Search Results
Results 451 - 500 of 3145
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Yagasaki Kaori - - 2013
As cancer treatment shifts from IV to oral chemotherapy, patients have less contact with nurses and face the increased responsibility of maintaining their own health care. The authors conducted focus group interviews with 18 oncology nurses using the grounded theory approach to explore the nurses' perceptions of current practices and ...
McKeever Amy E - - 2013
Pharmaceutical drug shortages are multifaceted and complex problems that affect all aspects of health care, including patients, caregivers, healthcare providers, third-party payers, the pharmaceutical industry, and regulators. Drug shortages have increased significantly since 2000, which cause increases in healthcare costs and compromised patient care. New government regulations have led the ...
Sanders Judith Brown - - 2013
Altruism often is expressed by patients with advanced cancer as a coping mechanism and a motivational factor for participation in clinical trials. Those who participate develop a sense of hope that their life is a contribution, which may continue to live beyond their deaths.
Mayer Deborah K - - 2013
The University of North Carolina is switching electronic health records (EHRs) next year, and the University of Michigan did so last year. Many others already have or will be adopting them for the first time. What is behind these recent efforts? In two words: meaningful use (see Figure 1). The ...
Jiang Qi - - 2013
Classical crystal growth models posit that crystallization outcomes are determined by nuclei that resemble mature crystal phases, but at a critical size where the volume free energy of nuclei begins to offset the unfavorable surface free energy arising from the interface with the growth medium. Crystallization under nanoscale confinement offers ...
Rolls A - - 2013
Memories are consolidated and strengthened during sleep. Here we show that memories can also be weakened during sleep. We used a fear-conditioning paradigm in mice to condition footshock to an odor (conditioned stimulus (CS)). Twenty-four hours later, presentation of the CS odor during sleep resulted in an enhanced fear response ...
Zhang Juan - - 2013
In this work, we demonstrated a novel sensitive sandwich-type pseudobienzyme aptasensor for thrombin detection. Greatly amplified sensitivity was based on mesoporous silica-multiwalled carbon nanotube (mSiO2@MWCNT) nanocomposites as enhanced materials and a pseudobienzyme electrocatalytic system. Firstly, the mSiO2@MWCNT nanocomposites not only have good biocompatibility and a suitable microenvironment for stabilizing the ...
Quax Rogier A - - 2013
Glucocorticoids regulate many physiological processes and have an essential role in the systemic response to stress. For example, gene transcription is modulated by the glucocorticoid-glucocorticoid receptor complex via several mechanisms. The ultimate biologic responses to glucocorticoids are determined by not only the concentration of glucocorticoids but also the differences between ...
Disteche Christine M - - 2013
Trisomy 21 in human causes Down syndrome, a common chromosome disorder with devastating phenotypes ranging from early death in utero to intellectual disability together with an array of physical anomalies and late-onset diseases. In a recent study published in Nature, Jeanne Lawrence and her colleagues restored normal gene expression in ...
Kachnic L A - - 2013
Background:RTOG 0518 evaluated the potential benefit of zoledronic acid therapy in preventing bone fractures for patients with high grade and/or locally advanced, non-metastatic prostate adenocarcinoma receiving luteinizing hormone-releasing hormone (LHRH) agonist and radiotherapy (RT).Methods:Eligible patients with T-scores of the hip (<-1.0, but >-2.5 vs >-1.0) and negative bone scans were ...
Xie Shaohua - - 2013
Three-dimensionally ordered macroporous Co3O4 (3DOM Co3O4) and its supported gold (xAu/3DOM Co3O4, x = 1.1-8.4 wt%) nanocatalysts were prepared using the polymethyl methacrylate-templating and bubble-assisted polyvinyl alcohol-protected reduction methods, respectively. The 3DOM Co3O4 and xAu/3DOM Co3O4 samples exhibited a surface area of 22-27 m(2) g(-1). The Au nanoparticles with a ...
Jensen Aaron R - - 2013
Abstract Background: Laparoscopic repair of congenital duodenal obstruction has become popularized over the past decade. Comparative data on outcomes, however, are sparse. We hypothesized that laparoscopic repair of congenital duodenal obstruction could be performed with similar outcomes to traditional open repair. Patients and Methods: Medical records for all cases of ...
Qiu Jianguo - - 2013
Abstract Background: Although current guidelines recommend performing cholecystectomy via laparoscopy, consensus on the application of single-incision laparoscopic surgery for cholecystectomy is still lacking. The aim of the current study was to perform a meta-analysis of randomized controlled trials (RCTs) and nonrandomized comparative studies (NRCSs), comparing single-port laparoscopic cholecystectomy (SPLC) and ...
- - 2013
This policy statement serves to combine and update 2 previously independent but overlapping statements from the American Academy of Pediatrics (AAP) on culturally effective health care (CEHC) and workforce diversity. The AAP has long recognized that with the ever-increasing diversity of the pediatric population in the United States, the health ...
Skoczylas Laura C - - 2013
In 2008 and 2011, the US Food and Drug Administration (FDA) released notifications regarding vaginal mesh. In describing prolapse surgery trends over time, we predicted vaginal mesh use would decrease and native tissue repairs would increase. Operative reports were reviewed for all prolapse repairs performed from 2008 to 2011 at ...
Bandarian Fatemeh - - 2013
Low high density lipoprotein cholesterol (HDL-C) is a known risk factor of coronary artery disease. Apolipoprotein A1 (APOA1) is the most abundant component of HDL-C. This study aimed at identifying sequence variations (rare and common) in the APOA1 gene and its association with serum HDL-C levels. This study was conducted ...
Armour Cherie - - 2013
The factor structure of posttraumatic stress disorder (PTSD) currently used by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), has received limited support. A four-factor dysphoria model is widely supported. However, the dysphoria factor of this model has been hailed as a nonspecific factor of PTSD. The ...
Estrada Raquel Vidal - - 2013
The aim of the present study was to assess the efficacy of psychoeducation as compared with cognitive behavioral group therapy in adults with attention deficit hyperactivity disorder (ADHD) who still had significant symptoms and were in pharmacological treatment. This is the first study on psychoeducation in adults with ADHD. Thirty-two ...
Willems Leen - - 2013
Allogeneic hematopoietic stem cell transplantation and donor leukocyte infusion (DLI) may hold potential as a novel form of immunotherapy for high-risk neuroblastoma. DLI, however, carries the risk of graft-versus-host disease (GvHD). Recipient leukocyte infusion (RLI) induces graft-versus-leukemia responses without GvHD in mice and is currently being explored clinically. Here, we ...
Raptaki Maria - - 2013
Chronic Granulomatous Disease (CGD) is an uncommon primary immunodeficiency caused by the absence or dysfunction of one of NADPH oxidase subunits, with heterogeneous genetic aetiologies. The aim of this study was the CGD patient registry in Greece, the identification of the responsible genotype and the potential correlation with the patient's ...
Caldieraro Marco Antonio - - 2013
The best classification of depressive disorders is still to be established. A melancholic subtype has a lengthy history, and recent research demonstrates its relevance. This study compares the prevalence of psychotic symptoms in nonmelancholic and melancholic depression and assesses whether there is a dimensional pattern in the severity of symptoms ...
Nillni Yael I - - 2013
The current study examined demographic and psychosocial factors that predict major depressive disorder (MDD) and comorbid MDD/posttraumatic stress disorder (MDD/PTSD) diagnostic status after Hurricane Katrina, one of the deadliest and costliest hurricanes in the history of the United States. This study expanded on the findings published in the article by ...
Fried M - - 2013
In 2012, an expert panel composed of presidents of each of the societies, the European Chapter of the International Federation for the Surgery of Obesity (IFSO-EC), and of the European Association for the Study of Obesity (EASO), as well as of the chair of EASO Obesity Management Task Force (EASO ...
Gehrke Cody - - 2013
In this work, an innovative vascular coupling device (VCD) is created to realize quick and reliable vessel anastomosis. Vessel anastomosis is common and often necessary during trauma, replantation and free tissue transfer surgeries. The current method of vessel anastomosis is traditional hand suturing. This technique is time consuming (20-30 min), difficult, ...
Lakhan Shaheen E - - 2013
A 27-year-old man with cholestasis presented with 4 weeks of progressive spastic quadriparesis and hypophonia. MRI revealed T2/fluid-attenuated inversion recovery hyperintensities in the basal ganglia and thalamus (figure 1). He was treated with IV methylprednisolone for acute disseminated encephalomyelitis. His condition worsened. MRI 4 weeks later showed larger symmetric hyperintensities ...
Vishnu V Y - - 2013
A 33-year-old man with bipolar affective disorder presented with acute onset of rigidity, tremors, and confusion. He had been taking oral lithium (1,200 mg daily) for the past 2 months. Baseline blood, EEG, and CSF analyses were normal. Serum lithium level was 0.67 mEq/L (0.3-1.3). Gadolinium MRI brain showed multiple ...
Joy Susan M - - 2013
As more studies report on patient preferences, techniques are needed to identify, assess and, eventually, synthesize results from a diverse set of methodologies. Data on patient preferences are valuable to decision makers in a variety of ways. Preferences for outcomes can be used to inform decision and cost-effectiveness models, while ...
Singhal Tarun - - 2013
The title of the article by Portnow et al.(1) is not suitable because there is uneven coverage of the development of PET imaging devices and inadequate coverage of radiopharmaceuticals or their translational applications. There are some key conceptual and factual errors as well.
Kang Dawon - - 2013
The goal of this study was to determine the molecular identity of a small-conductance (~5-pS) background K(+) channel expressed in trigeminal ganglion (TG) neurons. We tested the hypothesis that the 5-pS channel is a K2P channel by comparing the pharmacological and single-channel properties of THIK-1 expressed in HEK293 cells. As ...
Tanne David - - 2013
Stroke is a major cause of long-term adult disability, death, and health care costs worldwide. This overwhelming burden on global health necessitates ongoing improvements in stroke management. Indeed, considerable progress in stroke care is evident nowadays, in part owing to better prevention and the increasing use of acute stroke units, ...
Shankar Hari - - 2013
Introduction: Boceprevir is an NS3/NS4A serine protease inhibitor that was approved for use in Hepatitis C virus (HCV) genotype 1 patients by the US Food and Drug Administration (FDA) in May 2011. The approval of this protease inhibitor marked a major paradigm shift in the treatment of HCV, as it ...
Lee Donggun - - 2013
Iridium-catalyzed direct ortho C-H amidation of arenes has been shown to work well with sulfonyl- and aryl azides as the nitrogen source. The reaction proceeds efficiently with a broad range of substrates bearing conventional directing groups with excellent functional group compatibility under mild conditions. In addition, substrates forming not only ...
Boyd Owen - - 2013
Goal-directed perioperative therapy (GDT) is now part of a number of international perioperative protocols and, to some extent, seems to have come of age, but no research takes place in isolation and it is valuable to retrospectively look at influential papers to understand the context and influences of the time ...
Grimaldi Tamiris B - - 2013
We present here our results on potassium tert-butoxide promoted annulation reaction of (2-alkynylphenyl) propargyl ethers to give two different types of hetecocycles; 3-benzyl-2-alkynylbenzofurans and 12H-benzoannulenbenzo[b]furans. A series of functionalized (2-alkynylphenyl) propargyl ethers were efficiently cyclized by potassium tert-butoxide to the corresponding products. The optimized reaction condition tolerated a large variety ...
Belal Fathalla F - - 2013
Levofloxacin hemihydrate (LEV) and ambroxol HCl (AMB) are available for the treatment of upper and lower respiratory tract infections. A survey of the literature reveals that two reversed phase HPLC methods were e reported for the simultaneous determination of LEV and AMB in pharmaceutical preparations. However the reported methods suffers ...
Nomura Takayoshi - - 2013
Extraoral maxillofacial rehabilitation for compromised or lost facial anatomy resulting from the surgical eradication of malignancy, trauma, or congenital anomalies is commonly accomplished with a silicone prosthesis. However, with increasing size and weight, a silicone prosthesis can lose retention. This report presents 2 patient treatments to introduce a fabrication and ...
Nagasawa Masayuki - - 2013
We retrospectively analyzed 60 cases of pediatric patients who received allogeneic stem cell transplantation (SCT) between 2000 and 2008, using the tentative scoring system for evaluation of early (<30 days) coagulation disorders. In the 41 patients who survived, D-dimer levels showed a transient increase 2 weeks after SCT and normalized thereafter, ...
Langella Francesca - - 2013
Phytoremediation is an environmental friendly, cost-effective technology for a soft restoration of abandoned mine sites. The grasses Agrostis capillaris, Deschampsia flexuosa and Festuca rubra, and the annual herb Helianthus annuus were combined with microbial consortia in pot experiments on multi-metal polluted substrates collected at a former uranium mine near Ronneburg, ...
Tajbakhsh Sharareh - - 2013
Documentation of long-term changes in food intake is lacking for those treated with a maxillary complete denture opposed by a mandibular, screw-retained, implant-supported fixed prosthesis. The purpose of this study was to evaluate the selection patterns of dietary foods over 5 years for edentulous participants treated in a multicenter prospective ...
Bandettini Di Poggio Monica - - 2013
The Brown-Vialetto-Van Laere syndrome (BVVLS) is a rare neurological disorder characterized by progressive pontobulbar palsy, sensorineural deafness and mixed spinal and upper motor neuropathy. Mutations in the C20orf54 gene have been linked to the disease and recently we reported the first Italian case of a BVVLS family with an intriguing ...
Majidi Ali Reza - - 2013
Closure of the peripheral iridectomy (PI) may lead to forward displacement of silicone oil (SO) in some but not all SO-filled aphakic eyes. In this study, we report three patients with a history of a combined three-port pars plana vitrectomy and cataract surgery, SO injection and inferior PI who underwent ...
Mitchell Alex J - - 2013
OBJECTIVE People with severe mental illness have a higher risk of developing cardiovascular disease and die sooner than the general population. This study of a national sample of primary care patients in the United Kingdom compared screening for cardiometabolic risk factors among patients with severe mental illness and diabetes. METHODS ...
Moon Sung-Hoon - - 2013
This review addresses the role of endoscopy in the diagnosis and treatment of autoimmune pancreatitis (AIP) and provides a diagnostic process for patients with suspected AIP. When should AIP be suspected? When can it be diagnosed without endoscopic examination? Which endoscopic approaches are appropriate in suspected AIP, and when? What ...
Widmer Jessica - - 2013
Over the last 2 decades there has been continuing development in endoscopic ultrasonography (EUS). EUS-guided pancreatic drainage is an evolving procedure that can be offered to patients who are high-risk surgical candidates and in whom the pancreatic duct cannot be accessed by endoscopic retrograde pancreatography. Although EUS-guided pancreatic drainage is ...
Appelbaum Paul S - - 2013
Idaho is one of four states that have abolished the insanity defense. Hence, John Delling, on trial for two murders in Idaho, was unable to plead insanity or to argue that he lacked intent to kill, the only available option under Idaho law. After being sentenced to life in prison ...
Dumonceau Jean-Marc - - 2013
Endoscopic therapy is recommended as the first-line therapy for painful chronic pancreatitis with an obstacle on the main pancreatic duct (MPD). The clinical response should be evaluated at 6 to 8 weeks. Calcified stones that obstruct the MPD are first treated by extracorporeal shockwave lithotripsy; dominant MPD strictures are optimally treated ...
Stevens Tyler - - 2013
Endoscopic ultrasonography (EUS) can be a useful tool for detecting underlying causes of acute pancreatitis and establishing the severity of fibrosis in chronic pancreatitis. Ancillary techniques include fine needle aspiration and core biopsy, bile collection for crystal analysis, pancreatic function testing, and celiac plexus block. This review focuses on the ...
Shweikeh Faris - - 2013
Object Positional plagiocephaly (PP) has been on the rise in recent years. In this review, the authors' aim was to assess the effectiveness of current recommendations to parents on this exceedingly common problem through a comprehensive literature search. Additionally, the current treatment options and the most recent studies on PP ...
Manig M - - 2013
The clinical course of Legg-Calvé-Perthes disease (LCPD) is variable. Diagnosis, nonsurgical and surgical methods of treatment have evolved over many decades, from abduction casts and braces to advanced surgical containment methods which are now the mainstay of treatment. This article presents a general view and a critical evaluation of the ...
Vayá Ignacio - - 2013
The photooxygenation of model compounds containing the two enantiomers of naproxen (NPX) covalently linked to histidine (His), tryptophan (Trp) and tyrosine (Tyr) has been investigated by steady state irradiation, fluorescence spectroscopy and laser flash photolysis. The NPX-His systems presented the highest oxygen-mediated photoreactivity. Their fluorescence spectra matched that of isolated ...
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