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Deretic Vojo V Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, North East, Albuquerque, New Mexico 87131, - - 2013
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and ...
Lam Matthew M Department of Radiology, University of California Davis School of Medicine, 4860 Y St, Suite 3100, Sacramento, CA 95817. - - 2013
Ultrasound backscatter microscopy (UBM), or ultrasound biomicroscopy, is a noninvasive, label-free, and ionizing radiation-free technique allowing high-resolution 3-dimensional structural imaging. The goal of this study was to evaluate UBM for resolving anatomic features associated with squamous cell carcinoma of the oral cavity. The study was conducted in a hamster buccal ...
Teixeira Pedro G PG From the Los Angeles County + University of Southern California Medical Center, Los Angeles, - - 2013
Experimental data have demonstrated a potential survival benefit for animals undergoing splenectomy immediately after traumatic brain injury. The aim of this study was to investigate the effect of splenectomy on survival in patients with moderate or severe traumatic brain injury (TBI). This is a National Trauma Data Bank (2002-2009) analysis ...
Stall Alec A From the R Adams Cowley Shock Trauma Center, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, - - 2013
Higher concentrations of fraction of inspired oxygen (FIO2) have been shown to be associated with lower risk for surgical site infection in multiple studies outside the domain of orthopedic surgery. We evaluated the efficacy of high FIO2 administered during the perioperative period to reduce the rate of surgical site infection ...
Gordon Christopher James CJ From the Sydney Nursing School, The University of Sydney, Sydney, New South Wales, - - 2013
Mastery of auscultatory blood pressure is challenging for preregistration nursing students. This phenomenon has been attributed to the psychomotor skills required, knowledge about blood pressure measurement, and the teaching modality type. Most studies focus on developing blood pressure proficiency without determining the measurement accuracy. We sought to determine the efficacy ...
Stark H H CT1 Trauma & - - 2013
Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness is unknown. To evaluate the effectiveness of local corticosteroid injection for carpal ...
Gärtner Fania R FR From the Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, Amsterdam, the - - 2013
To study the effectiveness of a mental module for workers' health surveillance for health care workers. Nurses and allied health care professionals from one organization were cluster-randomized at ward level to an intervention or control group. The intervention included screening for work functioning impairments and mental health complaints. Positively screened ...
Depestel Daryl D DD Medical Affairs, Cubist Pharmaceuticals Inc, Lexington, MA, - - 2013
There has been dramatic change in the epidemiology of Clostridium difficile infection (CDI) since the turn of the 21st century noted by a marked increase in incidence and severity, occurring at a disproportionately higher frequency in older patients. Historically considered a nosocomial infection associated with antibiotic exposure, CDI has now ...
Looper Jessica K JK Department of Civil Engineering, Auburn University, Auburn, AL 36849, USA. - - 2013
We investigated the impact of the Deepwater Horizon oil spill on microbial communities in wetland sediment and seawater samples collected from sites along the Gulf shore. Based on GC/MS analysis, the sediment from Bay Jimmy, LA had detectable signs of hydrocarbon contamination, identified as n-alkanes in the GC/MS spectrum similar ...
Ryan Patrick H PH Cincinnati Children's Hospital Medical Center, Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, ML 5041, Cincinnati, OH 45229, USA. - - 2013
Idling school buses may increase concentrations of air pollutants including fine particulate matter (PM2.5) and elemental carbon (EC) near schools. Efforts to reduce vehicle idling near schools have rarely included air sampling to objectively assess changes in concentrations of air pollutants. The objective was to determine the impact of an ...
Froehner Sandro S Department of Environmental Engineering, Federal University of Parana, CEP 81531-990, Curitiba, Parana, Brazil. - - 2013
The use of biofilms for adsorption of sterols was investigated for the first time to evaluate sewage contamination in the Barigüi River, Curitiba (Brazil). The characteristics of a biofilm that favor its use in monitoring include the relatively rapid development of biofilms and their capacity to sorb hydrophobic compounds. Some ...
Payne Zachary M ZM Environet, Inc., 1286 Queen Emma Street, Honolulu, Hawaii 96813, USA. - - 2013
A nine-month in situ bioremediation study was conducted in Makua Military Reservation (MMR) in Oahu, Hawaii (USA) to evaluate the potential of molasses to enhance biodegradation of royal demolition explosive (RDX) and high-melting explosive (HMX) contaminated soil below the root zone. MMR has been in operation since the 1940's resulting ...
Barnard Katharine K Corresponding author: Katharine Barnard, - - 2013
Antidepressant use has risen sharply over recent years. Recent concerns that antidepressants may adversely affect glucose metabolism require investigation. Our aim was to assess the risk of type 2 diabetes associated with antidepressants through a systematic review. Data sources were MEDLINE, Embase, PsycINFO, The Cochrane Library, Web of Science, meeting ...
Abdul-Ghani Muhammad A MA Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, - - 2013
Inhibitors of sodium-glucose cotransporter 2 (SGLT2) are a novel class of antidiabetes drugs, and members of this class are under various stages of clinical development for the management of type 2 diabetes mellitus (T2DM). It is widely accepted that SGLT2 is responsible for >80% of the reabsorption of the renal ...
Karlsson Fredrik F Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, - - 2013
Recent findings have demonstrated that the gut microbiome complements our human genome with at least 100-fold more genes. In contrast to our Homo sapiens-derived genes, the microbiome is much more plastic, and its composition changes with age and diet, among other factors. An altered gut microbiota has been associated with ...
McClung Christopher D CD From the Ohio State Medical Center (C.D.M.), Columbus, Ohio; Department of Urology (J.M.H., H.W., B.B.V.), University of Washington Medical Center; and Harborview Injury Prevention and Research Center (J.W., H.W., B.B.V.), Seattle, - - 2013
The National Trauma Data Bank was used to analyze open surgical management of renal trauma during the first 24 hours of hospital admission, excluding those who were treated with conservative measures. A descriptive analysis of initial management trends following renal trauma was also performed as a secondary analysis. With the ...
Goldner Whitney S WS From the Diabetes, Endocrinology and Metabolism Division (Dr Goldner), Department of Internal Medicine, University of Nebraska Medical Center, Omaha; Department of Biostatistics (Dr Yu and Ms Shostrom), College of Public Health, University of Nebraska Medical Center, Omaha; Pulmonary, Critical Care, Sleep, and Allergy Division (Dr LeVan), Departments of Internal Medicine and Epidemiology, University of Nebraska Medical Center, Omaha; Epidemiology Branch (Drs Sandler, Hoppin, and Kamel), National Institute of Environmental Health Sciences, Research Triangle Park, NC; and VA Nebraska-Western Iowa Health Care System Research Service (Dr LeVan), Department of Veterans Affairs Medical Center, - - 2013
Evaluate the association between thyroid disease and use of insecticides, herbicides, and fumigants/fungicides in male applicators in the Agricultural Health Study. We examined the association between use of 50 specific pesticides and self-reported hypothyroidism, hyperthyroidism, and "other" thyroid disease among 22,246 male pesticide applicators. There was increased odds of hypothyroidism ...
Jacobsen Henrik Borsting HB From the Harvard School of Public Health (Drs Jacobsen, Caban-Martinez, Sorensen, Dennerlein, and Reme and Ms Onyebeke), Northeastern University (Dr Dennerlein), and Dana-Farber Cancer Institute (Dr Sorensen), Boston, Mass; Uni Health (Dr Reme), Uni Research, Bergen, Norway; and Norwegian University of Science and Technology (Dr Jacobsen), Trondheim, - - 2013
We aimed to investigate how mental distress was associated with pain and injuries in a convenience sample of construction workers. A cross-sectional, mental health assessment was conducted in a convenience sample of construction workers (N = 172). A subsample participated in a clinical interview (n = 10). We used a ...
Calanna Salvatore S Corresponding author: Filip K. Knop, - - 2013
To investigate glucose-dependent insulinotropic polypeptide (GIP) secretion in patients with type 2 diabetes and nondiabetic control subjects during oral glucose or meal tests. Eligible trials were identified by The Cochrane Library, MEDLINE, Embase, and Web of Science. Data were retrieved and random-effects models for the primary meta-analysis, random-effects meta-regression, and ...
Luque-Fernandez Miguel Angel MA Corresponding author: Miguel Angel Luque-Fernandez, - - 2013
Recently, sleep-disordered breathing (SDB) has been reported to be associated with the development of gestational diabetes mellitus (GDM). Accordingly, as this is emergent area of research that has significant clinical relevance, the objective of this meta-analysis is to examine the relationship between SDB with GDM. We searched several electronic databases ...
McCauley Linda L From the Nell Hodgson School of Nursing (Drs McCauley, Runkle, and Williams and Ms Semple), Emory University, Atlanta, Ga.; Oregon Law Center (Dr Samples), Hillsboro, Ore.; Oregon Law Center (Dr Shadbeh), Portland, Ore.; and Nutrition Sciences Department of the College of Nursing and Health Professions (Dr Muniz), Drexel University, Philadelphia, - - 2013
To examine changes in health beliefs, pesticide safety knowledge, and biomarkers of pesticide exposure in indigenous farmworkers who received enhanced pesticide safety training compared with those receiving the standard training. Farmworkers in Oregon were randomly assigned to either a promotors pesticide safety training program or a standard video-based training. Spot ...
Johnson Richard J RJ Division of Kidney Diseases and Hypertension, University of Colorado Denver, Aurora, - - 2013
The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup has increased dramatically in the last hundred years and correlates closely with the rise in obesity, metabolic syndrome, and diabetes. Fructose is a major component of added sugars and is distinct from other sugars in ...
Brancolini Giorgia G CNR Institute of Nanoscience , S3 Center, Via Campi 213/A, 41125 Modena, - - 2013
We address the issue of whether chemical alterations of nucleobases are an effective tool to modulate charge transfer through DNA molecules. Our investigation uses a multilevel computational approach based on classical molecular dynamics and quantum chemistry. We find yet another piece of evidence that structural fluctuations are a key factor ...
Zhang Long Jiang - - 2013
To investigate the pattern of brain volume changes in patients with end-stage renal disease (ESRD) using voxel-based morphometry (VBM) and correlation with clinical and neuropsychological (NP) tests. Fifty seven ESRD patients with no anatomical abnormalities in conventional magnetic resonance imaging [24 patients with abnormal NP scores, 16 male, 39 ± 12 years; 33 ...
Esposito Katherine - - 2013
Metabolic syndrome has become a major public health problem worldwide and represents a common clinical condition in countries with a high incidence of obesity and western dietary patterns. Metabolic syndrome associates with common cancers at many sites, including liver, colorectal, and bladder cancers in men, and endometrial, pancreatic, breast post-menopausal, ...
Huang Wen - - 2013
Elevated thyrotropin (TSH) and hypercholesterolemia commonly coexist in patients with subclinical hypothyroidism, which can cause and aggravate heart disease. However, it is unclear whether TSH has a direct effect on cardiac function. To determine the expression of the thyrotropin receptor (TSHR) and the effects of TSH on ventricular function, we ...
Wu Xiaohong - - 2013
To investigate whether Nischarin participated in neuronal apoptosis induced by neuroinflammation and via the phosphatidylinositol 3-kinase (PI3K) and PKB-dependent pathway. Use of male Sprague-Dawley rats, rat pheochromocytoma (PC12), and murine microglial cells (BV-2). Treatment lipopolysaccharides (LPS) were injected into the brain lateral ventricle of the rat. The BV-2 cells were ...
Wang Quanfu - - 2013
Thioredoxin (Trx) is a highly conserved and multi-functional protein that plays a pivotal role in maintaining the redox state of the cell and in protecting the cell against oxidative stress. Trx gene from Antarctic sea-ice bacteria Pseudoalteromonas sp. AN178 was cloned and expressed as soluble protein in Escherichia coli (designated ...
Wang Shengman - - 2013
Heavy metal pollution and soil acidification are serious global environmental issues. The combined pollution from acidification and heavy metal has become a new environmental issue in regions where the two issues simultaneously occur. However, studies on combined pollution are still limited. In the current study, we investigated the combined effect ...
Markov Dmitry A - - 2013
Polydimethylsiloxane (PDMS) is a commonly used polymer in the fabrication of microfluidic devices due to such features as transparency, gas permeability, and ease of patterning with soft lithography. The surface characteristics of PDMS can also be easily changed with oxygen or low pressure air plasma converting it from a hydrophobic ...
Kim Jin Wook - - 2013
Despite the favorable outcomes of radiosurgery for central neurocytoma (CN), these results are based on case series that included a limited number of patients and short follow-up periods because of the scarcity of CN. Because CN is a benign tumor with an indolent clinical course, long-term follow-up and analysis of ...
Bode K - - 2013
In western countries one in ten of elderly persons (> 65 years old) will develop atrial fibrillation. The main goal in atrial fibrillation therapy is the prophylaxis of thromboembolic complications through anticoagulation according to the individual risk profile (CHA2DS2-Vasc score) of patients and treatment of cardiovascular comorbidities. Symptoms during atrial fibrillation ...
- - 2013
It is more than seven months since the government was asked to draw up a national uniform policy so that patients in English hospitals could distinguish easily between nurses and other staff. To date ministers have had nothing to say on the issue.
- - 2013
Essential facts About one in five patients who are emergency admissions to hospital will present with acute kidney injury (AKI), a condition that involves the loss of kidney function over hours or days. Despite its prevalence, there are low levels of awareness and education about AKI among healthcare professionals. Care ...
Savage Melanie - - 2013
Nurses are required to keep their knowledge and skills up to date to ensure their practice is evidence-based. Reflection in and on practice can be used to ensure care provision is evidence-based, to increase self-awareness and to promote positive change. Timely communication of high-quality information tailored to patients' needs is ...
Vaughan Julie - - 2013
Ambulatory emergency care units are present in many hospitals and accommodate patients who need urgent medical assessment or procedures but do not require inpatient admission to achieve this. This article reports on a project undertaken in the ambulatory care unit at the Royal United Hospital Bath, which introduced a nurse-led ...
Jones Ben - - 2013
Few jobs in nursing and health care are as stressful as those of nurse managers.
Colwell Ginny - - 2013
Increasing the probability of getting promoted usually starts long before the job advertisement appears.
Davies Nicola - - 2013
You covered a colleague's shifts last weekend and worked your regular shifts this week and have not been at home for 36 consecutive hours for 12 days. As you update a patient's medication chart, you realise that you just recorded administering 10cc of morphine instead of 4cc. You have made ...
Ballantyne Helen - - 2013
To be honest, my memories of the first few months of nurse training are rather hazy. As late-night partying is not my style, I attribute my amnesia to the kaleidoscope of emotions and events that I experienced.
Adams Michael - - 2013
At the beginning of your nursing career, remember that being a caring and compassionate nurse is an absolute priority. Studying for a degree does not change this - in fact, a better education should enhance these skills.
Day Karen - - 2013
Some students do not discover that they have dyslexia until they reach university and the realisation can be both a shock and a relief. Many develop good coping strategies and may not disclose their disability.
Bennetts Brett - - 2013
Uniquely, the ClC family harbours dissipative channels and anion/H(+) transporters that share unprecedented functional characteristics. ClC-1 channels are homodimers in which each monomer supports an identical pore carrying three anion-binding sites. Transient occupancy of the extracellular binding site by a conserved glutamate residue, E232, independently gates each pore. A common ...
Li Wei-Zhen - - 2013
The development of thermally stable, nanometer-sized precious metal-based catalysts remains a daunting challenge. Such materials, especially those based on the use of costly platinum metal, are essential and, to date, non-replaceable for a large number of industrially important catalytic processes. Here we report a well-defined cuboctahedral MgAl2O4 spinel support material ...
Rhodes Lesley - - 2013
This review article outlines harmful algal bloom (HAB) monitoring practices in New Zealand and highlights the shift from light microscope (LM)-based identification and quantification of the early 1990s to the use of molecular tools to support the HAB monitoring programmes two decades later. Published research and available client information from ...
Gillen Sally - - 2013
The RCN is calling for swift action to implement a recommendation on safe staffing by Robert Francis in his report on care failings at Mid Staffs.
Trueland Jennifer - - 2013
Nurses should be trained in recognising vision problems in patients following an acute stroke, according to guidance launched last week.
Keogh Kat - - 2013
Each year, front line NHS staff are offered a free seasonal flu vaccination to help protect them and their patients from picking up the virus.
Arif Zeba - - 2013
The health select committee has called on hospitals in England to display publicly the number of nurses on duty on each ward. The committee members say this would lead to greater openness and would help to increase trust in the NHS.
Stockwell Felicity - - 2013
I write in support of Benny Goodman's letter (September 18) questioning if revalidation can make any difference in improving nursing standards.
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