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Guo Zhong Z From the Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, - - 2013
Small G-proteins of the Ras superfamily control the temporal and spatial coordination of intracellular signaling networks by acting as molecular on/off switches. Guanine nucleotide exchange factors (GEFs) regulate the activation of these G-proteins through catalytic replacement of GDP by GTP. During nucleotide exchange, three distinct substrate·enzyme complexes occur: a ternary ...
Jia Honglei H From the Key Laboratory of Cell Activities and Stress Adaptations of the Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou 730000, China - - 2013
Higher order actin filament structures are necessary for cytoplasmic streaming, organelle movement, and other physiological processes. However, the mechanism by which the higher order cytoskeleton is formed in plants remains unknown. In this study, we identified a novel actin-cross-linking protein family (named CROLIN) that is well conserved only in the ...
Rusakova Irina L - - 2013
A double perturbation theory (DPT) at the second order level of approximation formalism has been applied to examine the dihedral angle dependence of the Fermi-contact (FC) contribution to nuclear spin-spin coupling constants. The unperturbed wave function of the ground state in DPT was approximated by the Hartree-Fock Slater determinant, while ...
Fürer Karin - - 2013
Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves and ...
Aleixandre-Tudó José Luis - - 2013
The effect of prefermentative and postfermentative caffeic acid addition (CFA), prefermentative cold maceration and micro-oxygenation on the phenolic and color composition of Tempranillo wines was investigated. Cold soaking and dry ice addition were performed as prefermentative techniques. Wines were analyzed after the end of the malolactic fermentation, and after six ...
Neyt Mattias - - 2013
A health technology assessment (HTA) of catheter ablation for atrial fibrillation (CA-AF) was commissioned by the Belgian government and performed by the Belgian Health Care Knowledge Centre (KCE). In this context, a systematic review of the economic literature was performed to assess the procedure's value for money. A systematic search ...
Li Yang - - 2013
Genome-wide association studies (GWASs) have revealed a large number of genetic risk loci for many autoimmune diseases. One clear finding emerging from the published genetic studies of autoimmunity is that different autoimmune diseases, such as psoriasis and systemic lupus erythematosus (SLE), share susceptibility loci. Our study explores additional susceptibility loci ...
Carlson Coby - - 2013
A major hurdle for cardiovascular disease researchers has been the lack of robust and physiologically relevant cell-based assays for drug discovery. Derivation of cardiomyocytes from human-induced pluripotent stem (iPS) cells at high purity, quality, and quantity enables the development of relevant models of human cardiac disease with source material that ...
Kessler Chad - - 2013
This study aimed to assess practices in emergency department (ED) handoffs as perceived by emergency medicine (EM) residency program directors and other senior-level faculty and to determine if there are deficits in resident handoff training. This cross-sectional survey study was guided by the Kern model for medical curriculum development. A ...
Lurman Glenn J - - 2013
For low-energy organisms like bivalves, the costs of thermal compensation of biological rates (synonymous with acclimation and acclimatization) may be higher than the benefits. In the first experiment, we examined the effects of seasonal temperature changes on the bivalve Anodonta anatina, making measurements each month for a year at the ...
Schold Jesse D JD Department of Quantitative Health Sciences,, ‡Glickman Urological and Kidney Institute, and, §Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio;, †Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, ‖The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, - - 2013
Since 1998, 35% of kidney transplants in the United States have been derived from living donors. Research suggests minimal long-term health consequences after donation, but comprehensive studies are limited. The primary objective was to evaluate trends in comorbidity burden and complications among living donors. The National Inpatient Sample (NIS) was ...
Troian-Gautier Ludovic - - 2013
An efficient oxidation reaction of various electron-poor quinoxaline-core containing compounds, such as quinoxalines, 1,4,5,8-tetraazaphenanthrenes and 1,4,5,8,9,12-hexaazatriphenylene using [bis(trifluoroacetoxy)iodo]benzene is reported. These compounds are converted into the corresponding quinoxaline-diones, with good to high yields, at room temperature, using a solvent mixture acetonitrile/water. This unprecedented reaction should enable the synthesis of a ...
Shen Kan - - 2013
Molecular depth profiling of organic thin films by erosion with energetic cluster ion beams is a unique aspect of secondary ion mass spectrometry (SIMS) experiments. Although depth profiles of complex multilayer organic structures can be acquired with little damage accumulation and with depth resolution of <10 nm using either C60+ ...
Lan Qing - - 2013
Two new porous frameworks [Ni(bix)2][VW12O40]·(H2bix)·H2O () and [Co(bix)2][VW12O40]·(H2bix)·2H2O () (bix = 1,4-bis(imidazol-1-ylmethyl)-benzene) composed of Keggin polyoxometalates (POMs) and metal-organic coordination polymer sheets have been successfully obtained, and characterized by elemental analysis, IR spectra, thermal gravimetric analysis, and single crystal X-ray diffraction. Structural analysis reveals that the 2D metal-organic coordination polymer ...
Wilens Tim E - - 2013
Objective: To examine efficacy and safety of adjunctive guanfacine extended release (GXR) on morning and evening ADHD symptoms using the Conners' Global Index-Parent (CGI-P) and Before-School Functioning Questionnaire (BSFQ). Method: Participants 6 to 17 years with ADHD (N = 461) and suboptimal psychostimulant response were maintained on current psychostimulants and ...
Aitken R John - - 2013
Capacitation is a remarkable process whereby spermatozoa prepare themselves for engagement with the oocyte. Although the existence of this process has been appreciated as a biological phenomenon for more than half a century, its molecular underpinnings still await clarification. We know that some of the major changes involve sterol oxidation ...
Vandendriessche Stien - - 2013
To investigate the genetic diversity of methicillin-susceptible Staphylococcus aureus (MSSA) carriage isolates from animals and humans on pig, veal, dairy, beef and broiler farms. S. aureus isolates were genotyped using spa typing and multilocus sequence typing (MLST). Antimicrobial susceptibility phenotypes and genotypes were determined. The presence of staphylococcal cassette chromosome ...
Alawad Azza O - - 2013
Both obesity and type II diabetes mellitus are associated with insulin resistance and abnormal metabolic reactions. This study was conducted to evaluate resting metabolic rate in obese diabetic patients and to assess its relation to glycaemic control. This is a case control study conducted in Gabir AbuEliz centre in Khartoum, ...
Milojevic Julijana - - 2013
Background: A promising approach for treating Alzheimer's disease relies on the net efflux of the amyloid-β (Aβ) peptide from the brain to peripheral plasma, as a result of plasma Aβ clearance promoted by plasma removal and therapeutic albumin replacement. Objective: To assess the binding of therapeutic albumin (Albutein®, Grifols) to ...
Lanza Mario - - 2013
After one decade of analyzing the intrinsic properties of graphene, interest into the development of graphene-based devices and micro electromechanical systems is increasing. Here, we fabricate graphene-coated atomic force microscope tips by growing the graphene on copper foil and transferring it onto the apex of a commercially available AFM tip. ...
Pearse Ian S - - 2013
Introduced plants may out-compete natives by belowground allelopathic effects on soil communities including the symbionts of native plants. We tested for an allelopathic effect of an introduced crucifer, Raphanus sativus, on a common neighboring legume, Lupinus nanus, on the legume's rhizobium affiliates, and on the broader soil community. In both ...
Luo Zhiqiang - - 2013
The liquid crystalline phase behavior and sol-gel transition in halloysite nanotubes (HNTs) aqueous dispersions have been investigated by applying polarized optical microscopy (POM), macroscopic observation, rheometer, small-angle X-ray scattering, scanning electron microscopy, and transmission electron microscopy. The liquid crystalline phase starts to form at the HNT concentration of 1 wt ...
Lewicka Zuzanna A - - 2013
Polystyrene nanoring arrays with outer diameters ranging from 130 to 230 nm were fabricated using low cost and simple fabrication techniques, including nanosphere lithography, argon plasma treatment, immersion in organic solvents and sonication. These nanorings were developed from polystyrene nanospheres pre-assembled on substrates. Scanning electron microscopy revealed that the argon ...
Varagunam Mira - - 2013
To determine the impact of introducing patient reported outcome measures (PROMs) on the selection of patients for surgery and on outcome for four elective operations (hip replacement, knee replacement, varicose vein surgery and groin hernia repair). Patient-level data from the National PROMs programme for England from April 2009 to March ...
Gardell Alison M - - 2013
This study aimed to determine the regulation of the de novo myo-inositol biosynthetic (MIB) pathway in Mozambique tilapia (Oreochromis mossambicus) brain following acute (25 parts per thousand (ppt)) and chronic (30, 60, 90ppt) salinity acclimations. The MIB pathway plays an important role in cells for accumulating the compatible osmolyte, myo-inositol, ...
Berard Roberta A - - 2013
Introduction: Juvenile idiopathic arthritis (JIA) is a relatively common multidimensional and heterogeneous chronic disease of childhood. Children with JIA are at risk for significant morbidity in terms of joint damage, impairments in physical function and health-related quality of life. Outcomes for children with JIA have significantly improved with the use ...
Acharya Bipul R BR From the Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York - - 2013
KIF17 is a kinesin-2 family motor that interacts with EB1 at microtubule (MT) plus-ends and contributes to MT stabilization in epithelial cells. The mechanism by which KIF17 affects MTs and how its activity is regulated are not yet known. Here, we show that EB1 and the KIF17 autoinhibitory tail domain ...
Kho Abel N AN Feinberg School of Medicine, Northwestern University, Chicago, Illinois, - - 2013
Genetic testing has had limited impact on routine clinical care. Widespread adoption of electronic health records presents a promising means of disseminating genetic testing into diverse care settings. Practical challenges to integration of genomic data into electronic health records include size and complexity of genetic test results, inadequate use of ...
Chien Yi-Hsin - - 2013
The major challenge in current chemotherapy is to increase local effective therapeutic concentration of drugs as well as to minimize toxicity and side effects for patients. The targeted delivery of drugs to their desired site of action in a controlled manner plays an essential role in the development of drug ...
Joo Jaeyong - - 2013
Using a density functional theory calculation including van der Waals (vdW) corrections, we report that H2 adsorption in a cubic-crystalline microporous metal-organic framework (MOF-5) leads to volume shrinkage, which is in contrast to the intuition that gas adsorption in a confined system (e.g., pores in a material) increases the internal ...
Frogner Matthew - - 2013
Electron-diffraction experiments on the vapor of 1,4-cyclohexanedione have been carried out at a nominal temperature of 435 K. The results are consistent with the presence of a mixture of a chair form of C2h symmetry and a twisted boat form of D2 symmetry. The former has the familiar dynamic properties ...
Ostronoff Fabiana - - 2013
Introduction: Approximately one-third of the patients with acute myeloid leukemia (AML) harbor internal tandem duplication (ITD) in the gene encoding FMS-like tyrosine kinase 3 (FLT3-ITD), which is associated with poor prognosis. Over the course of the last decade, several FLT3 inhibitors have been developed. Nevertheless, the pharmacokinetic limitations of some ...
Drulis-Kawa Zuzanna - - 2013
A novel giant phage of the family Myoviridae is described. Pseudomonas phage PA5oct was isolated from a sewage sample from an irrigated field near Wroclaw, Poland. The virion morphology indicates that PA5oct differs from known giant phages. The phage has a head of about 131 nm in diameter and a ...
Gupta Aditya K - - 2013
Introduction: Onychomycosis is the fungal infection of the nail plate by dermatophytes, yeasts and nondermatophyte molds. The treatment of onychomycosis poses many challenges due to low initial cure rates and a high rate of relapse and recurrence. Oral therapy is limited by adverse events and drug-drug interactions, whereas topical therapy ...
Johnson Blake - - 2013
Monitoring of cyanotoxins in source waters is currently done through toxin-targeting assays which suffer from low sensitivity due to poor antibody avidity. We present a biosensor-based method as an alternative for detecting toxin-producing cyanobacteria M. aeruginosa via species-selective region of 16S rRNA at concentrations as low as 50 cells/mL, and ...
Bire Solenne - - 2013
Up to now, the different uptake pathways and the subsequent intracellular trafficking of plasmid DNA have been largely explored. By contrast, the mode of internalization and the intracellular routing of an exogenous mRNA in transfected cells are poorly investigated and remain to be elucidated. The bioavailability of internalized mRNA depends ...
Mohammed Hisham - - 2013
Significant insight into the function of proteins, can be delineated by discovering and characterising interacting proteins. There are numerous methods for the discovery of unknown associated protein networks, with purification of the bait (the protein of interest) followed by Mass Spectrometry (MS) as a common theme. In recent years, advances ...
Fairbairn Timothy A - - 2013
Purpose:To determine if myocardial perfusion cardiac magnetic resonance (MR) imaging can show changes in myocardial blood flow (MBF) during the cold pressor test (CPT) and can allow identification of the differing endothelial function of smokers and nonsmokers when compared during adenosine stress.Materials and Methods:The study was approved by the institutional ...
Park Serk In SI Authors' Affiliations: Departments of Medicine and Cancer Biology; Center for Bone Biology; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry; Comprehensive Cancer Center Biostatistics Core; and Department of Pathology, University of Michigan Medical School, Ann Arbor, - - 2013
In the tumor microenvironment, CD11b(+)Gr1(+) bone marrow-derived cells are a predominant source of protumorigenic factors such as matrix metalloproteinases (MMP), but how distal tumors regulate these cells in the bone marrow is unclear. Here we addressed the hypothesis that the parathyroid hormone-related protein (PTHrP) potentiates CD11b(+)Gr1(+) cells in the bone ...
Katz David A - - 2013
Recent changes in health care delivery may reduce continuity with the patient's primary care provider (PCP). Little is known about the association between continuity and quality of communication during ongoing efforts to redesign primary care in the Veterans Administration (VA). To evaluate the association between longitudinal continuity of care (COC) ...
Revuelta-López Elena - - 2013
Hypoxia disturbs vascular function by promoting extracellular matrix remodeling. Extracellular matrix integrity and composition are modulated by metalloproteinases (MMPs). Our aim was to investigate the role of low-density lipoprotein receptor-related protein 1 (LRP1) in regulating MMP-9/MMP-2 activation and vascular smooth muscle cells (VSMCs) migration in response to hypoxia, and to ...
Estévez V - - 2013
The interplay between the ferromagnetism and the charging effects strongly affects the electron transport through nanoparticle arrays when they are placed between two ferromagnetic electrodes with collinear magnetizations. There are oscillations in the current for the parallel orientation of magnetizations, and large values of the tunneling magnetoresistance (TMR). We analyze ...
Zhang Guiqiu - - 2013
Recently, Legon et al. reported the first generation and characterization of H2O/H2S•••AgCl complexes by rotational spectroscopy and proposed whether there is a silver bond analogous to the more familiar hydrogen and halogen bonds. In this study, a theoretical investigation was performed to answer this question and to deepen the nature ...
Goodman Daniel B - - 2013
Most amino acids are encoded by multiple codons, and codon choice has strong effects on protein expression. Rare codons are enriched at the N terminus of genes in most organisms, although the causes and effects of this bias are unclear. Here, we measure expression from >14,000 synthetic reporters in Escherichia ...
Matar Hosam E HE *To whom correspondence should be addressed; Department of Trauma and Orthopaedics, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK; tel: +44-782-669-2764, e-mail: - - 2013
Fluphenazine, a phenothiazine derivative, was one of the first drugs to be classed as an "antipsychotic" and was approved by the Food and Drug Administration in 1959. In Britain, it was first used for the relief of anxiety. The American reports, however, were the first to indicate its value in ...
Mirheydari Pantea - - 2013
GABAA receptors are the major inhibitory neurotransmitter receptors in the central nervous system and are the targets of many clinically important drugs, which modulate GABA induced chloride flux by interacting with separate and distinct allosteric binding sites. Recently, we described an allosteric modulation occurring upon binding of pyrazoloquinolinones to a ...
Nagata Wayne - - 2013
We study a chemical reaction-diffusion model (the Brusselator) for pattern formation on developing plant tips. A family of spherical cap domains is used to represent tip flattening during development. Applied to conifer embryos, we model the chemical prepatterning underlying cotyledon ("seed leaf") formation, and demonstrate the dependence of patterns on ...
Russo Andrea - - 2013
Abstract Purpose: To investigate topographic optic disc changes after surgical intraocular pressure (IOP) reduction in adults with open angle glaucoma (OAG). Methods: Optic discs of patients with advanced primary open angle or exfoliation glaucoma were imaged using optical coherence tomography within 1 week before trabeculectomy. Patients were rescanned 1 week, ...
Kingwell Elaine - - 2013
Multiple sclerosis (MS) is the most common cause of neurological disability in young adults worldwide and approximately half of those affected are in Europe. The assessment of differential incidence and prevalence across populations can reveal spatial, temporal and demographic patterns which are important for identifying genetic and environmental factors contributing ...
Leone Roberti Maggiore Umberto - - 2013
Introduction: Sunitinib malate (SU11248; Sutent®; Pfizer, Inc., New York) is a multi-kinase inhibitor currently approved for use in advanced renal cell carcinoma (RCC), imatinib-resistant/-intolerant gastrointestinal stromal tumours and progressive, well-differentiated pancreatic neuroendocrine tumours in patients with unresectable, locally advanced or metastatic disease. Areas covered: This article describes the mechanism of ...
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