using photoelectrochemical techniques. Efficient water oxidation is achieved by doping with 1.8% Mo, resulting in a several-fold enhancement in photooxidation rate versus ...
Smolinska S - - 2013
Histamine is a biogenic amine with extensive effects on many cell types, mediated by the activation of its four receptors (H1R-H4R). Distinct effects are dependent on receptor subtypes and their differential expression. Within the gastrointestinal tract, histamine is present at relatively high concentrations, particularly during inflammatory responses. In this review, ...
Fergusson Rosalie J - - 2013
Heavy menstrual bleeding (HMB), which includes both menorrhagia and metrorrhagia, is an important cause of ill health in women. Surgical treatment of HMB often follows failed or ineffective medical therapy. The definitive treatment is hysterectomy, but this is a major surgical procedure with significant physical and emotional complications, as well ...
Wang Xia - - 2013
A novel multifunctional nanotheranostic agent with targeting, redox-responsive ultrasound imaging and ultrasound imaging-guided high-intensity focused ultrasound (HIFU) therapy (MSNC-PEG-HASS -PFH, abbreviated as MPHSS -PFH) capabilities is developed. The redox-responsive guest molecule release and ultrasound imaging functions can be both integrated in such a "smart" theranostic agent, which is accomplished by the redox-triggered ...
Hao Xiaojun - - 2013
We developed core-shell silica-coated dye nanoparticles as highly bright and ultrastable red-emitting fluorescent probes for long-term cellular imaging and ultrasensitive in vivo animal imaging.
Feng Lingling - - 2013
Cyanobacterial fructose-1,6/sedoheptulose-1,7-bisphosphatase (cy-FBP/SBPase) plays a vital role in gluconeogenesis and in photosynthetic carbon reduction pathway and is thus a potential enzymatic target for inhibition of harmful cyanobacterial blooms. Here, we describe the crystal structure of cy-FBP/SBPase in complex with adenosine monophosphate (AMP) and fructose-1,6-bisphosphate (FBP). The allosteric inhibitor AMP and ...
Liu Hsin-Yi - - 2013
Abstract Purpose: Powered seating functions (PSFs) provide powered wheelchair users an independent means to adjust posture dynamically. To facilitate the best use of PSFs in daily living, we conducted this structured interview study to develop a preliminary user guide to provide "take-home" information to powered wheelchair users. Method: An internally ...
Ha Yonghwang - - 2013
α-Synuclein oligomers can induce neurotoxicity and are implicated in Parkinson's disease etiology and disease progression. Many studies have reported α-synuclein oligomerization by dopamine (DA) and transition metal ions, but few studies provide insight into joint influences of DA and Cu(2+) . In this study, DA and Cu(2+) were coadministered aerobically ...
Moelans Cathy B - - 2013
Intratumor heterogeneity may lead to sampling bias and may present major challenges to personalized medicine and biomarker development. Despite many studies investigating genetic heterogeneity, epigenetic intratumor heterogeneity of promoter hypermethylation has only rarely been examined in breast cancer. To examine clonal intratumor heterogeneity of promotor hypermethylation, we performed methylation-specific multiplex ...
Gu Ning Yan - - 2013
Background and purpose An internet-based discrete choice experiment (DCE) was conducted to elicit preferences for a wide range of Dupuytren's contracture (DC)-related health states. An algorithm was subsequently developed to convert these preferences into health state utilities that can be used to assess DC's impact on quality of life and ...
Koeppen Veronika A - - 2013
Background and purpose The risk of atypical fracture of the femur is associated with bisphosphonate use. While characterizing atypical fractures from a previous nationwide study in radiographic detail, we had the impression that the fractures were located either in the subtrochanteric region or in the shaft. We determined whether there ...
Bekerom Michel P J van den - - 2013
Background Numerous papers have been published on the medium- and long-term results of hemiarthroplasties (HAs) after femoral neck fracture in the elderly. We were not aware of any articles that describe the outcome of HA until the patient dies. Methods Between 1975 and 1989, 307 bipolar hemiarthroplasties were performed in ...
Benz A - - 2013
The interaction between cavity modes and optical transitions leads to new coupled light-matter states in which the energy is periodically exchanged between the matter states and the optical mode. Here we present experimental evidence of optical strong coupling between modes of individual sub-wavelength metamaterial nanocavities and engineered optical transitions in ...
Xu Jin-Shi - - 2013
Revivals of quantum correlations in composite open quantum systems are a useful dynamical feature against detrimental effects of the environment. Their occurrence is attributed to flows of quantum information back and forth from systems to quantum environments. However, revivals also show up in models where the environment is classical, thus ...
Cuevas A - - 2013
Any practical realization of entanglement-based quantum communication must be intrinsically secure and able to span long distances avoiding the need of a straight line between the communicating parties. The violation of Bell's inequality offers a method for the certification of quantum links without knowing the inner workings of the devices. ...
Nache Vasilica - - 2013
Tetrameric cyclic nucleotide-gated (CNG) channels mediate receptor potentials in olfaction and vision. The channels are activated by the binding of cyclic nucleotides to a binding domain embedded in the C terminus of each subunit. Here using a fluorescent cGMP derivative (fcGMP), we show for homotetrameric CNGA2 channels that ligand unbinding ...
von Maltzahn Julia - - 2013
Wnt signaling has essential roles during embryonic development and tissue homoeostasis. Wnt proteins are post-translationally modified and the attachment of a palmitate moiety at two conserved residues is believed to be a prerequisite for the secretion and function of Wnt proteins. Here we demonstrate that a mammalian Wnt protein can ...
Angulo-Rojo Carla - - 2013
The Notch pathway is a highly conserved signaling system essential for modulating neurogenesis and promoting astrogenesis. Similarly, the cAMP signaling cascade can promote astrocytic commitment in several cell culture models, such as the C6 glioma cell line. These cells have the capacity to differentiate into oligodendrocytes or astrocytes, characteristics that ...
Smith Amanda K - - 2013
The spared nerve injury (SNI) model of neuropathic pain produces robust and reproducible behavioral mechanical hypersensitivity. Although this rodent model of neuropathic pain has been well established and widely used, peripheral mechanisms underlying this phenotype remain incompletely understood. Here we investigated the role of cutaneous sensory fibers in the maintenance ...
Zhai Shenyu S Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, - - 2013
The late phase of long-term potentiation (LTP) at glutamatergic synapses, which is thought to underlie long-lasting memory, requires gene transcription in the nucleus. However, the mechanism by which signaling initiated at synapses is transmitted into the nucleus to induce transcription has remained elusive. Here, we found that induction of LTP ...
Sköldenberg Olof - - 2013
Background and purpose Articular resurfacing metal implants have been developed to treat full-thickness localized articular cartilage defects. Evaluation of the fixation of these devices is mandatory. Standard radiostereometry (RSA) is a validated method for evaluation of prosthetic migration, but it requires that tantalum beads are inserted into the implant. For ...
Paulsen Aksel - - 2013
Background and purpose - The increased use of patient-reported outcomes (PROs) in orthopedics requires data on estimated minimal clinically important improvements (MCIIs) and patient-acceptable symptom states (PASSs). We wanted to find cut-points corresponding to minimal clinically important PRO change score and the acceptable postoperative PRO score, by estimating MCII and ...
Gregory Thomas - - 2013
Background and purpose It is difficult to evaluate glenoid component periprosthetic radiolucencies in total shoulder arthroplasties (TSAs) using plain radiographs. This study was performed to evaluate whether computed tomography (CT) using a specific patient position in the CT scanner provides a better method for assessing radiolucencies in TSA. Methods Following ...
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