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Keshari Ravi S RS 1 Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, - - 2014
Sepsis-induced inflammation of the lung leads to acute respiratory distress syndrome (ARDS), which may trigger persistent fibrosis. The pathology of ARDS is complex and poorly understood, and the therapeutic approaches are limited. We used a baboon model of Escherichia coli sepsis that mimics the complexity of human disease to study ...
Bhardwaj Chhavi C Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607-7061, USA. - - 2013
7.87 to 10.5 eV vacuum ultraviolet (VUV) photon energies were used in laser desorption postionization mass spectrometry (LDPI-MS) to analyze biofilms comprised of binary cultures of interacting microorganisms. The effect of photon energy was examined using both tunable synchrotron and laser sources of VUV radiation. Principal components analysis (PCA) was ...
Dungchai Wijitar W Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Prachautid Road, Thungkru, Bangkok, 10140, - - 2013
Airborne particulate matter (PM) pollution significantly impacts human health, but the cellular mechanisms of PM-induced toxicity remain poorly understood. A leading hypothesis on the effects of inhaled PM involves the generation of cellular oxidative stress. To investigate PM-induced oxidative stress, analytical methods have been developed to study the chemical oxidation ...
Matsui Elizabeth C EC 1 Division of Pediatric Allergy and Immunology - - 2013
The effect of endotoxin on asthma morbidity in urban populations is unclear. To determine if indoor pollutant exposure modifies the relationships between indoor airborne endotoxin and asthma health and morbidity. One hundred forty-six children and adolescents with persistent asthma underwent repeated clinical assessments at 0, 3, 6, 9, and 12 ...
Binning Jennifer M JM Department of Pathology and Immunology, Washington University School of Medicine , St. Louis, Missouri 63110, United - - 2013
Viral protein 35 (VP35), encoded by filoviruses, is a multifunctional dsRNA binding protein that plays important roles in viral replication, innate immune evasion, and pathogenesis. The multifunctional nature of these proteins also presents opportunities to develop countermeasures that target distinct functional regions. However, functional validation and the establishment of therapeutic ...
Machado Pedro P MRC Centre for Neuromuscular Diseases, Institute of Neurology, University College London, London, UK *Pedro Machado and Stefen Brady have contributed equally to this - - 2013
The purpose of this study is to review recent scientific advances relating to the natural history, cause, treatment and serum and imaging biomarkers of inclusion body myositis (IBM). Several theories regarding the aetiopathogenesis of IBM are being explored and new therapeutic approaches are being investigated. New diagnostic criteria have been ...
Bullock C M - - 2013
Osteoarthritis (OA) pain is poorly understood and managed, as current analgesics have only limited efficacy and unwanted side effect profiles. A broader understanding of the pathological mechanisms driving OA joint pain is vital for the development of improved analgesics. Both clinical and preclinical data suggest an association between joint levels ...
Wardell Jennifer R JR Pathobiology Graduate Program, Brown University, Providence, Rhode - - 2013
Estrogen signaling in the ovary is a fundamental component of normal ovarian function, and evidence also indicates that excessive estrogen is a risk factor for ovarian cancer. We have previously demonstrated that the gonadally enriched TFIID subunit TAF4B, a paralog of the general transcription factor TAF4A, is required for fertility ...
Greenberg Steven A - - 2013
Inclusion body myositis (IBM) is a poorly understood autoimmune and degenerative disorder of skeletal muscle. Here, pathophysiological and diagnostic biomarkers of IBM are reviewed. Muscle histopathological biomarkers have been successful in stimulating the study of IBM pathophysiology for over three decades. Their use as diagnostic biomarkers, in contrast, has significant ...
Finkel Alan G - - 2013
The clinical expression of migraine is significantly impacted by dietary and gastrointestinal issues. This includes gut dysfunction during and between attacks, food triggers, increase in migraine with obesity, comorbid GI and systemic inflammation influenced by diet, and specific food allergies such as dairy and gluten. Practitioners often encourage migraineurs to ...
D'Onofrio Brian M BM Department of Psychological and Brain Sciences, Indiana - - 2013
Preterm birth is associated with increased mortality and morbidity. However, previous studies have been unable to rigorously examine whether confounding factors cause these associations rather than the harmful effects of being born preterm. To estimate the extent to which the associations between early gestational age and offspring mortality and morbidity ...
Malcarne Vanessa L - - 2013
In 2010, an international consortium of researchers published a consensus agenda for research on psychosocial aspects of systemic sclerosis (SSc; scleroderma). The present review summarizes recent research on SSc-related depression and anxiety, fatigue and sleep, pain, pruritus, body image distress, sexual function, work disability, healthcare needs, psychosocial interventions, and psychoneuroimmunology. ...
Shear M Katherine MK Columbia University School of Social Work, Room 829, 1255 Amsterdam Avenue, New York, NY, 10027, USA, - - 2013
Bereavement is a common experience in adults aged 60 and older. Loss of a loved one usually leads to acute grief characterized by yearning and longing, decreased interest in ongoing activities, and frequent thoughts of the deceased. For most, acute grief naturally evolves into a state of integrated grief, where ...
Rothwell Simon - - 2013
To review the progress that has been made in understanding the genetics of the idiopathic inflammatory myopathies (IIMs) in the past 2 years, with particular focus on polymyositis, dermatomyositis and inclusion body myositis. Candidate gene studies in the Japanese population have implicated signal transducer and activator of transcription 4 as ...
Ludvigsson Jonas F JF Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden3Department of Pediatrics, Orebro University Hospital, Orebro University, Orebro, Sweden4Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, - - 2013
Most case reports suggest an association between autistic spectrum disorders (ASDs) and celiac disease (CD) or positive CD serologic test results, but larger studies are contradictory. To examine the association between ASDs and CD according to small intestinal histopathologic findings. Nationwide case-control study in Sweden. Through 28 Swedish biopsy registers, ...
Hall Scott S SS Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, - - 2013
Fragile X syndrome (FXS) is an X-linked neurogenetic disorder characterized by a cognitive and behavioral phenotype resembling features of autism spectrum disorder. Until now, research has focused largely on identifying regional differences in brain structure and function between individuals with FXS and various control groups. Very little is known about ...
Cideciyan Artur V AV 1 Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA - - 2013
Human X-linked blue-cone monochromacy (BCM), a disabling congenital visual disorder of cone photoreceptors, is a candidate disease for gene augmentation therapy. BCM is caused by either mutations in the red (OPN1LW) and green (OPN1MW) cone photoreceptor opsin gene array or large deletions encompassing portions of the gene array and upstream ...
Deshmukh Lalit L Laboratory of Chemical Physics and ‡Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892-0520, United - - 2013
The HIV-1 capsid protein plays a crucial role in viral infectivity, assembling into a cone that encloses the viral RNA. In the mature virion, the N-terminal domain of the capsid protein forms hexameric and pentameric rings, while C-terminal domain homodimers connect adjacent N-terminal domain rings to one another. Structures of ...
Llandres Ana L - - 2013
Habitat heterogeneity that occurs within an individual's lifetime may favour the evolution of reversible plasticity. Colour reversibility has many different functions in animals, such as thermoregulation, crypsis through background matching and social interactions. However, the mechanisms underlying reversible colour changes are yet to be thoroughly investigated. This study aims to ...
Snyder Rae Ana RA Department of Chemistry, Stanford University , Stanford, California 94305, United - - 2013
myo-Inositol oxygenase (MIOX) catalyzes the 4e(-) oxidation of myo-inositol (MI) to D-glucuronate using a substrate activated Fe(II)Fe(III) site. The biferrous and Fe(II)Fe(III) forms of MIOX were studied with circular dichroism (CD), magnetic circular dichroism (MCD), and variable temperature variable field (VTVH) MCD spectroscopies. The MCD spectrum of biferrous MIOX shows ...
Gmeiner Florian - - 2013
GABAergic signalling is important for normal sleep in humans and flies. Here we advance the current understanding of GABAergic modulation of daily sleep patterns by focusing on the role of slow metabotropic GABAB receptors in the fruit fly Drosophila melanogaster. We asked whether GABAB-R2 receptors are regulatory elements in sleep ...
Nowack Julia - - 2013
The capacity for nonshivering thermogenesis (NST) plays an important role during arousal from torpid states. Recent data on heterotherms inhabiting warmer regions, however, suggest that passive rewarming reduces the need of metabolic heat production during arousal significantly, leading to the question: to what extent do subtropical or tropical heterotherms depend ...
Denny Mark - - 2013
Intertidal organisms are subjected to intense hydrodynamic forces as waves break on the shore. These repeated insults can cause a plant or animal's structural materials to fatigue and fail, even though no single force would be sufficient to break the organism. Indeed, the survivorship and maximum size of at least ...
Lisher John P JP Department of Chemistry and ‡Interdisciplinary Graduate Program in Biochemistry, Indiana University , Bloomington, Indiana 47405-7102, United - - 2013
Transition metals, including manganese, are required for the proper virulence and persistence of many pathogenic bacteria. In Streptococcus pneumoniae (Spn), manganese homeostasis is controlled by a high-affinity Mn(II) uptake complex, PsaBCA, and a constitutively expressed efflux transporter, MntE. psaBCA expression is transcriptionally regulated by the DtxR/MntR family metalloregulatory protein pneumococcal ...
Lin Sibo S Department of Chemistry and Chemical Engineering, California Institute of Technology , 1200 East California Boulevard MC127-72, Pasadena, California 91125, United - - 2013
A para-terphenyl diphosphine was employed to support a dipalladium(I) moiety. Unlike previously reported dipalladium(I) species, the present system provides a single molecular hemisphere for binding of ligands across two metal centers, enabling the characterization and comparison of the binding of a wide variety of saturated and unsaturated organic molecules. The ...
Krasnoslobodtsev Alexey V AV Department of Pharmaceutical Sciences, University of Nebraska Medical Center , 986025 Nebraska Medical Center, Omaha, Nebraska 68198, United - - 2013
Misfolding and subsequent aggregation of alpha-synuclein (α-Syn) protein are critically involved in the development of several neurodegenerative diseases, including Parkinson's disease (PD). Three familial single point mutations, A30P, E46K, and A53T, correlate with early onset PD; however, the molecular mechanism of the effects of these mutations on the structural properties ...
Ruzzini Antonio C AC Departments of †Biochemistry & Molecular Biology and ‡Microbiology & Immunology, The University of British Columbia , Vancouver, British Columbia V6T 1Z4, - - 2013
The meta-cleavage product (MCP) hydrolases utilize a Ser-His-Asp triad to hydrolyze a carbon-carbon bond. Hydrolysis of the MCP substrate has been proposed to proceed via an enol-to-keto tautomerization followed by a nucleophilic mechanism of catalysis. Ketonization involves an intermediate, ES(red), which possesses a remarkable bathochromically shifted absorption spectrum. We investigated ...
Jensen Gary C GC Department of Chemistry, University of Michigan , 930 North University Ave., Ann Arbor, Michigan 48109-1055, United - - 2013
An improved planar amperometric nitric oxide (NO) sensor with enhanced selectivity over carbon monoxide (CO), which represents a volatile interfering species for NO sensors that has been largely overlooked until recently, is described. Formation of an oxide film on the inner platinum working electrode via anodic polarization using an inner ...
Espejo Luis A - - 2013
Objective-To evaluate the effect of delayed exposure of dairy cattle to Mycobacterium avium subsp paratuberculosis (MAP) on the incidence of those cows testing positive for MAP and developing clinical Johne's disease (CJD). Animals-79 cows not exposed to MAP as calves (unexposed cohort) and 260 cows exposed to MAP as calves ...
Song Youn Mi - - 2013
Anemia and iron deficiency are common complications in patients with chronic kidney disease (CKD). However, information about the diagnostic indicators of bleeding-related upper gastrointestinal (GI) tract lesions is sparse and few studies have investigated anemic upper GI tract lesions. We included 165 anemic patients with non-dialysis-dependent CKD stages 3 to ...
Locci Emanuela - - 2013
Abstract To date, cytomegalovirus (CMV) is one of the most studied and characterized virus, however the current knowledge on the effect of the human CMV (HCMV) infection on global metabolism is still poorly understood. Metabolomics is a new approach based on the systematic study of the complete set of low ...
Potera Carol - - 2013
Global Nurses United launched in June by National Nurses United.
Selden Nathan R - - 2013
Restrictions on duty hours and shift length by the Accreditation Council for Graduate Medical Education and public pressure to reduce complications and to improve outcomes in the clinical educational environment have enhanced interest in the use of procedural and surgical simulation to train neurosurgical residents. To introduce simple, available, and, ...
Herisko Camellia - - 2013
A literature review of nurses' attitudes, beliefs, and barriers regarding the medical emergency team (MET) process is limited to medical hospitals. How psychiatric nurses view the MET process and their prior experiences with METs are important because they are often the ones assessing the need for, and then calling, the ...
Papp Kim - - 2013
Background:Patents on several biologics will expire in Canada in the coming years. As they expire, applications to market subsequent entry biologics (SEBs) may be filed in Canada.Objective:To provide an understanding of the regulatory pathway and types of trials used for SEB authorization in Canada.Methods:Health Canada's draft guidance on SEBs was ...
- - 2013
THE SAFE Staffing Alliance has launched a website in support of its campaign to implement evidence-based, safe, staff-patient ratios for older patients.
Kanaki Kalliopi - - 2013
Errors in the paper by Kanaki, Jackson, Hall-Wilton, Piscitelli, Kirstein & Andersen [J. Appl. Cryst. (2013), 46, 1031-1037] are corrected.[This corrects the article DOI: 10.1107/S0021889813011862.].
Herrenkohl Todd I TI School of Social Work, University of Washington, Seattle, Washington. Electronic address: - - 2013
To examine evidence of the continuity in abusive discipline across two generations (G1 and G2) and the role of safe, stable, and nurturing relationships (SSNRs) as protective factors. Data are from the Lehigh Longitudinal Study, a prospective investigation of the causes and consequences child maltreatment that began in the 1970s ...
Chong Barrie Fong - - 2013
Breeding energy cane for cellulosic biofuel production involves manipulating various traits. An important trait to optimize is cell wall degradability as defined by enzymatic hydrolysis. We investigated the feasibility of using near-infrared spectroscopy (NIRS) combined with multivariate calibration to predict energy cane cell wall digestibility based upon fiber samples from ...
Chitale Rohan - - 2013
The learning and development of technical skills are paramount for neurosurgical trainees. External influences and a need for maximizing efficiency and proficiency have encouraged advancements in simulator-based learning models. To confirm the importance of establishing an educational curriculum for teaching minimally invasive techniques of pedicle screw placement using a computer-enhanced ...
Loupiac Alexandra - - 2013
Hemolytic uremic syndrome related to pneumococcal infection (P+HUS) can be difficult to diagnose due to the lack of a specific test and the absence of a consensus for definite diagnostic criteria. A retrospective study was conducted on the cases that have been considered as P+HUS in the participating centers during ...
Schofield Thomas J TJ Human Development and Family Studies, Iowa State University, Ames, Iowa. Electronic address: - - 2013
The present paper summarizes findings of the special issue papers on the intergenerational continuity of child maltreatment and through meta-analysis explores the potential moderating effects of safe, stable, nurturing relationships (SSNRs). Studies were selected for inclusion in this meta-analysis if they (1) were published in peer-reviewed journals; (2) tested for ...
Kennedy Maureen Shawn - - 2013
These nursses have seized the opportunity-will you?
Flores Edgar - - 2013
A novel method for determining the accuracy of laboratory-based measurements of nitrogen dioxide (NO2) and nitric acid (HNO3) mole fractions using Fourier transform infrared (FT-IR) spectroscopy 1 cm(-1) resolution instruments calibrated with synthetic spectra has been developed. The traceability of these measurement results is to the reference line strength data ...
Ghobrial George M - - 2013
In the era of surgical resident work hour restrictions, the traditional apprenticeship model may provide fewer hours for neurosurgical residents to hone technical skills. Spinal dura mater closure or repair is 1 skill that is infrequently encountered, and persistent cerebrospinal fluid leaks are a potential morbidity. To establish an educational ...
Conger Rand D - - 2013
Harsh, abusive, and rejecting behavior by parents toward their children is associated with increased risk for many developmental problems for youth. Earlier research also shows that children raised by harsh parents are more likely to treat their own children harshly. The present study evaluated nurturing and supportive behaviors of spouses ...
Taplin Francis - - 2013
We evaluated the normal Raman (NR) and the surface-enhanced Raman scattering (SERS) of three sympathomimetic amines: phenethylamine, ephedrine, and 3,4-methylenedioxymethamphetamine (MDMA). In addition, quantum mechanical calculations-geometry optimization and calculations of the harmonic vibrational frequencies-were performed using the density functional theory (DFT) approach. Vibrational assignments were made by comparing the experimental ...
Havlíková Lucie - - 2013
Background: Matrix effects are considered to be a main obstacle of quantitative bioanalytical LC-MS/MS methods. Therefore it is often required to minimize them in order to increase method reliability. HILIC has been referenced as one of possible approaches. However, there is a lack of experimental evidence in scientific literature so ...
Bassareo Pier Paolo - - 2013
Abstract Background: Prematurity at birth is a known risk factor for the development of an early chronic renal disease. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a well established biomarker of kidney injury, while high blood levels of asymmetric dimethylarginine (ADMA) are associated with the future development of adverse cardiovascular events ...
Matzo Marianne - - 2013
An overview of symptoms and recommendations for management.
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