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Zeng Xue - - 2013
Psoriasis is an inflammatory, immune-mediated disease of the skin. Several studies have suggested that natural killer (NK) cells and their receptors may be important for its pathogenesis. Here, we examined whether deletion of the activating natural killer receptor gene NKG2C, which has a frequency of 20% in the European population, ...
Sigruener Alexander - - 2013
Keratinocyte sphingolipids are structural elements of epidermal permeability barrier and potential regulators of epidermal functions. We tested the influence of sphingoid bases sphinganine, sphingosine and phytosphingosine on in vitro keratinocyte differentiation. Lipidomic and transcriptomic analysis after treatment emphasizes sphinganine and phytosphingosine as potent modulators of keratinocyte differentiation and lipid metabolism. ...
Li Jie - - 2013
A porcine deep partial-thickness wound model was used to evaluate the effects of a newly developed topical aqueous oxygen emulsion (TOE) on wound repair. The wounds were treated with TOE, which contains super-saturated oxygen or vehicle control. Semiquantitative immunofluorescent staining was performed to examine protein production for type I and ...
Hsiao Yu-Ping - - 2013
The lack of a human papillomavirus (HPV)-infected skin cancer cell line has hampered the investigation of the interaction of UV and HPV in skin carcinogenesis. We identified a human basal cell carcinoma (BCC-1/KMC) cell line integrated with E6 and E7 genes of high-risk HPV type 18 and demonstrated that repression ...
Arai Iwao - - 2013
We investigated the effects of a single dose of mouse interleukin-31 (IL-31) on scratching behaviour in comparison with spontaneous skin-lesion- or serotonin (5-HT)- induced scratching behaviour in NC/Nga and BALB/c mice. Intradermal (i.d.) injection of IL-31 caused a gradual increase in long-lasting scratching (LLS, over 1.5 s) about 3 h after administration ...
van Bragt S - - 2013
To assess psychometric properties of the Pelican instrument, an online Dutch self-administered Quality of Life instrument for childhood asthma for scientific and clinical use. A cohort study was done in two asthma populations and healthy children. One asthma population had assessment at start, 4 and 8 weeks. The other asthma population ...
Dahlhoff Maik - - 2013
The epidermal growth factor receptor (EGFR) system is an established regulator of the development and homeostasis of the hair follicle and interfollicular epidermis. Here, we evaluated EGFR actions on the sebaceous glands (SGs) by employing Dsk5 mice, a mutant line in which the EGFR is constitutively activated in a ligand-independent ...
Stern Christina - - 2013
Preeclampsia (PE) is a serious life event that can change women's psychological profile. The aim of this study was to evaluate the physical and mental health-related quality of life (HR-QoL) in women after PE and the impact of contributing factors. Ninety-five women who had suffered from PE answered the Short-Form-12 ...
Koene Paul - - 2013
This project aimed to estimate a species' adaptations in nature and in captivity, assess welfare, suggest environmental changes, and find species characteristics that underlie welfare problems in nonhuman animals in the zoo. First, the current status of zoo animal welfare assessment was reviewed, and the behavioral ecology approach was outlined. ...
Hosey Geoff - - 2013
Contact with people, both familiar (e.g., caretakers) and unfamiliar (e.g., members of the public), is a significant part of the lives of nonhuman animals in zoos. The available empirical evidence shows that in many cases this contact represents a source of stress to the animals, although there is sufficient overall ...
Carlstead Kathy - - 2013
Multi-institutional studies of welfare have proven to be valuable in zoos but are hampered by limited sample sizes and difficulty in evaluating more than just a few welfare indicators. To more clearly understand how interactions of husbandry factors influence the interrelationships among welfare outcomes, epidemiological approaches are needed as well ...
Siegford Janice M - - 2013
Nonhuman animal welfare is a complex concept that encompasses an animal's biological functioning, emotional states, and opportunities to experience a natural life, including the performance of natural behaviors. Further, animal welfare can be viewed as quality of life from the perspective of the animal and thus must consider the animal's ...
Xavier Stephanie P - - 2013
Notch pathway genes have been implicated in the commitment of mesenchymal cells to a wool follicle cell fate. Notch1 and Delta1 transcripts were quantified in fetal skin of fine-woolled (Merino) and strong-woolled (Tukidale) sheep at two time points: either preceding (d56) or during (d70) the first wave of follicle initiation. ...
Toberer Ferdinand - - 2013
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disease. Different pathogenetic mechanisms, including the accumulation of apoptotic keratinocytes in CLE, have been reported. Therefore, we investigated whether CLE and other inflammatory skin diseases differ with regard to the epidermal expression of molecules that are crucial for the initiation and regulation ...
Kotzerke Kristina - - 2013
It has long been known that keratinocytes influence cutaneous immunity through secretion of soluble factors. Exosomes, small membrane vesicles of endocytotic origin, have been implicated in intercellular communication processes such as the transfer of tumor cell antigens and the activation of recipient dendritic cells (DC). However, little is known about ...
Luke Courtney T - - 2013
Hairless (HR) is a nuclear protein with corepressor activity that is highly expressed in the skin and hair follicle. Mutations in Hairless lead to hair loss accompanied by the appearance of papules (atrichia with papular lesions), and similar phenotypes appear when the key polyamine enzymes ornithine decarboxylase (ODC) and spermidine/spermine ...
Hinde Eleanor - - 2013
The skin of most mammals is characterised by the presence of sebaceous glands (SGs), whose predominant constituent cell population is sebocytes, that is, lipid-producing epithelial cells, which develop from the hair follicle. Besides holocrine sebum production (which contributes 90% of skin surface lipids), multiple additional SG functions have emerged. These ...
McVittie Chris - - 2013
We examine from a discursive perspective momentary confabulations generated by patients in clinical interviews based on confabulation questionnaires. Commonly, neuropsychology treats such confabulations solely as evidence of patients' inabilities or deficits. Here we argue that patients' descriptions indicate the interaction of memory deficits with preserved interactional skills. More than this, ...
Singh Brij - - 2013
The propagation of shear-horizontal (SH) waves is studied for a functionally gradient magnetoelectric (ME) material. The material properties of the ME half-space are normal to the free surface. The ME open conditions are applied to the free surface. Dispersion relations are obtained in explicit form for different forms of the ...
Nakazawa Marie - - 2013
In this paper, we present a polyurea transducer that works at 100 MHz under water. The transducer was designed using an equivalent circuit model so that an aluminum (top)-polyurea-aluminum (bottom)-polyimide layer had a resonant frequency of 100 MHz and output sound pressure became maximum at that frequency. The thicknesses of ...
Toprak Alperen - - 2013
This paper presents a novel optimization method for interdigitated electrode (IDE)-based, cantilever-type piezoelectric energy harvesters at microelectromechanical system (MEMS) scale. A new two-stage approach based on the finite element method is proposed to examine the performance of such devices. First, detailed electrostatic poling simulations are presented. The results of these ...
Bartsch Stephen - - 2013
A protocol was originally designed to study breathing control during and following cardiac arrest in humans, taking advantage of the period of pulseless ventricular fibrillation (PVF) produced while testing a newly implanted cardioverter-defibrillator device. A patient aged in his 60s with New York Heart Association class III heart failure (HF) ...
Wang Yujue - - 2013
A power harvester with adjustable frequency, which consists of a hinged¿hinged piezoelectric bimorph and a concentrated mass, is studied by the precise electric field method (PEFM), taking into account a distribution of the electric field over the thickness. Usually, using the equivalent electric field method (EEFM), the electric field is ...
Kadota Michio - - 2013
Currently, an ultra-wideband resonator is greatly needed to realize a tunable filter with a wide tunable range, because mobile phones with multiple bands and cognitive radio systems require such tunable filters to simplify their circuits. Although tunable filters have been studied using SAW resonators, their tunable range was insufficient for ...
Nikolovski Jean-Pierre - - 2013
Tactile sensing is widely used in human-computer interfaces. However, mechanical integration of touch technologies is often perceived as difficult by engineers because it often limits the freedom of style or form factor requested by designers. Recent work in active ultrasonic touch technologies has made it possible to transform thin glass ...
Nagpal Kamal - - 2013
The information provided during the postoperative handover influences the delivery of care of patients in the postoperative recovery unit through their care on the ward. There is a need for a structured and systematic approach to postoperative handover. The aim of this study was to improve postoperative handover through the ...
Perelli Alessandro - - 2013
Compressive sensing (CS) has emerged as a potentially viable technique for the efficient compression and analysis of high-resolution signals that have a sparse representation in a fixed basis. In this work, we have developed a CS approach for ultrasonic signal decomposition suitable to achieve high performance in Lamb-wave-based defect detection ...
Fiordelli Maddalena - - 2013
A good collaboration between health professionals is considered to have benefits for patients, healthcare staff, and organizations. Nevertheless, effective interprofessional collaboration is difficult to achieve. This is particularly true for collaboration between Medical Residents (MRs) and the immediate colleagues they interact with, as Senior Doctors (SDs) and Head Nurses (HNs). ...
Hanania Nicola A - - 2013
The goals of management of COPD include reducing exposure to risk factors; improving lung function, exercise tolerance, and quality of life; and decreasing exacerbations and mortality. Pharmacologic treatments, such as inhaled β2-agonists, anticholinergics, and inhaled corticosteroids, are widely used to help achieve these goals. In addition to efficacy, medication safety ...
Palmeri Mark - - 2013
The uterine cervix softens, shortens, and dilates throughout pregnancy in response to progressive disorganization of its layered collagen microstructure. This process is an essential part of normal pregnancy, but premature changes are associated with preterm birth. Clinically, there are no reliable noninvasive methods to objectively measure cervical softening or assess ...
Alkoy Sedat - - 2013
Textured ceramic fibers were fabricated from the tungsten-bronze-type piezoelectric (KSr2Nb5O15) . Development of crystallographic texture was evaluated through rocking curve analysis and a texture with Lotgering factor of 0.97 was achieved. 1-3 piezocomposites were prepared from the textured fibers and their electrical properties were evaluated. Highly enhanced properties that are ...
Chaisson Neal F - - 2013
Pulmonary arterial hypertension (PAH) is the leading cause of death in systemic sclerosis (SSc) and affects up to 12% of all patients with SSc, with a 50% mortality rate within 3 years of PAH diagnosis. Compared with the idiopathic form of PAH (IPAH), patients with SSc-associated PAH (SSc-PAH) have a ...
Nguyen Van - - 2013
This work presents for the first time a flexible over-moded resonator (OMR) based on P(VDF-TrFE) thin films. The devices were manufactured on commercially available elastic substrate with inkjet-printed electrodes. The sensing copolymer films used in the devices were polarized by the corona method after electrode deposition. The main performance parameters ...
Schols Annemie M W J - - 2013
COPD is an important global health problem. In addition to pulmonary impairment, systemic inflammation, musculoskeletal abnormalities, and cardiovascular comorbidity influence disease burden and mortality risk. Body weight and body composition are important discriminants in classifying disease heterogeneity. The rationale for and efficacy of caloric supplementation in preventing and treating involuntary ...
Lufi Dubi - - 2013
Fifty-nine adults slept five nights with an Actigraph and answered two questionnaires related to sleeping quality and morningness/eveningness preferences. Next they performed a computerized attention task (the mathematics continuous performance test (MATH-CPT)) to assess various measures of attention. Results showed significant correlations between six attention variables and two measures of ...
Manthous Constantine A - - 2013
Physicians are moving increasingly from self-employed, private practices to at-will employment relationships. This historic change in the organizational administration of medical services is likely to accelerate as the Affordable Care Act is implemented and as accountable care organizations permeate the medical marketplace. Physicians vow an ascendant oath to safeguard patients' ...
Rigby Barbara - - 2013
Cells derived from human embryonic stem cells have great therapeutic potential. Patents are key to allowing companies that develop methods of generating such cells to recuperate their investment. However, in Europe, inventions relating to the use of human embryos for commercial purposes are excluded from patentability on moral grounds. The ...
Tang Xianghu - - 2013
Here, Au nanoparticles (NPs) grafted on dendritic α-Fe2O3 (NPGDF) are designed as a highly uniform surface-enhanced Raman scattering (SERS) substrate with a feature of optical visualization by an optical microscope (OM) system and used for in situ detection of pesticide residues that are annually used in agriculture. With this strategy, ...
Wang Fei - - 2013
Cubic silver cages were prepared on monolithic activated carbon (MAC) pre-absorbed with Cl(-), SO4(2-), or PO4(3-) anions. Silver insoluble salts served as templates for the morphosynthesis of silver cages. The silver ions were reduced by reductive functional groups on MAC micropores through a galvanic cell reaction mechanism.
Kim Jae Min - - 2013
We report two cases of surgical removal of a retained subfoveal perfluorocarbon liquid (PFCL) bubble through a therapeutic macular hole combined with intravitreal PFCL injection and gas tamponade. Two patients underwent pars plana vitrectomy with PFCL injection for rhegmatogenous retinal detachment. In both cases, a retained subfoveal PFCL bubble was ...
Mironov Vladimir A - - 2013
Chromoprotein asFP595 and its A143G variant called kindling fluorescent protein (KFP) are among the chronologically first species for which trans-cis chromophore isomerization has been proposed as a driving force of photoswitching. In spite of long-lasting efforts to characterize the route between protein conformations referring to the trans and cis forms ...
Kim Sang Jin - - 2013
A pair of 19-year-old female identical twins was referred to our hospital with progressive visual loss. They exhibited bilateral chorioretinal atrophy involving the midperiphery on fundoscopy and fluorescein angiography. Bilateral visual field constriction was noted on dynamic Goldmann perimetry, and a markedly impaired response was observed on both photopic and ...
Okubo Akiko - - 2013
It has been reported that pulsations in abnormal vessels are observed on indocyanine green (ICG) angiography in half of patients with polypoidal choroidal vasculopathy (PCV), although the mechanism of the pulsation is unknown. In this study, we report a case of PCV showing venous pulsations at an arterio-venous (A-V) crossing, ...
Parnami Nupur - - 2013
Psoriasis is an autoimmune, chronic, inflammatory skin disease characterized by epidermal hyperplasia, proliferation of blood vessels, and infiltration of leukocytes in dermis and epidermis. Several immunosuppressants such as methotrexate (MXT) and cyclosporine are used but they are associated with adverse effects due to down regulation of immune system. Numerous approaches ...
Kavakçıoğlu Berna - - 2013
In this study, in vitro and in vivo effects of some commonly used fungicides, antibiotics, and various chemicals on isolated and purified catalase from Phanerochaete chrysosporium were investigated. The catalase was purified 129.10-fold by using 60% ammonium sulfate and 60% ethanol precipitations, DEAE-cellulose anion exchange and Sephacryl-S-200 gel filtration chromatographies ...
Ryoo Na-Kyung - - 2013
Recent reports suggest the association of human papilloma virus (HPV) with retinoblastoma. This study was performed to elucidate whether HPV infection is related to retinoblastoma among Koreans. A total of 54 cases diagnosed with retinoblastoma were enrolled from Seoul National University Children's Hospital and Seoul Metropolitan Government-Seoul National University Boramae ...
Koh Kyung Min - - 2013
To compare the success rates, complications, and visual outcomes between silicone Ahmed glaucoma valve (AGV) implantation with 96 mm(2) (FP8) or 184 mm(2) (FP7) surface areas. This study is a retrospective review of the records from 132 adult patients (134 eyes) that underwent silicone AGV implant surgery. Among them, the ...
Seo Jeong Hyun - - 2013
Surface plasmon resonance (SPR) can provide kinetic information about an interaction, and it can also be used to rapidly monitor dynamic processes, such as adsorption and degradation, without the need for sample labeling. Here, we employed SPR to analyze carbohydrate-protein interactions, particularly GM1-related carbohydrate-Vibrio cholera toxin interactions. The interaction between ...
Kurtz Pedro - - 2013
The brain is dependent on glucose to meet its energy demands. We sought to evaluate the potential importance of impaired glucose transport by assessing the relationship between brain/serum glucose ratios, cerebral metabolic distress, and mortality after severe brain injury. We studied 46 consecutive comatose patients with subarachnoid or intracerebral hemorrhage, ...
Wilk Kevin E - - 2013
There exists a wide range of shoulder instabilities, from subtle subluxations (as seen in overhead athletes) to gross instability. An appropriate rehabilitation program plays a vital role in the successful outcome following an episode of shoulder instability. Nonoperative rehabilitation is often implemented for patients diagnosed with various shoulder instabilities. Based ...
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