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Yetgin T T Department of Cardiology, Thoraxcentre Room Ee-2355, Erasmus MC, Dr. Molewaterplein 50-60, 3015 GE, Rotterdam, the - - 2014
Platelet inhibition is crucial in reducing both short- and long-term atherothrombotic risks in patients with acute coronary syndromes (ACS) managed with percutaneous coronary intervention (PCI). Based on randomised trials, recent recommendations in the current guidelines include the endorsement of prasugrel as a first-choice adenosine diphosphate receptor inhibitor. Yet, there is ...
Gaikwad Nitin N Department of Pharmacology, All India Institute of Medical Sciences, Tatibandh, G. E. Road, Raipur, 492099, Chhattisgarh, India, - - 2014
Many medical educators are experimenting with innovative ways of E-learning. E-learning provides opportunities to students for self-directed learning in addition to other advantages. In this study, we designed and evaluated an interactive E-learning module in pharmacology for effectiveness, acceptability and feasibility, with the aim of promoting active learning in this ...
O'Dwyer David N DN 1 School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, - - 2013
Idiopathic pulmonary fibrosis (IPF) is a fatal progressive interstitial pneumonia. The innate immune system provides a crucial function in the recognition of tissue injury and infection. Toll-like receptor 3 (TLR3) is an innate immune system receptor. We investigated the role of a functional TLR3 single-nucleotide polymorphism in IPF. To characterize ...
Díaz Agustín A Department of Chemistry, University of Puerto Rico, PO Box 23346, Río Piedras, PR 00931-3346, USA. - - 2013
We report the use of zirconium phosphate (ZrP) nanoplatelets for the encapsulation of the anticancer drug cisplatin and its delivery to tumor cells. Cisplatin was intercalated into ZrP by direct ion exchange and was tested in vitro for cytotoxicity in the human breast cancer (MCF-7) cell line. The structural characterization ...
Nicolai M P J MP Department of Urology, Leiden University Medical Center, PO box 9600, 2300, RC, Leiden, the Netherlands, - - 2013
Several cardiovascular agents, such as diuretics and β-blockers, can negatively affect sexual function, leading to noncompliance with therapy. Others such as angiotensin II receptor blockers (ARBs) can improve patients' sexual function. We aimed to gain insight into cardiologists' knowledge about the effects of cardiovascular drugs on sexual function and whether ...
Cox Daniel J DJ Behavioral Medicine Center, University of Virginia School of Medicine, 1300 JPA, UVA Hospital West, Barringer IV, Charlottesville, VA, 22908, USA, - - 2013
Research on the role of behavior change as an efficacious intervention for adults with type 2 diabetes is evolving. Searching PubMed and Ovid Medline, we identified and reviewed primarily randomized controlled trials from 2010 to 2013 of adults managing type 2 diabetes without insulin. All studies are evaluated in terms ...
Kheterpal Sachin S * Assistant Professor, ‡ Lead Statistician, § Resident, ‖ Research Fellow, ** Clinical Instructor, ‖‖ Software Analyst, ## Professor and Chairman, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan. † Associate Professor, Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon. # Acting Assistant Professor, Department of Anesthesiology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington. †† Associate Professor and Chairman, Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, Tennessee. ‡‡ Assistant Professor, §§ Associate Professor and Vice Chair, Department of Anesthesiology, University of Colorado, Aurora, Colorado. *** The members of the Multicenter Perioperative Outcomes Group (MPOG) Perioperative Clinical Research Committee are included in the - - 2013
Research regarding difficult mask ventilation (DMV) combined with difficult laryngoscopy (DL) is extremely limited even though each technique serves as a rescue for one another. Four tertiary care centers participating in the Multicenter Perioperative Outcomes Group used a consistent structured patient history and airway examination and airway outcome definition. DMV ...
Acharya Abhinav P AP Department of Bioengineering, University of California, Berkeley, California 94720, USA. - - 2013
The low detection sensitivity of enzyme linked immunosorbent assays (ELISAs) is a central problem in science and limits progress in multiple areas of biology and medicine. In this report we demonstrate that the hydrocyanines, a family of fluorescent reactive oxygen species (ROS) probes, can act as turn on fluorescent horseradish ...
Lee Eun-Shil - - 2013
Calcium-binding proteins (CBPs) are important components in calcium-mediated cellular signal transduction. Among the many CBPs, at least three EF-hand CBPs, calbindin-D28K (CB), calretinin (CR), and parvalbumin (PV), have been extensively studied in the retina. In the present study, we investigated the expression patterns of these three CBPs in cholinergic starburst ...
Tao Weidong - - 2013
The body inversion effect is the finding that inverted body posture pictures are more difficult to recognize than upright body posture pictures are. The present study reinvestigated the body inversion effect in human observers using behavioral and eye movement measures to explore whether the body inversion effect correlates with specific ...
Gilek-Seibert Katarzyna - - 2013
Increasing evidence suggests low disease activity or remission is achievable in rheumatoid arthritis (RA). Using a treat to target strategy (T2T) has been shown to achieve these targets of remission or low disease activity in RA. In order to successfully treat to target, rheumatologists need reliable measures of disease activity ...
Torres-Del-Pliego Elisa - - 2013
Osteoporosis is defined as a reduction in bone mass and impairment of bone quality that lead to bone fragility and fracture risk. Bone quality includes a hierarchy of properties from macroscopic to nanoscale level. Several techniques have been developed in an attempt to measure these non-density properties. Densitometry, high-resolution images ...
Bottini Nunzio - - 2013
Epigenetic anomalies are emerging as key pathogenic features of rheumatoid arthritis (RA). The effect of epigenetics in RA ranges from contributing to complex disease mechanisms to identifying biomarkers for early diagnosis and response to therapy. This review focuses on three key epigenetic areas in RA, namely DNA methylation, histone modification, ...
Weitz Joshua E - - 2013
Psoriasis and psoriatic arthritis are common chronic inflammatory conditions associated with substantial local and systemic morbidity. The genetic and phenotypic heterogeneity of these disorders presents great challenges to investigators of disease mechanisms. Valid and reliable animal models that combine the main elements of human skin and joint disease have not ...
Thomas Laine - - 2013
In clinical studies, covariates are often measured with error due to biological fluctuations, device error and other sources. Summary statistics and regression models that are based on mismeasured data will differ from the corresponding analysis based on the "true" covariate. Statistical analysis can be adjusted for measurement error, however various ...
Alfonso F F Network of the European, Society of Cardiology, Madrid, Spain, - - 2013
European Society of Cardiology (ESC) National Society Cardiovascular Journals (NSCJs) are high-quality biomedical journals focused on cardiovascular diseases. The Editors' Network of the ESC devises editorial initiatives aimed at improving the scientific quality and diffusion of NSCJ. In this article we will discuss on the importance of the Internet, electronic ...
Verheugt F W A FW Heartcenter, Department of Cardiology, Onze Lieve Vrouwe Gasthuis (OLVG), Oosterpark 9, 1091 AC, Amsterdam, the Netherlands, - - 2013
In patients with nonvalvular atrial fibrillation, oral anticoagulation with the vitamin K antagonists acenocoumarol, phenprocoumon and warfarin reduces the risk of stroke by more than 60 %, whereas single or double antiplatelet therapy is much less effective and sometimes associated with a similar bleeding risk as vitamin K antagonists. Besides bleeding, ...
Houard Xavier X UPMC, Univ Paris 06, UR4 "Ageing, Stress and Inflammation", Labex Transimmunom, Inflammation- Immunopathology-Biotherapy department (I2B), F-75252, Cedex 5, Paris, - - 2013
Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its cause (aging, genetic predisposition, trauma or metabolic disorder) induces profound phenotypic modifications of chondrocytes, which then promote the synthesis of a subset ...
Rassiwala Jasmine J Ms. Rassiwala is a medical student, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Dr. Vaduganathan is a resident, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Ms. Kupershtok is a medical student, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Dr. Castillo is assistant professor, Department of Family and Community Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois. Dr. Evert is executive director, Child Family Health International, and clinical faculty, Department of Family and Community Medicine, University of California, San Francisco, San Francisco, - - 2013
Global health learning experiences for medical students sit at the intersection of capacity building, ethics, and education. As interest in global health programs during medical school continues to rise, Northwestern University Alliance for International Development, a student-led and -run organization at Northwestern University Feinberg School of Medicine, has provided students ...
Cherniak William A WA Dr. Cherniak is a family medicine resident, Scarborough Hospital, University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada. Dr. Drain is instructor of medicine, Massachusetts General Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Dr. Brewer is professor of medicine, David Geffen School of Medicine, Department of Medicine, University of California, Los Angeles, Los Angeles, - - 2013
Although most medical schools and residency programs offer international medical electives (IMEs), little guidance on the educational objectives for these rotations exists; thus, the authors reviewed the literature to compile and categorize a comprehensive set of educational objectives for IMEs. In February and July 2012, the authors searched SciVerse Scopus ...
Lee Jennifer I JI Dr. Lee is assistant professor, Division of Hospital Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York. Dr. Ganz-Lord is assistant professor, Weill Cornell Internal Medicine Associates, Department of Medicine, Weill Cornell Medical College, New York, New York. Dr. Tung is associate professor, Weill Cornell Internal Medicine Associates, and acting chief, Division of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, New York, New York. Dr. Bishop is assistant professor, Weill Cornell Internal Medicine Associates, Department of Medicine, and Division of Outcomes and Effectiveness, Department of Public Health, Weill Cornell Medical College, New York, New York. Ms. DeJesus is director, Department of Social Work and Care Coordination, New York-Presbyterian Hospital, New York, New York. Ms. Ocampo is improvement manager, Division of Quality and Patient Safety, New York-Presbyterian Hospital, New York, New York. Ms. Tinghitella is improvement manager, Division of Quality and Patient Safety, New York-Presbyterian Hospital, New York, New York. Dr. Scott is vice president, Division of Quality and Patient Safety, New York-Presbyterian Hospital, New York, New - - 2013
Academic medical centers face unique challenges to ensuring patient safety after a hospital discharge, including those related to providing patient follow-up care in practices staffed by residents who are not comfortable managing care transitions. In 2011, the authors designed a quality improvement program for early postdischarge follow-up (bridge visits) at ...
Ehrmann Daniel E DE Mr. Ehrmann is a fourth-year medical student, University of Michigan Medical School, Ann Arbor, - - 2013
In this commentary, the author argues that medical students and residents often find themselves overwhelmed with the realities of facilitating coordinated care. He suggests that the difficulty in obtaining outside records for newly transferred patients leads to both unnecessary duplication of procedures and learned helplessness for new physicians. He provides ...
Grimm Lars J LJ Dr. Grimm is resident physician, Department of Radiology, Duke University Medical Center, Durham, North Carolina. Dr. Maxfield is associate professor, Departments of Radiology and Pediatrics, Duke University Medical Center, Durham, North - - 2013
This study was designed to assess the ultimate publication rate of unpublished manuscripts listed on radiology residency applications. A retrospective review was performed on all 628 Electronic Residency Application Service applications submitted to a single-institution radiology residency program in 2010. Publication status of unpublished manuscripts listed as "accepted," "in press," ...
Godoy Heidi H Roswell Park Cancer Institute, Buffalo, New - - 2013
Developmentally restricted differentiation antigens or cancer-placental antigens, tastin and bystin, are components of an adhesion molecule that plays a critical role in the implantation of the embryo to the uterus. Cell adhesion molecules have been implicated in the metastasis of carcinomas and could be critical targets for immunotherapy in epithelial ...
Myers Michael F MF Dr. Myers is professor of clinical psychiatry, immediate past vice chair of education, and program director, Department of Psychiatry, and medical student ombudsman, SUNY Downstate Medical Center College of Medicine, Brooklyn, New York. Ms. Herb is clinical professor, Departments of OB/GYN and Family Practice, SUNY Downstate Medical Center College of Medicine, Brooklyn, New - - 2013
A sound clinical education should include the opportunity for medical students to engage in a spirited and informed discussion with faculty about the ethical challenges they will undoubtedly face. Unfortunately, in many medical schools today this goal is thwarted by many factors, including denial that a problem exists, relentless system ...
Jagsi Reshma R Dr. Jagsi is associate professor, Center for Bioethics and Social Sciences in Medicine, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Mr. Griffith is statistician expert, Center for Cancer Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan. Dr. Stewart is professor, Department of Psychology, Women's Studies Program, University of Michigan, Ann Arbor, Michigan. Ms. Sambuco is research area specialist intermediate, Center for Bioethics and Social Sciences in Medicine, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Ms. DeCastro is research area specialist intermediate, Center for Bioethics and Social Sciences in Medicine, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan. Dr. Ubel is professor, Fuqua School of Business, Sanford School of Public Policy, Duke University, Durham, North - - 2013
Studies have suggested that male physicians earn more than their female counterparts. The authors examined whether this disparity exists in a recently hired cohort. In 2010-2011, the authors surveyed recent recipients of National Institutes of Health (NIH) mentored career development (i.e., K08 or K23) awards, receiving responses from 1,275 (75% ...
Gray Mark R MR From the Department of Radiology, University of Mississippi Medical Center, 2500 N State St, Jackson, MS - - 2014
To predict survival in patients with metastatic melanoma by evaluating a combination of serum lactate dehydrogenase (LDH) level and initial computed tomographic (CT) findings of tumor devascularization after antiangiogenic therapy. Consent was waived for this institutional review board-approved, retrospective, secondary analysis. Forty-four patients with metastatic melanoma received bevacizumab therapy in ...
Sprague Brian L BL From the Department of Surgery, University of Vermont, 1 S Prospect St, Burlington, VT - - 2014
To determine whether the 2009 U.S. Preventive Services Task Force (USPSTF) guidelines for breast cancer mammography screening were followed by changes in screening utilization in the state of Vermont. This retrospective study was HIPAA compliant and approved by the institutional review board, with waiver of informed consent. Trends in screening ...
Freeley Michael - - 2013
The specificity of RNAi and its ability to silence 'undruggable' targets has made inhibition of gene expression in T-cells with siRNAs an attractive potential therapeutic strategy for the treatment of inflammatory disease, cancer and infection. However, delivery of siRNAs into primary T-cells represents a major hurdle to their use as ...
Lally James S V - - 2013
Skeletal muscle is critical for whole-body glucose homoeostasis. Insulin and muscle contractions induced by exercise can increase glucose uptake through distinct intracellular signalling pathways involving PKB (protein kinase B)/Akt and AMPK (AMP-activated protein kinase) respectively. Whereas the proximal events governing these processes are becoming well understood, less is known about ...
Qiao Jichao J Université de Lyon, CNRS , Lyon, - - 2013
The relaxational dynamics in metallic glasses (MGs) is investigated by using mechanical spectroscopy. The spectra show that in MGs there are two relaxations: (i) the α relaxation, linked to the glass transition, as observed in other classes of amorphous materials; and (ii) the β relaxation, well observed below the glass ...
Chou Feng-Pai - - 2013
Membrane-associated serine protease matriptase is widely expressed by epithelial/carcinoma cells in which its proteolytic activity is tightly controlled by the Kunitz-type protease inhibitor, hepatocyte growth factor activator inhibitor (HAI-1). We demonstrate that, although matriptase is not expressed in lymphoid hyperplasia, roughly half of the non-Hodgkin B-cell lymphomas analyzed express significant ...
Li Hongzhen - - 2013
The olfactomedin 4 (OLFM4) gene is located on chromosome 13q14.3, which frequently is deleted in human prostate cancer. However, direct genetic evidence of OLFM4 gene alteration in human prostate cancer has not yet been obtained. In this study, we investigated the genetics, protein expression, and functions of the OLFM4 gene ...
Huang Qiang - - 2013
Two experiments were conducted to determine the effects of inclusion level of wheat middlings and soya bean meal on apparent total tract digestibility (ATTD) of energy and chemical components of these ingredients in growing pigs. Furthermore, the effects of the inclusion level on their contents of digestible energy (DE) and ...
He Zhixiong - - 2013
Wheat dried distillers grains with solubles (DDGS) is widely used as a partial replacement for forages or concentrates in ruminant diets. We hypothesised that using exogenous enzymes (ENZ) would increase neutral detergent fibre (NDF) degradability of DDGS. The aims of the study were to (i) evaluate the effects of ENZ ...
Hanon Elodie A - - 2013
Abstract Parathyroid hormone (PTH) is relatively unstable: optimisation of pre-analytical conditions, including specimen type, sampling time and storage conditions, is essential. We have undertaken a systematic review of these pre-analytical conditions. An electronic search of the PubMed, Embase, Cochrane, Centre for Research and Dissemination and Bandolier databases was undertaken. Of ...
Carobene Anna - - 2013
Abstract Background: Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyl transferase (GGT) are enzymes measured in serum or plasma to investigate liver disease. The aim of this work is to assess the validity of published biological variation (BV) data currently available for these enzymes. Methods: Publications containing BV data for ...
Morovat Alireza - - 2013
Abstract Background: We carried out a technical evaluation of the Immunodiagnostic Systems (IDS) automated intact procollagen-I N-terminus propeptide (PINP) assay on the iSYS platform, and established reference intervals for PINP in both adults and children. Methods: Assay imprecision, recovery and interference were studied. Serum and plasma values were compared, and ...
Giannitsis Evangelos - - 2013
Abstract Background: The simultaneous assessment of high-sensitivity cardiac troponin T (hscTnT) and NT-proBNP for predicting death in stable coronary artery disease (CAD) has yet not been examined. We investigated the additional contribution of hscTnT to the risk of mortality prediction of NT-proBNP in patients with stable CAD. Methods: We studied ...
Thammasitboon Satid - - 2013
Diagnostic errors are the most common errors in primary care. Diagnostic errors have been found to be the leading cause of malpractice litigation, accounting for twice as many claims and settled cases as medication errors. Diagnostic error is common, harmful, costly, and very critical to the patient-safety issues in health ...
Wang Lei - - 2013
ABSTRACT In chronic thromboembolic pulmonary hypertension (CTEPH), central thrombi are the most likely disease initiators, and progressive pulmonary vascular remodeling, which is characterized by marked proliferation of pulmonary artery smooth muscle cells (PASMCs), may also contribute to the long-term progression of CTEPH. This study was designed to investigate the cellular ...
Kougias Marios - - 2013
ABSTRACT Introduction: Smoking is known to have a long-term impact on lung function; however, the acute physiological response of smoking a single cigarette and the influential role of pack years and cigarettes per day on pulmonary indices remains an area of interest, especially among young smokers. Methods: 50 naive smokers ...
Elmeery A - - 2013
A preterm female infant born of 32 weeks gestational age was presenting with musculoskeletal abnormalities, and cholestasis that later on resolved. Later on, she developed renal tubular acidosis (RTA), poor weight gain, unexplained intermittent fever and recurrent spontaneous bleeding episodes. ARC is an acronym that stands for arthrogryposis, renal dysfunction ...
Carrafiello Gianpaolo - - 2013
To evaluate the safety and efficacy of percutaneous microwave (MW) ablation treatment in locally advanced, nonresectable, nonmetastatic pancreatic head cancer. Ten patients with pancreatic head cancer treated with percutaneous (n = 5) or laparotomic (n = 5) MW ablation were retrospectively reviewed. The MW generator used (45 W at 915 ...
Lewallen Susan - - 2013
Abstract Purpose: To apply a previously described mathematical model, designed to estimate cataract incidence from age-specific prevalence, to Rapid Assess of Avoidable Blindness survey data from Sub-Saharan Africa in order to estimate the incidence of cataract and therefore surgical needs. Methods: All Rapid Assessment of Avoidable Blindness surveys from Sub-Saharan ...
Lip Gregory Y H - - 2013
The purpose of this European Heart Rhythm Association (EHRA) survey was to assess clinical practice in relation to stroke prevention in atrial fibrillation (AF), particularly into the use of novel oral anticoagulants (NOACs) for stroke prevention, among members of the EHRA electrophysiology (EP) research network. In this EP Wire survey, ...
Thammasitboon Satid - - 2013
A significant portion of diagnostic errors arises through cognitive errors resulting from inadequate knowledge, faulty data gathering, and/or faulty verification. Experts estimate that 75% of diagnostic failures can be attributed to clinician diagnostic thinking failure. The cognitive processes that underlie diagnostic thinking of clinicians are complex and intriguing, and it ...
Cutrer William B - - 2013
Clinical reasoning serves as a crucial skill for all physicians regardless of their area of expertise. Helping trainees develop effective and appropriate clinical reasoning abilities is a central aim of medical education. Teaching clinical reasoning however can be a very difficult challenge for practicing physicians. Better understanding of the different ...
Pfister K M - - 2013
We report a case of non-immune hydrops fetalis (NIHF) caused by herpes simplex virus type 2 (HSV-2) in an infant whose mother had recurrent HSV-2 infection. In spite of prematurity, severe disseminated infection and hydrops, the infant survived and was neurologically intact. HSV-2-induced NIHF is extremely rare, particularly in the ...
Mirakhur Anirudh - - 2013
The authors have seen four cases of asymptomatic delayed intimal injury adjacent to a stent graft diagnosed 7 to 16 months after thoracic endovascular aortic repair. Endovascular repeat intervention was successfully performed in three of the four cases as described in the present report. A second consecutive "intimal blowout" in ...
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