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Results 301 - 350 of 4478
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Aizawa Nobuhiro - - 2013
This study aimed to examine the therapeutic effect and prognostic indicators of pegylated interferon (PEG-IFN) and ribavirin (RBV) combination therapy in thrombocytopenic patients with chronic hepatitis C, hepatitis C virus (HCV)-related cirrhosis, and those who underwent splenectomy or partial splenic embolization (PSE). Of 326 patients with HCV-related chronic liver disease ...
Jang Hae Jin - - 2013
Abstract Taurine is one of the abundant amino acids present in mammalian cells. It exerts various physiological actions such as wound healing, radioprotection, neuroprotection and anti-anxiety. In the present study, we sought to determine if taurine could inhibit osteoclastogenesis and explore the potential role of cyclooxygenase-2 (COX-2) and Jun N-terminal ...
Webb Joanna R - - 2013
The controlled conversion of hydrocarbons to functionalized products requires selective C-H bond cleavage. This perspective provides an overview of 1,2-CH-addition of hydrocarbons across d(0) transition metal imido complexes and compares and contrasts these to examples of analogous reactions that involve later transition metal amide, hydroxide and alkoxide complexes with d(6) ...
Liu Chung-Pin - - 2013
Abstract The effect of angiotensin II (Ang II) on cytosolic Ca(2+) concentrations ([Ca(2+)]i) in MDCK renal tubular cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. Ang II at concentrations of 5-40 µM induced a [Ca(2+)]i rise in a concentration-dependent manner. The response was reduced partly by ...
Wei Wei - - 2013
The first copper-catalyzed oxysulfonylation reaction of alkenes with dioxygen and sulfonylhydrazides for the construction of β-ketosulfones has been developed under mild conditions without any ligand or additive.
Goovaerts Vincent - - 2013
The interaction between the plenary Keggin H3PW12O40, lacunary Keggin K7PW11O39 and the Eu(iii)-substituted Keggin K4EuPW11O39 (Eu-Keggin) type polyoxometalates (POMs), and the proteins human and bovine serum albumin (HSA and BSA) was studied using steady state and time-resolved Eu(iii) luminescence and tryptophan (Trp) fluorescence spectroscopy. The excitation spectrum of the Eu-Keggin ...
Ueno Hideki - - 2013
Novel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases. A pathology review ...
Holló András - - 2013
Summary Several disorders, both systemic and those of the nervous system, have been linked with vitamin D deficiency. Neurological disorders with a vitamin D link include but are not limited to multiple sclerosis, Alzheimer and Parkinson disease as well as cerebrovascular disorders. Epilepsy which is the second leading neurological disorder ...
Ricci Maria Teresa - - 2013
The identification of women with a high probability of being carriers of pathogenic BRCA mutation is not straightforward and a major improvement would be the availability of markers of mutations that could be directly evaluated in individuals asking for genetic testing. The FMR1 gene testing was recently proposed as a ...
van Duyvenvoorde Hermine A - - 2013
Height is a highly heritable and classic polygenic trait. Recent genome-wide association studies (GWAS) have revealed that at least 180 genetic variants influence adult height. However, these variants explain only about 10% of the phenotypic variation in height. Genetic analysis of short individuals can lead to the discovery of novel ...
Kuila Biplab K - - 2013
Here, we describe a novel and versatile approach for fabrication of multilayer polymeric thin films with a tunable, ordered periodic structure in each layer using self-assembly of block copolymers. Different functional nanomaterials are selectively introduced in different layers with controlled arrays and network formation resulting in ordered multifunctional nanocomposite thin ...
Sancheti Jayant - - 2013
The present study was to investigate the anticonvulsant and antiepileptogenic potential of thymol. Anticonvulsant activity of thymol (5-100 mg/kg i.p.) was studied using maximal electroshock, pentylenetetrazole (PTZ), strychnine and 4-aminopyridine (4-AP) models. Thymol at the selected dose was also studied for its effect on locomotion. Antiepileptogenic property of thymol (5-25 mg/kg) was evaluated ...
Liu Tao - - 2013
Light-regulated ion channel-transport across lipid bilayers was realized using structurally simple azobenzene-based amphiphilic small molecules. UV or visible irradiation triggers molecular photoisomerization, which induces structural and membrane affinity changes in self-assembled channels, thus resulting in light-regulated ion transmembrane transport.
Sun Song - - 2013
The amine elimination of lanthanide tris(amide) complexes with the phenylene-bridged bis(β-diketiminate) ligands PARA(Me)-H2, META(Me)-H2 and PARA(Pr)-H2 (PARA(Me)-H2 = 2[2,6-Me2C6H3NHC(Me)C(H)C(Me)N]-(para-phenylene), META(Me)-H2 = 2[2,6-Me2C6H3NHC(Me)C(H)C(Me)N]-(meta-phenylene), PARA(Pr)-H2 = 2[2,6-(i)Pr2C6H3NHC(Me)C(H)C(Me)N]-(para-phenylene)), and the mono-β-diketiminate ligand L(2,6-iPr2)Ph-H (2,6-(i)Pr2C6H3)NHC(Me)CHC(Me)N(C6H5)) afforded the bimetallic lanthanide amide complexes PARA(Me)-{Ln[N(SiMe3)2]2}2 (Ln = Y (), Sm ()), META(Me)-{Y[N(SiMe3)2]2}2 (), PARA(Pr)-{Ln[N(HSiMe2)2]2}2 (Ln = Y ...
Ley S H - - 2013
Background/objectives:Beneficial effects of vitamin E on insulin sensitivity have been reported in observational and short-term intervention studies in non-pregnant populations. We aimed to investigate whether dietary vitamin E intake during the second trimester would be associated with glucose metabolism later in pregnancy and whether this association would be influenced by ...
Gaboreau Y - - 2013
BACKGROUND/OBJECTIVES:Malnutrition is associated with a high morbi-mortality in elderly populations and their institutionalization at an early stage. The incidence is well known despite being often under-diagnosed in primary care. General practitioners (GPs) have a key role in home care. What are the factors affecting malnutrition-screening implementation by French GPs?SUBJECTS/METHODS:We conducted ...
de Morais C - - 2013
Background/objectives:The elderly constitute a population group with a high prevalence of non-communicable chronic diseases and high risk of malnutrition. The aim of this study was to identify factors associated to nutritional risk in free-living European elderly.Subjects/methods:The sample included 644 European citizens, free living in the community, aged 65 years or ...
Solanas Guiomar - - 2013
In the past years, our view of the molecular and cellular mechanisms that ensure the self-renewal of the skin has dramatically changed. Several populations of stem cells have been identified that differ in their spatio-temporal contribution to their compartment in steady-state and damaged conditions, suggesting that epidermal stem cell heterogeneity ...
Fuest M - - 2013
Multiple sclerosis (MS) is the most common chronic disease of the central nervous system in Germany. In 80 % of patients early stages of the disease are characterized by a clinically isolated episodic course. Ocular manifestations are common and mostly affect the optic nerve or the uvea and in some cases ...
Birner B - - 2013
The purpose of this study was to analyze if anterior chamber parameters are risk factors for the development of pigment dispersion syndrome (PDS) and/or for the conversion to pigmentary glaucoma (PG). This study included a total of 63 eyes from 35 patients with PDS and PG and 65 eyes from ...
Gupta Bhanushree - - 2013
Oxime-assisted reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) is a crucial step in the post-inhibitory treatment of OP intoxication. The limited efficacy of oxime reactivators for all OP nerve agents and pesticides led to the development of various novel oximes and their thorough kinetic investigations. Hence, in the present investigation, we ...
Kanbe Hiroki - - 2013
Epidemiological studies demonstrate a possible relationship between chronic ethanol drinking and thrombotic diseases, such as myocardial infarction and stroke. However, the precise mechanism for this association remains unclear. Sulfatides are endogenous glycosphingolipids composed of ceramide, galactose, and sulfate, known to have anti-thrombotic properties. Low (0.5 g/kg/day), middle (1.5 g/kg/day), and high (3.0 g/kg/day) ...
Lindgren Anna - - 2013
The Narodichesky region, Zhitomir Oblast, Ukraine, is situated ∼80 km from the Chernobyl Nuclear Power Plant, which exploded in 1986 and polluted the environment. A previous study found that children living in villages with high activity of (137)Cesium (Cs) in the soil had decreased levels of hemoglobin, erythrocytes and thrombocytes. These ...
Sudan Madhuri - - 2013
In this study, we demonstrate the complexities of performing a sibling analysis with a re-examination of associations between cell phone exposures and behavioral problems observed previously in the Danish National Birth Cohort. Children (52,680; including 5441 siblings) followed up to age 7 were included. We examined differences in exposures and ...
Cheng Kai-Chung - - 2013
For an actively emitting source such as cooking or smoking, indoor measurements have shown a strong "proximity effect" within 1 m. The significant increase in both the magnitude and variation of concentration near a source is attributable to transient high peaks that occur sporadically-and these "microplumes" cause great uncertainty in estimating ...
Serrano Ana Julissa - - 2013
Abstract The aim of this meta-analysis was to evaluate the efficacy and safety of two bisphosphonates (alendronate and zoledronate) in the treatment of postmenopausal osteoporosis. The incidence of fractures was considered as primary endpoint. Only randomized trials with a follow-up period of 1 year or more were included in this ...
Sadasivan Sajanikumari - - 2013
Morphologically similar cobalt oxide nanoparticles (Co3O4) of four different sizes (3 nm, 6 nm, 11 nm and 29 nm) with narrow size distribution were prepared by subtle variation of synthesis conditions. These nanoparticles were used as model materials to understand the structural and morphological changes that occur to cobalt oxide ...
Sassi Federica - - 2013
In this study we used an affective priming task to address the issue of whether the processing of emotional facial expressions occurs automatically independent of attention or attentional resources. Participants had to attend to the emotion expression of the prime face, or to a nonemotional feature of the prime face, ...
Han Sang Myung - - 2013
Patients with aneurysmal subarachnoid hemorrhage (SAH) frequently have deficits in learning and memory that may or may not be associated with detectable brain lesions. We examined mediators of long-term potentiation after SAH in rats to determine what processes might be involved. There was a reduction in synapses in the dendritic ...
Rupp Thomas - - 2013
This study investigated the changes in cerebral near-infrared spectroscopy (NIRS) signals, cerebrovascular and ventilatory responses to hypoxia and CO2 during altitude exposure. At sea level (SL), after 24 hours and 5 days at 4,350 m, 11 healthy subjects were exposed to normoxia, isocapnic hypoxia, hypercapnia, and hypocapnia. The following parameters were measured: ...
Rodriguez-Rodriguez Patricia - - 2013
The rates of glucose oxidized at glycolysis and pentose-phosphate pathway (PPP) in neurons are controversial. Using [3-(3)H]-, [1-(14)C]-, and [6-(14)C]glucose to estimate fluxes through these pathways in resting, intact rat cortical primary neurons, we found that the rate of glucose oxidized through PPP was, apparently, ∼14% of total glucose metabolized. ...
Wang Kai-Ping - - 2013
In this study, five novel polysaccharides SLNT1, SLNT2, JLNT1, JLNT2 and JLNT3 were isolated from the fruit body of Lentinus edodes. Chemical and physical analyses showed that the five polysaccharides consist of glucose with the structure of β-(1→3)-D-glucose main chains and β-(1→6)-D-glucose side chains. Moreover, all of them had triple-helical ...
Civile Ciro - - 2013
The face inversion effect (FIE) is a reduction in recognition performance for inverted faces (compared to upright faces) that is greater than that typically observed with other stimulus types (e.g., houses). The work of Diamond and Carey, suggests that a special type of configural information, "second-order relational information" is critical ...
Cheng Yu-Jie - - 2013
IbMYB1, a transcription factor (TF) for R2R3-type MYB TFs, is a key regulator of anthocyanin biosynthesis during storage of sweet potatoes. Anthocyanins provide important antioxidantsof nutritional value to humans, and also protect plants from oxidative stress. This study aimed to increase transgenic potatoes' (Solanum tuberosum.cv. LongShu No.3) tolerance to environmental ...
Beas-Catena Alba - - 2013
The aim of this paper was to study the effect of spent medium recycle on proliferation, metabolism and baculovirus production by the Spodoptera exigua Se301 cell line when grown in batch suspension cultures in Ex-Cell 420 serum-free medium. The results showed that the recycle of 20% of spent medium from ...
Huong Nguyen Lan - - 2013
Biotransformation approach using microbes as biocatalysts can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds, to create the previously uncharacterized therapeutic agents. By employing a recombinant Streptomyces venezuelae as a microbial catalyst, a reduced macrolide, 10,11-dihydrorosamicin was created from rosamicin macrolide. Its chemical structure was ...
Kwon Jae Won - - 2013
Bacillus subtilis JW-1 was isolated from rhizosphere soil as a potential biocontrol agent of bacterial wilt caused by Ralstonia solanacearum. Seed treatment followed by a soil drench application with this strain resulted in > 80% reduction in bacterial wilt disease compared with that in the untreated control under greenhouse conditions. ...
Roux Sébastien - - 2013
This study investigated whether in speech production object properties flow in a cascaded manner or whether cascaded processing is restricted to the object's identity. In Experiments 1 and 2, participants saw pictured objects and had to state either their size (GRAND or PETIT-meaning big and small) or their name. The ...
Jhr Amit Kumar - - 2013
Structurally herboxidiene contains the tetrahydropyran acetic acid moiety and a side chain including a conjugated diene, has been isolated from Streptomyces chromofuscus ATCC49982. Its production was significantly elevated nearly 13.5-fold (0.74 g L(-1)) in a medium supplemented with glycerol (medium No. 6A6), and more efficacious (1.08 g L(-1); 19.8-fold) in ...
Li Jiang - - 2013
An extracellular agarase was purified from Bacillus sp. BI-3, a thermophilic agar-degrading bacterium isolated from a hot spring in Indonesia. The purified agarase revealed a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, with an apparent molecular weight of 58 kDa. The optimum pH and temperature of the agarase were ...
Huang Wenhui - - 2013
Abstract Objective: To evaluate the efficacy and tolerability of lanthanum carbonate(LC) in the treatment of hyperphosphatemia in dialysis patients. Method: Multiple databases were used for recruit the published clinical randomized controlled trials(RCTs) comparing LC with placebo for hyperphosphatemia in dialysis patients from inception to March 2013. Results were expressed using ...
Joyce C W - - 2013
Abstract The number of citations that a published article has received reflects the importance that paper has on that area of practice. In hand surgery, it is unknown which journal articles are cited most frequently. The purpose of this study was to identify and analyze the characteristics of the top ...
Harel Dipak - - 2013
The high antiplasmodial activity of racemic benzylamines rac- and rac- stimulated the synthesis of pure enantiomers. Ellman's chiral sulfinamides (S)- and (R)- were used as chiral auxiliaries. Condensation of prochiral ketone with enantiomerically pure sulfinamides (S)- and (R)- and subsequent NaBH4 reduction provided predominantly unlike configured diastereomers (S,R)- and (R,S)- ...
Guzowski Jan - - 2013
We report automated generation of arbitrary sequences of multiple microdroplets with online and individual control over the number of cores and volumes of all the constituents (cores and shells) of each of the multiple droplets. We show that a given sequence of volumes of the cores always folds to the ...
Aswad Muhammad - - 2013
We report a coupling reaction of thioamides and sulfonyl azides to generate sulfonyl amidines in the absence of any activation additives. The reaction progresses in various solvents under mild conditions. Water exhibits the highest performance with respect to efficiency.
Mills Matthew J L - - 2013
Electrostatic effects play a large part in determining the properties of chemical systems. In addition, a treatment of the polarisation of the electron distribution is important for many systems, including solutions of monatomic ions. Typically employed methods for describing polarisable electrostatics use a number of approximations, including atom-centred point charges ...
Kim Jinsu - - 2013
Aims: S-nitrosylation and S-glutathionylation, redox based modifications of protein thiols, are recently emerging as an important signaling mechanisms. Here, we assessed S-nitrosylation based regulation of JAK2/STAT3 pathway that plays critical roles in immune/inflammatory responses and tumorigenesis. Results: Our studies show that STAT3 in stimulated microglia underwent two distinct redox-dependent modifications, ...
Shah Vishal - - 2013
Exposure of an ecosystem to ionizing radiation remains a possibility either due to accidents involving nuclear fuel rods or contamination with high-level radioactive wastes. While the short and long-term effect of ionizing radiation on higher eukaryotes has been well documented, we do not have an understanding on the recovery of ...
Anderson Stacey E - - 2013
Abstract Allergic disease is an important occupational health concern, with work-related asthma and allergic contact dermatitis being the most frequently diagnosed occupational illnesses. Diisocyanates, particularly toluene 2,4-diisocyanate (TDI), have been the leading cause of occupational asthma for many years. Understanding the mechanisms behind allergic disease is critical for treatment and ...
Calero Christian Solis - - 2013
A liquid is composed of an ensemble of molecules that populate a large number of different states, so calculation of the solvation energy of a molecule in solution requires a method for summing the interactions with the environment over all of these states. The surface site interaction model for the ...
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