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Kim Soon Ok SO Physiological - - 2013
Prostaglandin E2 (PGE2) produced within the ovarian follicle is necessary for ovulation. PGE2 is recognized by four distinct G-protein-coupled receptors. Among them, PTGER3 (also known as EP3) is unique in that mRNA splicing generates multiple isoforms. Each isoform has a distinct amino acid composition in the C-terminal region, which is ...
Vamvini Maria T MT Division of Endocrinology, Diabetes and Metabolism, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, - - 2013
Skeletal muscle is considered to be an endocrine organ that secretes a number of myokines including follistatin (FST), myostatin (MSTN), activin A, and the newly identified irisin. Irisin's biology and function exhibit similarities with the functions of the FST-MSTN-activin A axis. It remains unknown whether there is any interplay among ...
Berbasova Tetyana T Department of Chemistry, Michigan State University , East Lansing, Michigan 48824, United - - 2013
Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described. Through rational alterations of the binding pocket, electrostatic perturbations of the embedded retinylidene chromophore that favor delocalization of the iminium charge lead to exquisite control in the regulation ...
Yin Tao T Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts 02115, United - - 2013
To establish a homing signal in the lung to recruit circulating stem cells for tissue repair, we formulated a nanoparticle, SDF-1α NP, by complexing SDF-1α with dextran sulfate and chitosan. The data show that SDF-1α was barely released from the nanoparticles over an extended period of time in vitro (3% ...
Palekar Rohun U RU Department of Biomedical Engineering, ‡Department of Cell Biology and Physiology, §Department of Medicine, and ∥Department of Physics, Washington University in St. Louis, Consortium for Translational Research in Advanced Imaging and Nanomedicine , 4320 Forest Park Avenue, St. Louis, Missouri 63108, United - - 2013
The goal of the present work was to design and test an acute-use nanoparticle-based antithrombotic agent that exhibits sustained local inhibition of thrombin without requiring a systemic anticoagulant effect to function against acute arterial thrombosis. To demonstrate proof of concept, we functionalized the surface of liposomes with multiple copies of ...
Odokonyero Denis D Department of Biochemistry and Biophysics, Texas A&M University , 2128 TAMU, College Station, Texas 77843-2128, United - - 2013
Thermobifida fusca o-succinylbenzoate synthase (OSBS), a member of the enolase superfamily that catalyzes a step in menaquinone biosynthesis, has an amino acid sequence that is 22 and 28% identical with those of two previously characterized OSBS enzymes from Escherichia coli and Amycolatopsis sp. T-1-60, respectively. These values are considerably lower ...
Morse Jessica L JL Department of Pathology and Laboratory Medicine, Brown University , 70 Ship Street, Providence, Rhode Island 02912, United - - 2013
Hexavalent chromium is a human carcinogen activated primarily by direct reduction with cellular ascorbate and to a lesser extent, by glutathione. Cr(III), the final product of Cr(VI) reduction, forms six bonds allowing intermolecular cross-linking. In this work, we investigated the ability of Cr(VI) to cause interstrand DNA cross-links (ICLs) whose ...
Magut Paul K S PK Department of Chemistry, Louisiana State University , Baton Rouge, Louisiana 70803, United - - 2013
Chemotherapeutic agents with low toxicity to normal tissues are a major goal in cancer research. In this regard, the therapeutic activities of cationic dyes, such as rhodamine 6G, toward cancer cells have been studied for decades with observed toxicities toward normal and cancer cells. Herein, we report rhodamine 6G-based organic ...
Gattás-Asfura Kerim M KM Diabetes Research Institute, University of Miami , Miami, Florida 33136 United - - 2013
Encapsulation of viable tissues via layer-by-layer polymer assembly provides a versatile platform for cell surface engineering, with nanoscale control over the capsule properties. Herein, we report the development of a hyperbranched polymer-based, ultrathin capsule architecture expressing bioorthogonal functionality and tailored physiochemical properties. Random carbodiimide-based condensation of 3,5-dicarboxyphenyl glycineamide on alginate ...
Maiti Atanu A Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine , Baltimore, Maryland 21201, United - - 2013
5-Methylcytosine (mC) is an epigenetic mark that impacts transcription, development, and genome stability, and aberrant DNA methylation contributes to aging and cancer. Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-carboxylcytosine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and restoration ...
Qin Xiaoyan X Interdisciplinary Graduate Program in Human Toxicology, University of Iowa , Iowa City, Iowa 52242, United - - 2013
Human hydroxysteroid sulfotransferase (hSULT2A1) catalyzes the sulfation of a broad range of environmental chemicals, drugs, and other xenobiotics in addition to endogenous compounds that include hydroxysteroids and bile acids. Polychlorinated biphenyls (PCBs) are persistent environmental contaminants, and oxidized metabolites of PCBs may play significant roles in the etiology of their ...
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THIS BOOK identifies important lessons for nurses interested in becoming executive leaders in healthcare organisations. The text draws from the literature on business and executive leadership, and applies the key concepts to the nursing and healthcare contexts.
Cohn Stephen M - - 2013
We sought to perform the first characterization of vasopressin and other vasoactive mediators released during resuscitation of hypotensive trauma patients. This institutional review board-approved study was conducted under waiver of consent. Adults with clinical evidence of acute traumatic injury and systolic blood pressure less than or equal to 90 mm ...
Desille Hélène - - 2013
Since 2007, we have identified 2 cases of central uterine necrosis after uterine arterial embolization for postpartum hemorrhage. Contrast-enhanced sonography showed an absence of enhancement of the internal myometrium. Magnetic resonance imaging with gadolinium confirmed the diagnosis. The images obtained for the first case were corroborated by histologic analysis from ...
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POORLY DEFINED goals, too much box ticking and regulation, and variable staff support are stifling the NHS, an analysis of its culture and behaviours has shown.
Lee Seon-Young - - 2013
Randomized controlled trials (RCTs) are the criterion standard for assessing new interventions. However, bias can result from poor reporting, which also makes critical appraisal and systematic review challenging. The Consolidated Standards of Reporting Trials (CONSORT) criteria for nonpharmacological trials published in 2008 provided a set of 23 mandatory items that ...
Park Dae Woo - - 2013
This study investigated the use of ultrasound speckle decorrelation- and correlation-based lateral speckle-tracking methods for transverse and longitudinal blood velocity profile measurement, respectively. By studying the blood velocity gradient at the vessel wall, vascular wall shear stress, which is important in vascular physiology as well as the pathophysiologic mechanisms of ...
Miyague Andre H - - 2013
Spatiotemporal image correlation can be used to acquire 3-dimensional power Doppler information across a single cardiac cycle. Assessment and comparison of the systolic and diastolic components of the data sets allow measurement of the recently introduced "volumetric pulsatility index" (vPI) through algorithms comparable with those used in 2-dimensional Doppler waveform ...
McCauley Linda L From the Nell Hodgson School of Nursing (Drs McCauley, Runkle, and Williams and Ms Semple), Emory University, Atlanta, Ga.; Oregon Law Center (Dr Samples), Hillsboro, Ore.; Oregon Law Center (Dr Shadbeh), Portland, Ore.; and Nutrition Sciences Department of the College of Nursing and Health Professions (Dr Muniz), Drexel University, Philadelphia, - - 2013
To examine changes in health beliefs, pesticide safety knowledge, and biomarkers of pesticide exposure in indigenous farmworkers who received enhanced pesticide safety training compared with those receiving the standard training. Farmworkers in Oregon were randomly assigned to either a promotors pesticide safety training program or a standard video-based training. Spot ...
Balsam Rosemary - - 2013
These three early psychoanalysts, who differed in important ways from Freud, each tried to shift his fundamental beliefs about women's bodies in basic developmental theory. This paper illustrates this point by elaborating their materials concerning the centrality of childbirth. One thematic aspect of Freud's disruptive fights with colleagues lay in ...
Chen T - - 2013
Objectives: The objective of this study is to determine the prevalence of antibiotic resistance factors, including the production of extended-spectrum beta-lactamases (ESBLs) and the presence of class 1 integrons among Escherichia coli isolated from clinical specimens. Materials and Methods: Bacterial species identification was performed using a VITEK-2 system (VITEK2 GN-card; ...
Porter Zoe - - 2013
A large-scale study ( Forder et al 2012 ) piloting personal health budgets for people with long-term conditions found that they improved patients' quality of life and psychological wellbeing. They were cost-effective and reduced the use of other healthcare services. From April next year, people receiving NHS continuing healthcare funding ...
Barczyk Amanda N - - 2013
Unintentional injury is the leading cause of death for children in the United States. An association between parental alcohol use and the frequency and severity of childhood injuries has been found; however, research is limited. The purpose of this study was to (1) describe demographics, child safety behaviors, and parental ...
- - 2013
A booklet that guides people through a new diagnosis of dementia has been launched by the Alzheimer's Society. It is designed for front line healthcare professionals to offer people who have recently been diagnosed with the condition and their relatives.
Roh Hyun-Jin - - 2013
Objectives- Cervical length assessment is helpful to predict and prevent preterm birth. However, transvaginal sonography is not easy to perform. The aim of this study was to investigate the relationship and discrepancies between cervical lengths measured by transabdominal and transvaginal sonography in midpregnancy. Methods- Transabdominal and transvaginal cervical lengths were ...
Elliott Sarah - - 2013
THE NEW commissioning architecture of NHS England offers a unique opportunity for nurses to use their knowledge, insight and clinical skills to meet the changing needs of patients and populations.
Foy Pamela M - - 2013
Objectives- The purpose of this study was to determine whether normal fetal cardiac anatomy could be successfully demonstrated and congenital heart disease detected transabdominally at 14 to 18 weeks' gestation in fetuses with a nuchal translucency greater than or equal to the 95th percentile. Methods- In this retrospective chart review, ...
Teixeira Pedro G R - - 2013
The use of a "quality rounds checklist" (QRC) is an effective tool for improving compliance with evidence-based preventative measures and outcomes in the surgical intensive care unit (SICU). Our aim was to evaluate the long-term sustainability and outcome impact of this quality improvement strategy. Prospective observational study evaluates the use ...
Pintoffl Jan P - - 2013
Objective- To measure blood perfusion in extramedullary myeloma by contrast-enhanced sonography, correlate it with specific hematologic parameters, and determine their utility for local and systemic response monitoring. Methods- Twenty-five consecutive patients (14 male and 11 female; median age, 68 years) with extramedullary myeloma were included. After intravenous administration of 2.4 ...
Hamidi-Fard M - - 2013
Background: It has been revealed that mutations can occur spontaneously and naturally in HBV reverse transcriptase (RT) region among untreated patients. These HBV mutants pre-exist as minor viral population in naive patients and can emerge as major viral population, conferring drug resistance and treatment failure. Objectives: The aim of this ...
Khyriem A B - - 2013
Subcutaneous Human Dirofilariasis is an uncommon zoonotic infection caused by Dirofilariarepens. The reports of this infection in humans in India are limited, although increasingly being reported worldwide. We report a case of Dirofilariasis with subcutaneous presentation from the state of Meghalaya and to emphasize the importance of considering this entity ...
- - 2013
THE NURSING and Midwifery Council (NMC) has committed to introduce a 'proportionate and effective' model of revalidation by the end of 2015 to enhance public protection.
Gedo John E - - 2013
To demonstrate the relevance of an artist's biography to the understanding of her creations, no instance is more persuasive than the career of the 17th-century Italian painter Artemisia Gentileschi. Numerous scholars have attempted to correlate the nature of her subject matter with the more dramatic events of her picaresque private ...
Clement R Carter - - 2013
Many hospitals in the United States are seeking to obtain and maintain trauma credentialing. Assessment of trauma center success has traditionally focused on mortality without directed measure of surgical subspecialization. However, survival alone may not be a sufficient marker of success with modern health care. The purpose of this study ...
Praharaj I - - 2013
Nontyphoidal Salmonella (NTS) are established foodborne pathogens, most commonly reported in cases of gastroenteritis. These pathogens are however, increasingly being implicated in cases of bacteraemia and other extraintestinal manifestations. We report a case of a scalp abscess due to Salmonella enterica serotype Enteritidis, which is a serotype of NTS, in ...
Stark H H CT1 Trauma & - - 2013
Carpal tunnel syndrome is a clinical syndrome manifested by signs and symptoms of irritation of the median nerve at the carpal tunnel in the wrist. Local corticosteroid injection for carpal tunnel syndrome has been studied but its effectiveness is unknown. To evaluate the effectiveness of local corticosteroid injection for carpal ...
- - 2013
NEW BEDS that allow patients to close curtains and control the lighting themselves are being trialled.
Sharma V - - 2013
Purpose: There are increasing reports on failure of clinical response to ciprofloxacin in typhoid fever despite the strain being sensitive to drug in in-vitro using standard guidelines and showing mutations in DNA gyrase. But this increased MIC and clinical failures with ciprofloxacin are not always co-related with mutations presently identified ...
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THIS IS a fascinating and timely look at American health care and the healthcare business in the US.
Reeves Fairleigh - - 2013
Patients with blunt head injury are at high risk of venous thromboembolism. However, pharmacologic thromboprophylaxis (PTP) may cause progression of intracranial hemorrhage, and clinicians must often weigh up the risks and benefits. This review aimed to determine whether adding PTP to mechanical prophylaxis confers net benefit or harm and the ...
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MENTAL HEALTH service users have more than double the attendance rate across hospital services compared with the general population, figures for 2011/12 suggest.
Bergmann Martin S - - 2013
The relationship between love and the symbiotic phase of childhood is explored from a new angle in terms of a conflict between "the woman I love" and "the woman I cannot live without." Love requires dependency, but it can also lead to giving up independent existence; then it becomes inimical ...
Gordon Christopher James CJ From the Sydney Nursing School, The University of Sydney, Sydney, New South Wales, - - 2013
Mastery of auscultatory blood pressure is challenging for preregistration nursing students. This phenomenon has been attributed to the psychomotor skills required, knowledge about blood pressure measurement, and the teaching modality type. Most studies focus on developing blood pressure proficiency without determining the measurement accuracy. We sought to determine the efficacy ...
Lalwani S - - 2013
Trauma contributes to a significant proportion of mortality and morbidity in the economically productive age group of 15-45 years. Infections are the second most important cause of death in trauma patients after head injury. Despite advances in trauma care, deaths due to septicemia are increasing. An epidemiological study of septicemia-related ...
Mica Ladislav - - 2013
Obesity is a growing problem in western societies. The aim of this retrospective cohort study was to determine the association between the overweight and obese polytrauma patients and pneumonia after injury. A total of 628 patients with an Injury Severity Score (ISS) of 16 or greater and 16 years or ...
Cheng Qiansong - - 2013
Acquired hemophilia A (AHA) is a rare disease induced by autoantibodies to factor VIII (FVIII) and may be correlated with pregnancy, underlying malignancies, autoimmune diseases or drug administration. An 81-year-old man who presented with cough, expectoration, hemoptysis and multiple ecchymoses was diagnosed with community-acquired pneumonia by computed tomography scan. Respiratory ...
Wang Nancy E - - 2013
Trauma centers (TCs) have been shown to decrease mortality in adults, but this has not been demonstrated at a population level in all children. We hypothesized that seriously injured children would have increased survival in a TC versus nontrauma center (nTC), but there would be no increased benefit from pediatric-designated ...
Aarthi P - - 2013
Purpose: To detect and identify the aetiological agent in the peripheral blood from the cases of neonatal sepsis. Materials and Methods: Four neonates from geographically different regions of South India presented with signs of neonatal sepsis and all the routine clinical and laboratory investigations were performed. Blood culture by Bac ...
Ahmed Mohanad M - - 2013
The aim of this study was to explore baseline data, laboratory and molecular analyses to determine if any could serve as potential prognostic marker(s) for treatment response to second line tuberculosis regimens. Of a total number of 50 multi-drug resistant tuberculosis (MDR-TB) patients starting second-line drug MDR-TB treatment in Iraq, ...
Hess Dean R - - 2013
Evidence-based medicine (EBM) is the integration of individual clinical expertise with the best available research evidence from systematic research and the patient's values and expectations. A hierarchy of evidence can be used to assess the strength upon which clinical decisions are made. The efficient approach to finding the best evidence ...
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