Search Results
Results 451 - 500 of 2729
< 5 6 7 8 9 10 11 12 13 14 15 >
Wojnarowska Z - - 2013
This study for the first time investigates physicochemical properties of amorphous indapamide drug (IND), which is a known diuretic agent commonly used in the treatment of hypertension. The solid-state properties of the vitrified, cryomilled and ball-milled IND samples were analyzed using X-ray powder diffraction (XRD), mass spectrometry, nuclear magnetic resonance ...
Carlson David A - - 2013
DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases that regulate programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. We have developed a fluorescence linked enzyme chemoproteomic strategy (FLECS) for the rapid identification of inhibitors for any element of the purinome and identified a ...
Gadelrab Karim - - 2013
The monitoring of the deflection of a micro-cantilever, as the end of a sharp probe mounted at its end, i.e. the tip, interacts with a surface, forms the foundation of atomic force microscopy AFM. In a nutshell, developments in the field are driven by the requirement of obtaining ever increasing ...
Rosiaux Y - - 2013
To elucidate the mass transport mechanisms controlling drug release from recently proposed, ethanol-resistant, polymeric film coatings. Theophylline matrix pellets were coated with ethylcellulose: guar gum blends. Drug release from single pellets and ensembles of pellets was measured in various release media. Changes in the systems' morphology, composition and mechanical properties ...
Nigmatullina Yuliya - - 2013
Sensory input evokes low-order reflexes and higher-order perceptual responses. Vestibular stimulation elicits vestibular-ocular reflex (VOR) and self-motion perception (e.g., vertigo) whose response durations are normally equal. Adaptation to repeated whole-body rotations, for example, ballet training, is known to reduce vestibular responses. We investigated the neuroanatomical correlates of vestibular perceptuo-reflex adaptation ...
Bennion Kelly A - - 2013
Separate lines of research have demonstrated that rises in cortisol can benefit memory consolidation, as can the occurrence of sleep soon after encoding. For the first time, we demonstrate that pre-learning cortisol interacts with sleep to benefit memory consolidation, particularly for negative arousing items. Resting cortisol levels during encoding were ...
Vähänikkilä Hannu - - 2013
Abstract Objective. The aim of this epidemiological, data-based survival study was to study the longevity of restorations in permanent molars of adolescents in the 1990 and 1995 birth cohorts during the period of 1992-2005 in the City of Vantaa, Finland. Materials and methods. The dental records of 2975 (1990 cohort) ...
Rivera-Betancourt Omar E - - 2013
This report examines lipophilic extracts containing mycolic acids isolated from tuberculosis (MTB) and non-tuberculosis (NTM) mycobacterial strains using chromatography, mass spectrometry (MS), nuclear magnetic resonance (NMR), and Raman spectroscopy. Gas chromatography-MS was used to identify major fatty acid mycolate components, while proton NMR confirmed the presence of characteristic cis- and ...
Yusoff Abd Rashid Bin Mohd - - 2013
One approach to harvest a wide solar spectral solar energy is to stack two solar cells with different absorption characteristics in a tandem cell architecture. Herein, solution processed tandem solar cells, with highly transparent titanium oxide (TiO2) and graphene oxide (GO) as an efficient recombination layer, were designed, fabricated and ...
Jaczewska Justyna - - 2013
Inflammatory conditions induce redistribution of junctional adhesion receptors toward the apical regions of endothelial cells promoting lymphocyte TEM. Much of the molecular structures of TEM have been revealed; however, the biophysical mechanisms underlying this process remain to be fully elucidated. Here, we used immunofluorescence microscopy and AFM to study endothelial ...
Crawley Angela M - - 2013
IL-7 plays an important role in T cell survival, function, and memory cell development, yet the role of cytokine signaling pathways in these processes has not been fully elucidated. Moreover, the underlying mechanisms for the observed impairment of IL-7 activity in diseases, such as HIV infection, breast cancer, and autoimmunity, ...
Pereira-Manfro Wânia F - - 2013
We investigated how apoptosis pathways mediated by death receptors and caspase-8 affect cytokine responses and immunity to Leishmania major parasites. Splenic CD4 T cells undergo activation-induced apoptosis, and blockade of FasL-Fas interaction increased IFN-γ and IL-4 cytokine responses to L. major antigens. To block death receptor-induced death, we used mice ...
Hebert Craig E - - 2013
Mercury levels were measured in colonial waterbird eggs collected from two sites in northern Alberta and one site in southern Alberta, Canada. Northern sites in the Peace-Athabasca Delta and Lake Athabasca were located in receiving waters of the Athabasca River which drains the oil sands industrial region north of Fort ...
Wright Patricia - - 2013
Fragmentation of molecules under collision-induced dissociation (CID) conditions is not well-understood. This may make interpretation of MSMS spectra difficult and limit the effectiveness of software tools intended to aid mass spectral interpretation. Density Functional Theory (DFT) has been successfully applied to explain the thermodynamics of fragmentation in the gas phase ...
Paiva Bruno - - 2013
Circulating myeloma tumor cells (CTCs) as defined by the presence of peripheral blood (PB) clonal plasma cells (PCs) are a powerful prognostic marker in multiple myeloma (MM). However, the biological features of CTCs and their pathophysiological role in MM remains unexplored. Here, we investigate the phenotypic, cytogenetic and functional characteristics ...
Busó-Rogero C - - 2013
The co-adsorption of CO and OH on two Pt stepped surfaces vicinal to the (111) orientation has been evaluated by means of density functional theory (DFT) calculations. Focusing on Pt(533) and Pt(221), which contain (100) and (111)-steps, respectively, we find that (111)-steps should be more reactive towards CO oxidation than ...
Goodman Daniel B - - 2013
Most amino acids are encoded by multiple codons, and codon choice has strong effects on protein expression. Rare codons are enriched at the N terminus of genes in most organisms, although the causes and effects of this bias are unclear. Here, we measure expression from >14,000 synthetic reporters in Escherichia ...
Vlastakis Brian - - 2013
In contrast to a single quantum bit, an oscillator can store multiple excitations and coherences, provided one has the ability to generate and manipulate complex multiphoton states. We demonstrate multiphoton control using a superconducting transmon qubit coupled to a waveguide cavity resonator with a highly ideal off-resonant coupling. This dispersive ...
Zhang Jun - - 2013
We report a real-space visualization of the formation of hydrogen bonding in 8-hydroxyquiline (8-hq) molecular assemblies on a Cu(111) substrate using noncontact atomic force microscopy (NC-AFM). The atomically resolved molecular structures enable a precise determination of the characteristics of hydrogen bonding networks, including the bonding sites, orientations, and lengths. The ...
Grandhi Ramesh - - 2013
The complication rates of carotid artery stenting (CAS) vary from 3.0% to 4.4%, and most commonly include ischemic stroke, intracranial hemorrhage, or groin complications. We present the rare complication of a patient who underwent CAS for a symptomatic 90% left internal carotid artery stenosis and developed an expanding cervical hematoma ...
Mohammed Hisham - - 2013
Significant insight into the function of proteins, can be delineated by discovering and characterising interacting proteins. There are numerous methods for the discovery of unknown associated protein networks, with purification of the bait (the protein of interest) followed by Mass Spectrometry (MS) as a common theme. In recent years, advances ...
Varagunam Mira - - 2013
To determine the impact of introducing patient reported outcome measures (PROMs) on the selection of patients for surgery and on outcome for four elective operations (hip replacement, knee replacement, varicose vein surgery and groin hernia repair). Patient-level data from the National PROMs programme for England from April 2009 to March ...
Cuesta Manuel J - - 2013
There is now growing evidence that parkinsonism and other extrapyramidal signs are highly prevalent in patients with first-episode psychosis who have never been exposed to antipsychotic drugs. However, the neurocognitive correlates of parkinsonism in this population remained to be clarified. A sample comprising 100 consecutive drug-naive patients with first-episode psychosis ...
Olbert Charles M - - 2013
It is unknown whether measures adapted from social neuroscience linked to specific neural systems will demonstrate relationships to external variables. Four paradigms adapted from social neuroscience were administered to 173 clinically stable outpatients with schizophrenia to determine their relationships to functionally meaningful variables and to investigate their incremental validity beyond ...
Vornanen Matti - - 2013
The upper thermal tolerance and mechanisms of heat-induced cardiac failure in the brown trout (Salmo trutta fario) was examined. The point above which ion channel function and sinoatrial contractility in vitro, and electrocardiogram (ECG) in vivo, started to fail (break point temperature, BPT) was determined by acute temperature increases. In ...
Wang Ya-Dan - - 2013
Five new diterpenoids (1-5), five new sesquiterpenoids (6-10), and three known compounds (11-13) were isolated from the roots of Illicium majus. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was assigned by X-ray crystallography, whereas those of the 1,2-diol moieties in 3 and 4 were ...
Gutteridge Adrian - - 2013
Unlike other elasmobranchs, batoids exhibit sexually dimorphic dentition. The functional implications of such dentition, however, remain understudied. For the present study ontogenetic and sexual dimorphism in tooth and jaw structure, together with the functional implications of this dimorphism, was determined in the eastern shovelnose ray, Aptychotrema rostrata (Shaw & Nodder, ...
Jernigan Christopher M - - 2013
Associative color learning has been demonstrated to be very poor using restrained European honey bees unless the antennae are amputated. Consequently, our understanding of proximate mechanisms in visual information processing is handicapped. Here we test learning performance of Africanized honey bees under restrained conditions with visual and olfactory stimulation using ...
Zeder-Lutz G - - 2013
The recalcitrance of lignocellulose to bioprocessing represents the core problem and remains the limiting factor in creating an economy based on lignocellulosic ethanol production. Lignin is responsible for unproductive interactions with enzymes, and understanding how lignin impairs the susceptibility of biomass to enzymatic hydrolysis represents a significant aim in optimising ...
Hickey James Laurence - - 2013
One of the pathological hallmarks of Alzheimer's disease is the presence of amyloid-β plaques in the brain and the major constituent of these plaques is aggregated amyloid-β peptide. New thiosemicarbazone-pyridylhydrazine based ligands that incorporate functional groups designed to selectively bind amyloid-β plaques have been synthesized. The new ligands form stable ...
Gardell Alison M - - 2013
This study aimed to determine the regulation of the de novo myo-inositol biosynthetic (MIB) pathway in Mozambique tilapia (Oreochromis mossambicus) brain following acute (25 parts per thousand (ppt)) and chronic (30, 60, 90ppt) salinity acclimations. The MIB pathway plays an important role in cells for accumulating the compatible osmolyte, myo-inositol, ...
Davenport John - - 2013
Cetaceans are neckless, so the trachea is very short. The upper respiratory tract is separate from the mouth and pharynx. The dorsal blowhole connects, via the vestibular and nasopalatine cavities, directly to the larynx. Toothed cetaceans (Odontoceti) are capable of producing sounds at depth, either for locating prey, or for ...
Nagl Michaela - - 2013
The Patient Reported Outcomes Measurement Information System (PROMIS) initiative aims to provide reliable and precise item banks measuring patient-reported outcomes in different health domains. The aim of the present work was to provide a German translation of the PROMIS item banks for satisfaction with participation and to psychometrically test these ...
O'Connor Stacy D - - 2013
Purpose:To determine renal cancer incidence in simple cyst-appearing renal masses detected at unenhanced computed tomography (CT).Materials and Methods:Institutional review board approval and an informed consent waiver for this retrospective HIPAA-compliant study were obtained. Patients who had renal masses with homogeneous water attenuation, hairline-thin smooth walls, and no calcifications or septations ...
Berard Roberta A - - 2013
Introduction: Juvenile idiopathic arthritis (JIA) is a relatively common multidimensional and heterogeneous chronic disease of childhood. Children with JIA are at risk for significant morbidity in terms of joint damage, impairments in physical function and health-related quality of life. Outcomes for children with JIA have significantly improved with the use ...
Chen Yansu - - 2013
JWA, a multifunctional microtubule-binding protein, plays an important role in regulating tumor metastasis via inhibition of MMP-2. Recent investigations suggest that MMP-2 is an angiogenesis associated molecule. In this study, we provide novel evidence that JWA inhibits tumor angiogenesis in gastric cancer (GC). In two independent retrospective GC cohorts, we ...
Avonto Cristina - - 2013
German chamomile (Matricaria chamomilla) is one of the most popular medicinal plants used in Western herbal medicine. Among the various phytochemicals present in the essential oil of the flowers of German chamomile, bisabolol and its oxidized metabolites are considered as marker compounds for distinguishing different chemotypes. These compounds are influential ...
Khan Naghma - - 2013
In preclinical animal models, several phytochemicals have shown excellent potential to be used as effective agents in preventing and treating many cancers. However, the limited bioavailability of active agents could be one reason for their limited usefulness for human consumption. To overcome this limitation, we recently introduced the concept of ...
Kaya Selçuk - - 2013
Infective endocarditis is very rare clinical form caused by Erysipelothrix rhusiopathiae. It rarely seen in immunocompetent individuals and despite surgery, it may cause mortality rates as high as 30-40%. This report describes a case of native valve endocarditis caused by Erysipelothrix rhusiopathiae and cured with crystalized penicillin G and surgery.
Dessau Ram Benny - - 2013
Two assays (Diasorin-Liaison and Oxoid-IDEIA) for detection of Borrelia specific antibodies were compared. A case control design was chosen using patients with Neuroborreliosis (n=48) laboratory defined by positive specific Borrelia antibody index in the spinal fluid were available and intended to represent the serological response of disseminated early Lyme borreliosis ...
Romero-Gómez María Pilar - - 2013
We present a case of bacteraemia due to MRSA carrying the mecC gene. The susceptibility to methicillin of S. aureus was investigated directly from one blood culture bottle using GenomEra™ MRSA/SA (Abacus Diagnostica Oy, Turku, Finland) test. This test identified the S. aureus but the presence of the mecA gene ...
La Vignera Sandro - - 2013
The role of inflammation and/or infection of the male accessory sex glands is very important for the potential effects that these conditions have on male fertility. The clinical Andrologist should be aware of the pathophysiological role of the main determinants of sperm damage when these conditions occur, in particular seminal ...
Yagupsky Pablo - - 2013
Brucella organisms are highly transmissible to man because of the low infecting dose and multiple routes of entry to the human body, posing a serious threat to Clinical Microbiology laboratory personnel in endemic areas. Three separate events of inadvertent exposure to Brucella melitensis among technologists working with cultures of genital ...
Coid Jeremy W - - 2013
Structured risk assessment aims to help clinicians classify offenders according to likelihood of future violent and criminal behaviour. We investigated how confident clinicians can be using three commonly used instruments (HCR-20, VRAG, OGRS-II) in individuals with different diagnoses. Moderate to good predictive accuracy for future violence was achieved for released ...
Hickey Graeme L - - 2013
The Society for Cardiothoracic Surgery in Great Britain and Ireland (SCTS) has published named mortality data since 2001. The importance of accurate and robust clinical outcome reporting has been emphasized by a number of high-profile cases in England. In this article, we give a technical review of the United Kingdom ...
Goldberg Sarah B - - 2013
Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer has an oncogene-addicted biology that confers sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Published data suggest that EGFR addiction persists after development of TKI acquired resistance, leading many clinicians to continue TKI with subsequent chemotherapy; however, this strategy has not been ...
Verhoye Jean-Philippe - - 2013
To describe the early and mid-term clinical and instrumental results of the frozen elephant trunk (FET) procedure using the recent Evita Open Plus hybrid endoprosthesis for elective one-stage treatment of extensive thoracic aortic disease. We reviewed 16 patients undergoing FET for post-dissection aneurysm (50%), true aneurysm (31%) or other aetiologies ...
Santarpia Libero - - 2013
DNA repair pathways can enable tumor cells to survive DNA damage induced by chemotherapy and thus provide prognostic and/or predictive value. We evaluated Affymetrix gene expression profiles for 145 DNA repair genes in untreated breast cancer (BC) patients (n = 684) and BC patients treated with regimens containing neoadjuvant taxane/anthracycline ...
Lam Wai Han - - 2013
Platinum(II) alkynyl complexes of various tridentate pincer ligands, [Pt(trpy)(C≡CR)](+) (trpy = 2,2':6',2″-terpyridine), [Pt(R'-bzimpy)(C≡CR)](+) (R'-bzimpy = 2,6-bis(N-alkylbenzimidazol-2'-yl)pyridine and R' = alkyl), [Pt(R'-bzimb)(C≡CR)] (R'-bzimb = 1,3-bis(N-alkylbenzimidazol-2'-yl)benzene and R' = C4H9), have been found to possess rich photophysical properties. The emission in dilute solutions of [Pt(trpy)(C≡CR)](+) originated from a triplet alkynyl-to-tridentate pincer ligand-to-ligand ...
Ke Xiayi - - 2013
Many human diseases are multifactorial, involving multiple genetic and environmental factors impacting on one or more biological pathways. Much of the environmental effect is believed to be mediated through epigenetic changes. Although many genome-wide genetic and epigenetic association studies have been conducted for different diseases and traits, it is still ...
< 5 6 7 8 9 10 11 12 13 14 15 >