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Results 401 - 450 of 4478
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Bulgarelli Adriana - - 2013
Nanoemulsions (LDE) with a lipid composition resembling that of LDL can concentrate in aortic lesions and when associated with anti-blastic agents, such as paclitaxel or etoposide, decrease atherosclerotic lesions induced in rabbits. Our aim was to test the association of a lipophilic derivative of methotrexate, didodecyl-methotrexate (ddMTX) to LDE on ...
Seidensticker M - - 2013
This study was conducted to investigate the capacity of (99m)Tc-labeled 1-thio-β-D-glucose ((99m)Tc-1-TG) and 5-thio-D-glucose ((99m)Tc-5-TG) to act as a marker for glucose metabolism in tumor cells in vitro. We investigated the cellular uptake of (99m)Tc-1-TG, (99m)Tc-5-TG, and 2-deoxy-2-[(18) F]fluoro-D-glucose((18) F-FDG) in a human colorectal carcinoma and human lung adenocarcinoma cell line (HCT-116, ...
Zhang Kai - - 2013
Increasing evidence has demonstrated that high metastasis-associated in colon cancer-1 (MACC1) level is tightly associated with the development, progression, and poor prognosis of a variety of tumors. However, the relationship between MACC1 and the occurrence, development, and progression of osteosarcoma (OS) remains to be clarified. To facilitate and deepen the ...
Krupar Rosemarie - - 2013
HPV infection is considered as an independent risk factor for head and neck squamous cell carcinomas (HNSCC). Due to highly variable prevalence results in numerous studies, it is, however, difficult to estimate the relevance of HPV infection as risk factor for a specific patient collective. This study aimed to elucidate ...
Lionello Marco - - 2013
Epidermal growth factor receptor (EGFR) is a trans-membrane tyrosine kinase taking part in cell transformation and tumor progression. One of the downstream pathways controlled by EGFR involves the mammalian target of rapamycin (mTOR), a proto-oncogene activated in several cell functions. Recent evidence seems to confirm that both EGFR and mTOR ...
de Bruin Rick - - 2013
Endoscopic surgery of the skull base has been on the rise for several years. Endoscopic access for surgery can be achieved from the frontal sinus anteriorly along the skull base to the odontoid process posterior inferiorly. An endoscope is inserted through one nasal corridor and allows visualization of the working ...
Grabowska Iwona - - 2013
The duo-genosensor consisting of two different oligonucleotide probes immobilized covalently on the surface of one gold electrode via Au-S bond formation was used for simultaneous determination of two different oligonucleotide targets. One of the probes, decorated on its 5'-end with ferrocene (SH-ssDNA-Fc), is complementary to the cDNA representing sequence encoding ...
Belluti Federica - - 2013
Malaria, a disease of worldwide significance, is responsible for over one million deaths annually. The liver-stage of Plasmodium's life cycle is the first, obligatory, but clinically silent step in malaria infection. The P. falciparum type II fatty acid biosynthesis pathway (PfFAS-II) has been found to be essential for complete liver-stage ...
Cai Bin - - 2013
Manipulating the electronic structure of semiconductor photocatalysts represents an ideal approach for the exploration and development of photocatalysis. However, it still remains a challenge in terms of silver halide photocatalysts. Herein, we report ternary alloyed AgClxBr1-x nanocrystals (NCs) synthesized by controlling the crystal growth process within a facile microemulsion system. ...
Wallace Charity J - - 2013
This report describes the effect of rhamnolipids (RLs), an amphiphilic biosurfactant produced by the bacterium Pseudomonas aeruginosa, on the integrity and permeability across Caco-2 cell monolayers. We measured the trans-epithelial electrical resistance (TEER) and permeability of [(14)C]mannitol across Caco-2 cell monolayers upon incubation with 0.01-5.0% v/v RLs as a function of ...
Armour J Al - - 2013
Handedness is a human behavioural phenotype that appears to be congenital, and is often assumed to be inherited, but for which the developmental origin and underlying causation(s) have been elusive. Models of the genetic basis of variation in handedness have been proposed that fit different features of the observed resemblance ...
Xing Ruijun - - 2013
Gene therapy is becoming a promising strategy to treat various kinds of genetic and acquired diseases. However, the development of safe, efficient, and targetable gene delivery systems remains a major challenge in gene therapy. The unique material characteristics of magnetic nanoparticles (MNPs), including high surface area, facile surface modification, controllable ...
Shih Tsung-Ting - - 2013
We developed a selective and sensitive hyphenated system employing a microfluidic-based vapor generation (VG) system in conjunction with high-performance liquid chromatography (HPLC) separation and inductively coupled plasma-mass spectrometry (ICP-MS) detection for the determination of trace inorganic selenium (Se) species. The VG system exploited poly(methyl methacrylate) (PMMA) substrates of high optical ...
Wang J - - 2013
Despite the evidence that the Pleistocene climatic fluctuations have seriously affected the distribution of intraspecific diversity, less is known on its impact on interspecific divergence. In this study, we aimed to test the hypothesis that the divergence of two desert poplar species Populus euphratica Oliv. and P. pruinosa Schrenk. occurred ...
Tian L - - 2013
Combination of divergent genomes in allopolyploids creates genome-wide gene expression changes including many miRNA targets in Arabidopsis allotetraploids relative to the parents Arabidopsis thaliana and Arabidopsis arenosa. Here we report expression and epigenetic changes in a chromosomal region containing the MIR172b locus in the allotetraploids. Although mature miRNA sequences are ...
Wolf Eckhard - - 2013
Diabetes mellitus (DM) has emerged into a steadily increasing health problem and the predicted future dimension of the global DM epidemic is alarming: an increase from currently 346 million to over 400 million affected people worldwide by the year 2030 was extrapolated. Thus concerted research efforts are imperative to gain ...
Lin Yulong - - 2013
To prepare and characterize the co-crystal of dipfluzine and benzoic acid. To investigate the feasibility of the co-crystal for improving solubility and a faster dissolution rate in vitro and evaluate the bioavailability and tissue distribution of co-crystal in vivo. A novel dipfluzine-benzoic acid co-crystal prepared using the solvent-assisted co-grinding and ...
Woodson Benjamin - - 2013
Objective To assess application of cystatin C and NGAL as biomarkers for renal ischemic injury. We also evaluated the use of allopurinol as a renoprotective agent. A second goal was to assess cystatin C as a biomarker in patients undergoing partial nephrectomy. Materials and Methods Using 58 Sprague-Dawley rats, we ...
Weight Alisha K - - 2013
Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro-using the plaque reduction assay-a highly potent 1-polymer conjugate, and subsequently test its antiviral efficacy in vivo. By examining the ...
Dubey Archana - - 2013
We have determined the structure and coordination chemistry of rhizoferrin (Rf), which is a particular type of siderophore, and its Fe(III) complexes using density functional theory calculations. Our results show that the Fe(III) ion binds in an octahedral coordination, with a low-spin (S = 1/2) charge-neutral chiral complex having the largest binding ...
Peña Isabel - - 2013
Crystalline samples of d-xylose have been vaporized by laser ablation and probed in the gas phase using Fourier transform microwave spectroscopy. The rotational spectrum revealed the existence of two α-d-xylopyranose conformers stabilized by the anomeric effect and cooperative hydrogen bond networks. The experiment spectroscopically tracked fine structural changes upon clockwise ...
Li Rujun - - 2013
The aim of this study is to investigate the inhibitory effects of 2T-P400, a derivative of temozolomide (TMZ), on glioma growth. SHG-44 and U373 human glioblastoma cell lines and SHG-44 cell subcutaneous and intracranial xenograft mouse models were used as the model system for these studies. Cell growth was analyzed ...
Balachandran Subramanian - - 2013
In this article, we report the fabrication of a stable Ag-ZnO-SnO2 nanochain by template free hydrothermal method and its photocatalytic activity for the first time. This composite material represents a potential new class of photocatalysts with enhanced light absorption, hydrophobic and electronic properties of ZnO. This catalyst has been characterized ...
Matteson Lindsay K - - 2013
In the past, shared environmental influences on personality traits have been found to be negligible in behavior genetic studies (e.g., Bouchard and McGue, J Neurobiol 54:4-45, 2003). However, most studies have been based on biometrical modeling of twins only. Failure to meet key assumptions of the classical twin design could ...
Jayasiri H B - - 2013
Nine metals were monitored in the beach sediment in Mumbai from May 2011 to March 2012 to evaluate the spatial and temporal distributions. The average heavy metal concentrations exhibited the following order: Fe > Mn > Cr > Co > Ni > Pb > Zn > Cu > Cd for ...
Altunkaya Arzu - - 2013
Grape seed extract (GSE), a by-product from the wine industry, was explored for its use as enrichment to mayonnaise, due to its potential health effects. Mayonnaises were enriched with 0 mg GSE per mL, 0.5 mg GSE per mL (∼0.050%), 0.9 mg GSE per mL (∼0.10%) and 1.4 mg GSE ...
Viberg Jennifer - - 2013
Incidental findings (IFs) are acknowledged to be among the most important ethical issues to consider in biobank research. Genome-wide association studies and disease-specific genetic research might reveal information about individual participants that are not related to the research purpose, but may be relevant to those participants' future health. In this ...
Sabbaghian Nelly - - 2013
DICER1 is an endoribonuclease responsible for the production of mature microRNAs which are small, single-stranded RNA molecules that regulate gene expression post-transcriptionally by binding to mRNA and repressing the expression of target genes. Germ-line mutations in DICER1 are responsible for a rare cancer syndrome, including tumors that can co-occur with ...
Meng Huaxing - - 2013
ABSTRACT rhEPO has previously been shown to exert neuroprotective action in focal cerebral ischemia. However, its mechanism is not clear. We established the model of permanent focal cerebral ischemia. rhEPO was administered (5000 IU/kg i.p.) 2h later after the successful ischemia model in rhEPO group, rhEPO increased translation of Nrf2, ...
Osváth Zoltán - - 2013
Metal-graphene interfaces generated by electrode deposition induce barriers or potential modulations influencing the electronic transport properties of graphene based devices. However, their impact on the local mechanical properties of graphene is much less studied. Here we show that graphene near a metallic interface can exhibit a set of ripples self-organized ...
Duval K - - 2013
BACKGROUND/OBJECTIVE:The purpose of this study was to investigate changes in dietary intake and appetite across the menopausal transition.SUBJECTS/METHODS:This was a 5-year observational, longitudinal study on the menopausal transition. The study included 94 premenopausal women at baseline (age: 49.9±1.9 years; BMI: 23.3±2.3 kg/m(2)). Body composition (dual-energy X-ray absorptiometry), appetite (visual analogue scale), ...
da Silva L S M - - 2013
BACKGROUND/OBJECTIVES:The objectives of this study were to evaluate nutritional status, aptitude and physical activity at the beginning and end of the nutrition education and physical activity intervention program as compared with a control group.METHODS:We conducted a 28-week quasi-experimental study involving 238 students (108 in the intervention group (IG) and 130 ...
Bertelmann T - - 2013
Development of tears in the retinal pigment epithelium (RIP) has been described as a possible complication following anti-vascular endothelial growth factor (VEGF) antibody therapy with substances which have been available for years when treating pigment epithelium detachment (PED) in eyes affected by age-related macular degeneration (AMD). Aflibercept has become available ...
Wang Yan-Ning - - 2013
By employing the hydrothermal in situ acylation of N2H4 with aromatic polycarboxylic acids, three new acylhydrazidate-containing complexes [Zn(N2H4)(dphkh)]·H2O (dphkh = 4,4'-diphthalhydrazidatoketone hydrazone) , [Zn(npth)2] (npth = naphthalhydrazidate) and [Mn(mpdh)2(H2O)2]·2H2O , and two new acylhydrazide molecules [bpth]·0.5H2O (bpth = 3,3'-biphthalhydrazide) and [(chpth)2] (chpth = 4-chloro-5-hydrazinophthalhydrazide) were obtained. It is noteworthy that ...
Dionisio Kathie L - - 2013
Measurements from central site (CS) monitors are often used as estimates of exposure in air pollution epidemiological studies. As these measurements are typically limited in their spatiotemporal resolution, true exposure variability within a population is often obscured, leading to potential measurement errors. To fully examine this limitation, we developed a ...
Hagenbjörk-Gustafsson Annika - - 2013
Environmental levels of airborne carcinogenic and related substances are comparatively better known than individual exposure and its determinants. We report on a personal monitoring program involving five Swedish urban populations. The aim of the program was to investigate personal exposure to benzene, 1,3-butadiene, formaldehyde, and nitrogen dioxide (NO2). The measurements ...
Lu Tong - - 2013
Abstract Objective: To develop an image visualization system based on graphic processing unit (GPU) hardware acceleration for clinical use in hepatocellular carcinoma (HCC) interventional planning. Methods: We developed a liver tumor planning tool to assist the physician in providing patient-specific analysis and visualization. We employed a spatial distance computation algorithm ...
Rosa Flávia Troncon - - 2013
Some researchers found decreased levels of plasma taurine in obese subjects and animals, and reduced expression of an important enzyme of taurine synthesis. These evidences, coupled with the metabolic imbalance of obesity and the possible anti-inflammatory and antioxidant effects of taurine, highlighted the use of taurine as a supplement in ...
Zhang Yi-Hua - - 2013
New 1D lanthanide-organic frameworks, [Ln(dpdc)1.5(IP)(H2O)]n (Ln = Sm 1, Eu 2, Gd 3; dpdc = 2,2'-diphenyldicarboxylate and IP = 1H-imidazo[4,5-f][1,10]-phenanthroline), were synthesized. White light emission was realized by two approaches: a single component Sm(iii) framework and a two-component Eu(iii)-doped Gd(iii) framework.
Alipour Hossein - - 2013
The concentrations of four heavy metals (Pb, Cd, Ni and Cr) were measured in tissues of pelagic (Rutilus caspicus) and benthic (Neogobius gorlap) fishes from the Miankaleh international wetland. The maximum concentrations of Pb, Cd, Ni, and Cr (2.06, 1.20, 1.14 and 0.70 μg g(-1), respectively) were measured in the liver of ...
Laalami Soumaya - - 2013
The instability of messenger RNA is fundamental to the control of gene expression. In bacteria, mRNA degradation generally follows an "all-or-none" pattern. This implies that if control is to be efficient, it must occur at the initiating (and presumably rate-limiting) step of the degradation process. Studies of E. coli and ...
Dehaes Mathieu - - 2013
Pathophysiologic mechanisms involved in neonatal hypoxic ischemic encephalopathy (HIE) are associated with complex changes of blood flow and metabolism. Therapeutic hypothermia (TH) is effective in reducing the extent of brain injury, but it remains uncertain how TH affects cerebral blood flow (CBF) and metabolism. Ten neonates undergoing TH for HIE ...
Matsumoto Akira - - 2013
Field-effect-transistor (FET) based electrical signal transduction is an increasingly prevalent strategy for bio-sensing. This technique, often termed "Bio-FETs", provides an essentially label-free and real-time based bio-sensing platform effective for a variety of targets. This review highlights recent progress and challenges in the field. A special focus is on the comprehension ...
Ba Hengxing - - 2013
Abstract To further refine the classification and phylogeny of sika deer subspecies, the well-annotated sequences of the complete mitochondrial DNA (mtDNA) control region of 13 sika deer subspecies from GenBank were downloaded, aligned and analyzed in this study. By reconstructing the phylogenetic tree with an extended sample set, the results ...
Oh Kyung-Hwan - - 2013
In order to investigate the interaction of well-known regulation systems, quorum sensing and stringent response for the expression of virulence genes in enterohemorrhagic Escherichia coli (EHEC), E. coli strains with mutations in the two regulation systems, ΔluxS (ECM101) and ΔluxSΔrelAΔspoT (ECM201), and ΔluxS complemented strain to ECM201 (ECM202) were created ...
Hillock Kristina A - - 2013
Styela clava is a subtidal invasive marine species in Northern Europe, Atlantic Canada, Australia and New Zealand. It grows attached to solid substrata, including boat hulls, ropes, moorings, piers and aquaculture equipment, all of which can aid its spread to new locations. It interferes with feeding of mussels and oysters, ...
Banerjee Arnab - - 2013
A pyrene-thiophene conjugate has been used for the efficient detection of intracellular irons through the generation of bright green luminescence. Amongst three different probes being reported, it is observed that the efficiency for the naked eye green luminescent detection of iron increases on moving from naphthalene to anthracene to pyrene. ...
Samanta Subhas - - 2013
Introduction of S-ethyl groups in all four ortho positions of azobenzene prevents reduction of the azo group by intracellular glutathione, while enhancing the absorptivity to ∼10 000 M(-1) cm(-1) in the blue and green regions of the visible spectrum. cis-to-trans isomerization occurs thermally on the minutes timescale. Further, this substitution pattern ...
Kimber Ian - - 2013
Abstract There is considerable interest in the immunobiological processes through which the development of allergic sensitization to chemicals is initiated and orchestrated. One of the most intriguing issues is the basis for the elicitation by chemical sensitizers of different forms of allergic reaction; that is, allergic contact dermatitis or sensitization ...
Zhou Li - - 2013
Solvothermal reactions of 2,5-thiophenedicarboxylate (H2tdc) and N-auxiliary ligands in the presence of cobalt(ii), zinc(ii) and cadmium(ii) salts have given rise to seven new metal-organic frameworks, namely, [Co2(tdc)2(bpp)2(H2O)·(H2O)]n (bpp = 1,3-bis(4-pyridyl)propane) (), [Cd(tdc)(bpp)(H2O)·(H2O)2]n (), [Zn2(tdc)2(bbi)2·(H2O)2]n (bbi = 1,1'-(1,4-butanediyl)bis(imidazole)) (), [Co4(tdc)3(bimb)4(H2O)5·(tdc)·(DMF)·(H2O)2]n (bimb = 4,4'-bis(1-imidazolyl)biphenyl) (), [Zn4(O)(tdc)3(bimb)4·(H2O)5.25·(CH3OH)]n (), [Cd4(tdc)4(bimb)6·(H2O)2·(CH3OH)2·(DMF)4] () and [Co2(tdc)2(tib)2·(H2tdc)·(DMF)2] (tib ...
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