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Jacques Simon D M - - 2013
An emerging theme of modern composites and devices is the coupling of nanostructural properties of materials with their targeted arrangement at the microscale. Of the imaging techniques developed that provide insight into such designer materials and devices, those based on diffraction are particularly useful. However, to date, these have been ...
Tian Yancong - - 2013
According to transition state theory, the rate of a reaction that traverses multiple energy barriers is determined by the least stable (rate-determining) transition state. The preceding ('inner') energy barriers are kinetically 'invisible' but mechanistically significant. Here we show experimentally and computationally that the reduction rate of organic disulphides by phosphines ...
Liu Dazhi - - 2013
Small-angle neutron scattering (SANS) is the most significant neutron technique in terms of impact on science and engineering. However, the basic design of SANS facilities has not changed since the technique's inception about 40 years ago, as all SANS instruments, save a few, are still designed as pinhole cameras. Here ...
Adera Solomon - - 2013
Controlling wettability by varying surface chemistry and roughness or by applying external stimuli is of interest for a wide range of applications including microfluidics, drag reduction, self-cleaning, water harvesting, anti-corrosion, anti-fogging, anti-icing and thermal management. It has been well known that droplets on textured hydrophilic, that is superhydrophilic, surfaces form ...
Son Hyewon - - 2013
Ultrafast two-dimensional infrared (2DIR) spectroscopy was used to study H-bond exchange dynamics in aqueous NaPF6 solutions. Interestingly, there are two spectrally distinct hydrogen-bond (H-bond) configurations in aqueous NaPF6 solutions; water molecules that are H-bonded to PF6(-) ion (ODA) or other water molecules (ODW). These two spectrally distinct subsets of water ...
Patterson Dustin P - - 2013
Here we report the use of a self-assembling protein cage to sequester and solubilize recombinant proteins which are usually trafficked to insoluble inclusion bodies. Our results suggest that protein cages can be used as novel vehicles to rescue and produce soluble proteins that are otherwise difficult to obtain using conventional ...
Nakagawa Takafumi - - 2013
A platinum complex containing a tetracene dicarboxylic imide disulfide (TIDS) was synthesized and structurally characterized by X-ray analysis. Steady-state absorption and emission spectroscopy for Pt-TIDS revealed its extended π-conjugated structure. Excited state studies characterized its triplet state with a lifetime of 0.18-0.28 μs.
Haake Steve J - - 2013
Abstract Improvements in track and field sports have been attributed to factors such as population increase, drugs and new technologies, but previous research has found it difficult to distinguish the contributions from specific influences. Here it is shown how this is possible by means of a performance improvement index based ...
Wang Panpan - - 2013
An ultrasensitive photoelectrochemical (PEC) immunoassay was introduced into microfluidic paper-based analytical devices (μ-PADs) based on a multiple electron transfer system for the first time, which was constructed using narrow-band-gap semiconductor nanoparticles (NPs), wide-band-gap semiconductor NPs, and an electron-accepting medium.
Tejero Rubén - - 2013
A variety of cycloheptapyrane derivatives were prepared via Ni-catalyzed formal [8+3] cycloaddition of tropones with 1,1-cyclopropanediesters. The asymmetric version of the process can be achieved using either an enantiomerically enriched cyclopropane as the starting material or a racemic cyclopropane and a chiral Lewis acid.
Ueno Haruna - - 2013
Design and synthesis of a boronic acid based artificial receptor which selectively and effectively bound to a neurotransmitter, l-DOPA (), in aqueous media. In addition, the synthetic receptor was found to effectively inhibit the DDC (l-DOPA decarboxylase) enzymatic reaction under physiological conditions.
Xie Xiaochen - - 2013
The radical cation [1,2-B2{1,2-(MeN)2C6H4}2]˙(+) has been synthesised and its structure and bonding have been probed using a combination of X-ray crystallography, EPR spectroscopy and DFT calculations which show that it represents a new type of radical centred primarily on two N-heterocyclic units joined by a B2 linker but with only ...
Kubota Takayuki - - 2013
The consumption of probiotics by pregnant and lactating women may prevent the onset of allergic disorders in their children by increasing the concentrations of immunoactive agents such as cytokines in breast milk. Prebiotics such as fructo-oligosaccharides (FOS) increase the number of beneficial organisms such as bifidobacteria. Thus, prebiotics may have ...
Zhou Chengcheng - - 2013
It has long been considered that the addition of cyclodextrins (CDs) disfavors the self-assembly of surfactants in dilute solutions since the hydrophobic effect is destroyed upon the formation of hydrophiphilic CD/surfactant inclusion complex. However, in this work, we found that β-CD/nonionic surfactant inclusion complexes are able to self-assemble into vesicles ...
Manfo Faustin Pascal Tsagué - - 2013
Abstract Context: Male infertility is one of the leading causes of social frustration and marginalization, mainly in the developing world. It is attributed to many factors including exposure to agropesticides such as manganese ethylenebis (dithiocarbamate) (maneb), which is one of the most frequently used fungicides in Cameroon. Previous reports support ...
Haglund Lena - - 2013
Abstract Aim: This paper reports the measurement properties of the Occupational Circumstances Assessment Interview and Rating Scale - Sweden (OCAIRS-S V2). The OCAIRS is a semi-structured interview and rating scale designed to capture, in detail, a person's occupational participation. The English version 4.0 has been translated into Swedish. The psychometric ...
Deckersbach Thilo - - 2013
OBJECTIVE At least 50% of individuals with bipolar disorder have a lifetime anxiety disorder. Individuals with both bipolar disorder and a co-occurring anxiety disorder experience longer illness duration, greater illness severity, and poorer treatment response. The study explored whether comorbid lifetime anxiety in bipolar patients moderates psychotherapy treatment outcome. METHOD ...
Gastin Paul B - - 2013
Abstract Children and adolescents mature at different rates such that individuals competing in the same competition may differ in physical and biological maturity despite being of similar chronological age. Whether or not differences translate into on-field performance in competition is relatively unknown. This study investigated the influence of biological maturity ...
Scogin Forrest - - 2013
Objectives: Substantial evidence indicates that depressed participants perform more poorly than nondepressed participants on a number of memory tasks. Cognitive deficits associated with depression (i.e., poor allocation of attention, poor encoding strategies), may help explain why depressed older adults are particularly prone to evidence poorer memory performance. Method: The present ...
Larsson Ellinor - - 2013
Abstract Objective: To explore how client-centred occupational therapy intervention processes for participation in meaningful Social Internet-Based Activities (SIBAs) can be designed, and to explore the influences of participation in SIBAs on seniors' social activities and social contacts. Method. A qualitative, descriptive, multiple-case study was conducted, and an intervention was provided ...
Savel Paul - - 2013
The photophysical properties of 6-phenyl-2,2'-bipyridyl platinum(ii) complexes bearing different σ-alkynyl-linked azobenzene ancillary ligands were investigated. These complexes exhibited strong, broad, structureless charge-transfer bands in the visible region, which were red-shifted when the electron-donating ability of the para substituent on the azo-acetylide ligand increased. When excited at the charge-transfer absorption band, ...
Langenbach Fabian - - 2013
The standard procedure for the osteogenic differentiation of multipotent stem cells is treatment of a confluent monolayer with a cocktail of dexamethasone (Dex), ascorbic acid (Asc) and ?-glycerophosphate (?-Gly). This review describes the effects of these substances on intracellular signaling cascades that lead to osteogenic differentiation of bone marrow stroma-derived ...
Wang Shyang-Guang - - 2013
Aim:To investigate the effects of punicalagin, a polyphenol isolated from Punica granatum, on human U87MG glioma cells in vitro.Methods:The viability of human U87MG glioma cells was evaluated using MTT assay. Cell cycle was detected with flow cytometry analysis. The levels of Bcl-2, cleaved caspase-9, cleaved poly(ADP-ribose) polymerase (PARP), phosphor-AMPK and ...
Zhang Mei-Qi - - 2013
Aim:To investigate the mechanisms underlying the protective effects of sodium tanshinone IIA sulfonate (STS) in an ischemia-reperfusion (I/R)-induced rat myocardial injury model.Methods:Male SD rats were iv injected with STS, STS+LY294002 or saline (NS) for 15 d. Then the hearts were subjected to 30 min of global ischemia followed by 2 ...
Dai Da-Peng - - 2013
Aim:Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme that is responsible for the metabolism of approximately 15% of clinically important drugs. The aim of this study was to assess the catalytic characteristics of 37 CYP2C9 allelic isoforms found in Chinese Han population on the metabolism of tolbutamide in vitro.Methods:The wild-type ...
Hou Shurong - - 2013
Cocaine is one of the most addictive drugs, and there is still no FDA (Food and Drug Administration)-approved medication specific for cocaine abuse. A promising therapeutic strategy is to accelerate cocaine metabolism, producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. cocaine hydrolysis catalyzed by ...
Subramaniam Shankar - - 2013
Abstract Context: Chromobacterium violaceum Bergonzini (Neisseriaceae), a Gram-negative bacterium, secretes a spectacular pigment called violacein. Violacein is a quorum-sensing metabolite and is also an active antimicrobial, anticancer agent. However, its efficiency as a potential drug, alone or in synergy with other active principles, has not being completely exploited. With the ...
Knoepfli-Lenzin Claudia - - 2013
Abstract The aim of this study was to assess the validity of the heart rate formula 170 - 0.5 age ± 10 used to prescribe endurance training for healthy sedentary or moderately trained individuals. A total of 795 incremental tests of women and men during running and cycling were analysed. The maximum heart ...
Barbosa Virginia - - 2013
Objective: The implementation of bereavement interventions is frequently requested, and its effectiveness has been controversial. The aim of this study is to evaluate the effectiveness of a cognitive narrative intervention for complicated grief (CG) for controlling post-traumatic and depressive issues. Method: The study is a randomised controlled trial and uses ...
Quan Mao - - 2013
Chiral β-aryl-α,β-unsaturated amino alcohols were synthesized via a Pd-catalyzed asymmetric allylic amination of 4-aryl-1,3-dioxolan-2-one using planar chiral 1,2-disubstituted ferrocene-based phosphinooxazolines as ligands. Under the optimized reaction conditions, a series of substrates were examined and the products were obtained in good to excellent yields (up to 92%) and enantioselectivities (up to ...
O'Doherty Patrick J - - 2013
Abstract Eukaryotic microorganisms are constantly challenged by reactive oxygen species derived endogenously or encountered in their environment. Such adversity is particularly applied to Saccharomyces cerevisiae under harsh industrial conditions. One of the major oxidants to challenge S. cerevisiae is linoleic acid hydroperoxide (LoaOOH). This study, which used genome-wide microarray analysis ...
Rathinavelusamy Paramaguru - - 2013
Abstract Context: Pterospermum acerifolium (L.) Willd (Sterculiaceae) has been traditionally used in the treatment of diabetes mellitus but no scientific data has been published supporting the claimed ethnomedical use. Objective: The present study was designed to estimate the in silico, in vitro α-amylase inhibition potential and anti-diabetic activity of Pterospermum ...
Koskimies Pasi - - 2013
Objective: To characterize the pharmacokinetics of the oral, non-estrogen agent ospemifene, an estrogen agonist/antagonist with tissue-selective effects (also called a selective estrogen receptor modulator) that was recently approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy in postmenopausal women. Methods: Two open-label, Phase 1 studies were conducted ...
Shinand Sun Young - - 2013
Objective: The purpose of this study was to identify the correlation of skin toxicity and hypertension with clinical benefit in advanced hepatocellular carcinoma (HCC) patients treated with sorafenib by analyzing medical records retrospectively. Methods: Data from medical records was statistically analyzed to identify a correlation of skin toxicity and hypertension ...
Iyer Deepa - - 2013
Abstract Context. Salvadora indica Wight (Salvadoraceae) contains a number of medically beneficial properties including abrasives, astringents and antiseptics. Traditionally, it was used by ancient Arabs to whiten and polish teeth. Objective: This study explores the antihyperlipidemic and antitumor effects of an ethanol extract of S. indica and its isolated phytoconstituents ...
Flaherty Leah - - 2013
It is well understood that forces from multiple trophic levels simultaneously influence herbivore performance, but how the relative strength of these forces vary over space and time is less clear. We evaluated seasonal variation in the impact of bottom-up forces (host condition), top-down forces (natural enemies), and competition on the ...
Shi Haibin - - 2013
In this paper, a new live-cell permeable, fluorescent light-up probe comprised of a hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide and a hydrophobic tetraphenylethene pyridinium unit has been developed for in vivo cell apoptosis imaging and drug screening. The probe shows a specific light-up response to activated caspase-3/7 with a high signal-to-background ...
Ramak Hashemi Seyed Mahmood - - 2013
In this study, we report a rare case of intradiploic dermoid cyst in a patient who developed rapid symptoms of intracranial hypertension (ICH) that mimicked Pseudotumor cerebri syndrome clinically. A 25-year-old female presented with a history of headache, nausea, vertigo and blurred vision in the past 4 months. Images revealed ...
Dougherty Sarah M - - 2013
Physicians and other licensed health professionals are involved in force-feeding prisoners on hunger strike at the US Naval Base at Guantanamo Bay (GTMO), Cuba, the detention center established to hold individuals captured and suspected of being terrorists in the wake of September 11, 2001. The force-feeding of competent hunger strikers ...
Jurewicz Joanna - - 2013
Abstract The relationship between exposure to lifestyle factors and adverse effects on human reproductive health is debated in the scientific literature and these controversies have increased public and regulatory attention. The aim of the study was to examine the association between modifiable lifestyle factors and main semen parameters, sperm morphology, ...
Yin Jie - - 2013
Abstract Birth oxidative stress is an oxidative response to a sudden transition process from maternal mediated respiration in uterus to autonomous pulmonary respiration outside the uterus. Meanwhile, oxidative stress has been demonstrated to be associated with various pathologies recorded in newborns. So, this research aimed to study the oxidative stress ...
Ghio Lucio - - 2013
Mood disorders are common and often under-recognised in older people whereby, together with the general ageing of the population, they are becoming a significant and growing public health problem worldwide. However, the need to address the problem of late life mood disorders in a real-world setting is met with a ...
Reggiani-Bonetti Luca - - 2013
Abstract Objectives. The purposes of the study are to describe the incidence trend of malignant polyp of large bowel over a 25-year period in the District of Modena and to assess the effect of an organized colorectal cancer screening program. Material and methods. Through the data of a specialized colorectal ...
Song Jibin - - 2013
We have developed surface-initiated organocatalytic ring opening polymerization on functional nanocrystals and synthesized amphiphilic gold nanorods carrying well-defined mixed polymer brushes of poly(ethylene glycol) and polylactide. Self-assembly of the amphiphilic gold nanorods affords biodegradable plasmonic vesicles that can be destructed by both enzymatic degradation and near-infrared photothermal heating. When tagged ...
Smith Melissa E - - 2013
Ceramide is a sphingolipid that serves as an important second messenger in an increasing number of stress-induced pathways. Ceramide has long been known to affect the mitochondria, resulting in altered mitochondrial physiology. We sought to assess the impact of ceramide on skeletal muscle mitochondrial structure and function. A primary observation ...
Broster Lucas S - - 2013
Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care ...
Fujita Shinsuke - - 2013
Background: Abnormal cellular and humoral immunity underlie both immunoglobulin A (IgA) nephropathy and tubulointerstitial nephritis and uveitis (TINU) syndrome. We encountered a teenage boy who developed TINU syndrome during the course of IgA nephropathy. Case Report: 1 year after onset of IgA nephropathy following acute enteritis, a 14-year-old boy again ...
Perkins Robert M - - 2013
Aims: 30-day readmission rates after hospitalization for heart failure (HF) approach 25%, and patients with chronic kidney disease (CKD) are disproportionately represented. A retrospective cohort study was conducted to develop a prediction tool for 30-day readmission after hospitalization for HF among those with non-dialysis dependent CKD. Methods: Geisinger primary care ...
Torregrosa José-Vicente - - 2013
Background and objectives: Calcific uremic arteriolopathy (CUA) is a life-threatening condition almost exclusively affecting patients with end-stage renal failure. Several therapies have been employed to treat this disease with irregular results. Methods: Comparison of a prospective case series with a historical cohort. Group I: 12 patients with CUA diagnosed before ...
Rose J D - - 2013
The advantages and disadvantages of different methods of carrying objects on spine loading are still not fully understood. Previous studies have either examined the effects of carrying using physiological measures or examined isolated spine segments using biomechanical models. Additionally, most studies have been restricted to only a small number of ...
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