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Lim K S - - 2013
Hypoxic regions are frequent in glioblastoma (GBM), the most common type of malignant adult brain tumor, and increased levels of tumor hypoxia have been associated with worse clinical outcomes. To unmask genes important in hypoxia, we treated GBM neurospheres in hypoxia and identified monocarboxylate transporter-4 (MCT4) as one of the ...
Yao R - - 2013
The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been shown to be involved in this process. In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biological significance remains to ...
Dey P - - 2013
Estrogen receptor β (ERβ) is emerging as a critical factor in understanding prostate cancer biology. Although reduced in prostate cancer above Gleason grade 3, ERβ is a potential drug target at the initial stage of the disease. In human prostate cancer cells, we found that ERβ causes apoptosis by increasing ...
Kumar S - - 2013
Endoglin is a transforming growth factor β (TGF-β) coreceptor that serves as a prognostic, diagnostic and therapeutic vascular target in human cancer. A number of endoglin ectodomain-targeting antibodies (Abs) can effectively suppress both normal and tumor-associated angiogenesis, but their molecular actions remain poorly characterized. Here we define a key mechanism ...
Ren G - - 2013
Bone marrow mesenchymal stem/stromal cells (BM-MSCs) can infiltrate into tumors and subsequently evolve into tumor resident MSCs in tumor microenvironment. In this study, using a mouse lymphoma model, we showed that the lymphoma resident MSCs (L-MSCs) are able to confer tumor-promoting property to the naïve cocultured BM-MSCs. Examination of cytokines ...
Cagnet S - - 2013
The constitutive activation of β-catenin signaling in the mammary basal epithelial cell layer in transgenic K5ΔNβcat mice leads to basal-type tumor development. Integrins of the β1 family and integrin-mediated signaling events have an important role in breast tumor growth and progression. We show here that the deletion of α3β1 integrin, ...
Paz H - - 2013
The ability to degrade extracellular matrix is critical for tumor cells to invade and metastasize. Recent studies show that tumor cells use specialized actin-based membrane protrusions termed invadopodia to perform matrix degradation. Invadopodia provide an elegant way for tumor cells to precisely couple focal matrix degradation with directional movement. Here ...
Gefenaite G - - 2013
SUMMARY We aimed to assess whether the characteristics of influenza-like illness (ILI) cases in the general population were similar during the seasonal and pandemic A(H1N1)pdm09 influenza periods. We conducted a study using a general population database, which included demographic (sex, age) and clinical (underlying medical conditions, influenza vaccination status) information ...
Wang F - - 2013
Tuberous sclerosis complex 1 (TSC1) and TSC2 are suppressors of mechanistic target of rapamycin (mTOR). mTOR is the major component of two protein complexes: mTOR complex 1 (mTORC1) and mTORC2. Inactive mutation of either TSC1 or TSC2 unleashes mTOR signaling and consequently causes TSC, a benign tumor syndrome affecting multiple ...
Kalinina Svetlana A - - 2013
Abstract Context. Verbascum nigrum L. (Scrophulariaceae) is a perennial plant used in folk medicine for the treatment of kidney diseases due to its presumable diuretic properties. Objective: We investigated the diuretic activity and toxicity of extracts from different parts of V. nigrum and identified a group of compounds responsible for ...
Liao Szu-Chia - - 2013
Abstract Objective. To better assess the usefulness of miniature ultrasound probe (MUP) sonography in the evaluation of the adequacy of gastric variceal injection with cyanoacrylate to decrease the risk of post injection rebleeding. Material and methods. Sixty-nine patients with bleeding gastric varices were included in this study. Endoscopic cyanoacrylate injection ...
Keyte Ian J - - 2013
Polycyclic aromatic hydrocarbons (PAHs) are of considerable concern due to their well-recognised toxicity and especially due to the carcinogenic hazard which they present. PAHs are semi-volatile and therefore partition between vapour and condensed phases in the atmosphere and both the vapour and particulate forms undergo chemical reactions. This article briefly ...
Cameron Clare - - 2013
Introduction Although several theories of delusions have been put forward, most do not offer a comprehensive diagnosis-independent explanation of delusion aetiology. This study used a non-clinical sample to provide empirical support for a novel transdiagnostic model of delusions that implicates aberrant semantic memory and emotion perception processes as key factors ...
Saxena Sudhanshu - - 2013
Commonly consumed fruits showed remarkable variation in antimutagenicity when assayed by E. coli rifampicin resistance assay, and Java Plum (Syzygium cumini) was found to be one of the most potent fruits. Its anthocyanins contributed maximally to the observed antimutagenicity and resolved into three distinct bands in HPTLC. Although these bands ...
Sahlholm Kristoffer - - 2013
It has been suggested that the favorable side-effect profiles of atypical antipsychotics (e.g. clozapine and amisulpride) are related to their ���100-fold faster dissociation from dopamine D2 receptors (D2R) compared with typical antipsychotics (e.g. haloperidol and chlorpromazine). Fast dissociation would entail rapidly reversible antagonism; however, this has not been thoroughly studied ...
Meinert Marina - - 2013
The aim of this study was a proof of concept to examine the effects of a web-based office ergonomics intervention on subjects' individual workplace adjustments. An intervention study was conducted with 24 office workers lasting 6 weeks with three consecutive phases (before, 1 and 5 weeks after the intervention). Employees ...
Cheah Irwin K - - 2013
Abstract In addition to excretion of metabolic waste products, organic ionic transporters facilitate uptake of specific compounds of physiological importance. In humans, the organic cation transporter, OCTN1 was found to enable the specific uptake of the unique amino acid, ergothioneine (EGT). EGT can accumulate in the body at up to ...
Awad Dalal S - - 2013
Abstract Context. Zizyphus jujuba Mill. (Rhamnaceae) has long been used for the treatment of anxiety and insomnia in Chinese traditional medicine. The edible part is the fruit. Different parts of Z. jujuba possess medicinal properties such as anti-inflammatory, anticancer and antifertility. Objectives: This study evaluated the therapeutic effect of Z. ...
Wu Yuxin - - 2013
Amphibian skin secretions contain a plethora of pharmacologically-active substances and represent established sources of bioactive peptides, including tachykinins. Tachykinins are one of the most widelystudied peptide families in animals and are found in neuroendocrine tissues from the lowest vertebrates to mammals. They are characterized by the presence of a highly-conserved ...
Wei Guang-Feng - - 2013
The electrocatalytic oxygen reduction reaction (ORR) on nanoparticles has attracted much attention in recent years for its significance in fuel cell applications. Here by combining density functional theory (DFT) calculations with the periodic continuum solvation model based on modified-Poisson-Boltzmann (CM-MPB) electrostatics, we analyzed the ORR activity on a set of ...
Barker Gary M - - 2013
The South American weevil Listronotus bonariensis (Kuschel) is an important pest of pastures in New Zealand. As a component of management strategies for this pest, the South American parasitoid Microctonus hyperodae Loan (Hymenoptera: Braconidae) was released in northern New Zealand during 1991 as a biological control agent. Over the subsequent ...
Garfield Lauren D - - 2013
Objectives. Studies have reported an association between serotonin reuptake inhibitors (SRIs) and accelerated bone loss. Genetic variation in the serotonin system might modulate bone metabolism changes during SRI treatment. In a clinical trial we examined functional genetic polymorphisms of serotonin transporter and receptors involved in bone metabolism to determine whether ...
Aynali G - - 2013
Objective: To investigate the relationship between development of laryngeal cancer and the presence of polymorphisms of the MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genes in a smoking population. Patients and methods: Single nucleotide polymorphisms were determined in DNA from the peripheral blood erythrocytes of 48 heavy smokers (25 patients ...
Lebrun Alexander - - 2013
Abstract Objectives: The objective of this study was to develop and test computer algorithms to export micro computed tomography (microCT) images and to generate tumour geometry and specific absorption rate (SAR) distribution for heat transfer simulation in magnetic nanoparticle hyperthermia. Methods: Computer algorithms were written to analyse and export microCT ...
Keshmiri-Neghab Hoda - - 2013
Abstract Context: Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals, and beverages. Polyphenols occupy a unique place in biological science for their pharmacological properties. Gossypol is a polyphenolic compound that has attracted attention because of its biological effects. Objective: Gossypol is reported to exhibit antifertility, antioxidant, anticancer, antivirus, ...
Zhou Xuefeng - - 2013
Abstract Context: Epidioxy sterols and sterols with special side chains, such as hydroperoxyl sterols, usually obtained from marine natural products, are attractive for bioactivities. Objective: To isolate and screen bioactive and special sterols from China Sea invertebrates. Materials and methods: Two hydroperoxyl sterols (1 and 2) from the sponge Xestospongia ...
Ghasemi Pirbalouti Abdollah - - 2013
Abstract Context: A number Hypericum species are well known for their therapeutic efficacy and use in traditional medicine. The various species of Hypericum have been traditionally used for the treatment of wounds, eczema, burns, trauma, rheumatism, neuralgia, gastroenteritis, ulcers, hysteria, bedwetting and depression. Objective: This study evaluated the in vitro ...
Harlé Alexandre - - 2013
Breast cancer is the most common cancer among women with more than 53,000 new cases every year in France. The PI3K/AKT pathway is one of the major pathways involved in mammary tumorigenesis. The first effector of this pathway downstream Human Epidermal growth factor Receptor (HER receptors) is the enzyme phosphatidyl-inositol-3-kinase ...
Sun Xu Shan - - 2013
Primary lymphomas of the thyroid (LPT) are a rare entity. LPT represent between 5 and 15% of all thyroid neoplasms. Cytology has limited value; biopsy should be recommended. The differential diagnosis of thyroid carcinoma is differentiated forms indolent or aggressive forms for anaplastic and high grade that may occur by ...
Sasidharan Rashmi - - 2013
Complete submergence represses photosynthesis and aerobic respiration causing rapid mortality in most terrestrial plants. However, some plants have evolved traits allowing them to survive prolonged flooding, such as species of the genus Rorippa, close relatives of Arabidopsis. We studied plant survival, changes in carbohydrate and metabolite concentrations and transcriptome responses ...
Ledoux Mathilde - - 2013
In cancer patients, decision-making process is crucial and patient's involvement is described as a central component. In 2005, a new tool appears to convey patient's opinion even if he is not able to communicate anymore: advanced directives (AD). Unfortunately, their documentation is marginal. The objective of this study was to ...
Chen Dapeng - - 2013
Abstract Context: Ginsenosides are primary active ingredients of ginseng, which are believed to have various health benefits. It is found that the biotransformation of ginsenosides mainly takes place in the gastrointestinal tract and the information about ginsenosides-exerted effects on intestinal contractility is not sufficient. Aims: The present study proposed that ...
Wu Te-Lang - - 2013
Self-complementary adeno-associated viral (AAV) vectors expressing human factor IX (hF.IX) have achieved transient or sustained correction of hemophilia B in human volunteers. High doses of AAV2 or AAV8 vectors delivered to the liver caused in several patients an increase in transaminases accompanied by a rise in AAV capsid-specific T cells ...
Zhao Haifeng - - 2013
Resveratrol (Res), a polyphenol that is abundant in many medicinal plants and is a selective oestrogen receptor modulator, exhibits multiple biological activities. In the present study, we determined whether Res prevents oestrogen deficiency-induced osteopenia and whether Res administration decreases pathological changes in the endometrium and lumen of the uterus compared ...
Menard Melissa C - - 2013
Magnetite (Fe3O4) is an abundant, low cost, environmentally benign material with potential application in batteries. Recently, low temperature coprecipitation methods have enabled preparation of a series of nanocrystalline magnetite samples with a range of crystallite sizes. Electrochemical cells based on Li/Fe3O4 show a linear increase in capacity with decreasing crystallite ...
Morikawa Masa-Aki - - 2013
Luminescence of sodium tetrakis(naphthoyl trifluoroacetonato) europium(III) (Na[Eu(nta)4]) in binary aqueous-ethanol media is quenched continuously with increase in the water content, which is ascribed to commonly observed relaxation of photo-excited lanthanide complexes through vibrational coupling with coordinating water. Meanwhile, replacement of sodium ion with an ammonium amphiphile 1 gives a lipid ...
Ovalle-Magallanes Berenice - - 2013
Abstract Context. Conyza filaginoides (D.C.) Hieron (Asteraceae) is a medicinal Mexican plant highly prized in contemporary Mexico for the treatment of upset stomach and diabetes. Objective: This work was undertaken to develop a suitable high performance liquid chromatography (HPLC)-diode array detection (DAD) method for quantifying rutin (1), the main active ...
Tu Jiguo - - 2013
The Si-NC core-shell composite was synthesized by a modified oxidative template assembly route using a facile carbonization process. The images of the obtained Si-NC composites showed that an amorphous NC layer adsorbed stably and tightly on the nano-Si surface with an only several nanometers thickness to the formation of the ...
Samanta Dipak - - 2013
An organometallic building block 1,3,5-tris(4-trans-Pt(PEt3)2I(ethynyl)phenyl)benzene () incorporating Pt-ethynyl functionality has been synthesized and characterized. [2 + 3] self-assembly of its nitrate analogue 1,3,5-tris(4-trans-Pt(PEt3)2(ONO2)(ethynyl)phenyl)benzene () with "clip" type bidentate donors () separately afforded three trigonal prismatic architectures (), respectively. All these prisms were characterized and their shapes/sizes are predicted through geometry ...
Reddy M L P - - 2013
Visible-light sensitized luminescent europium(iii) molecular materials are of considerable importance because their outstanding photophysical properties make them well suited as labels in fluorescence-based bioassays and low-voltage driven pure red-emitters in optoelectronic technology. One challenge in this field is development of visible-light sensitizing ligands that can form highly emissive europium(iii) complexes ...
Yang Dan - - 2013
Lack of an appropriate small animal model remains a major hurdle for studying the immunotolerance and immunopathogenesis induced by hepatitis B virus (HBV) infection. In this study, we report a mouse model with sustained HBV viremia after infection with a recombinant adeno-associated virus (AAV) carrying a replicable HBV genome (AAV/HBV). ...
Wen Zhen - - 2013
A facile fluorine-mediated hydrothermal method was developed to synthesize mesoporous rhombic ZnO nanorod arrays. Fluorine ions play an essential role in the growth process. The novel ZnO nanorod array based gas sensor showed high performance for ethanol detection.
Sardar Samim - - 2013
In this study, we have investigated the efficacy of electron transfer processes in hematoporphyrin (HP) and iron hematoporphyrin ((Fe)HP) sensitized titania as potential materials for capturing and storing solar energy. Steady-state and picosecond-resolved fluorescence studies show the efficient photoinduced electron transfer processes in hematoporphyrin-TiO2 (HP-TiO2) and Fe(iii)-hematoporphyrin-TiO2 (Fe(iii)HP-TiO2) nanohybrids, which ...
Mateo David - - 2013
The dynamics following the photoexcitation of Ag atoms in (4)He nanodroplets via the 5p (2)P1/2 ← 5s (2)S1/2 and 5p (2)P3/2 ← 5s (2)S1/2 transitions has been investigated in a joint experimental and theoretical effort. It has been experimentally found that upon excitation to the (2)P1/2 state, the Ag atoms ...
Fernández de Larrea C - - 2013
The achievement of CR is the crucial step for a prolonged PFS and OS after an autologous SCT in multiple myeloma (MM). Unfortunately, even with the use of new regimens and the current high CR rates, most, if not all, patients will ultimately relapse or progress. We analyzed the type ...
Bodet-Milin C - - 2013
This prospective pilot study aimed to evaluate the predictive value of (18)F-FDG PET/CT for early diagnosis of acute gastrointestinal GVHD (GI-GVHD). In all, 42 consecutive patients who received allo-SCT were included. (18)F-FDG PET/CT was systematically performed at a median of 28 (range, 24-38) days after allo-SCT. (18)F-FDG PET/CT data review ...
Kanda J - - 2013
Few studies have evaluated the risk factors for chronic GVHD and organ involvement associated with different graft types, including unrelated cord blood (U-CB). We retrospectively studied 4818 adult patients who received their first allogeneic transplantation and survived for at least 100 days. The incidence of chronic GVHD at 2 years ...
Shu Z - - 2013
Transplantation of hematopoietic stem cells (HSCs) has been successfully developed as a part of treatment protocols for a large number of clinical indications, and cryopreservation of both autologous and allogeneic sources of HSC grafts is increasingly being used to facilitate logistical challenges in coordinating the collection, processing, preparation, quality control ...
Liu Kang-Sheng - - 2013
Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes, public health decision making, and primary prevention synthesis. Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies. Biomarkers are generally classified into three groups: biomarkers of ...
Xu Xie-Qun - - 2013
Methods Patients who received elective or emergency cholecystectomies in our center during 23 years were retrospectively evaluated. The data reviewed included demography, clinical presentations, diagnostic Methods , surgical procedures, postoperative complications, and follow-up.Results There were 27 patients diagnosed with MS among 8697 cholecystectomies performed during that period. The preoperative diagnostic ...
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